CY1124054T1 - Τεχνητα δακρυα που περιεχουν υαλουρονικο νατριο και καρβοξυμεθυλοκυτταρινη - Google Patents
Τεχνητα δακρυα που περιεχουν υαλουρονικο νατριο και καρβοξυμεθυλοκυτταρινηInfo
- Publication number
- CY1124054T1 CY1124054T1 CY20201101166T CY201101166T CY1124054T1 CY 1124054 T1 CY1124054 T1 CY 1124054T1 CY 20201101166 T CY20201101166 T CY 20201101166T CY 201101166 T CY201101166 T CY 201101166T CY 1124054 T1 CY1124054 T1 CY 1124054T1
- Authority
- CY
- Cyprus
- Prior art keywords
- carboxymethyl cellulose
- sodium hyaluronate
- containing sodium
- artificial tears
- tears containing
- Prior art date
Links
- 229920002385 Sodium hyaluronate Polymers 0.000 title 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 title 1
- 239000000607 artificial tear Substances 0.000 title 1
- 239000001768 carboxy methyl cellulose Substances 0.000 title 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 title 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 title 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 title 1
- 229940010747 sodium hyaluronate Drugs 0.000 title 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 229920002674 hyaluronan Polymers 0.000 abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- 230000004397 blinking Effects 0.000 abstract 1
- 210000004087 cornea Anatomy 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Οι υλοποιήσεις οι οποίες περιγράφονται στο παρόν σχετίζονται με σκευάσματα και μεθόδους χρήσης για σκευάσματα οφθαλμικών σταγόνων που περιέχουν καρβοξυμεθυλοκυτταρίνη (CMC) και υαλουρονικο οξύ (ΗΑ) με βελτιωμένη κατανομή στον κερατοειδή χιτώνα κατά τη διάρκεια του βλεφαρισμού.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759710P | 2013-02-01 | 2013-02-01 | |
| US201361785857P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/014505 WO2014121232A1 (en) | 2013-02-01 | 2014-02-03 | Artificial tears comprising sodium hyaluronate and carboxymethylcellulose |
| EP14704747.6A EP2950783B1 (en) | 2013-02-01 | 2014-02-03 | Artificial tears comprising sodium hyaluronate and carboxymethylcellulose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124054T1 true CY1124054T1 (el) | 2022-03-24 |
Family
ID=50113045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201101166T CY1124054T1 (el) | 2013-02-01 | 2020-12-09 | Τεχνητα δακρυα που περιεχουν υαλουρονικο νατριο και καρβοξυμεθυλοκυτταρινη |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20140221309A1 (el) |
| EP (2) | EP3517100B1 (el) |
| JP (2) | JP6527468B2 (el) |
| KR (1) | KR102227202B1 (el) |
| CN (2) | CN111419794A (el) |
| AU (2) | AU2014212025A1 (el) |
| BR (1) | BR112015018414B1 (el) |
| CA (1) | CA2898217C (el) |
| CY (1) | CY1124054T1 (el) |
| DK (2) | DK2950783T3 (el) |
| ES (2) | ES2741141T3 (el) |
| HK (1) | HK1218517A1 (el) |
| HR (1) | HRP20191382T1 (el) |
| HU (2) | HUE052793T2 (el) |
| LT (1) | LT2950783T (el) |
| MX (1) | MX367461B (el) |
| PL (2) | PL3517100T3 (el) |
| PT (2) | PT2950783T (el) |
| RS (1) | RS59271B1 (el) |
| RU (1) | RU2687275C2 (el) |
| SA (1) | SA517381008B1 (el) |
| SI (2) | SI3517100T1 (el) |
| WO (1) | WO2014121232A1 (el) |
| ZA (1) | ZA201505026B (el) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9492474B2 (en) | 2013-07-10 | 2016-11-15 | Matrix Biology Institute | Compositions of hyaluronan with high elasticity and uses thereof |
| US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| US20170014339A1 (en) * | 2015-07-17 | 2017-01-19 | i.com medical GmbH | Tear Substitute, Fluid for Being Used as a Tear Substitute, and Method for Producing a Tear Substitute |
| PL3352766T3 (pl) | 2015-09-24 | 2021-08-02 | Matrix Biology Institute | Kompozycie z hialuronanem o dużej elastyczności i sposoby ich użycia |
| US20180338911A1 (en) * | 2015-10-28 | 2018-11-29 | David B. Welch | Eye Drops |
| ES2621877B1 (es) * | 2016-01-04 | 2018-05-04 | Agencia Pública Empresarial Sanitaria Hospital De Poniente | Solución para resección endoscópica |
| US10632202B2 (en) | 2016-03-04 | 2020-04-28 | Johnson & Johnson Consumer Inc. | Preservative containing compositions |
| GB201618175D0 (en) * | 2016-10-27 | 2016-12-14 | Warneford Healthcare Ltd | Pharmaceutical compositions |
| EP3412276A3 (de) * | 2017-06-09 | 2019-07-17 | Omnivision GmbH | Zusammensetzung zur behandlung des trockenen auges |
| US20210353759A1 (en) * | 2018-09-20 | 2021-11-18 | The Hong Kong University Of Science And Technology | Eyedrop compositions |
| KR102051356B1 (ko) * | 2019-01-03 | 2019-12-03 | (주)휴온스 | 고농도의 히알루론산 또는 그의 염을 함유하는 점안 조성물 |
| CA3212305A1 (en) * | 2021-03-10 | 2022-09-15 | Bausch + Lomb Ireland Limited | Contact lens treating solution |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017229A (en) | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| US6271216B1 (en) * | 1989-07-24 | 2001-08-07 | Allergan | Stable solution of hyaluronate in a balanced salt medium |
| NZ513517A (en) * | 1999-02-19 | 2003-08-29 | Denki Kagaku Kogyo Kk | Hyaluronic acid gel composition containing a polymer for use as a wound dressing |
| AU3886600A (en) | 1999-03-15 | 2000-10-04 | Trustees Of Boston University | Angiogenesis inhibition |
| BR0015436A (pt) * | 1999-11-09 | 2002-07-16 | Alcon Inc | Sais de hidroxieicosatetraenoato, composições e métodos de uso no tratamento de distúrbios dos olhos secos |
| IL149800A0 (en) * | 1999-12-17 | 2002-11-10 | Genzyme Corp | Surgical prosthesis |
| CN1485395A (zh) * | 2002-09-25 | 2004-03-31 | 宋海涛 | 一种环保型“冷热液” |
| US20040137079A1 (en) * | 2003-01-08 | 2004-07-15 | Cook James N. | Contact lens and eye drop rewetter compositions and methods |
| JP2006052160A (ja) * | 2004-08-10 | 2006-02-23 | Rohto Pharmaceut Co Ltd | ドライアイ治療用眼科組成物 |
| JP2006143590A (ja) * | 2004-10-21 | 2006-06-08 | Rohto Pharmaceut Co Ltd | 粘膜適用組成物 |
| JP2008519846A (ja) * | 2004-11-09 | 2008-06-12 | アドバンスト メディカル オプティクス， インコーポレーテッド | 眼科用溶液 |
| US8569367B2 (en) * | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| KR20090053892A (ko) * | 2006-07-25 | 2009-05-28 | 오스모티카 코프. | 점안액 |
| WO2008073193A2 (en) * | 2006-11-06 | 2008-06-19 | Novartis Ag | Ocular devices and methods of making and using thereof |
| US8609634B2 (en) * | 2007-05-16 | 2013-12-17 | Mcneil-Ppc, Inc. | Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods |
| KR100827400B1 (ko) * | 2008-06-24 | 2008-05-06 | 김정춘 | 파이프 연결구를 갖는 수도계량기 및 그 제조방법 |
| KR100938500B1 (ko) * | 2008-06-24 | 2010-01-28 | 주식회사 디에이치피코리아 | 안과질환 예방 및 치료용 점안제 조성물 |
| US20100086512A1 (en) | 2008-10-02 | 2010-04-08 | Rolf Schaefer | Mucomimetic compositions and uses therefore |
| WO2010047927A1 (en) * | 2008-10-20 | 2010-04-29 | Allergan, Inc. | Ophthalmic compositions useful for improving visual acuity |
| AR079479A1 (es) * | 2009-12-15 | 2012-01-25 | Foresight Biotherapeutics Inc | Composiciones oftalmicas no irritantes de povidona iodada |
| CN101785852A (zh) * | 2010-01-21 | 2010-07-28 | 孙杰 | 一种真皮层微量介入美容抗衰除皱制剂与方法 |
| CN101884602A (zh) * | 2010-03-03 | 2010-11-17 | 孙杰 | 一种皮肤美容修复抗衰除皱的化妆品制剂 |
-
2014
- 2014-02-03 AU AU2014212025A patent/AU2014212025A1/en not_active Abandoned
- 2014-02-03 RS RSP20190971 patent/RS59271B1/sr unknown
- 2014-02-03 EP EP19151359.7A patent/EP3517100B1/en active Active
- 2014-02-03 RU RU2015132974A patent/RU2687275C2/ru active
- 2014-02-03 HU HUE19151359A patent/HUE052793T2/hu unknown
- 2014-02-03 ES ES14704747T patent/ES2741141T3/es active Active
- 2014-02-03 US US14/171,076 patent/US20140221309A1/en not_active Abandoned
- 2014-02-03 BR BR112015018414-6A patent/BR112015018414B1/pt active IP Right Grant
- 2014-02-03 CN CN202010439040.1A patent/CN111419794A/zh active Pending
- 2014-02-03 ES ES19151359T patent/ES2841434T3/es active Active
- 2014-02-03 CA CA2898217A patent/CA2898217C/en active Active
- 2014-02-03 SI SI201431728T patent/SI3517100T1/sl unknown
- 2014-02-03 CN CN201480007049.8A patent/CN104981234A/zh active Pending
- 2014-02-03 DK DK14704747.6T patent/DK2950783T3/da active
- 2014-02-03 MX MX2015009924A patent/MX367461B/es active IP Right Grant
- 2014-02-03 PL PL19151359T patent/PL3517100T3/pl unknown
- 2014-02-03 JP JP2015556212A patent/JP6527468B2/ja active Active
- 2014-02-03 PL PL14704747T patent/PL2950783T3/pl unknown
- 2014-02-03 WO PCT/US2014/014505 patent/WO2014121232A1/en active Application Filing
- 2014-02-03 LT LT14704747T patent/LT2950783T/lt unknown
- 2014-02-03 SI SI201431299T patent/SI2950783T1/sl unknown
- 2014-02-03 EP EP14704747.6A patent/EP2950783B1/en active Active
- 2014-02-03 PT PT14704747T patent/PT2950783T/pt unknown
- 2014-02-03 KR KR1020157023645A patent/KR102227202B1/ko active IP Right Grant
- 2014-02-03 PT PT191513597T patent/PT3517100T/pt unknown
- 2014-02-03 HU HUE14704747 patent/HUE044555T2/hu unknown
- 2014-02-03 DK DK19151359.7T patent/DK3517100T3/da active
-
2015
- 2015-07-13 ZA ZA2015/05026A patent/ZA201505026B/en unknown
- 2015-07-30 SA SA517381008A patent/SA517381008B1/ar unknown
-
2016
- 2016-04-27 US US15/140,291 patent/US20160235780A1/en not_active Abandoned
- 2016-06-08 HK HK16106565.4A patent/HK1218517A1/zh unknown
-
2018
- 2018-11-07 AU AU2018260857A patent/AU2018260857B2/en active Active
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2019
- 2019-02-12 JP JP2019022506A patent/JP6876079B2/ja active Active
- 2019-07-31 HR HRP20191382 patent/HRP20191382T1/hr unknown
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2020
- 2020-12-09 CY CY20201101166T patent/CY1124054T1/el unknown
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2021
- 2021-08-11 US US17/399,504 patent/US20220096531A1/en not_active Abandoned
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