ES2716395T3 - Esteres de acridinio hidrófilos de alto rendimiento cuántico con estabilidad mejorada y emisión rápida de luz - Google Patents
Esteres de acridinio hidrófilos de alto rendimiento cuántico con estabilidad mejorada y emisión rápida de luz Download PDFInfo
- Publication number
- ES2716395T3 ES2716395T3 ES14823526T ES14823526T ES2716395T3 ES 2716395 T3 ES2716395 T3 ES 2716395T3 ES 14823526 T ES14823526 T ES 14823526T ES 14823526 T ES14823526 T ES 14823526T ES 2716395 T3 ES2716395 T3 ES 2716395T3
- Authority
- ES
- Spain
- Prior art keywords
- succinimidyl
- analyte
- group
- acridinium ester
- acridinium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 Cc1cc(C(*)=O)cc(C)c1OC(c1c(cc(*)cc2)c2nc2c1cc(*)cc2)=O Chemical compound Cc1cc(C(*)=O)cc(C)c1OC(c1c(cc(*)cc2)c2nc2c1cc(*)cc2)=O 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
- C09K11/07—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials having chemically interreactive components, e.g. reactive chemiluminescent compositions
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21K—NON-ELECTRIC LIGHT SOURCES USING LUMINESCENCE; LIGHT SOURCES USING ELECTROCHEMILUMINESCENCE; LIGHT SOURCES USING CHARGES OF COMBUSTIBLE MATERIAL; LIGHT SOURCES USING SEMICONDUCTOR DEVICES AS LIGHT-GENERATING ELEMENTS; LIGHT SOURCES NOT OTHERWISE PROVIDED FOR
- F21K2/00—Non-electric light sources using luminescence; Light sources using electrochemiluminescence
- F21K2/06—Non-electric light sources using luminescence; Light sources using electrochemiluminescence using chemiluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Electromagnetism (AREA)
- General Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361843528P | 2013-07-08 | 2013-07-08 | |
| PCT/US2014/045505 WO2015006174A1 (en) | 2013-07-08 | 2014-07-04 | Hydrophilic high quantum yield acridinium esters with improved stability and fast light emission |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2716395T3 true ES2716395T3 (es) | 2019-06-12 |
Family
ID=52280476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14823526T Active ES2716395T3 (es) | 2013-07-08 | 2014-07-04 | Esteres de acridinio hidrófilos de alto rendimiento cuántico con estabilidad mejorada y emisión rápida de luz |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US20170320830A1 (enExample) |
| EP (1) | EP3019575B1 (enExample) |
| JP (1) | JP6735665B2 (enExample) |
| CN (2) | CN105378029B (enExample) |
| ES (1) | ES2716395T3 (enExample) |
| WO (1) | WO2015006174A1 (enExample) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918192A (en) | 1986-10-06 | 1990-04-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| US5110932A (en) | 1986-10-06 | 1992-05-05 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| EP0273115B1 (en) | 1986-10-22 | 1994-09-07 | Abbott Laboratories | Chemiluminescent acridinium and phenanthridinium salts |
| US5656426A (en) | 1988-08-01 | 1997-08-12 | Chiron Diagnostics Corporation | Functionaized hydrophilic acridinium esters |
| US6664043B2 (en) | 2001-07-03 | 2003-12-16 | Bayer Corporation | Acridinium ester labels having hydrophilic modifiers |
| US7309615B2 (en) * | 2002-09-27 | 2007-12-18 | Siemens Medical Solutions Diagnostic | High quantum yield acridinium compounds and their uses in improving assay sensitivity |
| ES2392900T3 (es) * | 2006-10-13 | 2012-12-14 | Siemens Healthcare Diagnostics Inc. | Ésteres de acridinio estables con emisión de luz rápida |
| WO2009067417A1 (en) * | 2007-11-20 | 2009-05-28 | Siemens Heathcare Diagnostics Inc. | Facile n-alkylation of acridine compounds in ionic liquids |
| ES2700649T3 (es) * | 2009-11-16 | 2019-02-18 | Siemens Healthcare Diagnostics Inc | Compuestos de acridinio que contienen zwiteriones |
-
2014
- 2014-07-04 ES ES14823526T patent/ES2716395T3/es active Active
- 2014-07-04 CN CN201480039328.2A patent/CN105378029B/zh active Active
- 2014-07-04 US US14/901,009 patent/US20170320830A1/en not_active Abandoned
- 2014-07-04 JP JP2016525393A patent/JP6735665B2/ja active Active
- 2014-07-04 CN CN202011347156.9A patent/CN112521335A/zh active Pending
- 2014-07-04 EP EP14823526.0A patent/EP3019575B1/en active Active
- 2014-07-04 WO PCT/US2014/045505 patent/WO2015006174A1/en not_active Ceased
-
2020
- 2020-02-26 US US16/801,354 patent/US11332445B2/en active Active
-
2022
- 2022-04-07 US US17/658,438 patent/US11932603B2/en active Active
-
2024
- 2024-02-15 US US18/442,393 patent/US12275708B2/en active Active
-
2025
- 2025-03-17 US US19/081,068 patent/US20250243167A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20200190037A1 (en) | 2020-06-18 |
| US11332445B2 (en) | 2022-05-17 |
| EP3019575A4 (en) | 2016-12-28 |
| CN112521335A (zh) | 2021-03-19 |
| CN105378029B (zh) | 2020-12-18 |
| EP3019575B1 (en) | 2018-12-19 |
| JP2016531099A (ja) | 2016-10-06 |
| WO2015006174A1 (en) | 2015-01-15 |
| US20220227711A1 (en) | 2022-07-21 |
| JP6735665B2 (ja) | 2020-08-05 |
| US20170320830A1 (en) | 2017-11-09 |
| US12275708B2 (en) | 2025-04-15 |
| US11932603B2 (en) | 2024-03-19 |
| US20240254088A1 (en) | 2024-08-01 |
| CN105378029A (zh) | 2016-03-02 |
| US20250243167A1 (en) | 2025-07-31 |
| EP3019575A1 (en) | 2016-05-18 |
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