CN112521335A - 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯 - Google Patents

具有改进的稳定性和快速发光的亲水高量子产率吖啶酯 Download PDF

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Publication number
CN112521335A
CN112521335A CN202011347156.9A CN202011347156A CN112521335A CN 112521335 A CN112521335 A CN 112521335A CN 202011347156 A CN202011347156 A CN 202011347156A CN 112521335 A CN112521335 A CN 112521335A
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CN
China
Prior art keywords
analyte
acridinium
acridinium ester
ester according
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202011347156.9A
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English (en)
Chinese (zh)
Inventor
A.纳特拉简
D.夏普
姜庆平
温大伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Publication of CN112521335A publication Critical patent/CN112521335A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C09K11/07—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials having chemically interreactive components, e.g. reactive chemiluminescent compositions
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21K—NON-ELECTRIC LIGHT SOURCES USING LUMINESCENCE; LIGHT SOURCES USING ELECTROCHEMILUMINESCENCE; LIGHT SOURCES USING CHARGES OF COMBUSTIBLE MATERIAL; LIGHT SOURCES USING SEMICONDUCTOR DEVICES AS LIGHT-GENERATING ELEMENTS; LIGHT SOURCES NOT OTHERWISE PROVIDED FOR
    • F21K2/00—Non-electric light sources using luminescence; Light sources using electrochemiluminescence
    • F21K2/06—Non-electric light sources using luminescence; Light sources using electrochemiluminescence using chemiluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Plasma & Fusion (AREA)
  • Electromagnetism (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202011347156.9A 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯 Pending CN112521335A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361843528P 2013-07-08 2013-07-08
US61/843528 2013-07-08
CN201480039328.2A CN105378029B (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480039328.2A Division CN105378029B (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯

Publications (1)

Publication Number Publication Date
CN112521335A true CN112521335A (zh) 2021-03-19

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Family Applications (2)

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CN202011347156.9A Pending CN112521335A (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯
CN201480039328.2A Active CN105378029B (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201480039328.2A Active CN105378029B (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯

Country Status (6)

Country Link
US (5) US20170320830A1 (enExample)
EP (1) EP3019575B1 (enExample)
JP (1) JP6735665B2 (enExample)
CN (2) CN112521335A (enExample)
ES (1) ES2716395T3 (enExample)
WO (1) WO2015006174A1 (enExample)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101918367A (zh) * 2007-11-20 2010-12-15 西门子医疗保健诊断公司 吖啶化合物在离子液体中的简便n-烷基化方法
CN102762539A (zh) * 2009-11-16 2012-10-31 西门子医疗保健诊断公司 含两性离子的吖啶*化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918192A (en) 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US5110932A (en) 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
DE3750503T2 (de) 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.
US5656426A (en) 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
US6664043B2 (en) 2001-07-03 2003-12-16 Bayer Corporation Acridinium ester labels having hydrophilic modifiers
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
EP2074101B1 (en) * 2006-10-13 2012-08-08 Siemens Healthcare Diagnostics Inc. Stable acridinium esters with fast light emission

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101918367A (zh) * 2007-11-20 2010-12-15 西门子医疗保健诊断公司 吖啶化合物在离子液体中的简便n-烷基化方法
CN102762539A (zh) * 2009-11-16 2012-10-31 西门子医疗保健诊断公司 含两性离子的吖啶*化合物

Also Published As

Publication number Publication date
EP3019575A4 (en) 2016-12-28
US20240254088A1 (en) 2024-08-01
US20170320830A1 (en) 2017-11-09
WO2015006174A1 (en) 2015-01-15
US11332445B2 (en) 2022-05-17
US20250243167A1 (en) 2025-07-31
JP2016531099A (ja) 2016-10-06
US11932603B2 (en) 2024-03-19
US20200190037A1 (en) 2020-06-18
ES2716395T3 (es) 2019-06-12
EP3019575B1 (en) 2018-12-19
EP3019575A1 (en) 2016-05-18
CN105378029B (zh) 2020-12-18
JP6735665B2 (ja) 2020-08-05
US12275708B2 (en) 2025-04-15
US20220227711A1 (en) 2022-07-21
CN105378029A (zh) 2016-03-02

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