ES2710921T3 - Composiciones para tratar y prevenir lesión y enfermedad tisular - Google Patents
Composiciones para tratar y prevenir lesión y enfermedad tisular Download PDFInfo
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- ES2710921T3 ES2710921T3 ES13839621T ES13839621T ES2710921T3 ES 2710921 T3 ES2710921 T3 ES 2710921T3 ES 13839621 T ES13839621 T ES 13839621T ES 13839621 T ES13839621 T ES 13839621T ES 2710921 T3 ES2710921 T3 ES 2710921T3
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Epidemiology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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| US201261703203P | 2012-09-19 | 2012-09-19 | |
| PCT/US2013/060181 WO2014047067A1 (en) | 2012-09-19 | 2013-09-17 | Compositions and methods for treating and preventing tissue injury and disease |
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| ES2710921T3 true ES2710921T3 (es) | 2019-04-29 |
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| EP (2) | EP2898064B1 (https=) |
| JP (2) | JP6456829B2 (https=) |
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| DK (1) | DK2898064T3 (https=) |
| ES (2) | ES2710921T3 (https=) |
| WO (1) | WO2014047067A1 (https=) |
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| US9044430B2 (en) | 2011-03-18 | 2015-06-02 | Microvascular Tissues, Inc. | Allogeneic microvascular tissue for soft tissue treatments |
| ES2710921T3 (es) | 2012-09-19 | 2019-04-29 | Microvascular Tissues Inc | Composiciones para tratar y prevenir lesión y enfermedad tisular |
| US10596202B2 (en) | 2012-09-19 | 2020-03-24 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US11819522B2 (en) | 2012-09-19 | 2023-11-21 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US9872937B2 (en) | 2012-09-19 | 2018-01-23 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| WO2016111899A1 (en) | 2015-01-05 | 2016-07-14 | Petrucci Gary M | Methods and materials for treating lung disorders |
| US12551509B2 (en) | 2015-11-18 | 2026-02-17 | Lucina Patent Holdco, Llc | Acellular regenerative products and methods of their manufacture |
| EP3381458B1 (en) * | 2015-11-24 | 2023-06-07 | Rohto Pharmaceutical Co., Ltd. | Therapeutic agent for liver disease containing stromal cells derived from adipose tissue and method for producing the same |
| US10993969B2 (en) | 2016-02-05 | 2021-05-04 | Gary M. Petrucci | Methods and materials for treating nerve injuries and neurological disorders |
| AU2017225797A1 (en) * | 2016-03-02 | 2018-07-19 | Microvascular Tissues, Inc | Enhanced multipotent cells and microvascular tissue and methods of use thereof |
| EP3223181B1 (en) * | 2016-03-24 | 2019-12-18 | Sofradim Production | System and method of generating a model and simulating an effect on a surgical repair site |
| AR104691A1 (es) * | 2016-05-18 | 2017-08-09 | Labyes De Uruguay S A | Composición veterinaria de imidacloprid, moxidectina y praziquantel de administración tópica cutánea (spot on) para tratamiento y prevención de las ecto y endoparasitosis que afectan a los perros |
| WO2017223520A1 (en) * | 2016-06-24 | 2017-12-28 | Osiris Therapeutics, Inc. | Viable lyophilized compositions derived from human tissues and methods of making the same |
| CA3029233A1 (en) | 2016-06-24 | 2017-12-28 | Osiris Therapeutics, Inc. | Human tissue derived compositions and uses thereof |
| US10478531B2 (en) | 2017-06-22 | 2019-11-19 | Gary M. Petrucci | Methods and materials for treating blood vessels |
| WO2019006328A1 (en) * | 2017-06-30 | 2019-01-03 | Allosource | CELL BONE GRAFTS, AND METHODS OF MAKING AND USING |
| US20190083547A1 (en) * | 2017-09-19 | 2019-03-21 | Gary M. Petrucci | Transdermal delivery of amnion tissue preparations |
| US10251917B1 (en) | 2017-09-19 | 2019-04-09 | Gary M. Petrucci | Methods and materials for treating tumors |
| CN114340647A (zh) * | 2019-08-09 | 2022-04-12 | 艾索洛特巴罗克有限公司 | 衍生自人羊膜细胞的组合物及相关方法 |
| US20240216572A1 (en) * | 2019-11-29 | 2024-07-04 | Novadip Biosciences | Biomaterials for the prevention and the treatment of tissue disorders |
| CN116195741B (zh) * | 2021-11-30 | 2024-07-09 | 内蒙古伊利实业集团股份有限公司 | 乳双歧杆菌bb-12在保护软骨中的应用 |
| JP7376897B2 (ja) * | 2022-03-09 | 2023-11-09 | 成浩 小島 | 摘出組織処理装置、および摘出組織処理方法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5358931A (en) | 1990-01-17 | 1994-10-25 | The Regents Of The University Of California | Interaction of thermal hysteresis proteins with cells and cell membranes and associated applications |
| DE69534151T2 (de) | 1994-02-22 | 2006-01-12 | Nippon Telegraph And Telephone Corp. | Gefriergetrocknete Blutzellen, Stammzellen und Plättchen und Verfahren zu deren Herstellung |
| JP3183074B2 (ja) | 1994-06-14 | 2001-07-03 | 松下電器産業株式会社 | 音声符号化装置 |
| US5786907A (en) | 1994-12-20 | 1998-07-28 | International Business Machines Corporation | High speed color compensation system |
| US6200606B1 (en) | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| EP0877795A4 (en) | 1996-01-16 | 2003-03-05 | Depuy Orthopaedics Inc | INSULATION OF PROCUREMENT CELLS FROM HEMATOPOIETIC AND NON-HEMATOPOIETIC TISSUES AND THEIR USE |
| US5786207A (en) | 1997-05-28 | 1998-07-28 | University Of Pittsburgh | Tissue dissociating system and method |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US6200506B1 (en) | 1999-12-10 | 2001-03-13 | Tachi-Co., Ltd | Method for forming a headrest |
| US7659111B2 (en) | 2002-06-27 | 2010-02-09 | Core Dynamics Limited | Method for freezing viable cells |
| ES2353116T3 (es) | 2002-07-16 | 2011-02-25 | Bio Syntech Canada Inc. | Composiciones para disoluciones de quitosano citocompatibles, inyectables, autogelificantes para encapsular y administrar células vivas o factores biológicamente activos. |
| AR047712A1 (es) | 2002-09-07 | 2006-02-15 | Royal Veterinary College | Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas |
| US7270946B2 (en) | 2002-10-04 | 2007-09-18 | Organ Recovery Systems, Inc. | Method for treatment of cellular materials with sugars prior to preservation |
| US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| US7344716B2 (en) | 2003-05-13 | 2008-03-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of pro-inflammatory cytokines |
| US7553827B2 (en) | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
| EP2399990B1 (en) | 2003-06-27 | 2015-07-22 | DePuy Synthes Products, Inc. | Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system |
| JP2007508018A (ja) | 2003-10-08 | 2007-04-05 | べト−ステム インコーポレイテッド | 新規の幹細胞組成物の調製法および使用法、ならびにこの組成物を含有するキット |
| EP1576957A1 (en) * | 2004-03-18 | 2005-09-21 | Universiteit Twente | Tissue repair using pluripotent cells |
| TR200402809A1 (tr) | 2004-07-07 | 2006-02-21 | General Mills, Inc. | Sakız bazlı meyve çerezlerinin üretilmesi için buharlaşmasız işlem |
| EP1830862B1 (en) * | 2004-12-30 | 2012-12-19 | PrimeGen Biotech LLC | Adipose-derived stem cells for tissue regeneration and wound healing |
| EP1909565A2 (en) | 2005-08-03 | 2008-04-16 | Interface Multigrad Technology (IMT) Ltd. | Somatic cells for use in cell therapy |
| US9132208B2 (en) * | 2008-08-07 | 2015-09-15 | Lifenet Health | Composition for a tissue repair implant and methods of making the same |
| WO2007106582A2 (en) | 2006-03-15 | 2007-09-20 | Promethean Lifesciences, Inc. | Preparation and storage of stable, biologically active materials |
| US20070292401A1 (en) | 2006-06-20 | 2007-12-20 | Harmon Alexander M | Soft tissue repair and regeneration using stem cell products |
| US20100015104A1 (en) | 2006-07-26 | 2010-01-21 | Cytori Therapeutics, Inc | Generation of adipose tissue and adipocytes |
| US20080033572A1 (en) | 2006-08-03 | 2008-02-07 | Ebi L.P. | Bone graft composites and methods of treating bone defects |
| KR100771058B1 (ko) * | 2007-05-18 | 2007-10-30 | 이희영 | 지질이 제거된 인체 부피 대체용 또는 세포 배양용 지지체및 그 제조방법 |
| US8481253B2 (en) | 2008-03-19 | 2013-07-09 | Cryo-Save Ag | Cryopreservation of adipose tissue for the isolation of mesenchymal stem cells |
| EP3246038B1 (en) | 2008-09-30 | 2021-04-07 | The Regents of the University of California | Compositions comprising decellularized extracellular matrix obtained from cardiac tissue |
| US8865199B2 (en) | 2008-11-17 | 2014-10-21 | Ingeneron, Inc. | Biomatrix composition and methods of biomatrix seeding |
| US8470308B2 (en) * | 2009-01-03 | 2013-06-25 | Ray C. Wasielewski | Enhanced medical implant comprising disrupted tooth pulp and tooth particles |
| EP2411023B1 (en) * | 2009-03-27 | 2017-11-29 | Orthocell Limited | Method of tissue repair |
| KR101072732B1 (ko) | 2009-04-01 | 2011-10-11 | 국립암센터 | 이식골 성형 시스템 및 이를 이용한 이식골 성형 방법 |
| CN101757691B (zh) * | 2010-02-05 | 2013-04-24 | 陕西瑞盛生物科技有限公司 | 一种组织工程角膜的制备方法 |
| WO2012024573A2 (en) * | 2010-08-19 | 2012-02-23 | The Regents Of The University Of California | Compositions comrpising perivascular stem cells and nell-1 protein |
| SG188369A1 (en) * | 2010-09-01 | 2013-04-30 | Univ Minnesota | Methods of recellularizing a tissue or organ for improved transplantability |
| NZ612801A (en) | 2010-12-27 | 2014-12-24 | Intellicell Biosciences Inc | Ultrasonic cavitation derived stromal or mesenchymal vascular extracts and cells derived therefrom obtained from adipose tissue and use thereof |
| US9044430B2 (en) | 2011-03-18 | 2015-06-02 | Microvascular Tissues, Inc. | Allogeneic microvascular tissue for soft tissue treatments |
| ES2822301T3 (es) * | 2011-06-10 | 2021-04-30 | Tissuetech Inc | Métodos de procesamiento de tejidos de soporte fetal |
| SG11201405875PA (en) | 2012-03-19 | 2014-11-27 | Richard Burt | Methods and compositions for regenerating and repairing damaged tissue using nonviable irradiated or lyophilized pluripotent stem cells |
| US9872937B2 (en) | 2012-09-19 | 2018-01-23 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| ES2710921T3 (es) | 2012-09-19 | 2019-04-29 | Microvascular Tissues Inc | Composiciones para tratar y prevenir lesión y enfermedad tisular |
| US10596202B2 (en) | 2012-09-19 | 2020-03-24 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| CA2938268A1 (en) | 2014-01-31 | 2015-08-06 | Dsm Ip Assets B.V. | Adipose tissue processing centrifuge and methods of use |
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2013
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- 2013-09-17 BR BR112015006055A patent/BR112015006055A2/pt not_active Application Discontinuation
- 2013-09-17 AU AU2013318243A patent/AU2013318243B2/en active Active
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| US20150231183A1 (en) | 2015-08-20 |
| EP3476410A1 (en) | 2019-05-01 |
| JP2018065881A (ja) | 2018-04-26 |
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| AU2013318243A1 (en) | 2015-03-26 |
| AU2019203555A1 (en) | 2019-06-13 |
| EP2898064A1 (en) | 2015-07-29 |
| CN104955464A (zh) | 2015-09-30 |
| WO2014047067A1 (en) | 2014-03-27 |
| EP2898064A4 (en) | 2016-04-27 |
| ES2899209T3 (es) | 2022-03-10 |
| AU2013318243B2 (en) | 2019-07-11 |
| US9713629B2 (en) | 2017-07-25 |
| JP2015529687A (ja) | 2015-10-08 |
| JP6456829B2 (ja) | 2019-01-23 |
| DK2898064T3 (en) | 2019-03-04 |
| CA2885419A1 (en) | 2014-03-27 |
| JP6755893B2 (ja) | 2020-09-16 |
| CN104955464B (zh) | 2020-02-28 |
| AU2019203555B2 (en) | 2022-01-27 |
| BR112015006055A2 (pt) | 2017-07-04 |
| US10729729B2 (en) | 2020-08-04 |
| KR20150061642A (ko) | 2015-06-04 |
| US20170360845A1 (en) | 2017-12-21 |
| KR102270617B1 (ko) | 2021-06-30 |
| EP3476410B1 (en) | 2021-08-18 |
| EP2898064B1 (en) | 2018-11-14 |
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