ES2709873T3 - Sistema de análisis de biosensor electroquímico - Google Patents
Sistema de análisis de biosensor electroquímico Download PDFInfo
- Publication number
- ES2709873T3 ES2709873T3 ES07702749T ES07702749T ES2709873T3 ES 2709873 T3 ES2709873 T3 ES 2709873T3 ES 07702749 T ES07702749 T ES 07702749T ES 07702749 T ES07702749 T ES 07702749T ES 2709873 T3 ES2709873 T3 ES 2709873T3
- Authority
- ES
- Spain
- Prior art keywords
- electrode structure
- measurement
- test area
- biosensor
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004458 analytical method Methods 0.000 title claims abstract description 72
- 238000005259 measurement Methods 0.000 claims abstract description 118
- 238000012360 testing method Methods 0.000 claims abstract description 96
- 239000007788 liquid Substances 0.000 claims abstract description 71
- 238000011156 evaluation Methods 0.000 claims abstract description 44
- 239000000463 material Substances 0.000 claims abstract description 29
- 238000006243 chemical reaction Methods 0.000 claims abstract description 19
- 238000010521 absorption reaction Methods 0.000 claims abstract description 7
- 230000008859 change Effects 0.000 claims abstract description 5
- 238000009736 wetting Methods 0.000 claims abstract description 4
- 210000001124 body fluid Anatomy 0.000 claims abstract description 3
- 239000010839 body fluid Substances 0.000 claims abstract description 3
- 239000004020 conductor Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 13
- 230000004048 modification Effects 0.000 claims description 11
- 238000012986 modification Methods 0.000 claims description 11
- 238000009434 installation Methods 0.000 claims description 10
- 238000009529 body temperature measurement Methods 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 7
- 238000003780 insertion Methods 0.000 claims description 6
- 230000037431 insertion Effects 0.000 claims description 6
- 230000000873 masking effect Effects 0.000 claims description 6
- 230000008961 swelling Effects 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 description 11
- 239000004033 plastic Substances 0.000 description 6
- 238000010276 construction Methods 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000005534 hematocrit Methods 0.000 description 4
- 230000002123 temporal effect Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000007772 electrode material Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000001566 impedance spectroscopy Methods 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000009365 direct transmission Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000840 electrochemical analysis Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000000491 multivariate analysis Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- IPQVTOJGNYVQEO-KGFNBKMBSA-N sennoside A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC2=C1C(=O)C1=C(O)C=C(C(O)=O)C=C1[C@@H]2[C@H]1C2=CC(C(O)=O)=CC(O)=C2C(=O)C2=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C=CC=C21 IPQVTOJGNYVQEO-KGFNBKMBSA-N 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Electrochemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06001499A EP1813937A1 (de) | 2006-01-25 | 2006-01-25 | Elektrochemisches Biosensor-Analysesystem |
| PCT/EP2007/000277 WO2007085353A1 (de) | 2006-01-25 | 2007-01-13 | Elektrochemisches biosensor-analysesystem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2709873T3 true ES2709873T3 (es) | 2019-04-22 |
Family
ID=36507999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07702749T Active ES2709873T3 (es) | 2006-01-25 | 2007-01-13 | Sistema de análisis de biosensor electroquímico |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8357274B2 (enExample) |
| EP (2) | EP1813937A1 (enExample) |
| JP (1) | JP5258579B2 (enExample) |
| CN (1) | CN101371133B (enExample) |
| CA (1) | CA2637953C (enExample) |
| ES (1) | ES2709873T3 (enExample) |
| PL (1) | PL1977225T3 (enExample) |
| WO (1) | WO2007085353A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8148164B2 (en) * | 2003-06-20 | 2012-04-03 | Roche Diagnostics Operations, Inc. | System and method for determining the concentration of an analyte in a sample fluid |
| CA2682439A1 (en) | 2008-10-17 | 2010-04-17 | F. Hoffmann-La Roche Ag | Cell monitoring and molecular analysis |
| EP2450699A4 (en) * | 2009-06-30 | 2017-05-17 | ARKRAY, Inc. | Analysis device and analysis method |
| JP5281503B2 (ja) * | 2009-07-01 | 2013-09-04 | 日機装株式会社 | 酵素センサ用電極構造体、酵素センサ及び人工膵臓装置 |
| DE102010016102B4 (de) * | 2010-03-23 | 2016-11-03 | Andreas Hettich Gmbh & Co. Kg | Messvorrichtung umfassend einen Resonator |
| DE102010022153B4 (de) * | 2010-05-20 | 2018-10-25 | Austriamicrosystems Ag | Schaltungsanordnung und Verfahren zur Steuerung einer Kommunikation zwischen einer Steuerschaltung und einer Sender-Empfängereinheit über eine Versorgungsleitung |
| EP2651298A1 (en) * | 2010-12-17 | 2013-10-23 | Sanofi-Aventis Deutschland GmbH | Bodily fluid analysis device |
| JP5781256B2 (ja) | 2012-06-28 | 2015-09-16 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | リーダー装置および信号増幅方法 |
| JP6107054B2 (ja) * | 2012-10-30 | 2017-04-05 | セイコーエプソン株式会社 | 液体輸送装置 |
| WO2014115478A1 (ja) | 2013-01-28 | 2014-07-31 | ソニー株式会社 | 生体試料用インピーダンス測定装置および生体試料用インピーダンス測定システム |
| DE102013110291A1 (de) * | 2013-03-06 | 2014-09-11 | Heraeus Sensor Technology Gmbh | Verfahren zur Herstellung eines Rußsensors mit einem Laserstrahl |
| TWI479146B (zh) * | 2013-03-13 | 2015-04-01 | Univ Chang Gung | 離子感測裝置及其製作方法 |
| JP6356708B2 (ja) * | 2013-03-15 | 2018-07-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | パルスｄｃブロックを有するテスト・シーケンスで分析物を電気化学的に測定する方法およびデバイス、装置とそれらを組み込むシステム |
| EP3385706A1 (en) * | 2013-03-15 | 2018-10-10 | Roche Diabetes Care GmbH | Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same |
| CN104407019B (zh) * | 2014-11-05 | 2017-04-12 | 广东中烟工业有限责任公司 | 一种基于dfa和simca模型的烟用包装纸品质判别方法 |
| KR101920273B1 (ko) * | 2016-11-22 | 2019-02-08 | (주)인트인 | 체액 검사장치용 시료부 및 이를 구비하는 체액 검사장치 |
| CN107678467A (zh) * | 2017-09-11 | 2018-02-09 | 国力天（深圳）科技有限公司 | 一种在线可控温电化学检测仪及其检测方法 |
| SE541514C2 (en) * | 2017-12-28 | 2019-10-22 | Delaval Holding Ab | A cassette |
| JP7245738B2 (ja) * | 2019-07-19 | 2023-03-24 | 住友化学株式会社 | 電気化学センサユニット、電気化学センサ用電極および電気化学センサ用電極の製造方法 |
| CN112525959A (zh) * | 2019-09-19 | 2021-03-19 | 杭州微策生物技术股份有限公司 | 一种积分电极结构、生物传感器及积分式电极生物传感器的制造方法 |
| CN113008951B (zh) * | 2019-12-20 | 2024-04-19 | 利多(香港)有限公司 | 一种生物传感器及其在检测血液样品凝血指标中的应用 |
| CN114544710B (zh) * | 2022-02-25 | 2023-07-21 | 江苏经贸职业技术学院 | 电力电子元件测量装置 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61500508A (ja) * | 1983-11-10 | 1986-03-20 | センテツク メデイカル コ−ポレイシヨン | 臨床用化学分析装置 |
| JP2527933B2 (ja) | 1984-06-13 | 1996-08-28 | ユニリ−バ−・ナ−ムロ−ゼ・ベンノ−トシヤ−プ | 特異的反応性サンプルの収集及び試験デバイス並びにその製造方法 |
| JPH0648256B2 (ja) * | 1985-06-21 | 1994-06-22 | 松下電器産業株式会社 | バイオセンサ |
| DE68924026T3 (de) | 1988-03-31 | 2008-01-10 | Matsushita Electric Industrial Co., Ltd., Kadoma | Biosensor und dessen herstellung. |
| US5243516A (en) | 1989-12-15 | 1993-09-07 | Boehringer Mannheim Corporation | Biosensing instrument and method |
| FR2701117B1 (fr) * | 1993-02-04 | 1995-03-10 | Asulab Sa | Système de mesures électrochimiques à capteur multizones, et son application au dosage du glucose. |
| US5352351A (en) * | 1993-06-08 | 1994-10-04 | Boehringer Mannheim Corporation | Biosensing meter with fail/safe procedures to prevent erroneous indications |
| US6129823A (en) * | 1997-09-05 | 2000-10-10 | Abbott Laboratories | Low volume electrochemical sensor |
| EP1042667B1 (en) | 1997-12-22 | 2009-06-17 | Roche Diagnostics Operations, Inc. | Meter |
| US6262264B1 (en) | 1998-06-01 | 2001-07-17 | Roche Diagnostics Corporation | Redox reversible imidazole osmium complex conjugates |
| JP2000019146A (ja) * | 1998-07-06 | 2000-01-21 | Matsushita Electric Ind Co Ltd | 基質の定量法並びにそれに用いるバイオセンサおよび測定装置 |
| US7276146B2 (en) * | 2001-11-16 | 2007-10-02 | Roche Diagnostics Operations, Inc. | Electrodes, methods, apparatuses comprising micro-electrode arrays |
| US6645359B1 (en) * | 2000-10-06 | 2003-11-11 | Roche Diagnostics Corporation | Biosensor |
| DE19952215C2 (de) | 1999-10-29 | 2001-10-31 | Roche Diagnostics Gmbh | Testelement-Analysesystem |
| IL151477A0 (en) * | 2000-03-09 | 2003-04-10 | Clinical Analysis Corp | Medical diagnostic system |
| CA2403646A1 (en) * | 2000-03-28 | 2001-10-04 | Inverness Medical Technology, Inc. | Continuous process for manufacture of disposable electro-chemical sensor |
| JP2003156469A (ja) * | 2001-11-22 | 2003-05-30 | Matsushita Electric Ind Co Ltd | バイオセンサ、バイオセンサ用測定装置及び基質の定量方法 |
| US6447657B1 (en) * | 2000-12-04 | 2002-09-10 | Roche Diagnostics Corporation | Biosensor |
| US6558528B1 (en) * | 2000-12-20 | 2003-05-06 | Lifescan, Inc. | Electrochemical test strip cards that include an integral dessicant |
| US6797150B2 (en) * | 2001-10-10 | 2004-09-28 | Lifescan, Inc. | Determination of sample volume adequacy in biosensor devices |
| US6872298B2 (en) * | 2001-11-20 | 2005-03-29 | Lifescan, Inc. | Determination of sample volume adequacy in biosensor devices |
| AU2003234944A1 (en) | 2002-08-27 | 2004-03-18 | Bayer Healthcare, Llc | Methods of Determining Glucose Concentration in Whole Blood Samples |
| DE10244775A1 (de) | 2002-09-26 | 2004-04-08 | Roche Diagnostics Gmbh | Kapillarsensor-Analysesystem |
| EP1443325A1 (en) | 2003-02-01 | 2004-08-04 | Roche Diagnostics GmbH | System and method for determining a coagulation parameter |
| EP1467206A1 (en) | 2003-04-08 | 2004-10-13 | Roche Diagnostics GmbH | Biosensor system |
| WO2004113915A1 (en) * | 2003-06-20 | 2004-12-29 | Roche Diagnostics Gmbh | System and method for coding information on a biosensor test strip |
| US7452457B2 (en) * | 2003-06-20 | 2008-11-18 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
| US7867369B2 (en) * | 2003-06-20 | 2011-01-11 | Roche Diagnostics Operations, Inc. | Biosensor with multiple electrical functionalities |
| DE10350880A1 (de) * | 2003-10-31 | 2005-06-02 | Roche Diagnostics Gmbh | Verfahren zur Bestimmung eines Analyten mittels einer Extraktionsschicht |
-
2006
- 2006-01-25 EP EP06001499A patent/EP1813937A1/de not_active Withdrawn
-
2007
- 2007-01-13 CN CN200780002953XA patent/CN101371133B/zh not_active Expired - Fee Related
- 2007-01-13 WO PCT/EP2007/000277 patent/WO2007085353A1/de not_active Ceased
- 2007-01-13 ES ES07702749T patent/ES2709873T3/es active Active
- 2007-01-13 EP EP07702749.8A patent/EP1977225B1/de not_active Not-in-force
- 2007-01-13 JP JP2008551691A patent/JP5258579B2/ja not_active Expired - Fee Related
- 2007-01-13 PL PL07702749T patent/PL1977225T3/pl unknown
- 2007-01-13 CA CA2637953A patent/CA2637953C/en active Active
-
2008
- 2008-07-22 US US12/177,566 patent/US8357274B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5258579B2 (ja) | 2013-08-07 |
| EP1977225B1 (de) | 2019-01-02 |
| CA2637953C (en) | 2013-07-23 |
| US20090020439A1 (en) | 2009-01-22 |
| WO2007085353A1 (de) | 2007-08-02 |
| JP2009524805A (ja) | 2009-07-02 |
| PL1977225T3 (pl) | 2019-06-28 |
| EP1977225A1 (de) | 2008-10-08 |
| CA2637953A1 (en) | 2007-08-02 |
| EP1813937A1 (de) | 2007-08-01 |
| US8357274B2 (en) | 2013-01-22 |
| HK1129141A1 (en) | 2009-11-20 |
| CN101371133A (zh) | 2009-02-18 |
| CN101371133B (zh) | 2012-07-04 |
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