ES269988A1 - Un procedimiento para la preparaciën de la hidroxicobalamina - Google Patents
Un procedimiento para la preparaciën de la hidroxicobalaminaInfo
- Publication number
- ES269988A1 ES269988A1 ES0269988A ES269988A ES269988A1 ES 269988 A1 ES269988 A1 ES 269988A1 ES 0269988 A ES0269988 A ES 0269988A ES 269988 A ES269988 A ES 269988A ES 269988 A1 ES269988 A1 ES 269988A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxocobalamin
- zinc
- acid
- addition
- improved process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 title abstract 6
- 235000004867 hydroxocobalamin Nutrition 0.000 title abstract 3
- 239000011704 hydroxocobalamin Substances 0.000 title abstract 3
- 229960001103 hydroxocobalamin Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 abstract 2
- 239000007789 gas Substances 0.000 abstract 2
- 239000011701 zinc Substances 0.000 abstract 2
- 229910052725 zinc Inorganic materials 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- QVQLCTNNEUAWMS-UHFFFAOYSA-N barium oxide Chemical compound [Ba]=O QVQLCTNNEUAWMS-UHFFFAOYSA-N 0.000 abstract 1
- 229910001864 baryta Inorganic materials 0.000 abstract 1
- 238000007664 blowing Methods 0.000 abstract 1
- 235000000639 cyanocobalamin Nutrition 0.000 abstract 1
- 239000011666 cyanocobalamin Substances 0.000 abstract 1
- 229960002104 cyanocobalamin Drugs 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229940072033 potash Drugs 0.000 abstract 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 1
- 235000015320 potassium carbonate Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
Landscapes
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MC252A MC320A1 (fr) | 1960-09-22 | 1960-09-22 | Procédé de préparation de l'hydroxocobalamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES269988A1 true ES269988A1 (es) | 1961-12-16 |
Family
ID=19737440
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0269988A Expired ES269988A1 (es) | 1960-09-22 | 1961-08-18 | Un procedimiento para la preparaciën de la hidroxicobalamina |
| ES0270275A Expired ES270275A1 (es) | 1960-09-22 | 1961-09-06 | Un procedimiento de purificaciën de la hidroxocobalamina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0270275A Expired ES270275A1 (es) | 1960-09-22 | 1961-09-06 | Un procedimiento de purificaciën de la hidroxocobalamina |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE642487A (en, 2012) |
| CH (2) | CH396921A (en, 2012) |
| DE (1) | DE1182666B (en, 2012) |
| ES (2) | ES269988A1 (en, 2012) |
| FR (2) | FR1346256A (en, 2012) |
| GB (2) | GB916186A (en, 2012) |
| MC (1) | MC320A1 (en, 2012) |
| OA (2) | OA00124A (en, 2012) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2015012710A (es) * | 2013-03-13 | 2018-03-23 | Interquim S A De C V | Mejoras al proceso de preparacion de hidroxocobalamina y sus sales de alta pureza. |
-
1960
- 1960-09-22 MC MC252A patent/MC320A1/xx unknown
-
1961
- 1961-07-28 FR FR869338A patent/FR1346256A/fr not_active Expired
- 1961-08-02 FR FR869812A patent/FR1346257A/fr not_active Expired
- 1961-08-18 ES ES0269988A patent/ES269988A1/es not_active Expired
- 1961-08-22 CH CH977361A patent/CH396921A/fr unknown
- 1961-08-25 DE DEB63779A patent/DE1182666B/de active Pending
- 1961-08-30 GB GB31271/61A patent/GB916186A/en not_active Expired
- 1961-09-05 CH CH1028461A patent/CH398623A/fr unknown
- 1961-09-06 ES ES0270275A patent/ES270275A1/es not_active Expired
- 1961-09-07 GB GB32222/61A patent/GB934462A/en not_active Expired
-
1964
- 1964-01-14 BE BE642487A patent/BE642487A/xx unknown
- 1964-05-02 OA OA50089A patent/OA00124A/xx unknown
- 1964-06-30 OA OA50171A patent/OA00146A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES270275A1 (es) | 1962-02-01 |
| OA00146A (fr) | 1966-03-15 |
| MC320A1 (fr) | 1962-04-12 |
| CH398623A (fr) | 1966-03-15 |
| GB934462A (en) | 1963-08-21 |
| FR1346256A (fr) | 1963-12-20 |
| DE1182666B (de) | 1964-12-03 |
| BE642487A (en, 2012) | 1964-05-04 |
| FR1346257A (fr) | 1963-12-20 |
| GB916186A (en) | 1963-01-23 |
| OA00124A (fr) | 1966-01-15 |
| CH396921A (fr) | 1965-08-15 |
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