ES269516A1 - Procedimiento para la obtenciën de eteres nuevos - Google Patents
Procedimiento para la obtenciën de eteres nuevosInfo
- Publication number
- ES269516A1 ES269516A1 ES0269516A ES269516A ES269516A1 ES 269516 A1 ES269516 A1 ES 269516A1 ES 0269516 A ES0269516 A ES 0269516A ES 269516 A ES269516 A ES 269516A ES 269516 A1 ES269516 A1 ES 269516A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- salts
- sulphonic acid
- epi
- reserpate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 150000002170 ethers Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 sulphonic acid ester Chemical class 0.000 abstract 5
- 239000002585 base Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- MDJQWFFIUHUJSB-UQVJXISSSA-N Methyl reserpate Chemical compound COC1=CC=C2C(CCN3C[C@H]4C[C@@H](O)[C@@H]([C@H]([C@H]4C[C@@H]33)C(=O)OC)OC)=C3NC2=C1 MDJQWFFIUHUJSB-UQVJXISSSA-N 0.000 abstract 2
- MDJQWFFIUHUJSB-MIESRMKVSA-N Methyl reserpate Natural products O=C(OC)[C@@H]1[C@@H](OC)[C@H](O)C[C@H]2[C@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 MDJQWFFIUHUJSB-MIESRMKVSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- MDJQWFFIUHUJSB-UHFFFAOYSA-N Reserpinsaeure-methylester Natural products COC1=CC=C2C(CCN3CC4CC(O)C(C(C4CC33)C(=O)OC)OC)=C3NC2=C1 MDJQWFFIUHUJSB-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 238000006136 alcoholysis reaction Methods 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 2
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical class NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- HOPRXXXSABQWAV-UHFFFAOYSA-N anhydrous collidine Natural products CC1=CC=NC(C)=C1C HOPRXXXSABQWAV-UHFFFAOYSA-N 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- UTBIMNXEDGNJFE-UHFFFAOYSA-N collidine Natural products CC1=CC=C(C)C(C)=N1 UTBIMNXEDGNJFE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical group ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 229960005015 local anesthetics Drugs 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 239000012970 tertiary amine catalyst Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4691160A | 1960-08-02 | 1960-08-02 | |
| US7349060A | 1960-12-05 | 1960-12-05 | |
| US11032061A | 1961-05-16 | 1961-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES269516A1 true ES269516A1 (es) | 1962-04-16 |
Family
ID=27367016
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0269516A Expired ES269516A1 (es) | 1960-08-02 | 1961-08-02 | Procedimiento para la obtenciën de eteres nuevos |
| ES0269514A Expired ES269514A1 (es) | 1960-08-02 | 1961-08-02 | Procedimiento para la obtenciën del nuevo ester metilico del acido 18-epi-o-r-reserpico |
| ES0269515A Expired ES269515A1 (es) | 1960-08-02 | 1961-08-02 | Procedimiento para la obtenciën de eteres nuevos |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0269514A Expired ES269514A1 (es) | 1960-08-02 | 1961-08-02 | Procedimiento para la obtenciën del nuevo ester metilico del acido 18-epi-o-r-reserpico |
| ES0269515A Expired ES269515A1 (es) | 1960-08-02 | 1961-08-02 | Procedimiento para la obtenciën de eteres nuevos |
Country Status (6)
| Country | Link |
|---|---|
| AT (7) | AT252461B (enrdf_load_stackoverflow) |
| CH (8) | CH398628A (enrdf_load_stackoverflow) |
| ES (3) | ES269516A1 (enrdf_load_stackoverflow) |
| GB (6) | GB999398A (enrdf_load_stackoverflow) |
| NL (1) | NL139529B (enrdf_load_stackoverflow) |
| SE (7) | SE301478B (enrdf_load_stackoverflow) |
-
1961
- 1961-07-12 CH CH819161A patent/CH398628A/de unknown
- 1961-07-12 CH CH308565A patent/CH407144A/de unknown
- 1961-07-12 CH CH819061A patent/CH398627A/de unknown
- 1961-07-12 CH CH308765A patent/CH407146A/de unknown
- 1961-07-12 CH CH308665A patent/CH407145A/de unknown
- 1961-07-12 CH CH308465A patent/CH407143A/de unknown
- 1961-07-12 CH CH819261A patent/CH416658A/de unknown
- 1961-07-12 CH CH819361A patent/CH410969A/de unknown
- 1961-08-01 AT AT100262A patent/AT252461B/de active
- 1961-08-01 AT AT887662A patent/AT252463B/de active
- 1961-08-01 AT AT594861A patent/AT249273B/de active
- 1961-08-01 AT AT100062A patent/AT252459B/de active
- 1961-08-01 AT AT100162A patent/AT252460B/de active
- 1961-08-01 AT AT100362A patent/AT252462B/de active
- 1961-08-01 NL NL61267779A patent/NL139529B/xx unknown
- 1961-08-01 AT AT594961A patent/AT249274B/de active
- 1961-08-02 SE SE7892/61A patent/SE301478B/xx unknown
- 1961-08-02 GB GB49912/64A patent/GB999398A/en not_active Expired
- 1961-08-02 ES ES0269516A patent/ES269516A1/es not_active Expired
- 1961-08-02 GB GB46383/64A patent/GB999397A/en not_active Expired
- 1961-08-02 GB GB28119/61A patent/GB999393A/en not_active Expired
- 1961-08-02 GB GB28117/61A patent/GB999391A/en not_active Expired
- 1961-08-02 GB GB28118/61A patent/GB999392A/en not_active Expired
- 1961-08-02 GB GB52687/64A patent/GB999399A/en not_active Expired
- 1961-08-02 SE SE7893/61A patent/SE301650B/xx unknown
- 1961-08-02 ES ES0269514A patent/ES269514A1/es not_active Expired
- 1961-08-02 ES ES0269515A patent/ES269515A1/es not_active Expired
-
1965
- 1965-06-08 SE SE7481/65A patent/SE301486B/xx unknown
- 1965-06-08 SE SE7478/65A patent/SE301321B/xx unknown
- 1965-06-08 SE SE7482/65A patent/SE301487B/xx unknown
- 1965-06-08 SE SE7480/65A patent/SE301485B/xx unknown
- 1965-06-08 SE SE7479/65A patent/SE301484B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE301478B (enrdf_load_stackoverflow) | 1968-06-10 |
| AT252462B (de) | 1967-02-27 |
| GB999398A (en) | 1965-07-28 |
| SE301487B (enrdf_load_stackoverflow) | 1968-06-10 |
| GB999397A (en) | 1965-07-28 |
| AT252460B (de) | 1967-02-27 |
| CH407145A (de) | 1966-02-15 |
| CH407143A (de) | 1966-02-15 |
| GB999391A (en) | 1965-07-28 |
| CH398627A (de) | 1966-03-15 |
| GB999393A (en) | 1965-07-28 |
| SE301321B (enrdf_load_stackoverflow) | 1968-06-04 |
| AT252463B (de) | 1967-02-27 |
| GB999392A (en) | 1965-07-28 |
| SE301650B (enrdf_load_stackoverflow) | 1968-06-17 |
| CH416658A (de) | 1966-07-15 |
| CH407144A (de) | 1966-02-15 |
| SE301485B (enrdf_load_stackoverflow) | 1968-06-10 |
| CH398628A (de) | 1966-03-15 |
| AT252459B (de) | 1967-02-27 |
| SE301486B (enrdf_load_stackoverflow) | 1968-06-10 |
| AT249274B (de) | 1966-09-12 |
| AT249273B (de) | 1966-09-12 |
| CH410969A (de) | 1966-04-15 |
| ES269514A1 (es) | 1962-04-16 |
| SE301484B (enrdf_load_stackoverflow) | 1968-06-10 |
| CH407146A (de) | 1966-02-15 |
| NL139529B (nl) | 1973-08-15 |
| ES269515A1 (es) | 1962-04-16 |
| GB999399A (en) | 1965-07-28 |
| AT252461B (de) | 1967-02-27 |
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