GB1001356A - Substituted anthranilic acid esters - Google Patents
Substituted anthranilic acid estersInfo
- Publication number
- GB1001356A GB1001356A GB3664863A GB3664863A GB1001356A GB 1001356 A GB1001356 A GB 1001356A GB 3664863 A GB3664863 A GB 3664863A GB 3664863 A GB3664863 A GB 3664863A GB 1001356 A GB1001356 A GB 1001356A
- Authority
- GB
- United Kingdom
- Prior art keywords
- halogen
- r1r2r3
- methyl
- compounds
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of general formula <FORM:1001356/C2/1> wherein R1 and R2 are halogen, or R1 is methyl and R2 is halogen, or R1 is halogen and R2 is methyl, or R1 is halogen and R2 is ethyl; R3 is hydrogen, halogen or methyl; and their preparation as exemplified, comprising (1) reaction of corresponding acids or their reactive derivatives with esterifying agents, or (2) reaction of 2-halo or amino-benzoic acid esters with, respectively, amino- or halo-R1R2R3-benzenes. N - (R1R2R3-Phenyl)anthranilic acids and their salts are prepared by (1) reacting potassium o-halobenzoates with R1R2R3-anilines using an unreactive solvent, a copper-containing catalyst and a proton-acceptor, or (2) hydrolysis of the lower alkyl esters; acid halides are prepared with, for example, thionyl chloride, and acid anhydrides by reacting the acid chloride and sodium salt. Pharmaceutical compositions comprise compounds I with diluents and excipients. Forms are mentioned for oral (tablets, pills, sachets, powders, capsules) and parenteral (solutions, suspensions) administration. The compounds are anti-inflammatory and hypycholesteremic.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22452062A | 1962-09-18 | 1962-09-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1001356A true GB1001356A (en) | 1965-08-18 |
Family
ID=22841052
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3664863A Expired GB1001356A (en) | 1962-09-18 | 1963-09-17 | Substituted anthranilic acid esters |
GB3664663A Expired GB997653A (en) | 1962-09-18 | 1963-09-17 | N-aryl-isatoic anhydride derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3664663A Expired GB997653A (en) | 1962-09-18 | 1963-09-17 | N-aryl-isatoic anhydride derivatives |
Country Status (8)
Country | Link |
---|---|
BE (1) | BE637515A (en) |
BR (1) | BR6352807D0 (en) |
CH (4) | CH416631A (en) |
DE (1) | DE1470212A1 (en) |
ES (1) | ES291742A1 (en) |
FR (1) | FR2935M (en) |
GB (2) | GB1001356A (en) |
NL (2) | NL123926C (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2572072B1 (en) * | 1984-10-18 | 1989-04-14 | Basf Ag | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES |
-
0
- BE BE637515D patent/BE637515A/xx unknown
- NL NL298016D patent/NL298016A/xx unknown
- NL NL123926D patent/NL123926C/xx active
-
1963
- 1963-09-16 DE DE19631470212 patent/DE1470212A1/en active Pending
- 1963-09-17 CH CH673666A patent/CH416631A/en unknown
- 1963-09-17 CH CH1147663A patent/CH415635A/en unknown
- 1963-09-17 FR FR947774A patent/FR2935M/en active Active
- 1963-09-17 CH CH673766A patent/CH416632A/en unknown
- 1963-09-17 BR BR15280763A patent/BR6352807D0/en unknown
- 1963-09-17 GB GB3664863A patent/GB1001356A/en not_active Expired
- 1963-09-17 CH CH673566A patent/CH416630A/en unknown
- 1963-09-17 GB GB3664663A patent/GB997653A/en not_active Expired
- 1963-09-17 ES ES291742A patent/ES291742A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2935M (en) | 1964-11-16 |
CH416631A (en) | 1966-07-15 |
BR6352807D0 (en) | 1973-06-12 |
BE637515A (en) | |
DE1470212A1 (en) | 1969-04-24 |
CH416632A (en) | 1966-07-15 |
ES291742A1 (en) | 1964-02-16 |
CH416630A (en) | 1966-07-15 |
NL298016A (en) | |
NL123926C (en) | |
CH415635A (en) | 1966-06-30 |
GB997653A (en) | 1965-07-07 |
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