NL298015A - - Google Patents

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Publication number
NL298015A
NL298015A NL298015DA NL298015A NL 298015 A NL298015 A NL 298015A NL 298015D A NL298015D A NL 298015DA NL 298015 A NL298015 A NL 298015A
Authority
NL
Netherlands
Prior art keywords
acid
dimethylphenyl
reaction
esters
compounds
Prior art date
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication of NL298015A publication Critical patent/NL298015A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of general formula <FORM:1001354/C2/1> where lower alkyl radicals have 1-7 carbon atoms; and their preparation, as exemplified, comprising (1) esterification of corresponding acids or their reactive derivatives, (2) dehydrogenation of a corresponding dimethylcylohexanimine, (3) reaction of 2-halo-or 2-amino-benzoic esters with, respectively, amino- or halo-dimethylbenzenes, or (4) reaction of N-(2,3-dimethylphenyl)isatoic anhydride with a lower alkanol and an alkali metal alkoxide. N - (2,3 - Dimethylphenyl)anthranilic acid chloride is prepared from the acid with thionyl chloride; on reaction with the sodium salt of the acid it yields the acid anhydride. N - (o - lower-alkoxycarbonylphenyl) - 2,3-dimethylcyclohexanimine can be prepared from the anthranilic acid esters with dimethylcyclohexanone and an acidic catalyst. N - (2,3 - dimethylphenyl)anthranilic acid and its salts are obtainable by hydrolysis of the lower alkyl esters. Pharmaceutical compositions comprise compounds I with diluents and excipients. Forms for oral (tablets, pills, sachets, powders, capsules) and parenteral (solutions, suspensions) administrations are mentioned. The compounds are analgesic and anti-inflammatory. Specification 997,653 is referred to.
NL298015D 1962-09-18 NL298015A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22453262A 1962-09-18 1962-09-18

Publications (1)

Publication Number Publication Date
NL298015A true NL298015A (en)

Family

ID=22841092

Family Applications (1)

Application Number Title Priority Date Filing Date
NL298015D NL298015A (en) 1962-09-18

Country Status (6)

Country Link
BE (1) BE637514A (en)
CH (4) CH416670A (en)
ES (1) ES291737A1 (en)
FR (1) FR3035M (en)
GB (1) GB1001354A (en)
NL (1) NL298015A (en)

Also Published As

Publication number Publication date
FR3035M (en) 1964-12-28
CH416669A (en) 1966-07-15
CH421988A (en) 1966-10-15
ES291737A1 (en) 1964-02-16
BE637514A (en)
CH416671A (en) 1966-07-15
CH416670A (en) 1966-07-15
GB1001354A (en) 1965-08-18

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