ES2693085T1 - Uso de estriol en bajas dosis - Google Patents
Uso de estriol en bajas dosis Download PDFInfo
- Publication number
- ES2693085T1 ES2693085T1 ES08787631.4T ES08787631T ES2693085T1 ES 2693085 T1 ES2693085 T1 ES 2693085T1 ES 08787631 T ES08787631 T ES 08787631T ES 2693085 T1 ES2693085 T1 ES 2693085T1
- Authority
- ES
- Spain
- Prior art keywords
- estriol
- use according
- dose
- administration
- patient receives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 title claims abstract 8
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 title claims abstract 8
- 229960001348 estriol Drugs 0.000 title claims abstract 8
- 206010030247 Oestrogen deficiency Diseases 0.000 claims abstract 2
- 206010071018 Urogenital atrophy Diseases 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Uso de bajas dosis de estriol por vía vaginal para tratamiento y/o prevención de atrofia urogenital por déficit estrogénico en mujeres.
Claims (9)
- 51015REIVINDICACIONES1. Uso de estriol en la preparacion de una composicion farmaceutica de administracion vaginal para la prevencion y/o el tratamiento de la atrofia urogenital por deficit estrogenico en mujeres, en el que dicha composicion es administrada de tal manera que la paciente recibe una dosis de estriol menor de 0,5 mg / dfa.
- 2. Uso de acuerdo con la reivindicacion 1 en el que la paciente recibe una dosis de estriol menor o igual de 0,3 mg / dfa.
- 3. Uso de acuerdo con la reivindicacion 1 o 2 en el que la paciente recibe una dosis de estriol menor o igual de 0,1 mg / dfa.
- 4. Uso de acuerdo con la reivindicacion 1 en el que la paciente recibe una dosis de estriol entre 0,002 y 0,05 mg / dfa.
- 5. Uso de acuerdo con la reivindicacion 1 en el que la paciente recibe una dosis de estriol entre 0,02 y 0,05 mg / dfa.
- 6. Uso de acuerdo con cualquiera de las reivindicaciones precedentes, en el que la administracion es diaria durante al menos 3 semanas.
- 7. Uso de acuerdo con la reivindicacion 6, en el que la administracion es diaria durante al menos 30 dfas.
- 8. Uso de acuerdo con la reivindicacion 6, en el que la administracion es diaria durante al menos 60 dfas.
- 9. Uso de acuerdo con la reivindicacion 6, en el que la administracion es diaria durante al menos 90 dfas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200701755 | 2007-06-25 | ||
ES200701755A ES2310968B1 (es) | 2007-06-25 | 2007-06-25 | Uso de estriol en bajas dosis. |
PCT/ES2008/000450 WO2009000954A2 (es) | 2007-06-25 | 2008-06-25 | Uso de estriol en bajas dosis |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2693085T1 true ES2693085T1 (es) | 2018-12-07 |
Family
ID=40186085
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200701755A Active ES2310968B1 (es) | 2007-06-25 | 2007-06-25 | Uso de estriol en bajas dosis. |
ES08787631.4T Pending ES2693085T1 (es) | 2007-06-25 | 2008-06-25 | Uso de estriol en bajas dosis |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200701755A Active ES2310968B1 (es) | 2007-06-25 | 2007-06-25 | Uso de estriol en bajas dosis. |
Country Status (14)
Country | Link |
---|---|
US (1) | US8273730B2 (es) |
EP (2) | EP2158914A4 (es) |
JP (1) | JP5623273B2 (es) |
KR (1) | KR20100036337A (es) |
CN (2) | CN104739842A (es) |
AU (1) | AU2008269683B2 (es) |
BR (1) | BRPI0813947A2 (es) |
CA (1) | CA2689335C (es) |
CO (1) | CO6251259A2 (es) |
EC (1) | ECSP099826A (es) |
ES (2) | ES2310968B1 (es) |
MX (1) | MX2009013427A (es) |
RU (1) | RU2483734C2 (es) |
WO (1) | WO2009000954A2 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2344673B1 (es) * | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
ES2344675B1 (es) * | 2008-12-19 | 2011-04-28 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular. |
US8817769B2 (en) | 2009-01-26 | 2014-08-26 | Qualcomm Incorporated | Power decision pilot for wireless communication |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
LT2782584T (lt) | 2011-11-23 | 2021-09-10 | Therapeuticsmd, Inc. | Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
CN103405294A (zh) * | 2013-08-02 | 2013-11-27 | 苏州市马尔泰新材料有限公司 | 一种含有雌酚的阴道模具 |
CN103393488A (zh) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种含有雌三醇的阴道模具 |
CN103357074A (zh) * | 2013-08-02 | 2013-10-23 | 苏州市马尔泰新材料有限公司 | 一种缓释型制备模具的材料 |
CN103394130A (zh) * | 2013-08-13 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种含有雌酚和川芎的模具材料 |
AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1866M (fr) | 1961-04-07 | 1963-06-17 | Vismara Francesco Spa | Nouveaux éthers des hormones oestrogenes. |
US5543150A (en) | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
AT408067B (de) | 1995-03-17 | 2001-08-27 | Gebro Pharma Gmbh | Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung |
US5942243A (en) | 1996-11-12 | 1999-08-24 | Polytherapeutics, Inc. | Mucoadhesive compositions for administration of biologically active agents to animal tissue |
DE19917930A1 (de) * | 1999-04-15 | 2000-10-19 | Schering Ag | Ent-Steroide als selektiv wirksame Estrogene |
AR030312A1 (es) | 2000-08-03 | 2003-08-20 | Antares Pharma Ipl Ag | Composicion novedosa para la administracion transdermica y/o transmucosica de compuestos activos, que asegura adecuados niveles terapeuticos |
ES2237298B1 (es) | 2003-07-16 | 2006-11-01 | Italfarmaco, S.A. | Formulaciones mucoadhesivas semisolidas. |
RU2268726C2 (ru) * | 2004-03-30 | 2006-01-27 | ГУ "Научно-исследовательский институт экспериментальной медицины" РАМН (ГУ НИИЭМ РАМН) | Способ лечения нарушений мнестических функций |
CA2637608A1 (en) * | 2006-01-20 | 2007-07-26 | Pear Tree Pharmaceuticals, Inc. | Method of treating atrophic vaginitis |
-
2007
- 2007-06-25 ES ES200701755A patent/ES2310968B1/es active Active
-
2008
- 2008-06-25 CN CN201510088583.2A patent/CN104739842A/zh active Pending
- 2008-06-25 KR KR1020107001643A patent/KR20100036337A/ko active Search and Examination
- 2008-06-25 CN CN200880020402A patent/CN101702879A/zh active Pending
- 2008-06-25 RU RU2009148278/15A patent/RU2483734C2/ru active
- 2008-06-25 AU AU2008269683A patent/AU2008269683B2/en active Active
- 2008-06-25 BR BRPI0813947-4A2A patent/BRPI0813947A2/pt not_active Application Discontinuation
- 2008-06-25 US US12/440,638 patent/US8273730B2/en active Active
- 2008-06-25 EP EP08787631A patent/EP2158914A4/en not_active Ceased
- 2008-06-25 WO PCT/ES2008/000450 patent/WO2009000954A2/es active Application Filing
- 2008-06-25 MX MX2009013427A patent/MX2009013427A/es active IP Right Grant
- 2008-06-25 EP EP23219035.5A patent/EP4335501A3/en active Pending
- 2008-06-25 JP JP2010512722A patent/JP5623273B2/ja active Active
- 2008-06-25 ES ES08787631.4T patent/ES2693085T1/es active Pending
- 2008-06-25 CA CA2689335A patent/CA2689335C/en active Active
-
2009
- 2009-12-22 CO CO09146679A patent/CO6251259A2/es not_active Application Discontinuation
- 2009-12-23 EC EC2009009826A patent/ECSP099826A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ES2310968A1 (es) | 2009-01-16 |
EP4335501A2 (en) | 2024-03-13 |
BRPI0813947A2 (pt) | 2014-12-30 |
CA2689335C (en) | 2018-01-23 |
ES2310968B1 (es) | 2010-02-08 |
EP2158914A2 (en) | 2010-03-03 |
US20090318401A1 (en) | 2009-12-24 |
EP4335501A3 (en) | 2024-05-15 |
JP5623273B2 (ja) | 2014-11-12 |
US8273730B2 (en) | 2012-09-25 |
WO2009000954A3 (es) | 2009-02-12 |
RU2009148278A (ru) | 2011-06-27 |
MX2009013427A (es) | 2010-07-30 |
AU2008269683A1 (en) | 2008-12-31 |
CN104739842A (zh) | 2015-07-01 |
CO6251259A2 (es) | 2011-02-21 |
KR20100036337A (ko) | 2010-04-07 |
ECSP099826A (es) | 2010-04-30 |
RU2483734C2 (ru) | 2013-06-10 |
CN101702879A (zh) | 2010-05-05 |
AU2008269683B2 (en) | 2013-06-06 |
JP2010531302A (ja) | 2010-09-24 |
WO2009000954A2 (es) | 2008-12-31 |
EP2158914A4 (en) | 2010-06-30 |
CA2689335A1 (en) | 2008-12-31 |
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