ES2688993T3 - Composiciones antigénicas y métodos para el virus respiratorio sincicial - Google Patents
Composiciones antigénicas y métodos para el virus respiratorio sincicial Download PDFInfo
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- ES2688993T3 ES2688993T3 ES11731610.9T ES11731610T ES2688993T3 ES 2688993 T3 ES2688993 T3 ES 2688993T3 ES 11731610 T ES11731610 T ES 11731610T ES 2688993 T3 ES2688993 T3 ES 2688993T3
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Landscapes
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| US8883717B2 (en) * | 2012-03-30 | 2014-11-11 | Artificial Cell Technologies, Inc. | Antigenic compositions and methods |
| US9433671B2 (en) | 2012-03-30 | 2016-09-06 | Artificial Cell Technologies, Inc. | Anti-malaria compositions and methods |
| KR102435054B1 (ko) | 2012-08-01 | 2022-08-22 | 버베리안 노딕 에이/에스 | 재조합 변형된 백시니아 바이러스 앙카라(ankara) (mva) 호흡기 신시티알 바이러스(rsv) 백신 |
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| AU2015267312B2 (en) | 2014-05-27 | 2018-06-28 | Artificial Cell Technologies, Inc. | Automated layer by layer construction of multilayer coated cores by TFF |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| US9968665B2 (en) | 2015-09-16 | 2018-05-15 | Artificial Cell Technologies, Inc. | Anti-malaria compositions and methods |
| US20170230649A1 (en) * | 2016-02-05 | 2017-08-10 | Qualcomm Incorporated | Calibration of hybrid auto focus (af) imaging systems |
| HUE073526T2 (hu) | 2017-04-04 | 2026-01-28 | Univ Washington | Önmagát összeállító fehérje nanostruktúrák, amelyek paramyxovírus és/vagy pneumovírus F fehérjéket jelenítenek meg és azok használata |
| CA3079604A1 (en) | 2017-10-13 | 2019-04-18 | Trellis Bioscience, Llc | Conformational epitopes in respiratory syncytial virus g protein central conserved region |
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| FR2718452B1 (fr) | 1994-04-06 | 1996-06-28 | Pf Medicament | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. |
| EP0777685B1 (en) | 1994-08-25 | 1999-04-14 | Stichting Instituut voor Dierhouderij en Diergezondheid | Antigenic peptides derived from the g protein of rsv for type- and subtype-specific diagnosis of respiratory syncytial virus (rsv) infection |
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| FR2819810B1 (fr) | 2001-01-23 | 2004-05-28 | Pf Medicament | Peptides non glycosyles derives de la proteine g du vrs et leur utilisation dans un vaccin |
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| JP3997930B2 (ja) | 2003-02-27 | 2007-10-24 | 富士ゼロックス株式会社 | カーボンナノチューブの製造装置および製造方法 |
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| US7348399B2 (en) | 2003-08-29 | 2008-03-25 | Louisiana Tech University Foundation, Inc. | Nanofabricated polypeptide multilayer films, coatings, and microcapsules |
| US7615530B2 (en) | 2003-08-29 | 2009-11-10 | Artificial Cell Technologies, Inc. | Immunogenic compositions and methods of use |
| EP1768993A4 (en) * | 2004-06-16 | 2008-07-23 | Univ Johns Hopkins | CYSTIC REGION OF HUMAN RESPIRATORY SYNZYTIAL VIRUS AND METHOD OF USE THEREOF |
| US20080131450A1 (en) | 2004-07-23 | 2008-06-05 | Pierre Fabre Medicament | Immunogenic complexes, preparation method thereof and use of same in pharmaceutical compositions |
| US20080171070A1 (en) * | 2005-01-31 | 2008-07-17 | Pierre Schaaf | Polyelectrolyte Multilayer Film, Preparation And Uses Thereof |
| WO2006108226A1 (en) * | 2005-04-12 | 2006-10-19 | The University Of Queensland | Vaccine delivery system |
| CN101365724A (zh) * | 2005-10-25 | 2009-02-11 | 路易斯安那科技大学研究基金会 | 包含多肽的多层膜、涂层和微粒 |
| EP1972348A1 (en) | 2007-03-14 | 2008-09-24 | Pierre Fabre Medicament | Novel vaccine composition for the treatment of respiratory infectious diseases |
| WO2008114149A2 (en) | 2007-03-21 | 2008-09-25 | Id Biomedical Corporation Of Quebec | Chimeric antigens |
| US7723294B2 (en) | 2007-04-02 | 2010-05-25 | Artificial Cell Technologies, Inc. | Polypeptide films and methods |
| WO2009079066A2 (en) * | 2007-09-26 | 2009-06-25 | Aparna Biosciences | Therapeutic and vaccine polyelectrolyte nanoparticle compositions |
| EP2058002A1 (en) * | 2007-10-31 | 2009-05-13 | Bestewil Holding B.V. | Reconstituted respiratory syncytial virus membranes and use as respiratory syncytial virus vaccine |
| US20110177117A1 (en) | 2008-07-18 | 2011-07-21 | Normand Blais | Chimeric respiratory syncytial virus polypeptide antigens |
| WO2010075491A2 (en) | 2008-12-24 | 2010-07-01 | University Of Rochester | Recombinant expression of self-folding neutralizing epitope-bearing subdomains of the respiratory syncytial virus attachment and fusion proteins |
| US8846056B2 (en) | 2009-08-04 | 2014-09-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control | Anti-RSV immunogens and methods of immunization |
| US8883717B2 (en) * | 2012-03-30 | 2014-11-11 | Artificial Cell Technologies, Inc. | Antigenic compositions and methods |
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| CA2799934C (en) | 2020-01-28 |
| MX2012015030A (es) | 2013-06-13 |
| CN106008716B (zh) | 2019-08-13 |
| EP2590675B1 (en) | 2018-08-29 |
| AU2011276251A2 (en) | 2013-01-24 |
| IL222723B (en) | 2020-03-31 |
| WO2012006395A1 (en) | 2012-01-12 |
| RU2013101972A (ru) | 2014-08-20 |
| US20120009254A1 (en) | 2012-01-12 |
| AU2011276251B2 (en) | 2015-02-05 |
| IL222723A0 (en) | 2012-12-31 |
| JP5890407B2 (ja) | 2016-03-22 |
| CN106008716A (zh) | 2016-10-12 |
| MX340796B (es) | 2016-07-27 |
| RU2609661C2 (ru) | 2017-02-02 |
| BR112013000345A2 (pt) | 2016-05-31 |
| CA2799934A1 (en) | 2012-01-12 |
| AU2011276251A1 (en) | 2012-11-08 |
| US9487593B2 (en) | 2016-11-08 |
| EP2590675A1 (en) | 2013-05-15 |
| CN103037898A (zh) | 2013-04-10 |
| CN103037898B (zh) | 2016-06-29 |
| DK2590675T3 (en) | 2018-10-29 |
| JP2013535428A (ja) | 2013-09-12 |
| BR112013000345B1 (pt) | 2021-11-23 |
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