ES2683846T3 - ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano - Google Patents
ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano Download PDFInfo
- Publication number
- ES2683846T3 ES2683846T3 ES13176525.7T ES13176525T ES2683846T3 ES 2683846 T3 ES2683846 T3 ES 2683846T3 ES 13176525 T ES13176525 T ES 13176525T ES 2683846 T3 ES2683846 T3 ES 2683846T3
- Authority
- ES
- Spain
- Prior art keywords
- ros
- translocation
- mutant
- kinase
- small cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 230000005945 translocation Effects 0.000 title 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 2
- 201000005202 lung cancer Diseases 0.000 abstract 2
- 208000020816 lung neoplasm Diseases 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
Un método para caracterizar un cáncer de pulmón que comprende detectar la presencia de una mutación de ROS en una muestra biológica procedente de un cáncer de pulmón humano.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76063406P | 2006-01-20 | 2006-01-20 | |
US760634P | 2006-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2683846T3 true ES2683846T3 (es) | 2018-09-28 |
Family
ID=38288244
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07718104.8T Active ES2539830T3 (es) | 2006-01-20 | 2007-01-19 | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
ES13176525.7T Active ES2683846T3 (es) | 2006-01-20 | 2007-01-19 | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07718104.8T Active ES2539830T3 (es) | 2006-01-20 | 2007-01-19 | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
Country Status (10)
Country | Link |
---|---|
EP (4) | EP1973946B1 (es) |
JP (7) | JP5554925B2 (es) |
CN (2) | CN101528921B (es) |
DK (2) | DK2671954T3 (es) |
ES (2) | ES2539830T3 (es) |
HK (2) | HK1120272A1 (es) |
HU (1) | HUE039085T2 (es) |
PT (1) | PT2671954T (es) |
SI (1) | SI2671954T1 (es) |
WO (1) | WO2007084631A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
US8383799B2 (en) | 2006-01-20 | 2013-02-26 | Cell Signaling Technology, Inc. | Translocation and mutant ROS kinase in human non-small cell lung carcinoma |
PT2671954T (pt) * | 2006-01-20 | 2018-10-08 | Cell Signaling Technology Inc | Translocação e ros-cinase mutante no carcinoma do pulmão de células não pequenas humano |
DK2203558T3 (en) * | 2007-10-18 | 2016-06-27 | Cell Signaling Technology Inc | TRANSLOCATION AND mutant ROS kinase IN HUMAN NON-small cell lung carcinoma |
CA2744236C (en) | 2009-02-12 | 2021-03-16 | Cell Signaling Technology, Inc. | Mutant ros expression in human cancer |
JP5861244B2 (ja) | 2010-06-22 | 2016-02-16 | 公益財団法人がん研究会 | 新規ros1融合体の検出法 |
MX2014001354A (es) | 2011-08-02 | 2014-10-14 | Pfizer | Crizotinib para uso en el tratamiento de cancer. |
WO2013119950A2 (en) * | 2012-02-08 | 2013-08-15 | Insight Genetics, Inc. | Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer |
US10385401B2 (en) | 2013-11-21 | 2019-08-20 | Assistance Publique Hopitaux De Paris | Method for detecting chromosomal rearrangements |
CN107236818A (zh) * | 2017-07-19 | 2017-10-10 | 臻悦生物科技江苏有限公司 | 肺癌临床用药突变基因检测试剂盒 |
WO2019030311A1 (en) * | 2017-08-09 | 2019-02-14 | Pamgene Bv | METHOD OF PREDICTING THE RESPONSE OF PATIENTS WITH NON-SMALL CELL LUNG CARCINOMA TO A MEDICINAL PRODUCT |
CN108148912B (zh) * | 2018-03-08 | 2021-10-08 | 四川大学 | 肿瘤的生物标志物、应用和肿瘤检测试剂盒 |
CN114793437A (zh) * | 2019-04-30 | 2022-07-26 | Encodia 公司 | 用于从多肽上切割n端氨基酸的方法和试剂 |
CN110655080B (zh) * | 2019-10-25 | 2022-08-05 | 山东大学 | 一种具有选择性杀灭癌细胞功能的无氧化Ti3C2量子点及其制备方法与应用 |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3023787A1 (de) | 1980-06-25 | 1982-01-21 | Studiengesellschaft Kohle mbH, 4330 Mülheim | Verfahren zur erhoehung der inkorporation und der expression von genetischem material in die kerne von intakten zellen mit hilfe von liposomen |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4727022A (en) | 1984-03-14 | 1988-02-23 | Syntex (U.S.A.) Inc. | Methods for modulating ligand-receptor interactions and their application |
JPH07119760B2 (ja) | 1984-07-24 | 1995-12-20 | コモンウエルス・セ−ラム・ラボラトリ−ズ・コミッション | ミモトープを検出または決定する方法 |
EP0232262A4 (en) | 1985-08-15 | 1989-09-19 | Stauffer Chemical Co | MICROORGANISM PRODUCING TRYPTOPHANE. |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
CA1339069C (en) | 1987-11-09 | 1997-07-29 | Henry Lee Niman | Polypeptide-induced monoclonal receptors to protein ligand |
EP0394827A1 (en) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
DK0452457T3 (da) | 1989-11-03 | 1998-03-02 | Univ Vanderbilt | Fremgangsmåde til in vivo fjernelse af funktionelle fremmede gener |
JP2552047B2 (ja) * | 1990-01-26 | 1996-11-06 | ワシントン リサーチ ファウンデーション | 悪性腫瘍の検査方法 |
DE4002897A1 (de) | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken") |
ES2225816T5 (es) | 1990-02-01 | 2014-08-21 | Siemens Healthcare Diagnostics Products Gmbh | Producción y utilización de bancos de genes de anticuerpos humanos ("bibliotecas de anticuerpos humanos") |
ATE169030T1 (de) | 1990-06-28 | 1998-08-15 | Hoechst Ag | Fusionsproteine mit immunglobulinanteilen, ihre herstellung und verwendung |
WO1994002595A1 (en) | 1992-07-17 | 1994-02-03 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of animal diseases |
US6710174B2 (en) | 2001-09-13 | 2004-03-23 | Isis Pharmaceuticals, Inc. | Antisense inhibition of vascular endothelial growth factor receptor-1 expression |
IL108367A0 (en) | 1993-01-27 | 1994-04-12 | Hektoen Inst For Medical Resea | Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells |
US6340674B1 (en) | 1993-03-26 | 2002-01-22 | Thomas Jefferson University | Method of inhibiting the proliferation and causing the differentiation of cells with IGF-1 receptor antisense oligonucleotides |
US5480971A (en) | 1993-06-17 | 1996-01-02 | Houghten Pharmaceuticals, Inc. | Peralkylated oligopeptide mixtures |
US5734039A (en) | 1994-09-15 | 1998-03-31 | Thomas Jefferson University | Antisense oligonucleotides targeting cooperating oncogenes |
US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
US5783683A (en) | 1995-01-10 | 1998-07-21 | Genta Inc. | Antisense oligonucleotides which reduce expression of the FGFRI gene |
US5675063A (en) | 1995-02-28 | 1997-10-07 | Loyola University Of Chicago | Immortalized rabbit hybridoma fusion partner |
WO1997008320A1 (en) | 1995-08-18 | 1997-03-06 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
US6323316B1 (en) * | 1996-06-18 | 2001-11-27 | The United States Of America As Represented By The Secretary Of The Department Of And Human Services | Fibroblast growth factor receptor activating gene 1 and related compositions and methods |
US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
US6617162B2 (en) | 2001-12-18 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Antisense modulation of estrogen receptor alpha expression |
WO1999031262A2 (en) | 1997-12-16 | 1999-06-24 | Valentis, Inc. | Needle-free injection of formulated nucleic acid molecules |
US7198896B2 (en) | 1998-09-04 | 2007-04-03 | Cell Signaling Technology, Inc. | Immunoaffinity isolation of modified peptides from complex mixtures |
WO2000053722A2 (en) | 1999-03-10 | 2000-09-14 | Phogen Limited | Delivery of nucleic acids and proteins to cells |
US7662793B2 (en) | 1999-06-18 | 2010-02-16 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from a Pol III promoter |
US6362324B1 (en) * | 1999-06-30 | 2002-03-26 | Millennium Pharmaceuticals, Inc. | 17867 a novel human aminopeptidase |
US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
IL151928A0 (en) | 2000-03-30 | 2003-04-10 | Whitehead Biomedical Inst | Rna sequence-specific mediators of rna interference |
JP4095895B2 (ja) | 2000-12-01 | 2008-06-04 | マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー.ヴェー. | Rna干渉を媒介する短鎖rna分子 |
HUP0302525A2 (hu) | 2001-01-05 | 2003-10-28 | Abgenix, Inc. | Az inzulinszerű növekedési faktor I receptor elleni ellenanyagok |
JP2005514002A (ja) | 2001-05-17 | 2005-05-19 | ザ パブリック ヘルス リサーチ インスティテュート オブ ザ シティ オブ ニューヨーク,インコーポレーテッド | Rnaをアンチセンス攻撃するための標的部位の選択 |
US20030170891A1 (en) | 2001-06-06 | 2003-09-11 | Mcswiggen James A. | RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US20040209832A1 (en) | 2001-11-30 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
WO2002102854A2 (en) | 2001-06-20 | 2002-12-27 | Morphosys Ag | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
WO2003016861A2 (en) | 2001-08-14 | 2003-02-27 | President And Fellows Of Harvard College | Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry |
US20030219839A1 (en) | 2001-09-20 | 2003-11-27 | Katherine Bowdish | Anti-PDGF antibodies and methods for producing engineered antibodies |
US6734017B2 (en) | 2001-09-28 | 2004-05-11 | Isis Pharmaceuticals, Inc. | Antisense modulation of vascular endothelial growth factor receptor-2 expression |
DE10230997A1 (de) | 2001-10-26 | 2003-07-17 | Ribopharma Ag | Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels |
JP2006508899A (ja) | 2002-05-20 | 2006-03-16 | アブジエニツクス・インコーポレイテツド | EGFrに対する抗体を使用する腎癌の治療方法 |
AU2002325299A1 (en) * | 2002-07-04 | 2004-02-16 | Nalan Utku | Novel t-cell proteins, peptides and antibodies derived therefrom and uses thereof |
US20040023390A1 (en) | 2002-08-05 | 2004-02-05 | Davidson Beverly L. | SiRNA-mediated gene silencing with viral vectors |
AU2003289716A1 (en) * | 2002-09-12 | 2004-04-30 | Incyte Corporation | Molecules for diagnostics and therapeutics |
BRPI0408317A (pt) | 2003-03-14 | 2006-03-07 | Pharmacia Corp | anticorpos do receptor de igf-i para o tratamento de cáncer |
JP2007508801A (ja) * | 2003-10-24 | 2007-04-12 | エスバテック・アーゲー | 受容体チロシンキナーゼ阻害剤の同定および/または確認のための方法 |
JP2007520718A (ja) * | 2004-02-06 | 2007-07-26 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 治療可能性のあるアドヘシンおよびアドヘシン様タンパク質を同定するためのコンピュータを利用した方法 |
US20050214301A1 (en) | 2004-03-24 | 2005-09-29 | Cell Signaling Technology, Inc. | Antibodies specific for BCR-ABL fusion protein and uses thereof |
PT2671954T (pt) * | 2006-01-20 | 2018-10-08 | Cell Signaling Technology Inc | Translocação e ros-cinase mutante no carcinoma do pulmão de células não pequenas humano |
-
2007
- 2007-01-19 PT PT13176525T patent/PT2671954T/pt unknown
- 2007-01-19 CN CN2007800089653A patent/CN101528921B/zh active Active
- 2007-01-19 ES ES07718104.8T patent/ES2539830T3/es active Active
- 2007-01-19 DK DK13176525.7T patent/DK2671954T3/en active
- 2007-01-19 EP EP07718104.8A patent/EP1973946B1/en active Active
- 2007-01-19 EP EP17205134.4A patent/EP3360965A1/en not_active Withdrawn
- 2007-01-19 SI SI200732051T patent/SI2671954T1/sl unknown
- 2007-01-19 CN CN201310484766.7A patent/CN103981198B/zh active Active
- 2007-01-19 HU HUE13176525A patent/HUE039085T2/hu unknown
- 2007-01-19 EP EP21177974.9A patent/EP3936621A1/en active Pending
- 2007-01-19 WO PCT/US2007/001360 patent/WO2007084631A2/en active Application Filing
- 2007-01-19 EP EP13176525.7A patent/EP2671954B1/en not_active Revoked
- 2007-01-19 DK DK07718104.8T patent/DK1973946T3/da active
- 2007-01-19 JP JP2008551396A patent/JP5554925B2/ja active Active
- 2007-01-19 ES ES13176525.7T patent/ES2683846T3/es active Active
-
2009
- 2009-01-08 HK HK09100200.7A patent/HK1120272A1/xx unknown
-
2014
- 2014-03-04 JP JP2014041462A patent/JP6259320B2/ja active Active
-
2016
- 2016-11-04 JP JP2016215900A patent/JP6521928B2/ja active Active
-
2018
- 2018-11-30 HK HK18115370.8A patent/HK1256305A1/zh unknown
- 2018-12-06 JP JP2018228744A patent/JP7262214B2/ja active Active
-
2019
- 2019-03-29 JP JP2019065633A patent/JP6957546B2/ja active Active
-
2020
- 2020-09-09 JP JP2020151188A patent/JP2021006039A/ja active Pending
-
2022
- 2022-12-13 JP JP2022198413A patent/JP2023039988A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2683846T3 (es) | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano | |
WO2008073177A3 (en) | Expression profiles associated with irinotecan treatment | |
ES2570359T3 (es) | Regiones ultraconservadas que codifican ARNnc | |
RS52932B (en) | K-RAS AND B-RAF MUTATIONS AND ANTI-EGFR ANTIBODY TREATMENT | |
WO2008106175A3 (en) | Gene and protein expression profiles associated with the therapeutic efficacy of egfr-tk inhibitors | |
WO2008039769A3 (en) | Methods and devices for analyzing small rna molecules | |
WO2007067968A3 (en) | Effects of inhibitors of fgfr3 on gene transcription | |
WO2007098444A3 (en) | Methods for analysis of extracellular rna species | |
MX2007005174A (es) | Identificacion de una mutacion de jak2 en policitemia vera. | |
WO2008073899A3 (en) | Prrg4-associated compositions and methods of use thereof in methods of tumor diagnosis | |
WO2007143037A3 (en) | Gene methylation in cancer diagnosis | |
WO2008143717A3 (en) | Methods of determining lethality of pathogens and malignancies involving replikin peak genes | |
WO2007114986A3 (en) | Cooperative probes and methods of using them | |
WO2007092221A3 (en) | Method for identifying altered vitamin d metabolism | |
HK1145852A1 (zh) | 人類非小細胞肺癌中的易位和突變的活性氧 激酶 | |
WO2008070663A3 (en) | Companion diagnostic assays for cancer therapy | |
UA101814C2 (ru) | Фактор, задействованный в латентной инфекции герпесвирусом, и его применение | |
BRPI0920170A2 (pt) | métodos para diminuir a quantidade de partículas ldl pequenas e densas e de níveis de triglicerídeos e ldl no sangue em um humano, e para identificar um indivíduo candidato para tratamento com um composto ou um sal, prodroga ou isômero do mesmo, composto ou um sal, prodroga ou isômero do mesmo, e método. | |
WO2007112350A3 (en) | Method of assessing the metastatic status of a primary tumor | |
WO2008082673A3 (en) | Companion diagnostic assays for cancer therapy | |
AU316238S (en) | Lawning applicator for microbiological cultures | |
CL2009001907A1 (es) | Metodo de deteccion precoz de cancer gastrico que comprende detectar la presencia de marcadores especificos de cancer gastrico en muestras de plasma. | |
AT8823U3 (de) | Sonde, insbesondere zur ortung verschütteter personen, sowie verschütteten-suchsystem | |
WO2006109086A3 (en) | Method to predict the sensitivity of tumors to eg5 inhibitors | |
WO2007127002A3 (en) | Protein markers of responsiveness to type iii receptor tyrosine kinase inhibitors |