ES2665843T3 - Síntesis de una forma de maleato de asenapina monoclínica micronizada estable - Google Patents

Síntesis de una forma de maleato de asenapina monoclínica micronizada estable Download PDF

Info

Publication number
ES2665843T3
ES2665843T3 ES12723725.3T ES12723725T ES2665843T3 ES 2665843 T3 ES2665843 T3 ES 2665843T3 ES 12723725 T ES12723725 T ES 12723725T ES 2665843 T3 ES2665843 T3 ES 2665843T3
Authority
ES
Spain
Prior art keywords
asenapine maleate
monoclinic
micronized
synthesis
micronization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12723725.3T
Other languages
English (en)
Spanish (es)
Inventor
Agusti BERTRÁN
Josep TERRADAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuraxpharm Pharmaceuticals SL
Original Assignee
Laboratorios Lesvi SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Lesvi SL filed Critical Laboratorios Lesvi SL
Application granted granted Critical
Publication of ES2665843T3 publication Critical patent/ES2665843T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
ES12723725.3T 2011-05-18 2012-05-18 Síntesis de una forma de maleato de asenapina monoclínica micronizada estable Active ES2665843T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161487495P 2011-05-18 2011-05-18
US201161487495P 2011-05-18
PCT/GB2012/000450 WO2012156677A1 (en) 2011-05-18 2012-05-18 A stable micronised monoclinic form of asenapine maleate and its synthesis

Publications (1)

Publication Number Publication Date
ES2665843T3 true ES2665843T3 (es) 2018-04-27

Family

ID=46168537

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12723725.3T Active ES2665843T3 (es) 2011-05-18 2012-05-18 Síntesis de una forma de maleato de asenapina monoclínica micronizada estable

Country Status (5)

Country Link
US (1) US9505771B2 (https=)
EP (1) EP2709616B1 (https=)
JP (1) JP6014656B2 (https=)
ES (1) ES2665843T3 (https=)
WO (1) WO2012156677A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011159903A2 (en) * 2010-06-18 2011-12-22 Dr. Reddy's Laboratories Ltd. Asenapine maleate
US10085971B2 (en) * 2016-08-22 2018-10-02 Navinta Iii Inc Pharmaceutical solution of asenapine for sublingual or buccal use
ES2769286T3 (es) 2016-12-20 2020-06-25 Lts Lohmann Therapie Systeme Ag Sistema terapéutico transdérmico que contiene asenapina
WO2018115010A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
ES2881783T3 (es) 2017-06-26 2021-11-30 Lts Lohmann Therapie Systeme Ag Sistema terapéutico transdérmico que contiene asenapina y polímero de acrílico y silicona
CA3101420A1 (en) 2018-06-20 2019-12-26 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
CN112533593A (zh) 2018-06-20 2021-03-19 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
WO2023097204A1 (en) * 2021-11-24 2023-06-01 Oakwood Laboratories, Llc Microsphere formulations comprising asenapine and methods for making and using the same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
JP4099224B2 (ja) * 1994-03-02 2008-06-11 ナームローゼ・フエンノートチヤツプ・オルガノン 舌下又はバッカル医薬組成物
PT1345593E (pt) * 2000-12-27 2007-10-10 Ares Trading Sa Micropartículas lipídicas por micronização criogénica
US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
DE602006000080T2 (de) * 2005-04-07 2008-05-15 N.V. Organon Kristallform von Asenapinmaleat
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US7750167B2 (en) 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
EP2170399A1 (en) * 2007-06-05 2010-04-07 Synthon B.V. Intranasal administration of asenapine and pharmaceutical compositions therefor
WO2011159903A2 (en) * 2010-06-18 2011-12-22 Dr. Reddy's Laboratories Ltd. Asenapine maleate
US8653280B2 (en) * 2010-07-29 2014-02-18 Laboratories Lesvi, S.L. Process for the preparation of asenapine
WO2012038975A2 (en) * 2010-09-22 2012-03-29 Msn Laboratories Limited Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
WO2012066565A2 (en) * 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) * 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
ITMI20110734A1 (it) * 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
US9533994B2 (en) * 2011-05-18 2017-01-03 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution

Also Published As

Publication number Publication date
US9505771B2 (en) 2016-11-29
WO2012156677A1 (en) 2012-11-22
EP2709616A1 (en) 2014-03-26
US20140142158A1 (en) 2014-05-22
JP6014656B2 (ja) 2016-10-25
EP2709616B1 (en) 2018-01-24
JP2014513712A (ja) 2014-06-05

Similar Documents

Publication Publication Date Title
ES2665843T3 (es) Síntesis de una forma de maleato de asenapina monoclínica micronizada estable
AU2016384921B2 (en) Crystalline form of BTK kinase inhibitor and preparation method thereof
US11472770B2 (en) Process for the preparation of enantiomerically enriched 3-aminopiperidine
EA018227B1 (ru) Способ получения дабигатрана и его промежуточные соединения
JP2018538331A5 (https=)
JP2019529459A5 (https=)
JP2016531925A (ja) ペメトレキセド製造のための中間体製造方法及びこれを用いて高純度ペメトレキセドを製造する方法
KR101304640B1 (ko) 신규의 로수바스타틴 엔-메틸벤질아민 염 및 그의 제조방법
KR101427221B1 (ko) 플루복사민 자유 염기의 정제방법 및 이를 이용한 고순도 플루복사민 말레이트의 제조방법
CA2744949A1 (en) New process for preparing
CN105801438A (zh) 一种米拉贝隆中间体的合成方法
CN105218457A (zh) 一种3,5,5’-三取代-2-乙内酰硫脲的制备方法
AU2015311905B2 (en) Novel salts of 3-[(dimethylamino)methyl)-N-{2-(4-(hydroxycarbamoyl) phenoxy)ethyl}-1-benzofuran-2-carboxamide, related crystalline forms, method for preparing the same and pharmaceutical compositions containing the same
EP3188737A1 (en) Crystalline form of eltrombopag free acid
KR102389717B1 (ko) 인돌 또는 인다졸 화합물의 제조방법
CN102675205A (zh) 一种吡唑肟醚类化合物及其制备与在抗癌治疗中的应用
AU2010313521B2 (en) Methods of preparing 1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone
CN108586450B (zh) 一种胆碱m受体抗结剂的重结晶纯化方法
CN101445506B (zh) 3α-高托品烷胺盐及其晶型和制备方法
KR102389716B1 (ko) 인돌 또는 인다졸 화합물의 제조방법
CN103339124A (zh) 二(芳氨基)芳基化合物的制备方法及其合成中间体
US9908858B2 (en) Method for the synthesis of a hydrazine that can be used in the treatment of the papilloma virus
MXPA04008944A (es) Procedimiento para derivados de triterpeno.
CN120794985A (zh) 1,4,5,6-四氢哒嗪螺咪唑啉-2-酮类化合物、其合成方法及应用
CN103497125B (zh) 一种亚乙基肼甲酸酯的制备方法