ES2662051T3 - Tratamiento de neuropatía óptica hereditaria de Leber y atrofia óptica dominante con tocotrienol quinonas - Google Patents
Tratamiento de neuropatía óptica hereditaria de Leber y atrofia óptica dominante con tocotrienol quinonas Download PDFInfo
- Publication number
- ES2662051T3 ES2662051T3 ES10715650.7T ES10715650T ES2662051T3 ES 2662051 T3 ES2662051 T3 ES 2662051T3 ES 10715650 T ES10715650 T ES 10715650T ES 2662051 T3 ES2662051 T3 ES 2662051T3
- Authority
- ES
- Spain
- Prior art keywords
- tocotrienol
- tocotrienol quinone
- alpha
- treatment
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US318733P | 2001-09-12 | ||
| US21479509P | 2009-04-28 | 2009-04-28 | |
| US214795P | 2009-04-28 | ||
| US31873310P | 2010-03-29 | 2010-03-29 | |
| PCT/US2010/032624 WO2010126911A1 (en) | 2009-04-28 | 2010-04-27 | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2662051T3 true ES2662051T3 (es) | 2018-04-05 |
Family
ID=42244195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10715650.7T Active ES2662051T3 (es) | 2009-04-28 | 2010-04-27 | Tratamiento de neuropatía óptica hereditaria de Leber y atrofia óptica dominante con tocotrienol quinonas |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20100273894A1 (enExample) |
| EP (2) | EP3332766A1 (enExample) |
| JP (3) | JP2012525399A (enExample) |
| BR (1) | BRPI1013376A8 (enExample) |
| CA (1) | CA2777479C (enExample) |
| DK (1) | DK2424495T3 (enExample) |
| EA (1) | EA031126B1 (enExample) |
| ES (1) | ES2662051T3 (enExample) |
| HU (1) | HUE037574T2 (enExample) |
| MX (1) | MX336800B (enExample) |
| NO (1) | NO2424495T3 (enExample) |
| PL (1) | PL2424495T3 (enExample) |
| PT (1) | PT2424495T (enExample) |
| SI (1) | SI2424495T1 (enExample) |
| WO (1) | WO2010126911A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7470798B2 (en) | 2003-09-19 | 2008-12-30 | Edison Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
| EP2564843B1 (en) * | 2005-06-01 | 2018-12-26 | Bioelectron Technology Corporation | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| EP1986636B1 (en) | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases |
| DK2220030T3 (en) | 2007-11-06 | 2016-04-11 | Edison Pharmaceuticals Inc | 4- (P-QUINONYL) -2-HYDROXYBUTANAMIDDERIVATER TO TREAT mitochondrial |
| EP2237664A4 (en) * | 2008-01-08 | 2013-05-22 | Edison Pharmaceuticals Inc | (HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES |
| EP2262508B1 (en) | 2008-03-05 | 2018-10-03 | BioElectron Technology Corporation | SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| CA2729227C (en) | 2008-06-25 | 2018-05-22 | Andrew W. Hinman | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| MX363223B (es) | 2008-09-10 | 2019-03-15 | Bioelectron Tech Corp | Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox. |
| CA2740773A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| ES2553557T3 (es) | 2008-10-28 | 2015-12-10 | Edison Pharmaceuticals, Inc. | Proceso para la producción de alfa-tocotrienol y derivados |
| PL2424495T3 (pl) | 2009-04-28 | 2018-06-29 | Bioelectron Technology Corporation | Leczenie dziedzicznej neuropatii nerwów wzrokowych lebera i dominującego zaniku nerwu wzrokowego chinonami tokotrienolu |
| HUE037592T2 (hu) * | 2009-08-26 | 2018-09-28 | Bioelectron Tech Corp | Eljárások cerebrális ischemia megelõzésére és kezelésére |
| EP2519232A1 (en) * | 2009-12-31 | 2012-11-07 | Edison Pharmaceuticals, Inc. | Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones |
| US9114120B2 (en) | 2010-11-22 | 2015-08-25 | Sigma-Tau Industrie Farmaceutiche Riunite, S.P.A. | Therapeutical method for the treatment of the Leber optic neuropathy |
| US9464016B2 (en) | 2011-06-14 | 2016-10-11 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
| WO2013006737A1 (en) * | 2011-07-06 | 2013-01-10 | Edison Pharmaceuticals, Inc. | Treatment of methylmalonic aciduria, isovaleric aciduria, and other organic acidurias with tocotrienol quinones |
| JP2014520894A (ja) | 2011-07-19 | 2014-08-25 | エジソン ファーマシューティカルズ, インコーポレイテッド | 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法 |
| US9730949B2 (en) | 2012-06-29 | 2017-08-15 | Raouf Rekik | Angiotensin converting enzyme inhibitors for treating optic neuropathy or congenital optic atrophy |
| EP2892516A1 (en) | 2012-09-07 | 2015-07-15 | Edison Pharmaceuticals, Inc. | Quinone derivatives for use in the modulation of redox status of individuals |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| EP2970158B1 (en) | 2013-03-15 | 2019-02-20 | BioElectron Technology Corporation | Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| WO2015103577A1 (en) * | 2014-01-06 | 2015-07-09 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating dominant optic atrophy |
| PL3233786T3 (pl) | 2014-12-16 | 2022-06-13 | Ptc Therapeutics, Inc. | Polimorficzne i amorficzne postacie (r)-2-hydroksy-2-metylo-4-(2,4,5-trimetylo-3,6-dioksocykloheksa-1,4-dienylo)butanoamidu |
| HUE062134T2 (hu) * | 2015-06-05 | 2023-09-28 | Fundacio Hospital Univ Vall Dhebron Institut De Recerca | Mitokondriális betegségek kezelése |
| EP3390377A1 (en) | 2015-12-16 | 2018-10-24 | BioElectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| WO2017106803A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| US20210346332A1 (en) * | 2018-10-11 | 2021-11-11 | Imbria Pharmaceuticals, Inc. | Compositions and methods for treating and preventing leber's hereditary optic neuropathy |
| RU2704013C1 (ru) * | 2019-04-18 | 2019-10-23 | ФГБНУ "НИИ глазных болезней" | Способ коррекции окислительного стресса при наследственной оптической нейропатии Лебера |
| CN112385783B (zh) | 2020-10-10 | 2022-07-05 | 南京农业大学 | 一种控制炭烤肉中多环芳烃含量的烤制方法 |
| WO2024259130A1 (en) * | 2023-06-16 | 2024-12-19 | Ptc Therapeutics, Inc. | Methods for increasing vatiquinone plasma exposure with food |
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| CA2740773A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| ES2553557T3 (es) | 2008-10-28 | 2015-12-10 | Edison Pharmaceuticals, Inc. | Proceso para la producción de alfa-tocotrienol y derivados |
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-
2010
- 2010-04-27 PL PL10715650T patent/PL2424495T3/pl unknown
- 2010-04-27 MX MX2011011309A patent/MX336800B/es active IP Right Grant
- 2010-04-27 US US12/768,565 patent/US20100273894A1/en not_active Abandoned
- 2010-04-27 JP JP2012508609A patent/JP2012525399A/ja not_active Withdrawn
- 2010-04-27 HU HUE10715650A patent/HUE037574T2/hu unknown
- 2010-04-27 DK DK10715650.7T patent/DK2424495T3/en active
- 2010-04-27 BR BRPI1013376A patent/BRPI1013376A8/pt not_active Application Discontinuation
- 2010-04-27 WO PCT/US2010/032624 patent/WO2010126911A1/en not_active Ceased
- 2010-04-27 NO NO10715650A patent/NO2424495T3/no unknown
- 2010-04-27 SI SI201031630T patent/SI2424495T1/en unknown
- 2010-04-27 PT PT107156507T patent/PT2424495T/pt unknown
- 2010-04-27 EA EA201101575A patent/EA031126B1/ru not_active IP Right Cessation
- 2010-04-27 EP EP18151731.9A patent/EP3332766A1/en not_active Withdrawn
- 2010-04-27 CA CA2777479A patent/CA2777479C/en not_active Expired - Fee Related
- 2010-04-27 EP EP10715650.7A patent/EP2424495B1/en not_active Not-in-force
- 2010-04-27 ES ES10715650.7T patent/ES2662051T3/es active Active
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2013
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2014
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2016
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- 2016-09-21 JP JP2016183749A patent/JP2016216506A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EA031126B1 (ru) | 2018-11-30 |
| CA2777479C (en) | 2017-10-17 |
| JP2012525399A (ja) | 2012-10-22 |
| BRPI1013376A2 (pt) | 2017-03-21 |
| US9370496B2 (en) | 2016-06-21 |
| DK2424495T3 (en) | 2018-04-30 |
| EP3332766A1 (en) | 2018-06-13 |
| BRPI1013376A8 (pt) | 2018-01-09 |
| SI2424495T1 (en) | 2018-04-30 |
| CA2777479A1 (en) | 2010-11-04 |
| PT2424495T (pt) | 2018-03-13 |
| HUE037574T2 (hu) | 2018-09-28 |
| JP2015028084A (ja) | 2015-02-12 |
| US10195161B2 (en) | 2019-02-05 |
| MX2011011309A (es) | 2011-11-18 |
| US20170119695A1 (en) | 2017-05-04 |
| PL2424495T3 (pl) | 2018-06-29 |
| JP2016216506A (ja) | 2016-12-22 |
| EA201101575A1 (ru) | 2012-04-30 |
| NO2424495T3 (enExample) | 2018-06-16 |
| MX336800B (es) | 2016-02-02 |
| WO2010126911A1 (en) | 2010-11-04 |
| US20100273894A1 (en) | 2010-10-28 |
| EP2424495A1 (en) | 2012-03-07 |
| EP2424495B1 (en) | 2018-01-17 |
| US20140039065A1 (en) | 2014-02-06 |
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