|
JPS4875564A
(enExample)
|
1972-01-08 |
1973-10-11 |
|
|
|
JPS4988862A
(enExample)
|
1972-12-29 |
1974-08-24 |
|
|
|
US4883658A
(en)
|
1986-04-28 |
1989-11-28 |
Holly Frank J |
Ophthalmic solution for treatment of dry-eye syndrome
|
|
US4804539A
(en)
|
1986-07-28 |
1989-02-14 |
Liposome Technology, Inc. |
Ophthalmic liposomes
|
|
JPH0788376B2
(ja)
|
1986-09-02 |
1995-09-27 |
エーザイ株式会社 |
光学活性α−トコトリエノ−ルの製造方法
|
|
US4914088A
(en)
|
1987-04-02 |
1990-04-03 |
Thomas Glonek |
Dry eye treatment solution and method
|
|
US5278151A
(en)
|
1987-04-02 |
1994-01-11 |
Ocular Research Of Boston, Inc. |
Dry eye treatment solution
|
|
JP2685785B2
(ja)
|
1988-03-11 |
1997-12-03 |
エーザイ株式会社 |
光学活性α−トコトリエノールの製造方法
|
|
AU618791B2
(en)
|
1988-03-16 |
1992-01-09 |
Bioindustry Development Centre |
Production of high concentration tocopherols and tocotrienols from palm oil by-product
|
|
US5075104A
(en)
|
1989-03-31 |
1991-12-24 |
Alcon Laboratories, Inc. |
Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
|
|
US5157132A
(en)
|
1990-05-18 |
1992-10-20 |
Carotech Associates |
Integrated process for recovery of carotenoids and tocotrienols from oil
|
|
ES2084722T3
(es)
|
1990-05-29 |
1996-05-16 |
Boston Ocular Res |
Composicion para tratamiento del ojo seco.
|
|
ZA912797B
(en)
|
1990-05-29 |
1992-12-30 |
Boston Ocular Res |
Dry eye treatment process and solution
|
|
ZA927277B
(en)
|
1991-10-02 |
1993-05-19 |
Boston Ocular Res |
Dry eye treatment process and solution.
|
|
CA2124086A1
(en)
|
1991-11-22 |
1993-05-27 |
Ronald H. Lane |
Tocotrienols and tocotrienol-like compounds and methods for their use
|
|
US5318993A
(en)
*
|
1993-04-16 |
1994-06-07 |
Bristol-Myers Squibb Company |
Antihyperlipidemic benzoquinones
|
|
CA2166722A1
(en)
|
1994-05-06 |
1995-11-16 |
Manoj L. Maniar |
Use of vitamin e tocopheryl derivatives in ophthalmic compositions
|
|
DK0801564T3
(da)
|
1994-12-28 |
2002-07-15 |
Janssen Pharmaceutica Nv |
Anvendelse af nebivolol som et antiatherogent middel
|
|
US6232060B1
(en)
|
1996-01-19 |
2001-05-15 |
Galileo Laboratories, Inc. |
Assay system for anti-stress agents
|
|
US5801159A
(en)
|
1996-02-23 |
1998-09-01 |
Galileo Laboratories, Inc. |
Method and composition for inhibiting cellular irreversible changes due to stress
|
|
BR9907278A
(pt)
|
1998-01-29 |
2000-10-24 |
Eastman Chem Co |
Processos para separar um tocotrienol de uma primeira mistura de tocol, e, composição
|
|
WO2000078296A2
(en)
|
1999-06-17 |
2000-12-28 |
Basf Aktiengesellschaft |
Tocotrienol and/or tocotrienol derivatives for the treatment or prophylaxis of glutamate- and/or calcium-induced disorders
|
|
US6395915B1
(en)
|
1999-09-10 |
2002-05-28 |
Technikrom, Inc. |
Method for producing purified tocotrienols and tocopherols using liquid chromatography
|
|
US6426362B1
(en)
|
1999-10-08 |
2002-07-30 |
Galileo Laboratories, Inc. |
Formulations of tocopherols and methods of making and using them
|
|
US6528042B1
(en)
|
1999-10-08 |
2003-03-04 |
Galileo Laboratories, Inc. |
Compositions of flavonoids for use as cytoprotectants and methods of making and using them
|
|
MY127451A
(en)
|
1999-11-04 |
2006-12-29 |
Malaysian Palm Oil Board |
A method of chromatographic isolation for vitamin e isomers
|
|
DE10034233A1
(de)
|
2000-07-14 |
2002-01-24 |
Basf Ag |
Tocotrienolchinon-Cyclisierungsprodukte
|
|
GB0023555D0
(en)
*
|
2000-09-26 |
2000-11-08 |
Inst Of Ophthalmology |
Improvements in and relating to treatments for eye disease
|
|
CA2430415A1
(en)
|
2000-12-15 |
2002-06-20 |
Galileo Laboratories, Inc. |
Use of tocopherol, metabolites or derivatives thereof or flavonoid metabolites or derivatives thereof in the manufacture of a medicament for the treatment of tissue ischemia
|
|
US7034054B2
(en)
|
2000-12-15 |
2006-04-25 |
Galileo Pharmaceuticals, Inc. |
Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols
|
|
US6838104B2
(en)
|
2000-12-20 |
2005-01-04 |
Archer Daniels Midland Company |
Process for the production of tocotrienols
|
|
US6608196B2
(en)
|
2001-05-03 |
2003-08-19 |
Galileo Pharmaceuticals, Inc. |
Process for solid supported synthesis of pyruvate-derived compounds
|
|
CA2456743A1
(en)
|
2001-08-21 |
2003-02-27 |
Galileo Pharmaceuticals, Inc. |
Tocopherol enriched compositions and amelioration of inflammatory symptoms
|
|
WO2003043570A2
(en)
|
2001-11-15 |
2003-05-30 |
Galileo Laboratories, Inc. |
Formulations and methods for treatment or amelioration of inflammatory conditions
|
|
US6667330B2
(en)
|
2002-01-31 |
2003-12-23 |
Galileo Pharmaceuticals, Inc. |
Furanone derivatives
|
|
US7078541B2
(en)
|
2002-02-07 |
2006-07-18 |
Galileo Pharmaceuticals, Inc. |
Benzofuran derivatives
|
|
US6653346B1
(en)
|
2002-02-07 |
2003-11-25 |
Galileo Pharmaceuticals, Inc. |
Cytoprotective benzofuran derivatives
|
|
DE60211875T2
(de)
|
2002-07-01 |
2006-10-26 |
Santhera Pharmaceuticals (Schweiz) Ag |
Screeningverfahren und Verbindungen zur Behandlung von Friedreich ataxia
|
|
AU2003287250B9
(en)
|
2002-10-30 |
2010-01-28 |
Ptc Therapeutics, Inc. |
Identifying therapeutic compounds based on their physical-chemical properties
|
|
US7015243B2
(en)
*
|
2003-08-28 |
2006-03-21 |
Allergan, Inc. |
Cyclohexyl prostaglandin analogs as EP4-receptor agonists
|
|
US7470798B2
(en)
*
|
2003-09-19 |
2008-12-30 |
Edison Pharmaceuticals, Inc. |
7,8-bicycloalkyl-chroman derivatives
|
|
WO2005032478A2
(en)
*
|
2003-10-01 |
2005-04-14 |
Yasoo Health, Inc. |
Treatment for diabetic microvascular and macrovascular complications
|
|
WO2005035491A2
(en)
|
2003-10-10 |
2005-04-21 |
Yasoo Health, Inc. |
PROCESS FOR SYNTHESIZING d-TOCOTRIENOLS FROM 2- VINYLCHROMANE COMPOUND
|
|
WO2005090602A2
(en)
|
2004-03-18 |
2005-09-29 |
Sucampo Ag |
Method for diagnosing or predicting susceptibility to optic nueropathy
|
|
DE602004022523D1
(de)
|
2004-07-02 |
2009-09-24 |
Novagali Pharma Sa |
Verwendung von Emulsionen zur intra- und periocularen Injection
|
|
US7393662B2
(en)
|
2004-09-03 |
2008-07-01 |
Centocor, Inc. |
Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
|
|
ES2532997T3
(es)
|
2005-04-22 |
2015-04-06 |
Elizabeth Stuart |
Uso de tocotrienoles de vitamina E para la inhibición del patógeno intracelular obligado Chlamydia
|
|
EP2564843B1
(en)
*
|
2005-06-01 |
2018-12-26 |
Bioelectron Technology Corporation |
Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
|
|
LT1933821T
(lt)
|
2005-09-15 |
2020-11-10 |
Ptc Therapeutics, Inc. |
Šoninės grandinės variantai redoks aktyviųjų terapijos priemonių, skirtų mitochondrinių ligų ir kitokių būklių gydymui ir energijos biologinių žymenų moduliavimui
|
|
EP1924292A2
(en)
|
2005-09-16 |
2008-05-28 |
Allergan, Inc. |
Compositions and methods for the intraocular transport of therapeutic agents
|
|
EP1986636B1
(en)
|
2006-02-22 |
2013-04-24 |
Edison Pharmaceuticals, Inc. |
Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
|
|
JP2010515736A
(ja)
|
2007-01-10 |
2010-05-13 |
エジソン ファーマシューティカルズ， インコーポレイテッド |
エリスロポイエチン活性またはトロンボポイエチン活性を有する化合物を用いる呼吸鎖障害の治療
|
|
WO2008157747A1
(en)
|
2007-06-21 |
2008-12-24 |
The Jackson Laboratory |
Use of inhibition of exonuclease 1 in methods for therapy and diagnostic of neurodegenerative diseases, eye diseases, and mitochondrial disorders
|
|
US20100209436A1
(en)
|
2007-07-03 |
2010-08-19 |
Andreas Reichert |
Method for treating diseases related to mitochondrial dysfunction
|
|
WO2009023877A2
(en)
|
2007-08-16 |
2009-02-19 |
Macusight, Inc. |
Formulations for treatment of ocular diseases or conditions
|
|
US8075909B2
(en)
|
2007-09-04 |
2011-12-13 |
University Of Florida Research Foundation, Incorporated |
Contact lens based bioactive agent delivery system
|
|
DK2220030T3
(en)
|
2007-11-06 |
2016-04-11 |
Edison Pharmaceuticals Inc |
4- (P-QUINONYL) -2-HYDROXYBUTANAMIDDERIVATER TO TREAT mitochondrial
|
|
EP2242506A4
(en)
|
2008-01-07 |
2011-12-28 |
Janssen Biotech Inc |
METHOD FOR THE TREATMENT OF ERYTHROPOIETIN HYPORESPONSE ANIMALS
|
|
EP2237664A4
(en)
|
2008-01-08 |
2013-05-22 |
Edison Pharmaceuticals Inc |
(HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES
|
|
CA2717741C
(en)
|
2008-03-05 |
2018-04-03 |
Edison Pharmaceuticals, Inc. |
Treatment of hearing and balance impairments with redox-active therapeutics
|
|
EP2262508B1
(en)
|
2008-03-05 |
2018-10-03 |
BioElectron Technology Corporation |
SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES
|
|
US20110142834A1
(en)
|
2008-05-15 |
2011-06-16 |
Edison Pharmaceuticals, Inc. |
Treatment of hearing and balance impairments using compounds having erythropoietin activity
|
|
CA2724841A1
(en)
|
2008-05-22 |
2009-11-26 |
Edison Pharmaceuticals, Inc. |
Treatment of mitochondrial diseases with an erythropoietin mimetic
|
|
CA2729227C
(en)
|
2008-06-25 |
2018-05-22 |
Andrew W. Hinman |
2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases
|
|
US20100010100A1
(en)
|
2008-07-09 |
2010-01-14 |
Hinman Andrew W |
Dermatological compositions with anti-aging and skin even-toning properties
|
|
US20100029784A1
(en)
|
2008-07-30 |
2010-02-04 |
Hinman Andrew W |
Naphthoquinone compositions with anti-aging, anti-inflammatory and skin even-toning properties
|
|
MX363223B
(es)
|
2008-09-10 |
2019-03-15 |
Bioelectron Tech Corp |
Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox.
|
|
CN102238949A
(zh)
|
2008-10-09 |
2011-11-09 |
拉姆斯科股份有限公司 |
治疗干眼综合征的组合物和方法
|
|
CA2740773A1
(en)
|
2008-10-14 |
2010-04-22 |
Edison Pharmaceuticals, Inc. |
Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
|
|
ES2553557T3
(es)
|
2008-10-28 |
2015-12-10 |
Edison Pharmaceuticals, Inc. |
Proceso para la producción de alfa-tocotrienol y derivados
|
|
PL2424495T3
(pl)
|
2009-04-28 |
2018-06-29 |
Bioelectron Technology Corporation |
Leczenie dziedzicznej neuropatii nerwów wzrokowych lebera i dominującego zaniku nerwu wzrokowego chinonami tokotrienolu
|
|
US20100273892A1
(en)
|
2009-04-28 |
2010-10-28 |
Miller Guy M |
Formulations of tocotrienol quinones for the treatment of ophthalmic diseases
|
|
WO2010126910A1
(en)
|
2009-04-28 |
2010-11-04 |
Edison Pharmaceuticals, Inc. |
Topical, periocular, or intraocular use of tocotrienols for the treatment of ophthalmic diseases
|
|
EA201200054A1
(ru)
|
2009-06-25 |
2012-05-30 |
Эмпэр Лайф Сайнсиз, Инк. |
Лечение токотриенолами или экстрактами, богатыми токотриенолами, первазивных расстройств развития
|
|
HUE037592T2
(hu)
|
2009-08-26 |
2018-09-28 |
Bioelectron Tech Corp |
Eljárások cerebrális ischemia megelõzésére és kezelésére
|
|
WO2011041452A2
(en)
|
2009-10-01 |
2011-04-07 |
Ampere Life Sciences, Inc. |
Mouse model for identifying compounds for the treatment of oxidative stress
|
|
EP2519232A1
(en)
|
2009-12-31 |
2012-11-07 |
Edison Pharmaceuticals, Inc. |
Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones
|
|
WO2011113018A1
(en)
|
2010-03-12 |
2011-09-15 |
Ampere Life Sciences, Inc. |
Measurement and control of biological time
|
|
EA201201374A1
(ru)
|
2010-04-06 |
2013-04-30 |
Эдисон Фармасьютикалз, Инк. |
Лечение атаксии-телеангиэктазии
|
|
AU2011245384C1
(en)
|
2010-04-27 |
2016-09-01 |
Bioelectron Technology Corporation |
Formulations of quinones for the treatment of ophthalmic diseases
|
|
WO2012009271A1
(en)
|
2010-07-14 |
2012-01-19 |
Penwest Pharmaceuticals Co. |
Methods of providing anticoagulation effects in subjects
|
|
US20140031432A1
(en)
|
2010-08-06 |
2014-01-30 |
Ampere Life Sciences, Inc. |
Treatment of mitochondrial diseases with vitamin k
|
|
US20130345312A1
(en)
|
2010-08-06 |
2013-12-26 |
Orion D. Jankowski |
Treatment of mitochondrial diseases with naphthoquinones
|
|
WO2012068552A1
(en)
|
2010-11-19 |
2012-05-24 |
Edison Pharmaceuticals, Inc. |
Methods for improving blood glucose control
|
|
WO2012154613A1
(en)
|
2011-05-06 |
2012-11-15 |
Edison Pharmaceuticals, Inc. |
Improved process for the preparation of d-alpha-tocotrienol from natural extracts
|
|
WO2012170773A1
(en)
|
2011-06-08 |
2012-12-13 |
Edison Pharmaceuticals, Inc. |
Adjunctive therapy for the treatment of mitochondrial disorders with quinones and naphthoquinones
|
|
US9464016B2
(en)
|
2011-06-14 |
2016-10-11 |
Edison Pharmaceuticals, Inc. |
Catechol derivatives for treatment of oxidative stress diseases
|
|
WO2013006737A1
(en)
|
2011-07-06 |
2013-01-10 |
Edison Pharmaceuticals, Inc. |
Treatment of methylmalonic aciduria, isovaleric aciduria, and other organic acidurias with tocotrienol quinones
|
|
WO2013006736A1
(en)
|
2011-07-06 |
2013-01-10 |
Edison Pharmaceuticals, Inc |
Treatment of leigh syndrome and leigh-like syndrome, including complications of sucla2 mutations, with tocotrienol quinones
|
|
JP2014520894A
(ja)
|
2011-07-19 |
2014-08-25 |
エジソン ファーマシューティカルズ， インコーポレイテッド |
非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法
|
|
EP2892516A1
(en)
|
2012-09-07 |
2015-07-15 |
Edison Pharmaceuticals, Inc. |
Quinone derivatives for use in the modulation of redox status of individuals
|
|
EP2964182B1
(en)
|
2013-03-08 |
2018-02-14 |
Unilever PLC, a company registered in England and Wales under company no. 41424 of |
Resorcinol compounds for dermatological use
|
|
EP2970158B1
(en)
|
2013-03-15 |
2019-02-20 |
BioElectron Technology Corporation |
Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders
|
|
US20140275045A1
(en)
|
2013-03-15 |
2014-09-18 |
Edison Pharmaceuticals, Inc. |
Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
|
|
US9670170B2
(en)
|
2013-03-15 |
2017-06-06 |
Bioelectron Technology Corporation |
Resorufin derivatives for treatment of oxidative stress disorders
|
|
US9868711B2
(en)
|
2013-03-15 |
2018-01-16 |
Bioelectron Technology Corporation |
Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
|
|
US9296712B2
(en)
|
2013-03-15 |
2016-03-29 |
Edison Pharmaceuticals, Inc. |
Resorufin derivatives for treatment of oxidative stress disorders
|
|
HK1223369A1
(zh)
|
2013-05-31 |
2017-07-28 |
Bioelectron Technology Corporation |
用於治疗氧化应激障碍的羧酸衍生物
|