ES2657619T3 - Anticuerpos monoclonales específicos para el antígeno M2-1 del virus respiratorio sincicial (VRS) - Google Patents
Anticuerpos monoclonales específicos para el antígeno M2-1 del virus respiratorio sincicial (VRS) Download PDFInfo
- Publication number
- ES2657619T3 ES2657619T3 ES12851478.3T ES12851478T ES2657619T3 ES 2657619 T3 ES2657619 T3 ES 2657619T3 ES 12851478 T ES12851478 T ES 12851478T ES 2657619 T3 ES2657619 T3 ES 2657619T3
- Authority
- ES
- Spain
- Prior art keywords
- rsv
- monoclonal antibodies
- antibody
- respiratory syncytial
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000427 antigen Substances 0.000 title abstract description 11
- 102000036639 antigens Human genes 0.000 title abstract description 11
- 108091007433 antigens Proteins 0.000 title abstract description 11
- 241000725643 Respiratory syncytial virus Species 0.000 title abstract 5
- 101150039699 M2-1 gene Proteins 0.000 title 1
- 230000003612 virological effect Effects 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 5
- 238000003745 diagnosis Methods 0.000 abstract description 4
- 238000003556 assay Methods 0.000 abstract description 3
- 238000001514 detection method Methods 0.000 abstract description 3
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract description 2
- 210000004408 hybridoma Anatomy 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000010790 dilution Methods 0.000 description 12
- 239000012895 dilution Substances 0.000 description 12
- 239000002245 particle Substances 0.000 description 6
- 238000002965 ELISA Methods 0.000 description 5
- 239000000523 sample Substances 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 238000012286 ELISA Assay Methods 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000003759 clinical diagnosis Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 235000011149 sulphuric acid Nutrition 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 101100028789 Arabidopsis thaliana PBS1 gene Proteins 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/115—Paramyxoviridae, e.g. parainfluenza virus
- G01N2333/135—Respiratory syncytial virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2011003002A CL2011003002A1 (es) | 2011-11-25 | 2011-11-25 | Anticuerpo monoclonal o un fragmento del mismo que se une a la proteina m2-1 del virus respiratorio sincicial (vrs) humano; secuencias nucleotidicas; composicion farmaceutica; metodo de diagnostico de infeccion producida por vrs; kit; y uso de dicho anticuerpo para preparar un medicamento. |
| CL30022011 | 2011-11-25 | ||
| PCT/IB2012/056688 WO2013076702A2 (es) | 2011-11-25 | 2012-11-23 | Anticuerpos monoclonales específicos para el antígeno m2-1 del virus respiratorio sincicial (vrs) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2657619T3 true ES2657619T3 (es) | 2018-03-06 |
Family
ID=51205767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12851478.3T Active ES2657619T3 (es) | 2011-11-25 | 2012-11-23 | Anticuerpos monoclonales específicos para el antígeno M2-1 del virus respiratorio sincicial (VRS) |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9273122B2 (enExample) |
| EP (1) | EP2784088B1 (enExample) |
| CN (1) | CN103998465B (enExample) |
| AR (1) | AR088987A1 (enExample) |
| CA (1) | CA2856258C (enExample) |
| CL (1) | CL2011003002A1 (enExample) |
| ES (1) | ES2657619T3 (enExample) |
| IN (1) | IN2014CN04823A (enExample) |
| MX (1) | MX349235B (enExample) |
| PE (1) | PE20141683A1 (enExample) |
| PT (1) | PT2784088T (enExample) |
| WO (1) | WO2013076702A2 (enExample) |
| ZA (1) | ZA201403564B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2014003373A1 (es) * | 2014-12-11 | 2015-04-10 | Univ Pontificia Catolica Chile | Anticuerpos monoclonales especificos para el antígeno m del virus metapneumovirus humano (hmpv), producidos y secretados por hibridomas celulares , útiles para la deteccion y el diagnostico de la infeccion causada por hmpv. |
| JP6270781B2 (ja) * | 2015-06-30 | 2018-01-31 | 田中貴金属工業株式会社 | クロマト分析装置およびクロマト分析方法 |
| CL2015002152A1 (es) | 2015-07-31 | 2016-06-03 | Pontificia Universidad Católica De Chile | Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh |
| TW202228779A (zh) | 2017-03-01 | 2022-08-01 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| CN112912394B (zh) * | 2018-09-03 | 2024-04-16 | 智利天主教教皇大学 | 针对hrsv的n抗原的单抗，可用于治疗感染、其检测和诊断 |
| RU2713340C1 (ru) * | 2018-12-28 | 2020-02-04 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации | Моноклональные антитела, специфичные к различным штаммам респираторно-синцитиального вируса |
| CN115838419B (zh) * | 2022-09-27 | 2023-06-30 | 深圳重链生物科技有限公司 | 抗呼吸道合胞病毒抗体及其相关应用 |
| WO2024120516A1 (zh) * | 2022-12-08 | 2024-06-13 | 南京诺唯赞生物科技股份有限公司 | 特异性结合rsv的抗体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5762905A (en) * | 1992-09-16 | 1998-06-09 | The Scripps Research Institute | Human neutralizing monoclonal antibodies to respiratory syncytial virus |
| EP0724602A4 (en) | 1993-07-30 | 1998-12-23 | Oravax Inc | MONOCLONAL IgA ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS |
| WO2000050646A1 (en) * | 1999-02-26 | 2000-08-31 | The Uab Research Foundation | Methods of screening for antiviral compounds |
| US20020068066A1 (en) | 1999-08-20 | 2002-06-06 | Wenyuan Shi | Method for the treatment and prevention of dental caries |
| JP2004511807A (ja) | 2000-10-17 | 2004-04-15 | ベッスト−テスト アンパーツゼルスカブ | 体液サンプル中のｒｓウイルスに関連した生物学的細胞の直接的検出のためのアッセイ |
| WO2004028478A2 (en) * | 2002-09-27 | 2004-04-08 | Medimmune Vaccines, Inc. | Functional mutations in respiratory syncytial virus |
| CN101130765B (zh) | 2006-08-21 | 2011-04-06 | 北京阿斯可来生物工程有限公司 | 呼吸道合胞病毒检测试剂盒 |
| KR100938998B1 (ko) | 2008-01-08 | 2010-01-28 | (주) 에이프로젠 | 호흡기 신시티움 바이러스에 대한 항체 |
-
2011
- 2011-11-25 CL CL2011003002A patent/CL2011003002A1/es unknown
-
2012
- 2012-11-23 WO PCT/IB2012/056688 patent/WO2013076702A2/es not_active Ceased
- 2012-11-23 US US14/360,219 patent/US9273122B2/en active Active
- 2012-11-23 EP EP12851478.3A patent/EP2784088B1/en active Active
- 2012-11-23 CN CN201280062779.9A patent/CN103998465B/zh active Active
- 2012-11-23 ES ES12851478.3T patent/ES2657619T3/es active Active
- 2012-11-23 MX MX2014006248A patent/MX349235B/es active IP Right Grant
- 2012-11-23 AR ARP120104435A patent/AR088987A1/es active IP Right Grant
- 2012-11-23 PT PT128514783T patent/PT2784088T/pt unknown
- 2012-11-23 PE PE2014000728A patent/PE20141683A1/es active IP Right Grant
- 2012-11-23 CA CA2856258A patent/CA2856258C/en active Active
- 2012-11-23 IN IN4823CHN2014 patent/IN2014CN04823A/en unknown
-
2014
- 2014-05-16 ZA ZA2014/03564A patent/ZA201403564B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR088987A1 (es) | 2014-07-23 |
| CN103998465B (zh) | 2017-02-22 |
| IN2014CN04823A (enExample) | 2015-09-18 |
| US20140348858A1 (en) | 2014-11-27 |
| MX349235B (es) | 2017-07-19 |
| CL2011003002A1 (es) | 2012-05-25 |
| CA2856258C (en) | 2018-05-01 |
| PE20141683A1 (es) | 2014-11-28 |
| BR112014012608A2 (pt) | 2020-10-27 |
| US9273122B2 (en) | 2016-03-01 |
| EP2784088A2 (en) | 2014-10-01 |
| EP2784088A4 (en) | 2015-05-13 |
| ZA201403564B (en) | 2015-08-26 |
| EP2784088B1 (en) | 2017-10-25 |
| CA2856258A1 (en) | 2013-05-30 |
| WO2013076702A2 (es) | 2013-05-30 |
| MX2014006248A (es) | 2015-03-03 |
| CN103998465A (zh) | 2014-08-20 |
| PT2784088T (pt) | 2018-01-31 |
| WO2013076702A3 (es) | 2013-07-25 |
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