CA2856258C - Monoclonal antibodies specific for the m2-1 antigen of respiratory syncytial virus (rsv) - Google Patents

Monoclonal antibodies specific for the m2-1 antigen of respiratory syncytial virus (rsv) Download PDF

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Publication number
CA2856258C
CA2856258C CA2856258A CA2856258A CA2856258C CA 2856258 C CA2856258 C CA 2856258C CA 2856258 A CA2856258 A CA 2856258A CA 2856258 A CA2856258 A CA 2856258A CA 2856258 C CA2856258 C CA 2856258C
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Prior art keywords
antibody
rsv
monoclonal
antigen
fragment
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Active
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CA2856258A
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English (en)
French (fr)
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CA2856258A1 (en
Inventor
Alexis Mikes Kalergis Parra
Susan Marcela Bueno Ramirez
Jorge Eugenio MORA ALARCON
Roberto Sebastian Gomez Johnson
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Pontificia Universidad Catolica de Chile
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Pontificia Universidad Catolica de Chile
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Publication of CA2856258A1 publication Critical patent/CA2856258A1/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027Paramyxoviridae, e.g. respiratory syncytial virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/115Paramyxoviridae, e.g. parainfluenza virus
    • G01N2333/135Respiratory syncytial virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2856258A 2011-11-25 2012-11-23 Monoclonal antibodies specific for the m2-1 antigen of respiratory syncytial virus (rsv) Active CA2856258C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CL2011003002A CL2011003002A1 (es) 2011-11-25 2011-11-25 Anticuerpo monoclonal o un fragmento del mismo que se une a la proteina m2-1 del virus respiratorio sincicial (vrs) humano; secuencias nucleotidicas; composicion farmaceutica; metodo de diagnostico de infeccion producida por vrs; kit; y uso de dicho anticuerpo para preparar un medicamento.
CL3002-2011 2011-11-25
PCT/IB2012/056688 WO2013076702A2 (es) 2011-11-25 2012-11-23 Anticuerpos monoclonales específicos para el antígeno m2-1 del virus respiratorio sincicial (vrs)

Publications (2)

Publication Number Publication Date
CA2856258A1 CA2856258A1 (en) 2013-05-30
CA2856258C true CA2856258C (en) 2018-05-01

Family

ID=51205767

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2856258A Active CA2856258C (en) 2011-11-25 2012-11-23 Monoclonal antibodies specific for the m2-1 antigen of respiratory syncytial virus (rsv)

Country Status (13)

Country Link
US (1) US9273122B2 (enExample)
EP (1) EP2784088B1 (enExample)
CN (1) CN103998465B (enExample)
AR (1) AR088987A1 (enExample)
CA (1) CA2856258C (enExample)
CL (1) CL2011003002A1 (enExample)
ES (1) ES2657619T3 (enExample)
IN (1) IN2014CN04823A (enExample)
MX (1) MX349235B (enExample)
PE (1) PE20141683A1 (enExample)
PT (1) PT2784088T (enExample)
WO (1) WO2013076702A2 (enExample)
ZA (1) ZA201403564B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2014003373A1 (es) * 2014-12-11 2015-04-10 Univ Pontificia Catolica Chile Anticuerpos monoclonales especificos para el antígeno m del virus metapneumovirus humano (hmpv), producidos y secretados por hibridomas celulares , útiles para la deteccion y el diagnostico de la infeccion causada por hmpv.
JP6270781B2 (ja) * 2015-06-30 2018-01-31 田中貴金属工業株式会社 クロマト分析装置およびクロマト分析方法
CL2015002152A1 (es) 2015-07-31 2016-06-03 Pontificia Universidad Católica De Chile Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh
TW202228779A (zh) 2017-03-01 2022-08-01 英商梅迪繆思有限公司 抗rsv單株抗體配製物
CN112912394B (zh) * 2018-09-03 2024-04-16 智利天主教教皇大学 针对hrsv的n抗原的单抗,可用于治疗感染、其检测和诊断
RU2713340C1 (ru) * 2018-12-28 2020-02-04 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации Моноклональные антитела, специфичные к различным штаммам респираторно-синцитиального вируса
CN115838419B (zh) * 2022-09-27 2023-06-30 深圳重链生物科技有限公司 抗呼吸道合胞病毒抗体及其相关应用
WO2024120516A1 (zh) * 2022-12-08 2024-06-13 南京诺唯赞生物科技股份有限公司 特异性结合rsv的抗体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5762905A (en) * 1992-09-16 1998-06-09 The Scripps Research Institute Human neutralizing monoclonal antibodies to respiratory syncytial virus
EP0724602A4 (en) 1993-07-30 1998-12-23 Oravax Inc MONOCLONAL IgA ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS
WO2000050646A1 (en) * 1999-02-26 2000-08-31 The Uab Research Foundation Methods of screening for antiviral compounds
US20020068066A1 (en) 1999-08-20 2002-06-06 Wenyuan Shi Method for the treatment and prevention of dental caries
JP2004511807A (ja) 2000-10-17 2004-04-15 ベッスト−テスト アンパーツゼルスカブ 体液サンプル中のrsウイルスに関連した生物学的細胞の直接的検出のためのアッセイ
WO2004028478A2 (en) * 2002-09-27 2004-04-08 Medimmune Vaccines, Inc. Functional mutations in respiratory syncytial virus
CN101130765B (zh) 2006-08-21 2011-04-06 北京阿斯可来生物工程有限公司 呼吸道合胞病毒检测试剂盒
KR100938998B1 (ko) 2008-01-08 2010-01-28 (주) 에이프로젠 호흡기 신시티움 바이러스에 대한 항체

Also Published As

Publication number Publication date
AR088987A1 (es) 2014-07-23
CN103998465B (zh) 2017-02-22
IN2014CN04823A (enExample) 2015-09-18
US20140348858A1 (en) 2014-11-27
MX349235B (es) 2017-07-19
CL2011003002A1 (es) 2012-05-25
PE20141683A1 (es) 2014-11-28
BR112014012608A2 (pt) 2020-10-27
US9273122B2 (en) 2016-03-01
EP2784088A2 (en) 2014-10-01
EP2784088A4 (en) 2015-05-13
ES2657619T3 (es) 2018-03-06
ZA201403564B (en) 2015-08-26
EP2784088B1 (en) 2017-10-25
CA2856258A1 (en) 2013-05-30
WO2013076702A2 (es) 2013-05-30
MX2014006248A (es) 2015-03-03
CN103998465A (zh) 2014-08-20
PT2784088T (pt) 2018-01-31
WO2013076702A3 (es) 2013-07-25

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