AR088987A1 - Anticuerpos monoclonales especificos para el antigeno m2-1 del virus respiratorio sincicial (vrs), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrs - Google Patents
Anticuerpos monoclonales especificos para el antigeno m2-1 del virus respiratorio sincicial (vrs), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsInfo
- Publication number
- AR088987A1 AR088987A1 ARP120104435A ARP120104435A AR088987A1 AR 088987 A1 AR088987 A1 AR 088987A1 AR P120104435 A ARP120104435 A AR P120104435A AR P120104435 A ARP120104435 A AR P120104435A AR 088987 A1 AR088987 A1 AR 088987A1
- Authority
- AR
- Argentina
- Prior art keywords
- secreted
- monoclonal antibodies
- vrs
- rsv
- hybridoma
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 230000001413 cellular effect Effects 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 6
- 210000004408 hybridoma Anatomy 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/115—Paramyxoviridae, e.g. parainfluenza virus
- G01N2333/135—Respiratory syncytial virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Pulmonology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente se refiere al uso de anticuerpos monoclonales específicos para el virus respiratorio sincicial (VRS). Concretamente, a un anticuerpo monoclonal IgG2A secretado por la línea celular de hibridoma 8A4/G9 dirigido específicamente para el antígeno viral M2-1, el cual está asociado a la nucleocápside del virus. Los anticuerpos pueden ser utilizados para ensayos de detección y/o determinación de infección por VRS. Dichos anticuerpos se encuentran en estado puro y libre de cualquier otro material biológico contaminante. En otro aspecto, se proporciona un método para prevención y tratamiento de la infección causada por virus respiratorio sincicial (VRS) en un huésped dado, el cual comprende la administración de una composición que comprende los anticuerpos monoclonales secretados por el hibridoma 8A4/G9 en dosis suficientes para prevenir la enfermedad. El anticuerpo puede ser humanizado para minimizar la posibilidad de una respuesta inmune contra él en el paciente que lo utiliza. Además, permite proveer la formulación de cualquier forma farmacéutica de los anticuerpos monoclonales secretados por el hibridoma 8A4/G9, que sean adecuados para el tratamiento o prevención de la enfermedad causada por VRS. También proporciona métodos de diagnóstico y detección de antígenos virales de VRS en muestras biológicas, en la cual se utilicen los anticuerpos monoclonales producidos y secretados por células del hibridoma 8A4/G9.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2011003002A CL2011003002A1 (es) | 2011-11-25 | 2011-11-25 | Anticuerpo monoclonal o un fragmento del mismo que se une a la proteina m2-1 del virus respiratorio sincicial (vrs) humano; secuencias nucleotidicas; composicion farmaceutica; metodo de diagnostico de infeccion producida por vrs; kit; y uso de dicho anticuerpo para preparar un medicamento. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088987A1 true AR088987A1 (es) | 2014-07-23 |
Family
ID=51205767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120104435A AR088987A1 (es) | 2011-11-25 | 2012-11-23 | Anticuerpos monoclonales especificos para el antigeno m2-1 del virus respiratorio sincicial (vrs), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrs |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9273122B2 (es) |
| EP (1) | EP2784088B1 (es) |
| CN (1) | CN103998465B (es) |
| AR (1) | AR088987A1 (es) |
| CA (1) | CA2856258C (es) |
| CL (1) | CL2011003002A1 (es) |
| ES (1) | ES2657619T3 (es) |
| IN (1) | IN2014CN04823A (es) |
| MX (1) | MX349235B (es) |
| PE (1) | PE20141683A1 (es) |
| PT (1) | PT2784088T (es) |
| WO (1) | WO2013076702A2 (es) |
| ZA (1) | ZA201403564B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2014003373A1 (es) * | 2014-12-11 | 2015-04-10 | Univ Pontificia Catolica Chile | Anticuerpos monoclonales especificos para el antígeno m del virus metapneumovirus humano (hmpv), producidos y secretados por hibridomas celulares , útiles para la deteccion y el diagnostico de la infeccion causada por hmpv. |
| JP6270781B2 (ja) * | 2015-06-30 | 2018-01-31 | 田中貴金属工業株式会社 | クロマト分析装置およびクロマト分析方法 |
| CL2015002152A1 (es) | 2015-07-31 | 2016-06-03 | Pontificia Universidad Católica De Chile | Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh |
| TWI761453B (zh) | 2017-03-01 | 2022-04-21 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| CA3111336A1 (en) * | 2018-09-03 | 2020-03-12 | Pontificia Universidad Catolica De Chile | Specific monoclonal antibody against the n antigen of human respiratory syncytial virus (hrsv) useful for treating infection, detection thereof and diagnosis |
| RU2713340C1 (ru) * | 2018-12-28 | 2020-02-04 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации | Моноклональные антитела, специфичные к различным штаммам респираторно-синцитиального вируса |
| CN115838419B (zh) * | 2022-09-27 | 2023-06-30 | 深圳重链生物科技有限公司 | 抗呼吸道合胞病毒抗体及其相关应用 |
| WO2024120516A1 (zh) * | 2022-12-08 | 2024-06-13 | 南京诺唯赞生物科技股份有限公司 | 特异性结合rsv的抗体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0671927B1 (en) | 1992-09-16 | 2003-01-15 | The Scripps Research Institute | Human neutralizing monoclonal antibodies to respiratory syncytial virus |
| AU689489B2 (en) * | 1993-07-30 | 1998-04-02 | Oravax, Inc | Monoclonal IgA antibody against respiratory syncytial virus |
| WO2000050646A1 (en) * | 1999-02-26 | 2000-08-31 | The Uab Research Foundation | Methods of screening for antiviral compounds |
| US20020068066A1 (en) * | 1999-08-20 | 2002-06-06 | Wenyuan Shi | Method for the treatment and prevention of dental caries |
| DE60135147D1 (de) | 2000-10-17 | 2008-09-11 | Besst Test Aps | Nen biologischen zelle in einer körperflüssigkeitsprobe |
| AU2003295339B2 (en) * | 2002-09-27 | 2009-03-26 | Medimmune, Llc | Functional mutations in respiratory syncytial virus |
| CN101130765B (zh) | 2006-08-21 | 2011-04-06 | 北京阿斯可来生物工程有限公司 | 呼吸道合胞病毒检测试剂盒 |
| KR100938998B1 (ko) | 2008-01-08 | 2010-01-28 | (주) 에이프로젠 | 호흡기 신시티움 바이러스에 대한 항체 |
-
2011
- 2011-11-25 CL CL2011003002A patent/CL2011003002A1/es unknown
-
2012
- 2012-11-23 PT PT128514783T patent/PT2784088T/pt unknown
- 2012-11-23 PE PE2014000728A patent/PE20141683A1/es active IP Right Grant
- 2012-11-23 AR ARP120104435A patent/AR088987A1/es active IP Right Grant
- 2012-11-23 IN IN4823CHN2014 patent/IN2014CN04823A/en unknown
- 2012-11-23 US US14/360,219 patent/US9273122B2/en active Active
- 2012-11-23 ES ES12851478.3T patent/ES2657619T3/es active Active
- 2012-11-23 CA CA2856258A patent/CA2856258C/en active Active
- 2012-11-23 EP EP12851478.3A patent/EP2784088B1/en active Active
- 2012-11-23 CN CN201280062779.9A patent/CN103998465B/zh active Active
- 2012-11-23 MX MX2014006248A patent/MX349235B/es active IP Right Grant
- 2012-11-23 WO PCT/IB2012/056688 patent/WO2013076702A2/es active Application Filing
-
2014
- 2014-05-16 ZA ZA2014/03564A patent/ZA201403564B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103998465B (zh) | 2017-02-22 |
| EP2784088B1 (en) | 2017-10-25 |
| EP2784088A4 (en) | 2015-05-13 |
| CA2856258A1 (en) | 2013-05-30 |
| ES2657619T3 (es) | 2018-03-06 |
| WO2013076702A2 (es) | 2013-05-30 |
| CN103998465A (zh) | 2014-08-20 |
| US20140348858A1 (en) | 2014-11-27 |
| BR112014012608A2 (pt) | 2020-10-27 |
| CA2856258C (en) | 2018-05-01 |
| MX349235B (es) | 2017-07-19 |
| PT2784088T (pt) | 2018-01-31 |
| CL2011003002A1 (es) | 2012-05-25 |
| IN2014CN04823A (es) | 2015-09-18 |
| MX2014006248A (es) | 2015-03-03 |
| WO2013076702A3 (es) | 2013-07-25 |
| EP2784088A2 (en) | 2014-10-01 |
| US9273122B2 (en) | 2016-03-01 |
| ZA201403564B (en) | 2015-08-26 |
| PE20141683A1 (es) | 2014-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |