ES2651929T3 - Inhibidores de pan-selectina heterobifuncionales - Google Patents
Inhibidores de pan-selectina heterobifuncionales Download PDFInfo
- Publication number
- ES2651929T3 ES2651929T3 ES10011660.7T ES10011660T ES2651929T3 ES 2651929 T3 ES2651929 T3 ES 2651929T3 ES 10011660 T ES10011660 T ES 10011660T ES 2651929 T3 ES2651929 T3 ES 2651929T3
- Authority
- ES
- Spain
- Prior art keywords
- alkynyl
- compound
- selectin
- alkenyl
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71399405P | 2005-09-02 | 2005-09-02 | |
| US713994P | 2005-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2651929T3 true ES2651929T3 (es) | 2018-01-30 |
Family
ID=37603124
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06814078T Active ES2397850T3 (es) | 2005-09-02 | 2006-09-01 | Inhibidores de pan-selectina heterobifuncionales |
| ES10011660.7T Active ES2651929T3 (es) | 2005-09-02 | 2006-09-01 | Inhibidores de pan-selectina heterobifuncionales |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06814078T Active ES2397850T3 (es) | 2005-09-02 | 2006-09-01 | Inhibidores de pan-selectina heterobifuncionales |
Country Status (16)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2397850T3 (es) | 2005-09-02 | 2013-03-11 | Glycomimetics, Inc. | Inhibidores de pan-selectina heterobifuncionales |
| JP5298020B2 (ja) * | 2006-10-12 | 2013-09-25 | グリコミメティクス， インコーポレイテッド | ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換 |
| EP2117561A1 (en) * | 2007-02-09 | 2009-11-18 | GlycoMimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| WO2009073911A1 (en) | 2007-12-10 | 2009-06-18 | Mater Medical Research Institute | Treatment and prophylaxis |
| US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| US8518896B2 (en) * | 2008-06-13 | 2013-08-27 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
| JP5726171B2 (ja) * | 2009-05-01 | 2015-05-27 | グリコミメティックス インコーポレイテッド | Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤 |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| WO2012061662A1 (en) | 2010-11-03 | 2012-05-10 | Glycomimetics, Inc. | Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors |
| KR102055958B1 (ko) * | 2011-12-22 | 2019-12-13 | 글리코미메틱스, 인크. | E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법 |
| US20140059130A1 (en) * | 2012-08-22 | 2014-02-27 | Mainsoft R&D Ltd. | System and method for updating connections in social networks |
| AU2013355238B2 (en) | 2012-12-07 | 2017-12-14 | Glycomimetics, Inc. | Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells |
| US20170296566A9 (en) * | 2013-09-30 | 2017-10-19 | Glycomimetics, Inc. | Methods and compositions for treating and/or preventing mucositis |
| EP3569609A1 (en) | 2014-12-03 | 2019-11-20 | GlycoMimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| WO2016164394A1 (en) | 2015-04-08 | 2016-10-13 | Glycomimetics, Inc. | 2-halo-galactose-containing selectin antagonists |
| US20160331775A1 (en) * | 2015-05-14 | 2016-11-17 | The Regents Of The University Of Michigan | E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk |
| WO2016196221A1 (en) | 2015-05-29 | 2016-12-08 | Nike Innovate C.V. | System for operating multiple transceiver modules concurrently |
| JP2019501130A (ja) * | 2015-12-02 | 2019-01-17 | グリコミメティクス， インコーポレイテッド | トリアゾールリンカーを有するヘテロ二官能性の汎セレクチン拮抗剤 |
| HUE050811T2 (hu) | 2015-12-07 | 2021-01-28 | Merck Patent Gmbh | Avelumab anti-PD-1 ellenanyagot tartalmazó vizes gyógyászati kiszerelés |
| JP2019502727A (ja) | 2016-01-22 | 2019-01-31 | グリコミメティクス， インコーポレイテッド | Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤 |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| WO2017205269A1 (en) | 2016-05-24 | 2017-11-30 | Glycomimetics, Inc. | Haloalkyl fucose-containing selectin antagonists |
| EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
| KR102653723B1 (ko) | 2016-10-07 | 2024-04-01 | 글리코미메틱스, 인크. | 매우 강력한 다량체성 e-셀렉틴 길항물질 |
| CA3054605A1 (en) * | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| EP3717013A1 (en) | 2017-11-30 | 2020-10-07 | GlycoMimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| CN111566117A (zh) * | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | E-选择蛋白和半乳凝素-3的异双功能抑制剂 |
| KR20200128025A (ko) | 2018-03-05 | 2020-11-11 | 글리코미메틱스, 인크. | 급성 골수성 백혈병 및 관련 병태의 치료 방법 |
| WO2020123435A2 (en) | 2018-12-10 | 2020-06-18 | Glycomimetics, Inc. | Methods of treating hiv and aids and the elimination of latent reservoirs of hiv infection using selectin, galectin, and siglec antagonists |
| WO2020139962A1 (en) | 2018-12-27 | 2020-07-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| WO2020150263A1 (en) | 2019-01-14 | 2020-07-23 | Magnani John L | Selectin or galectin antagonists for treating cytokine release syndrome and crs-induced neurotoxicity |
| WO2020219419A1 (en) | 2019-04-24 | 2020-10-29 | Glycomimetics, Inc. | Multimeric pan–selectin antagonists |
| EP3958978A1 (en) | 2019-04-24 | 2022-03-02 | GlycoMimetics, Inc. | Galactose-linked multimeric glycomimetic inhibitors of e-selectins, galectin-3, and/or cxcr4 chemokine receptors |
| US20220265691A1 (en) | 2019-07-12 | 2022-08-25 | Glycomimetics, Inc. | Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types |
| CA3146048A1 (en) | 2019-07-31 | 2021-02-04 | Glycomimetics, Inc. | Use of e-selectin antagonists to enhance the survival of reconstituted, bone marrow-depleted hosts |
| WO2021195465A1 (en) * | 2020-03-27 | 2021-09-30 | Magnani John L | Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin |
| CN115666584A (zh) | 2020-05-31 | 2023-01-31 | 糖模拟物有限公司 | 用于减少癌细胞负荷和保护正常血细胞生成的化合物和方法 |
| AU2021292458A1 (en) | 2020-06-14 | 2023-01-19 | GlycoMimetics | Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting |
| CN116113637A (zh) * | 2020-09-17 | 2023-05-12 | 糖模拟物有限公司 | E-选择素靶向剂 |
| WO2023014690A1 (en) | 2021-08-03 | 2023-02-09 | Glycomimetics, Inc. | Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2510745A (en) * | 1945-11-15 | 1950-06-06 | Charles R Kilgore | Cover for electric service outlets |
| US2514745A (en) * | 1946-12-19 | 1950-07-11 | Heyer Ind Inc | Changeable scale electrical testing instrument |
| US2757817A (en) * | 1954-04-29 | 1956-08-07 | Warren R Egan | Electrical outlet box |
| US2983399A (en) * | 1959-04-20 | 1961-05-09 | Frank E Slater | Seal for electric outlet box |
| US4109095A (en) * | 1976-10-28 | 1978-08-22 | Mulberry Metal Products, Inc. | Weatherproof electrical outlet box cover |
| US4098423A (en) * | 1977-03-10 | 1978-07-04 | Louis Marrero | Self-aligning outlet box assembly |
| US4145857A (en) * | 1977-10-28 | 1979-03-27 | Concast, Inc. | Base for mounting electrical equipment |
| US4276730A (en) * | 1979-07-02 | 1981-07-07 | Lewis David M | Building wall construction |
| US4320606A (en) * | 1979-12-06 | 1982-03-23 | Home Crafts Corporation | Reinforced concrete panels and building constructed therewith |
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- 2006-09-01 EP EP10011660.7A patent/EP2264043B1/en active Active
- 2006-09-01 WO PCT/US2006/034274 patent/WO2007028050A1/en active Application Filing
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- 2006-09-01 AU AU2006284578A patent/AU2006284578B2/en active Active
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2016
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2017
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