ES2643576T3 - Dúplex oligonucleotídicos que comprenden nucleótidos de tipo ADN y de tipo ARN y usos de los mismos - Google Patents
Dúplex oligonucleotídicos que comprenden nucleótidos de tipo ADN y de tipo ARN y usos de los mismos Download PDFInfo
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- ES2643576T3 ES2643576T3 ES09757018.8T ES09757018T ES2643576T3 ES 2643576 T3 ES2643576 T3 ES 2643576T3 ES 09757018 T ES09757018 T ES 09757018T ES 2643576 T3 ES2643576 T3 ES 2643576T3
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5918608P | 2008-06-05 | 2008-06-05 | |
| US59186P | 2008-06-05 | ||
| CA002635187A CA2635187A1 (en) | 2008-06-05 | 2008-06-17 | Oligonucleotide duplexes and uses thereof |
| CA2635187 | 2008-06-17 | ||
| WOPCT/CA2008/002259 | 2008-12-19 | ||
| PCT/CA2008/002259 WO2009076775A1 (en) | 2007-12-19 | 2008-12-19 | Immune response modulation and uses thereof |
| PCT/CA2009/000789 WO2009146556A1 (en) | 2008-06-05 | 2009-06-05 | Oligonucleotide duplexes comprising dna-like and rna-like nucleotides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2643576T3 true ES2643576T3 (es) | 2017-11-23 |
Family
ID=41397419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09757018.8T Active ES2643576T3 (es) | 2008-06-05 | 2009-06-05 | Dúplex oligonucleotídicos que comprenden nucleótidos de tipo ADN y de tipo ARN y usos de los mismos |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9090649B2 (OSRAM) |
| EP (1) | EP2294195B1 (OSRAM) |
| JP (1) | JP5684116B2 (OSRAM) |
| CA (2) | CA2635187A1 (OSRAM) |
| ES (1) | ES2643576T3 (OSRAM) |
| WO (1) | WO2009146556A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007283022B2 (en) | 2006-08-08 | 2011-07-28 | Rheinische Friedrich-Wilhelms-Universitat Bonn | Structure and use of 5' phosphate oligonucleotides |
| WO2009141146A1 (en) | 2008-05-21 | 2009-11-26 | Gunther Hartmann | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| CA2635187A1 (en) | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
| WO2012065143A1 (en) | 2010-11-12 | 2012-05-18 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| DK2756080T3 (da) | 2011-09-14 | 2019-05-20 | Translate Bio Ma Inc | Multimeriske oligonukleotidforbindelser |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| AU2013262700A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating hemoglobin gene family expression |
| CN104540947A (zh) | 2012-05-16 | 2015-04-22 | Rana医疗有限公司 | 用于调节smn基因家族表达的组合物和方法 |
| JP2015518713A (ja) | 2012-05-16 | 2015-07-06 | ラナ セラピューティクス インコーポレイテッド | Ｕｔｒｎ発現を調節するための組成物及び方法 |
| CN104583401A (zh) | 2012-05-16 | 2015-04-29 | Rana医疗有限公司 | 用于调节atp2a2表达的组合物和方法 |
| CA2884608C (en) | 2012-09-14 | 2025-05-20 | Translate Bio Ma, Inc. | MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| JP2016534035A (ja) | 2013-10-04 | 2016-11-04 | ラナ セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症を治療するための組成物及び方法 |
| EP3212824A4 (en) | 2014-10-30 | 2018-08-08 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
| US10758558B2 (en) | 2015-02-13 | 2020-09-01 | Translate Bio Ma, Inc. | Hybrid oligonucleotides and uses thereof |
| EP3271460A4 (en) | 2015-03-17 | 2019-03-13 | The General Hospital Corporation | RNA INTERACTOM OF POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) |
| EP4013428A4 (en) * | 2019-08-15 | 2023-08-09 | Ionis Pharmaceuticals, Inc. | MODIFIED OLIGOMER COMPOUNDS AND USES THEREOF |
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| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US6336859B2 (en) * | 1993-03-31 | 2002-01-08 | Progressive Games, Inc. | Method for progressive jackpot gaming |
| US7084125B2 (en) * | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| US6639059B1 (en) * | 1999-03-24 | 2003-10-28 | Exiqon A/S | Synthesis of [2.2.1]bicyclo nucleosides |
| US6734291B2 (en) * | 1999-03-24 | 2004-05-11 | Exiqon A/S | Synthesis of [2.2.1]bicyclo nucleosides |
| AU776362B2 (en) * | 1999-05-04 | 2004-09-09 | Roche Innovation Center Copenhagen A/S | L-ribo-LNA analogues |
| US6083482A (en) * | 1999-05-11 | 2000-07-04 | Icn Pharmaceuticals, Inc. | Conformationally locked nucleosides and oligonucleotides |
| US6338859B1 (en) | 2000-06-29 | 2002-01-15 | Labopharm Inc. | Polymeric micelle compositions |
| US20020132788A1 (en) * | 2000-11-06 | 2002-09-19 | David Lewis | Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo |
| US20020173478A1 (en) * | 2000-11-14 | 2002-11-21 | The Trustees Of The University Of Pennsylvania | Post-transcriptional gene silencing by RNAi in mammalian cells |
| EP1386004A4 (en) * | 2001-04-05 | 2005-02-16 | Ribozyme Pharm Inc | MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID |
| US6780428B2 (en) * | 2001-06-08 | 2004-08-24 | Labopharm, Inc. | Unimolecular polymeric micelles with an ionizable inner core |
| US7094810B2 (en) * | 2001-06-08 | 2006-08-22 | Labopharm, Inc. | pH-sensitive block copolymers for pharmaceutical compositions |
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| US7018655B2 (en) * | 2002-03-18 | 2006-03-28 | Labopharm, Inc. | Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions |
| US6780324B2 (en) * | 2002-03-18 | 2004-08-24 | Labopharm, Inc. | Preparation of sterile stabilized nanodispersions |
| IL166546A0 (en) * | 2002-08-05 | 2006-01-15 | Atugen Ag | Further novel forms of interfering ran molecules |
| ES2332178T5 (es) | 2003-03-21 | 2014-02-04 | Santaris Pharma A/S | Análogos de ARN pequeños de interferencia (ARNpi) |
| US7262253B2 (en) * | 2003-12-02 | 2007-08-28 | Labopharm, Inc. | Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers |
| US7468431B2 (en) * | 2004-01-22 | 2008-12-23 | Isis Pharmaceuticals, Inc. | Modulation of eIF4E-BP2 expression |
| US20060198891A1 (en) * | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| US20090306177A1 (en) * | 2005-09-16 | 2009-12-10 | Coley Pharmaceutical Gmbh | Modulation of Immunostimulatory Properties of Short Interfering Ribonucleic Acid (Sirna) by Nucleotide Modification |
| EP1945267A2 (en) * | 2005-10-28 | 2008-07-23 | Topigen Pharmaceuticals Inc. | Small interfering oligonucleotides comprising arabinose modified nucleotides |
| US20090069263A1 (en) * | 2005-12-16 | 2009-03-12 | Damha Masad J | 4'-thioarabinonucleotide-containing oligonucleotides, compounds and methods for their preparation and uses thereof |
| CN102124107A (zh) | 2006-07-17 | 2011-07-13 | 瑟纳治疗公司 | 使用短干扰核酸(siNA)的RNA干扰介导的前蛋白转化酶枯草杆菌蛋白酶Kexin9(PCSK9)基因表达的抑制 |
| CA2699184A1 (en) * | 2006-09-22 | 2008-03-27 | Labopharm Inc. | Compositions and methods for ph targeted drug delivery |
| CA2635187A1 (en) | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
-
2008
- 2008-06-17 CA CA002635187A patent/CA2635187A1/en not_active Abandoned
-
2009
- 2009-06-05 EP EP09757018.8A patent/EP2294195B1/en active Active
- 2009-06-05 CA CA2764456A patent/CA2764456C/en active Active
- 2009-06-05 WO PCT/CA2009/000789 patent/WO2009146556A1/en not_active Ceased
- 2009-06-05 JP JP2011511949A patent/JP5684116B2/ja active Active
- 2009-06-05 ES ES09757018.8T patent/ES2643576T3/es active Active
- 2009-06-05 US US12/996,362 patent/US9090649B2/en active Active
-
2015
- 2015-07-27 US US14/810,148 patent/US9719091B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009146556A1 (en) | 2009-12-10 |
| US9090649B2 (en) | 2015-07-28 |
| EP2294195B1 (en) | 2017-07-19 |
| US20110077286A1 (en) | 2011-03-31 |
| US9719091B2 (en) | 2017-08-01 |
| CA2764456C (en) | 2020-09-15 |
| EP2294195A1 (en) | 2011-03-16 |
| EP2294195A4 (en) | 2012-12-19 |
| JP5684116B2 (ja) | 2015-03-11 |
| US20160145613A1 (en) | 2016-05-26 |
| CA2764456A1 (en) | 2009-12-10 |
| CA2635187A1 (en) | 2009-12-05 |
| JP2011521652A (ja) | 2011-07-28 |
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