CA2635187A1 - Oligonucleotide duplexes and uses thereof - Google Patents
Oligonucleotide duplexes and uses thereof Download PDFInfo
- Publication number
- CA2635187A1 CA2635187A1 CA002635187A CA2635187A CA2635187A1 CA 2635187 A1 CA2635187 A1 CA 2635187A1 CA 002635187 A CA002635187 A CA 002635187A CA 2635187 A CA2635187 A CA 2635187A CA 2635187 A1 CA2635187 A1 CA 2635187A1
- Authority
- CA
- Canada
- Prior art keywords
- sirna
- rna
- oligonucleotide
- oligonucleotides
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
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- C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects
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Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09757018.8T ES2643576T3 (es) | 2008-06-05 | 2009-06-05 | Dúplex oligonucleotídicos que comprenden nucleótidos de tipo ADN y de tipo ARN y usos de los mismos |
| PCT/CA2009/000789 WO2009146556A1 (en) | 2008-06-05 | 2009-06-05 | Oligonucleotide duplexes comprising dna-like and rna-like nucleotides and uses thereof |
| EP09757018.8A EP2294195B1 (en) | 2008-06-05 | 2009-06-05 | Oligonucleotide duplexes comprising dna-like and rna-like nucleotides and uses thereof |
| US12/996,362 US9090649B2 (en) | 2008-06-05 | 2009-06-05 | Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof |
| JP2011511949A JP5684116B2 (ja) | 2008-06-05 | 2009-06-05 | Ｄｎａ様ヌクレオチドおよびｒｎａ様ヌクレオチドを含むオリゴヌクレオチド二重鎖およびその使用 |
| CA2764456A CA2764456C (en) | 2008-06-05 | 2009-06-05 | Oligonucleotide duplexes comprising dna-like and rna-like nucleotides and uses thereof |
| US14/810,148 US9719091B2 (en) | 2008-06-05 | 2015-07-27 | Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5918608P | 2008-06-05 | 2008-06-05 | |
| US61/059,186 | 2008-06-05 |
Publications (1)
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|---|---|
| CA2635187A1 true CA2635187A1 (en) | 2009-12-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA002635187A Abandoned CA2635187A1 (en) | 2008-06-05 | 2008-06-17 | Oligonucleotide duplexes and uses thereof |
| CA2764456A Active CA2764456C (en) | 2008-06-05 | 2009-06-05 | Oligonucleotide duplexes comprising dna-like and rna-like nucleotides and uses thereof |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2764456A Active CA2764456C (en) | 2008-06-05 | 2009-06-05 | Oligonucleotide duplexes comprising dna-like and rna-like nucleotides and uses thereof |
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| US (2) | US9090649B2 (OSRAM) |
| EP (1) | EP2294195B1 (OSRAM) |
| JP (1) | JP5684116B2 (OSRAM) |
| CA (2) | CA2635187A1 (OSRAM) |
| ES (1) | ES2643576T3 (OSRAM) |
| WO (1) | WO2009146556A1 (OSRAM) |
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| AU2007283022B2 (en) | 2006-08-08 | 2011-07-28 | Rheinische Friedrich-Wilhelms-Universitat Bonn | Structure and use of 5' phosphate oligonucleotides |
| WO2009141146A1 (en) | 2008-05-21 | 2009-11-26 | Gunther Hartmann | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| CA2635187A1 (en) | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
| WO2012065143A1 (en) | 2010-11-12 | 2012-05-18 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| DK2756080T3 (da) | 2011-09-14 | 2019-05-20 | Translate Bio Ma Inc | Multimeriske oligonukleotidforbindelser |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
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| WO2009146556A1 (en) | 2009-12-10 |
| US9090649B2 (en) | 2015-07-28 |
| EP2294195B1 (en) | 2017-07-19 |
| US20110077286A1 (en) | 2011-03-31 |
| US9719091B2 (en) | 2017-08-01 |
| CA2764456C (en) | 2020-09-15 |
| EP2294195A1 (en) | 2011-03-16 |
| EP2294195A4 (en) | 2012-12-19 |
| JP5684116B2 (ja) | 2015-03-11 |
| US20160145613A1 (en) | 2016-05-26 |
| ES2643576T3 (es) | 2017-11-23 |
| CA2764456A1 (en) | 2009-12-10 |
| JP2011521652A (ja) | 2011-07-28 |
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