ES2640532T3 - Métodos para la detección de papilomavirus humano y proporcionar un pronóstico para el carcinoma de células escamosas de cabeza y cuello - Google Patents
Métodos para la detección de papilomavirus humano y proporcionar un pronóstico para el carcinoma de células escamosas de cabeza y cuello Download PDFInfo
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- ES2640532T3 ES2640532T3 ES12850526.0T ES12850526T ES2640532T3 ES 2640532 T3 ES2640532 T3 ES 2640532T3 ES 12850526 T ES12850526 T ES 12850526T ES 2640532 T3 ES2640532 T3 ES 2640532T3
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Classifications
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70585—CD44
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
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- Physics & Mathematics (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559974P | 2011-11-15 | 2011-11-15 | |
| US201161559974P | 2011-11-15 | ||
| US201261654595P | 2012-06-01 | 2012-06-01 | |
| US201261654595P | 2012-06-01 | ||
| PCT/US2012/065282 WO2013074793A1 (en) | 2011-11-15 | 2012-11-15 | Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2640532T3 true ES2640532T3 (es) | 2017-11-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12850526.0T Active ES2640532T3 (es) | 2011-11-15 | 2012-11-15 | Métodos para la detección de papilomavirus humano y proporcionar un pronóstico para el carcinoma de células escamosas de cabeza y cuello |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20140329230A1 (enExample) |
| EP (1) | EP2780714B1 (enExample) |
| JP (1) | JP6174035B2 (enExample) |
| CN (1) | CN104067126B (enExample) |
| AU (3) | AU2012340441A1 (enExample) |
| BR (1) | BR112014011563B1 (enExample) |
| CA (1) | CA2855971C (enExample) |
| CO (1) | CO6980621A2 (enExample) |
| ES (1) | ES2640532T3 (enExample) |
| IL (1) | IL232556A (enExample) |
| MX (1) | MX352642B (enExample) |
| PE (1) | PE20141565A1 (enExample) |
| WO (1) | WO2013074793A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6174035B2 (ja) | 2011-11-15 | 2017-08-02 | ユニヴァーシティ・オヴ・マイアミ | ヒトパピローマウイルスを検出し頭頸部扁平上皮癌を予後予測する方法 |
| JP2016527514A (ja) * | 2013-07-31 | 2016-09-08 | ユニバーシティー オブ マイアミ | 対象の癌リスクを明らかにするための組成物及び方法 |
| US20160208346A1 (en) * | 2013-08-19 | 2016-07-21 | Notre Dame Du Lac | Method and composition for detection of oncogenic hpv |
| US10247720B2 (en) | 2014-05-22 | 2019-04-02 | University Of Notre Dame Du Lac | Integrated membrane sensor for rapid molecular detection |
| US11268153B2 (en) | 2015-06-22 | 2022-03-08 | The Johns Hopkins University | Head and neck squamous cell carcinoma assays |
| JP6655243B2 (ja) * | 2015-09-01 | 2020-02-26 | 国立大学法人 鹿児島大学 | 口腔前癌病変の検出方法 |
| CN107092854B (zh) * | 2016-02-18 | 2020-05-22 | 财团法人金属工业研究发展中心 | 检测细胞受人类乳头瘤病毒(hpv)感染的装置及其检测方法 |
| GB201808839D0 (en) | 2018-05-30 | 2018-07-11 | Cancer Research Tech Ltd | Method of predicting survival rates for cancer patients |
| WO2020018954A1 (en) * | 2018-07-20 | 2020-01-23 | Predentome, Inc. | Methods and systems for oral microbiome analysis |
| EP3930834A4 (en) * | 2019-02-26 | 2023-01-04 | University of Miami | Device for methods of detecting cancer |
| US20240188897A1 (en) * | 2021-04-23 | 2024-06-13 | The University Of Chicago | Machine learning based histopathological recurrence prediction models for hpv+ head / neck squamous cell carcinoma |
| EP4605748A1 (en) * | 2022-10-17 | 2025-08-27 | Vigilant Biosciences, Inc. | Methods and compositions for oral cancer risk |
Family Cites Families (18)
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|---|---|---|---|---|
| US5403551A (en) | 1993-09-16 | 1995-04-04 | Roche Diagnostic Systems, Inc. | Assaying device and container for in field analysis of a specimen and later shipment of the unadulterated specimen |
| US6235470B1 (en) | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| US5990299A (en) * | 1995-08-14 | 1999-11-23 | Icn Pharmaceuticals, Inc. | Control of CD44 gene expression for therapeutic use |
| US5976895A (en) | 1996-03-11 | 1999-11-02 | American Biomedica Corporation | Device for the collection, testing and shipment of body fluid samples |
| DE19829473C2 (de) * | 1998-07-01 | 2000-08-10 | Magnus Von Knebel Doeberitz Ch | Verfahren zur frühen Diagnose von Carcinomen |
| US6379620B1 (en) | 1998-11-16 | 2002-04-30 | Barry M. Tydings | Assaying device and method for in field urinalysis |
| US6294349B1 (en) | 1999-03-01 | 2001-09-25 | University Of Mississippi Medical Ctr. | Method of diagnosing and monitoring malignant breast carcinomas |
| US7189397B2 (en) | 1999-10-08 | 2007-03-13 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
| US20040029114A1 (en) | 2001-01-24 | 2004-02-12 | Eos Technology, Inc. | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
| DE60300339T2 (de) * | 2003-08-25 | 2006-04-13 | Mtm Laboratories Ag | Verfahren zum Nachweis von Karzinomen in solubilisierten zervikalen Körperproben |
| JP4563186B2 (ja) | 2004-02-16 | 2010-10-13 | 理研ビタミン株式会社 | 耐熱性が改善されたアントシアニン色素 |
| US20050214880A1 (en) * | 2004-03-26 | 2005-09-29 | University Of Miami | Salivary soluble CD44: a molecular marker for head and neck cancer |
| WO2007129999A2 (en) | 2004-07-14 | 2007-11-15 | Biospectrum, Inc. | Antiproliferative peptides and antibodies for their detection |
| BRPI0619712A2 (pt) | 2005-11-10 | 2011-10-11 | Univ Kentucky | dispositivo para a identificação de um paciente como um candidato para testes radiográficos para o cáncer do pulmão, composição para detectar radiograficamente um cáncer do pulmão de estágio adiantado, dispositivo para o ensaio do cáncer do pulmão, uso de um painel, e, dispositivo de diagnóstico para a detecção do cáncer do pulmão |
| US8088591B2 (en) | 2006-05-12 | 2012-01-03 | University Of Miami | Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma |
| CN101230390A (zh) * | 2007-12-07 | 2008-07-30 | 湖北大学 | 一种用于妇科恶性肿瘤早期筛选的基因芯片及其检测方法 |
| US8715926B2 (en) * | 2008-11-24 | 2014-05-06 | Loma Linda University | Biomarkers for the detection of head and neck tumors |
| JP6174035B2 (ja) | 2011-11-15 | 2017-08-02 | ユニヴァーシティ・オヴ・マイアミ | ヒトパピローマウイルスを検出し頭頸部扁平上皮癌を予後予測する方法 |
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