ES2639578T3 - Briostatinas para el tratamiento de la enfermedad de Alzheimer y de la mejora cognitiva - Google Patents
Briostatinas para el tratamiento de la enfermedad de Alzheimer y de la mejora cognitiva Download PDFInfo
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- ES2639578T3 ES2639578T3 ES10000734.3T ES10000734T ES2639578T3 ES 2639578 T3 ES2639578 T3 ES 2639578T3 ES 10000734 T ES10000734 T ES 10000734T ES 2639578 T3 ES2639578 T3 ES 2639578T3
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| TW201207390A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
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| JP5323481B2 (ja) | 2005-07-29 | 2013-10-23 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 長期記憶を増強するための、ｐｋｃ賦活薬の単独またはｐｋｃ阻害剤と組み合わせての使用 |
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| US20170319541A9 (en) * | 2006-07-28 | 2017-11-09 | Blanchette Rockefeller Neuroscience Institute | Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory |
| JP2009544753A (ja) * | 2006-07-28 | 2009-12-17 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 細胞成長、シナプスリモデリング及び長期記憶の固定を刺激する方法 |
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| JP5123324B2 (ja) * | 2007-03-09 | 2013-01-23 | クゥアルコム・インコーポレイテッド | 不偏トレーニングシーケンスを使用した直交不平衡緩和 |
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| EP2283023A2 (en) | 2008-04-16 | 2011-02-16 | University of Utah Research Foundation | Bryostatin analogues and methods of making and using thereof |
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| US20110023152A1 (en) * | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Genome editing of cognition related genes in animals |
| EP2539709B1 (en) * | 2010-02-22 | 2015-05-20 | Blanchette Rockefeller Neurosciences, Institute | Alzheimer's disease-specific alterations of protein kinase c epsilon (pkc-epsilon) protein levels |
| EP2590642B1 (en) | 2010-07-08 | 2018-03-14 | Daniel L. Alkon | Pkc activators and anticoagulant in regimen for treating stroke |
| WO2012024630A1 (en) * | 2010-08-19 | 2012-02-23 | Blanchette Rockefeller Neurosciences Institute | Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators |
| EP2776018B1 (en) | 2011-11-13 | 2021-08-25 | Cognitive Research Enterprises, Inc. | Pkc activators and combinations thereof |
| US9034347B2 (en) | 2011-12-19 | 2015-05-19 | Arphios Corporation | Drug delivery system and method for the treatment of neuro-degenerative disease |
| US10828276B2 (en) | 2012-11-28 | 2020-11-10 | Aphios Corporation | Combination therapeutics and methods for the treatment of neurodegenerative and other diseases |
| CA2906164A1 (en) * | 2013-03-15 | 2014-09-18 | Daniel L. Alkon | Methods for identifying neuroprotective pkc activators |
| US20180217163A1 (en) | 2015-05-11 | 2018-08-02 | Daniel L. Alkon | Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele |
| WO2017053659A1 (en) | 2015-09-23 | 2017-03-30 | Khan Tapan K | Methods for survival and rejuvenation of dermal fibroblasts using pkc activators |
| WO2017062924A1 (en) | 2015-10-08 | 2017-04-13 | Alkon Daniel L | Dosing regimens of pkc activators |
| KR20190005158A (ko) * | 2016-05-04 | 2019-01-15 | 뉴로트롭 바이오싸이언스 인크. | 레트 증후군의 치료를 위한 방법 및 조성물 |
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| US12297244B2 (en) | 2019-06-05 | 2025-05-13 | Rensselaer Polytechnic Institute | Systems and methods for inhibiting γ-secretase production of amyloid-β peptides |
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| US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| US6821979B2 (en) | 2002-03-07 | 2004-11-23 | Blanchette Rockefeller Neurosciences Institute | Synergistic enhancement of cognitive ability |
| KR20050094761A (ko) | 2002-07-02 | 2005-09-28 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 브리오스타틴형 화합물을 사용한 ｓＡＰＰα 분비의 증진및 인지 개선을 위한 수단으로서의 ＰＫＣ 활성화 |
| US20040229292A1 (en) | 2002-11-26 | 2004-11-18 | Sebastiano Cavallaro | Use of FGF-18 in the diagnosis and treatment of memory disorders |
| US7803400B2 (en) | 2002-12-03 | 2010-09-28 | Blanchette Rockefeller Neurosciences Institute | Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier |
| NZ546226A (en) | 2003-09-30 | 2009-03-31 | Shire Llc | Oxycodone conjugates for prevention of overdose or abuse |
| TW201207390A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
| JP5323481B2 (ja) | 2005-07-29 | 2013-10-23 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 長期記憶を増強するための、ｐｋｃ賦活薬の単独またはｐｋｃ阻害剤と組み合わせての使用 |
| WO2007044094A1 (en) | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
| JP2009544753A (ja) | 2006-07-28 | 2009-12-17 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 細胞成長、シナプスリモデリング及び長期記憶の固定を刺激する方法 |
| EP2121000B1 (en) | 2007-02-09 | 2015-09-23 | Blanchette Rockefeller Neurosciences, Institute | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury |
| JP5987867B2 (ja) | 2014-07-10 | 2016-09-07 | コニカミノルタ株式会社 | シート搬送装置および画像形成システム |
-
2002
- 2002-06-13 US US10/167,491 patent/US6825229B2/en not_active Expired - Lifetime
-
2003
- 2003-03-07 WO PCT/US2003/007101 patent/WO2003075850A2/en not_active Ceased
- 2003-03-07 EP EP03716386.2A patent/EP1490050B1/en not_active Expired - Lifetime
- 2003-03-07 AU AU2003220096A patent/AU2003220096A1/en not_active Abandoned
- 2003-03-07 CA CA002477973A patent/CA2477973A1/en not_active Abandoned
- 2003-03-07 EP EP10000734.3A patent/EP2172246B1/en not_active Expired - Lifetime
- 2003-03-07 JP JP2003574126A patent/JP2005527512A/ja not_active Withdrawn
- 2003-03-07 ES ES10000734.3T patent/ES2639578T3/es not_active Expired - Lifetime
-
2004
- 2004-09-03 US US10/933,536 patent/US20050037984A1/en not_active Abandoned
-
2013
- 2013-03-27 US US13/851,161 patent/US9539235B2/en not_active Expired - Fee Related
-
2015
- 2015-11-02 US US14/929,731 patent/US9446020B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003220096A8 (en) | 2003-09-22 |
| AU2003220096A1 (en) | 2003-09-22 |
| EP1490050A4 (en) | 2008-07-30 |
| US9539235B2 (en) | 2017-01-10 |
| EP1490050A2 (en) | 2004-12-29 |
| EP2172246B1 (en) | 2017-08-30 |
| US6825229B2 (en) | 2004-11-30 |
| US20030171356A1 (en) | 2003-09-11 |
| WO2003075850A9 (en) | 2004-02-19 |
| EP1490050B1 (en) | 2019-01-30 |
| JP2005527512A (ja) | 2005-09-15 |
| CA2477973A1 (en) | 2003-09-18 |
| WO2003075850A2 (en) | 2003-09-18 |
| US20050037984A1 (en) | 2005-02-17 |
| EP2172246A3 (en) | 2010-05-05 |
| US20130281522A1 (en) | 2013-10-24 |
| WO2003075850A3 (en) | 2004-01-08 |
| EP2172246A2 (en) | 2010-04-07 |
| US20160051509A1 (en) | 2016-02-25 |
| US9446020B2 (en) | 2016-09-20 |
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