ES2626913T3 - Válvulas de corazón protésicas geométricas - Google Patents
Válvulas de corazón protésicas geométricas Download PDFInfo
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- ES2626913T3 ES2626913T3 ES13818926.1T ES13818926T ES2626913T3 ES 2626913 T3 ES2626913 T3 ES 2626913T3 ES 13818926 T ES13818926 T ES 13818926T ES 2626913 T3 ES2626913 T3 ES 2626913T3
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- valve
- frame
- prosthetic heart
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/243—Deployment by mechanical expansion
- A61F2/2433—Deployment by mechanical expansion using balloon catheter
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Prostheses (AREA)
Applications Claiming Priority (7)
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| US201261739721P | 2012-12-19 | 2012-12-19 | |
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| US201361802128P | 2013-03-15 | 2013-03-15 | |
| US201361802128P | 2013-03-15 | ||
| US14/133,491 US10039638B2 (en) | 2012-12-19 | 2013-12-18 | Geometric prosthetic heart valves |
| US201314133491 | 2013-12-18 | ||
| PCT/US2013/076504 WO2014100394A1 (en) | 2012-12-19 | 2013-12-19 | Geometric prosthetic heart valves |
Publications (1)
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| ES2626913T3 true ES2626913T3 (es) | 2017-07-26 |
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| AU (2) | AU2013361283B2 (enExample) |
| CA (1) | CA2891968C (enExample) |
| ES (1) | ES2626913T3 (enExample) |
| WO (1) | WO2014100394A1 (enExample) |
Families Citing this family (142)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008513060A (ja) | 2004-09-14 | 2008-05-01 | エドワーズ ライフサイエンシーズ アーゲー | 心臓弁逆流の処置のためのデバイスおよび方法 |
| US20090276040A1 (en) | 2008-05-01 | 2009-11-05 | Edwards Lifesciences Corporation | Device and method for replacing mitral valve |
| EP2367505B1 (en) | 2008-09-29 | 2020-08-12 | Edwards Lifesciences CardiAQ LLC | Heart valve |
| WO2010121076A2 (en) | 2009-04-15 | 2010-10-21 | Cardiaq Valve Technologies, Inc. | Vascular implant and delivery system |
| NZ624106A (en) | 2009-04-29 | 2015-12-24 | Cleveland Clinic Foundation | Apparatus and method for replacing a diseased cardiac valve |
| US9730790B2 (en) | 2009-09-29 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Replacement valve and method |
| US8449599B2 (en) | 2009-12-04 | 2013-05-28 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
| US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
| US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
| JP6125999B2 (ja) | 2010-06-21 | 2017-05-10 | カルディアック バルブ テクノロジーズ，インコーポレーテッド | 人工心臓弁 |
| US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
| EP3459500B1 (en) | 2010-09-23 | 2020-09-16 | Edwards Lifesciences CardiAQ LLC | Replacement heart valves and delivery devices |
| US9744033B2 (en) | 2011-04-01 | 2017-08-29 | W.L. Gore & Associates, Inc. | Elastomeric leaflet for prosthetic heart valves |
| US20140163673A1 (en) * | 2011-04-01 | 2014-06-12 | W. L. Gore & Associates, Inc. | Prosthetic heart valve leaflet adapted for external imaging |
| US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
| US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
| US9554806B2 (en) | 2011-09-16 | 2017-01-31 | W. L. Gore & Associates, Inc. | Occlusive devices |
| US9445893B2 (en) | 2011-11-21 | 2016-09-20 | Mor Research Applications Ltd. | Device for placement in the tricuspid annulus |
| US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
| US9283072B2 (en) | 2012-07-25 | 2016-03-15 | W. L. Gore & Associates, Inc. | Everting transcatheter valve and methods |
| US10376360B2 (en) | 2012-07-27 | 2019-08-13 | W. L. Gore & Associates, Inc. | Multi-frame prosthetic valve apparatus and methods |
| US12151092B2 (en) | 2012-11-06 | 2024-11-26 | Procardia Llc | Mechanical circulatory support device with centrifugal impeller designed for implantation in the descending aorta |
| US10857274B2 (en) | 2012-11-06 | 2020-12-08 | Queen Mary University Of London | Mechanical circulatory support device with centrifugal impeller designed for implantation in the descending aorta |
| US9737398B2 (en) | 2012-12-19 | 2017-08-22 | W. L. Gore & Associates, Inc. | Prosthetic valves, frames and leaflets and methods thereof |
| US10039638B2 (en) | 2012-12-19 | 2018-08-07 | W. L. Gore & Associates, Inc. | Geometric prosthetic heart valves |
| US10966820B2 (en) | 2012-12-19 | 2021-04-06 | W. L. Gore & Associates, Inc. | Geometric control of bending character in prosthetic heart valve leaflets |
| US9968443B2 (en) | 2012-12-19 | 2018-05-15 | W. L. Gore & Associates, Inc. | Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet |
| US9144492B2 (en) | 2012-12-19 | 2015-09-29 | W. L. Gore & Associates, Inc. | Truncated leaflet for prosthetic heart valves, preformed valve |
| US9101469B2 (en) | 2012-12-19 | 2015-08-11 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with leaflet shelving |
| US10321986B2 (en) | 2012-12-19 | 2019-06-18 | W. L. Gore & Associates, Inc. | Multi-frame prosthetic heart valve |
| US9439763B2 (en) | 2013-02-04 | 2016-09-13 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
| US20140277427A1 (en) | 2013-03-14 | 2014-09-18 | Cardiaq Valve Technologies, Inc. | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
| US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
| US9730791B2 (en) | 2013-03-14 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
| US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
| US11911258B2 (en) | 2013-06-26 | 2024-02-27 | W. L. Gore & Associates, Inc. | Space filling devices |
| SI3107500T1 (sl) * | 2014-02-18 | 2022-01-31 | Edwards Lifesciences Corporation | Gibko komisurno ogrodje |
| CN106170269B (zh) | 2014-02-21 | 2019-01-11 | 爱德华兹生命科学卡迪尔克有限责任公司 | 用于瓣膜替代品的受控部署的递送装置 |
| USD755384S1 (en) | 2014-03-05 | 2016-05-03 | Edwards Lifesciences Cardiaq Llc | Stent |
| US20150328000A1 (en) | 2014-05-19 | 2015-11-19 | Cardiaq Valve Technologies, Inc. | Replacement mitral valve with annular flap |
| US9532870B2 (en) | 2014-06-06 | 2017-01-03 | Edwards Lifesciences Corporation | Prosthetic valve for replacing a mitral valve |
| EP4066786B1 (en) | 2014-07-30 | 2025-05-14 | Cardiovalve Ltd. | Articulatable prosthetic valve |
| EP3182929B1 (en) | 2014-08-18 | 2023-08-09 | Edwards Lifesciences Corporation | Frame with integral sewing cuff for prosthetic valves |
| US9827094B2 (en) | 2014-09-15 | 2017-11-28 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with retention elements |
| CN106852115A (zh) | 2014-09-28 | 2017-06-13 | 卡迪欧凯尼迪克斯公司 | 用于治疗心功能不全的装置 |
| EP4410245A3 (en) | 2014-11-26 | 2024-10-16 | Edwards Lifesciences Corporation | Transcatheter prosthetic heart valve and delivery system |
| EP4344676A1 (en) | 2014-12-14 | 2024-04-03 | Trisol Medical Ltd. | Prosthetic valve and deployment system |
| US9974651B2 (en) * | 2015-02-05 | 2018-05-22 | Mitral Tech Ltd. | Prosthetic valve with axially-sliding frames |
| CA3162308A1 (en) | 2015-02-05 | 2016-08-11 | Cardiovalve Ltd. | Prosthetic valve with axially-sliding frames |
| EP3271000B1 (en) | 2015-03-20 | 2020-06-17 | Cardiokinetix, Inc. | Systems for delivering an implantable device |
| US10441416B2 (en) | 2015-04-21 | 2019-10-15 | Edwards Lifesciences Corporation | Percutaneous mitral valve replacement device |
| US10376363B2 (en) | 2015-04-30 | 2019-08-13 | Edwards Lifesciences Cardiaq Llc | Replacement mitral valve, delivery system for replacement mitral valve and methods of use |
| HK1250897A1 (zh) | 2015-05-14 | 2019-01-18 | W. L. Gore & Associates, Inc. | 用於心耳的堵塞的装置 |
| CA2990872C (en) | 2015-06-22 | 2022-03-22 | Edwards Lifescience Cardiaq Llc | Actively controllable heart valve implant and methods of controlling same |
| US10092400B2 (en) | 2015-06-23 | 2018-10-09 | Edwards Lifesciences Cardiaq Llc | Systems and methods for anchoring and sealing a prosthetic heart valve |
| US10117744B2 (en) | 2015-08-26 | 2018-11-06 | Edwards Lifesciences Cardiaq Llc | Replacement heart valves and methods of delivery |
| US10575951B2 (en) | 2015-08-26 | 2020-03-03 | Edwards Lifesciences Cardiaq Llc | Delivery device and methods of use for transapical delivery of replacement mitral valve |
| US10350066B2 (en) | 2015-08-28 | 2019-07-16 | Edwards Lifesciences Cardiaq Llc | Steerable delivery system for replacement mitral valve and methods of use |
| WO2017100927A1 (en) | 2015-12-15 | 2017-06-22 | Neovasc Tiara Inc. | Transseptal delivery system |
| CN108882981B (zh) | 2016-01-29 | 2021-08-10 | 内奥瓦斯克迪亚拉公司 | 用于防止流出阻塞的假体瓣膜 |
| US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
| USD815744S1 (en) | 2016-04-28 | 2018-04-17 | Edwards Lifesciences Cardiaq Llc | Valve frame for a delivery system |
| US10350062B2 (en) | 2016-07-21 | 2019-07-16 | Edwards Lifesciences Corporation | Replacement heart valve prosthesis |
| CA3033666A1 (en) | 2016-08-19 | 2018-02-22 | Edwards Lifesciences Corporation | Steerable delivery system for replacement mitral valve and methods of use |
| AU2017314852B2 (en) | 2016-08-26 | 2022-06-30 | Edwards Lifesciences Corporation | Multi-portion replacement heart valve prosthesis |
| US11524153B2 (en) | 2016-10-03 | 2022-12-13 | Queen Mary University Of London | Mechanical circulatory support device with axial flow turbomachine optimized for heart failure and cardio-renal syndrome by implantation in the descending aorta |
| GB201616777D0 (en) | 2016-10-03 | 2016-11-16 | Univ Southampton | A frame for an implantable medical device and a method of manufacturing a frame for an implantable medical device |
| US12090310B2 (en) | 2016-10-03 | 2024-09-17 | Procardia Llc | Mechanical circulatory support device with axial flow turbomachine optimized for heart failure and cardio-renal syndrome by implantation in the descending aorta |
| US10758348B2 (en) | 2016-11-02 | 2020-09-01 | Edwards Lifesciences Corporation | Supra and sub-annular mitral valve delivery system |
| CN109996581B (zh) | 2016-11-21 | 2021-10-15 | 内奥瓦斯克迪亚拉公司 | 用于快速收回经导管心脏瓣膜递送系统的方法和系统 |
| US10653523B2 (en) | 2017-01-19 | 2020-05-19 | 4C Medical Technologies, Inc. | Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves |
| US10561495B2 (en) | 2017-01-24 | 2020-02-18 | 4C Medical Technologies, Inc. | Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve |
| US12029647B2 (en) | 2017-03-07 | 2024-07-09 | 4C Medical Technologies, Inc. | Systems, methods and devices for prosthetic heart valve with single valve leaflet |
| US12036113B2 (en) | 2017-06-14 | 2024-07-16 | 4C Medical Technologies, Inc. | Delivery of heart chamber prosthetic valve implant |
| ES2923913T3 (es) | 2017-07-06 | 2022-10-03 | Edwards Lifesciences Corp | Sistema de suministro de carril orientable |
| WO2019028264A1 (en) * | 2017-08-03 | 2019-02-07 | The Regents Of The University Of California | AURICULAR CAGE FOR THE PLACEMENT, FASTENING AND ANCHORING OF ATRIOVENTRICULAR VALVES |
| US11793633B2 (en) | 2017-08-03 | 2023-10-24 | Cardiovalve Ltd. | Prosthetic heart valve |
| IL254099B (en) | 2017-08-22 | 2021-02-28 | Geonovation Medical Tech Ltd | Collapsible one-way valve bushing |
| CA3073834A1 (en) | 2017-08-25 | 2019-02-28 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
| AU2018334191B2 (en) | 2017-09-12 | 2021-04-08 | Edwards Lifesciences Corporation | Leaflet frame attachment for prosthetic valves |
| US12458493B2 (en) | 2017-09-19 | 2025-11-04 | Cardiovalve Ltd. | Prosthetic heart valve and delivery systems and methods |
| CA3155761C (en) | 2017-09-27 | 2025-11-18 | Gore & Ass | Prosthetic valves with mechanically coupled leaflets |
| CA3178271A1 (en) * | 2017-09-27 | 2019-04-04 | W.L. Gore & Associates, Inc. | Prosthetic valve with expandable frame and associated systems and methods |
| JP7036912B2 (ja) | 2017-10-13 | 2022-03-15 | ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド | 嵌込式人工弁および送達システム |
| US11173023B2 (en) | 2017-10-16 | 2021-11-16 | W. L. Gore & Associates, Inc. | Medical devices and anchors therefor |
| US11154397B2 (en) | 2017-10-31 | 2021-10-26 | W. L. Gore & Associates, Inc. | Jacket for surgical heart valve |
| CA3078608C (en) | 2017-10-31 | 2023-03-28 | W.L. Gore & Associates, Inc. | Prosthetic heart valve |
| US11439502B2 (en) | 2017-10-31 | 2022-09-13 | W. L. Gore & Associates, Inc. | Medical valve and leaflet promoting tissue ingrowth |
| US10987218B2 (en) | 2017-10-31 | 2021-04-27 | W. L. Gore & Associates, Inc. | Transcatheter deployment systems and associated methods |
| CN117481869A (zh) | 2018-01-25 | 2024-02-02 | 爱德华兹生命科学公司 | 在部署后用于辅助置换瓣膜重新捕获和重新定位的递送系统 |
| US11051934B2 (en) | 2018-02-28 | 2021-07-06 | Edwards Lifesciences Corporation | Prosthetic mitral valve with improved anchors and seal |
| CN112543656A (zh) | 2018-04-04 | 2021-03-23 | 亚历山大·狄奥多西 | 用于短期使用的可移除式机械循环支持装置 |
| WO2019195860A2 (en) | 2018-04-04 | 2019-10-10 | Vdyne, Llc | Devices and methods for anchoring transcatheter heart valve |
| US20190365538A1 (en) * | 2018-06-04 | 2019-12-05 | 4C Medical Technologies, Inc. | Devices, systems and methods for preventing prolapse of native cardiac valve leaflets |
| US10779937B2 (en) | 2018-06-22 | 2020-09-22 | Vdyne, Inc. | Transcatheter heart valve with plication window and tissue anchors |
| US11857441B2 (en) | 2018-09-04 | 2024-01-02 | 4C Medical Technologies, Inc. | Stent loading device |
| US12186187B2 (en) | 2018-09-20 | 2025-01-07 | Vdyne, Inc. | Transcatheter deliverable prosthetic heart valves and methods of delivery |
| US11278437B2 (en) | 2018-12-08 | 2022-03-22 | Vdyne, Inc. | Compression capable annular frames for side delivery of transcatheter heart valve replacement |
| US11071627B2 (en) | 2018-10-18 | 2021-07-27 | Vdyne, Inc. | Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis |
| US10595994B1 (en) | 2018-09-20 | 2020-03-24 | Vdyne, Llc | Side-delivered transcatheter heart valve replacement |
| US11344413B2 (en) | 2018-09-20 | 2022-05-31 | Vdyne, Inc. | Transcatheter deliverable prosthetic heart valves and methods of delivery |
| US12310850B2 (en) | 2018-09-20 | 2025-05-27 | Vdyne, Inc. | Transcatheter deliverable prosthetic heart valves and methods of delivery |
| US10321995B1 (en) | 2018-09-20 | 2019-06-18 | Vdyne, Llc | Orthogonally delivered transcatheter heart valve replacement |
| US11109969B2 (en) | 2018-10-22 | 2021-09-07 | Vdyne, Inc. | Guidewire delivery of transcatheter heart valve |
| USD926322S1 (en) | 2018-11-07 | 2021-07-27 | W. L. Gore & Associates, Inc. | Heart valve cover |
| AU2019374743B2 (en) | 2018-11-08 | 2022-03-03 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
| US11337798B2 (en) | 2018-12-06 | 2022-05-24 | Colorado Seminary Which Owns And Operates The University Of Denver | Optimization of replacement heart valve leaflets |
| US11253359B2 (en) | 2018-12-20 | 2022-02-22 | Vdyne, Inc. | Proximal tab for side-delivered transcatheter heart valves and methods of delivery |
| US10653522B1 (en) | 2018-12-20 | 2020-05-19 | Vdyne, Inc. | Proximal tab for side-delivered transcatheter heart valve prosthesis |
| WO2020146842A1 (en) | 2019-01-10 | 2020-07-16 | Vdyne, Llc | Anchor hook for side-delivery transcatheter heart valve prosthesis |
| US11185409B2 (en) | 2019-01-26 | 2021-11-30 | Vdyne, Inc. | Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis |
| US11273032B2 (en) | 2019-01-26 | 2022-03-15 | Vdyne, Inc. | Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis |
| US11497601B2 (en) | 2019-03-01 | 2022-11-15 | W. L. Gore & Associates, Inc. | Telescoping prosthetic valve with retention element |
| EP4364706B1 (en) | 2019-03-05 | 2025-12-03 | VDyne, Inc. | Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis |
| CA3132873C (en) | 2019-03-08 | 2024-07-02 | Neovasc Tiara Inc | RECOVERABLE PROSTHESIS PLACEMENT SYSTEM |
| US10631983B1 (en) | 2019-03-14 | 2020-04-28 | Vdyne, Inc. | Distal subannular anchoring tab for side-delivered transcatheter valve prosthesis |
| US10758346B1 (en) | 2019-03-14 | 2020-09-01 | Vdyne, Inc. | A2 clip for side-delivered transcatheter mitral valve prosthesis |
| US11076956B2 (en) | 2019-03-14 | 2021-08-03 | Vdyne, Inc. | Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis |
| US11173027B2 (en) | 2019-03-14 | 2021-11-16 | Vdyne, Inc. | Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same |
| WO2020206012A1 (en) | 2019-04-01 | 2020-10-08 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
| CN113924065A (zh) | 2019-04-10 | 2022-01-11 | 内奥瓦斯克迪亚拉公司 | 具有自然血流的假体瓣膜 |
| EP3952790A1 (en) | 2019-04-12 | 2022-02-16 | W.L. Gore & Associates, Inc. | Valve with multi-part frame and associated resilient bridging features |
| US11452628B2 (en) | 2019-04-15 | 2022-09-27 | 4C Medical Technologies, Inc. | Loading systems for collapsible prosthetic heart valve devices and methods thereof |
| CA3137105A1 (en) | 2019-04-23 | 2020-10-29 | Edwards Lifesciences Corporation | Motorized implant delivery system |
| CN120827457A (zh) | 2019-05-04 | 2025-10-24 | 维迪内股份有限公司 | 用于在自体瓣环中部署侧面递送的假体心脏瓣膜的束紧装置和方法 |
| US11779742B2 (en) | 2019-05-20 | 2023-10-10 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
| CA3140781A1 (en) | 2019-06-13 | 2020-12-17 | Bryan HUTCHINSON | Lightweight expanded polytetrafluoroethylene membranes having high intrinsic strength and optical transparency |
| EP3986332A4 (en) | 2019-06-20 | 2023-07-19 | Neovasc Tiara Inc. | FLAT ARTIFICIAL MITRAL VALVE |
| US11679250B2 (en) | 2019-06-28 | 2023-06-20 | Theodosios Alexander | Removable mechanical circulatory support for short term use |
| CN110236738A (zh) * | 2019-07-01 | 2019-09-17 | 上海长海医院 | 耐久性增强型带三叶生物瓣移植物及其制备方法 |
| AU2020334080B2 (en) | 2019-08-20 | 2025-11-27 | Vdyne, Inc. | Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves |
| CN120531525A (zh) | 2019-08-26 | 2025-08-26 | 维迪内股份有限公司 | 可侧面输送的经导管假体瓣膜及其输送和锚定方法 |
| US11234813B2 (en) | 2020-01-17 | 2022-02-01 | Vdyne, Inc. | Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery |
| US12133797B2 (en) | 2020-01-31 | 2024-11-05 | 4C Medical Technologies, Inc. | Prosthetic heart valve delivery system: paddle attachment feature |
| US11931253B2 (en) | 2020-01-31 | 2024-03-19 | 4C Medical Technologies, Inc. | Prosthetic heart valve delivery system: ball-slide attachment |
| US20230129792A1 (en) * | 2020-03-03 | 2023-04-27 | W. L. Gore & Associates, Inc. | Tissue cutting elements and retention features for implants, and associated systems and methods |
| US12053375B2 (en) | 2020-03-05 | 2024-08-06 | 4C Medical Technologies, Inc. | Prosthetic mitral valve with improved atrial and/or annular apposition and paravalvular leakage mitigation |
| US11992403B2 (en) | 2020-03-06 | 2024-05-28 | 4C Medical Technologies, Inc. | Devices, systems and methods for improving recapture of prosthetic heart valve device with stent frame having valve support with inwardly stent cells |
| US20240415642A1 (en) * | 2020-04-24 | 2024-12-19 | ReValve Solutions Inc. | Devices, systems, and methods for a valve replacement |
| US20210330455A1 (en) * | 2020-04-24 | 2021-10-28 | ReValve Solutions Inc. | Devices, systems, and methods for a collapsible replacement heart valve |
| EP4149393A4 (en) * | 2020-05-15 | 2023-11-01 | Revalve Solutions Inc. | Devices, systems, and methods for a collapsible and expandable replacement heart valve |
| EP4247297A1 (en) | 2020-12-18 | 2023-09-27 | Edwards Lifesciences Corporation | Storage jar assembly for aprosthetic heart valve |
Family Cites Families (272)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US654799A (en) | 1900-03-08 | 1900-07-31 | Morris H Levett | Display device. |
| CA962021A (en) | 1970-05-21 | 1975-02-04 | Robert W. Gore | Porous products and process therefor |
| US4340091A (en) | 1975-05-07 | 1982-07-20 | Albany International Corp. | Elastomeric sheet materials for heart valve and other prosthetic implants |
| US4178639A (en) | 1978-04-06 | 1979-12-18 | Carbomedics, Inc. | Two-leaflet heart valve |
| US4222126A (en) | 1978-12-14 | 1980-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare | Unitized three leaflet heart valve |
| US4265694A (en) | 1978-12-14 | 1981-05-05 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Method of making unitized three leaflet heart valve |
| US4477930A (en) | 1982-09-28 | 1984-10-23 | Mitral Medical International, Inc. | Natural tissue heat valve and method of making same |
| CA1232407A (en) | 1983-06-23 | 1988-02-09 | David K. Walker | Bubble heart valve |
| US4556996A (en) | 1983-08-04 | 1985-12-10 | Robert S. Wallace | Heart valve |
| US4626255A (en) | 1983-09-23 | 1986-12-02 | Christian Weinhold | Heart valve bioprothesis |
| FR2591100B1 (fr) | 1985-12-09 | 1990-08-17 | Clinique Residence Parc | Prothese valvulaire tricuspide. |
| US4851000A (en) | 1987-07-31 | 1989-07-25 | Pacific Biomedical Holdings, Ltd. | Bioprosthetic valve stent |
| FR2642960B1 (fr) | 1989-02-15 | 1994-02-25 | Dassault Breguet Aviation | Valve cardiaque prothetique |
| GB9012716D0 (en) | 1990-06-07 | 1990-08-01 | Frater Robert W M | Mitral heart valve replacements |
| US5163955A (en) | 1991-01-24 | 1992-11-17 | Autogenics | Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment |
| US5258023A (en) | 1992-02-12 | 1993-11-02 | Reger Medical Development, Inc. | Prosthetic heart valve |
| US5405378A (en) | 1992-05-20 | 1995-04-11 | Strecker; Ernst P. | Device with a prosthesis implantable in the body of a patient |
| IT1269443B (it) | 1994-01-19 | 1997-04-01 | Stefano Nazari | Protesi vascolare per la sostituzione o il rivestimento interno di vasi sanguigni di medio e grande diametro e dispositivo per la sua applicazione senza interruzione del flusso ematico |
| US5554185A (en) | 1994-07-18 | 1996-09-10 | Block; Peter C. | Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same |
| AU688404B2 (en) | 1994-09-02 | 1998-03-12 | W.L. Gore & Associates, Inc. | Porous polytetrafluoroethylene compositions |
| US5562729A (en) | 1994-11-01 | 1996-10-08 | Biocontrol Technology, Inc. | Heart valve |
| US5716399A (en) | 1995-10-06 | 1998-02-10 | Cardiomend Llc | Methods of heart valve repair |
| US6328763B1 (en) | 1995-10-06 | 2001-12-11 | Cardiomend, Llc | Optimized geometry of a tissue pattern for semilunar heart valve reconstruction |
| GB2312485B (en) | 1996-04-24 | 1999-10-20 | Endre Bodnar | Bioprosthetic conduits |
| US5628791A (en) | 1996-05-09 | 1997-05-13 | Medical Carbon Research Institute, Llc | Prosthetic trileaflet heart valve |
| DE19625202A1 (de) | 1996-06-24 | 1998-01-02 | Adiam Medizintechnik Gmbh & Co | Prothetische Mitral-Herzklappe |
| US5944654A (en) | 1996-11-14 | 1999-08-31 | Vista Medical Technologies, Inc. | Endoscope with replaceable irrigation tube |
| NL1004827C2 (nl) | 1996-12-18 | 1998-06-19 | Surgical Innovations Vof | Inrichting voor het reguleren van de bloedsomloop. |
| EP0850607A1 (en) | 1996-12-31 | 1998-07-01 | Cordis Corporation | Valve prosthesis for implantation in body channels |
| GB9701479D0 (en) | 1997-01-24 | 1997-03-12 | Aortech Europ Ltd | Heart valve |
| US6488702B1 (en) | 1997-01-24 | 2002-12-03 | Jomed Gmbh | Bistable spring construction for a stent and other medical apparatus |
| US5928281A (en) | 1997-03-27 | 1999-07-27 | Baxter International Inc. | Tissue heart valves |
| US6395024B1 (en) | 1997-05-20 | 2002-05-28 | Triflo Medical, Inc. | Mechanical heart valve |
| US5919226A (en) | 1997-07-22 | 1999-07-06 | Medtronic, Inc. | Mechanical heart valve prosthesis |
| US5935163A (en) | 1998-03-31 | 1999-08-10 | Shelhigh, Inc. | Natural tissue heart valve prosthesis |
| JP2002518131A (ja) | 1998-06-24 | 2002-06-25 | サルザー カーボメディクス インコーポレイテッド | 変化してリーフレット上の最大負荷圧力の位置および大きさに影響を及ぼす心臓弁リーフレット連結構造 |
| US6117169A (en) | 1998-06-24 | 2000-09-12 | Sulzer Carbomedics Inc. | Living hinge attachment of leaflet to a valve body |
| US6334873B1 (en) | 1998-09-28 | 2002-01-01 | Autogenics | Heart valve having tissue retention with anchors and an outer sheath |
| US6540780B1 (en) | 1998-11-23 | 2003-04-01 | Medtronic, Inc. | Porous synthetic vascular grafts with oriented ingrowth channels |
| US7049380B1 (en) | 1999-01-19 | 2006-05-23 | Gore Enterprise Holdings, Inc. | Thermoplastic copolymer of tetrafluoroethylene and perfluoromethyl vinyl ether and medical devices employing the copolymer |
| US6558418B2 (en) | 1999-01-26 | 2003-05-06 | Edwards Lifesciences Corporation | Flexible heart valve |
| US6736845B2 (en) | 1999-01-26 | 2004-05-18 | Edwards Lifesciences Corporation | Holder for flexible heart valve |
| US6283995B1 (en) | 1999-04-15 | 2001-09-04 | Sulzer Carbomedics Inc. | Heart valve leaflet with scalloped free margin |
| US6666885B2 (en) | 1999-04-16 | 2003-12-23 | Carbomedics Inc. | Heart valve leaflet |
| US6283994B1 (en) | 1999-04-16 | 2001-09-04 | Sulzer Carbomedics Inc. | Heart valve leaflet |
| US20020055773A1 (en) | 1999-07-12 | 2002-05-09 | Louis A. Campbell | Polymer heart valve with insert molded fabric sewing cuff |
| US6174331B1 (en) | 1999-07-19 | 2001-01-16 | Sulzer Carbomedics Inc. | Heart valve leaflet with reinforced free margin |
| AU1560401A (en) | 1999-10-16 | 2001-04-30 | Sumit Roy | Low-profile, non-stented prosthesis for transluminal implantation |
| US20030097175A1 (en) | 1999-12-08 | 2003-05-22 | O'connor Bernard | Heart valve prosthesis and method of manufacture |
| GB0114345D0 (en) | 2001-06-13 | 2001-08-08 | Aortech Europ Ltd | Heart valve prosthesis and method of manufacture |
| US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
| US6610088B1 (en) | 2000-05-03 | 2003-08-26 | Shlomo Gabbay | Biologically covered heart valve prosthesis |
| US8366769B2 (en) | 2000-06-01 | 2013-02-05 | Edwards Lifesciences Corporation | Low-profile, pivotable heart valve sewing ring |
| ATE514392T1 (de) | 2000-07-24 | 2011-07-15 | Jeffrey Grayzel | Versteifter ballonkatheter zur ausdehnung und anbringung von stents |
| AU2001287144A1 (en) | 2000-09-07 | 2002-03-22 | Viacor, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
| US8784482B2 (en) | 2000-09-20 | 2014-07-22 | Mvrx, Inc. | Method of reshaping a heart valve annulus using an intravascular device |
| ATE346571T1 (de) | 2000-09-21 | 2006-12-15 | St Jude Medical | Ventilprothesen mit blattelementen aus verstärktem kunststoff |
| US6461382B1 (en) | 2000-09-22 | 2002-10-08 | Edwards Lifesciences Corporation | Flexible heart valve having moveable commissures |
| US6482228B1 (en) | 2000-11-14 | 2002-11-19 | Troy R. Norred | Percutaneous aortic valve replacement |
| US6974476B2 (en) | 2003-05-05 | 2005-12-13 | Rex Medical, L.P. | Percutaneous aortic valve |
| US6953332B1 (en) | 2000-11-28 | 2005-10-11 | St. Jude Medical, Inc. | Mandrel for use in forming valved prostheses having polymer leaflets by dip coating |
| GB2369981B (en) | 2000-12-13 | 2004-05-26 | Alexander James Sandall | Horticultural chamber |
| US6454798B1 (en) | 2000-12-21 | 2002-09-24 | Sulzer Carbomedics Inc. | Polymer heart valve with helical coaption surface |
| WO2002074201A1 (en) | 2001-03-16 | 2002-09-26 | Mayo Foundation For Medical Education And Research | Synthethic leaflets for heart valve repair or replacement |
| US6936067B2 (en) | 2001-05-17 | 2005-08-30 | St. Jude Medical Inc. | Prosthetic heart valve with slit stent |
| EP1406561A4 (en) | 2001-07-16 | 2008-03-12 | Edwards Lifesciences Corp | FABRIC MADE OF FABRIC |
| US6562069B2 (en) | 2001-09-19 | 2003-05-13 | St. Jude Medical, Inc. | Polymer leaflet designs for medical devices |
| US6893460B2 (en) | 2001-10-11 | 2005-05-17 | Percutaneous Valve Technologies Inc. | Implantable prosthetic valve |
| US6541589B1 (en) | 2001-10-15 | 2003-04-01 | Gore Enterprise Holdings, Inc. | Tetrafluoroethylene copolymer |
| US6726715B2 (en) | 2001-10-23 | 2004-04-27 | Childrens Medical Center Corporation | Fiber-reinforced heart valve prosthesis |
| US6755857B2 (en) | 2001-12-12 | 2004-06-29 | Sulzer Carbomedics Inc. | Polymer heart valve with perforated stent and sewing cuff |
| US7033390B2 (en) | 2002-01-02 | 2006-04-25 | Medtronic, Inc. | Prosthetic heart valve system |
| US7163556B2 (en) | 2002-03-21 | 2007-01-16 | Providence Health System - Oregon | Bioprosthesis and method for suturelessly making same |
| EP2067499B1 (en) | 2002-04-25 | 2012-05-16 | The Board of Trustees of The Leland Stanford Junior University | Expandable guide sheath and apparatus and methods using such sheaths |
| WO2003092554A1 (en) | 2002-05-03 | 2003-11-13 | The General Hospital Corporation | Involuted endovascular valve and method of construction |
| US20030229394A1 (en) | 2002-06-06 | 2003-12-11 | Ogle Matthew F. | Processed tissue for medical device formation |
| US20040024448A1 (en) | 2002-08-05 | 2004-02-05 | Chang James W. | Thermoplastic fluoropolymer-coated medical devices |
| US20040026245A1 (en) | 2002-08-09 | 2004-02-12 | Vivek Agarwal | High temperature oleophobic materials |
| US7879085B2 (en) | 2002-09-06 | 2011-02-01 | Boston Scientific Scimed, Inc. | ePTFE crimped graft |
| US7137184B2 (en) | 2002-09-20 | 2006-11-21 | Edwards Lifesciences Corporation | Continuous heart valve support frame and method of manufacture |
| CN101081917B (zh) | 2003-02-19 | 2011-06-08 | 杜邦·三井氟化学株式会社 | 含氟树脂复合体组合物 |
| US7658759B2 (en) | 2003-04-24 | 2010-02-09 | Cook Incorporated | Intralumenally implantable frames |
| US7128759B2 (en) | 2003-05-19 | 2006-10-31 | Cook Incorporated | Implantable medical device with constrained expansion |
| US7153324B2 (en) | 2003-07-31 | 2006-12-26 | Cook Incorporated | Prosthetic valve devices and methods of making such devices |
| FR2863160B1 (fr) | 2003-12-09 | 2006-03-03 | Perouse Laboratoires | Dispositif de traitement d'un vaisseau sanguin et procede de preparation de ce dispositif |
| US8128681B2 (en) | 2003-12-19 | 2012-03-06 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
| US7261732B2 (en) | 2003-12-22 | 2007-08-28 | Henri Justino | Stent mounted valve |
| EP2526898B1 (en) | 2003-12-23 | 2013-04-17 | Sadra Medical, Inc. | Repositionable heart valve |
| US7780725B2 (en) | 2004-06-16 | 2010-08-24 | Sadra Medical, Inc. | Everting heart valve |
| US20050137686A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical, A Delaware Corporation | Externally expandable heart valve anchor and method |
| US7862610B2 (en) | 2004-01-23 | 2011-01-04 | James Quintessenza | Bicuspid vascular valve and methods for making and implanting same |
| US7871435B2 (en) | 2004-01-23 | 2011-01-18 | Edwards Lifesciences Corporation | Anatomically approximate prosthetic mitral heart valve |
| US7247167B2 (en) | 2004-02-19 | 2007-07-24 | Shlomo Gabbay | Low profile heart valve prosthesis |
| CA2549323C (en) | 2004-04-08 | 2009-07-21 | Aga Medical Corporation | Flanged occlusion devices and methods |
| US20060122693A1 (en) | 2004-05-10 | 2006-06-08 | Youssef Biadillah | Stent valve and method of manufacturing same |
| US20060008497A1 (en) | 2004-07-09 | 2006-01-12 | Shlomo Gabbay | Implantable apparatus having improved biocompatibility and process of making the same |
| US20060154365A1 (en) | 2004-08-30 | 2006-07-13 | Anthony Ratcliffe | Cultured three dimensional tissues and uses thereof |
| FR2874812B1 (fr) | 2004-09-07 | 2007-06-15 | Perouse Soc Par Actions Simpli | Valve protheique interchangeable |
| US7758640B2 (en) | 2004-12-16 | 2010-07-20 | Valvexchange Inc. | Cardiovascular valve assembly |
| US8303647B2 (en) | 2005-03-03 | 2012-11-06 | Cook Medical Technologies Llc | Medical valve leaflet structures with peripheral region receptive to tissue ingrowth |
| US8062359B2 (en) | 2005-04-06 | 2011-11-22 | Edwards Lifesciences Corporation | Highly flexible heart valve connecting band |
| US7513909B2 (en) | 2005-04-08 | 2009-04-07 | Arbor Surgical Technologies, Inc. | Two-piece prosthetic valves with snap-in connection and methods for use |
| US7914569B2 (en) | 2005-05-13 | 2011-03-29 | Medtronics Corevalve Llc | Heart valve prosthesis and methods of manufacture and use |
| EP1887980B1 (en) | 2005-05-17 | 2012-09-05 | Cook Medical Technologies LLC | Frameless valve prosthesis and system for its deployment |
| CA2609022C (en) | 2005-05-20 | 2010-07-20 | The Cleveland Clinic Foundation | Apparatus and methods for repairing the function of a diseased valve and method for making same |
| WO2006127756A2 (en) | 2005-05-24 | 2006-11-30 | Edwards Lifesciences Corporation | Rapid deployment prosthetic heart valve |
| EP3072475B1 (en) | 2005-05-27 | 2018-10-03 | HLT, Inc. | Stentless support structure |
| US7238200B2 (en) | 2005-06-03 | 2007-07-03 | Arbor Surgical Technologies, Inc. | Apparatus and methods for making leaflets and valve prostheses including such leaflets |
| US8267993B2 (en) | 2005-06-09 | 2012-09-18 | Coroneo, Inc. | Expandable annuloplasty ring and associated ring holder |
| FR2887139B1 (fr) | 2005-06-15 | 2008-04-25 | Perouse Soc Par Actions Simpli | Dispositif de traitement d'un vaisseau sanguin. |
| US7531611B2 (en) | 2005-07-05 | 2009-05-12 | Gore Enterprise Holdings, Inc. | Copolymers of tetrafluoroethylene |
| US7306729B2 (en) | 2005-07-18 | 2007-12-11 | Gore Enterprise Holdings, Inc. | Porous PTFE materials and articles produced therefrom |
| WO2007016251A2 (en) | 2005-07-28 | 2007-02-08 | Cook Incorporated | Implantable thromboresistant valve |
| US7563277B2 (en) | 2005-10-24 | 2009-07-21 | Cook Incorporated | Removable covering for implantable frame projections |
| WO2007062320A2 (en) | 2005-11-18 | 2007-05-31 | Innovia, Llc | Trileaflet heart valve |
| US20070142907A1 (en) | 2005-12-16 | 2007-06-21 | Micardia Corporation | Adjustable prosthetic valve implant |
| JP2009520535A (ja) | 2005-12-22 | 2009-05-28 | サイメティス エスアー | 弁置換用ステント弁および手術用関連方法とシステム |
| US20070213813A1 (en) | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
| WO2007075892A2 (en) | 2005-12-23 | 2007-07-05 | Clinasys Llc | An implantable prosthetic valve |
| FR2896405B1 (fr) | 2006-01-24 | 2008-04-18 | Perouse Soc Par Actions Simpli | Dispositif de traitement d'un conduit de circulation du sang et procede de preparation associe |
| US8585753B2 (en) | 2006-03-04 | 2013-11-19 | John James Scanlon | Fibrillated biodegradable prosthesis |
| US20080026190A1 (en) | 2006-07-28 | 2008-01-31 | General Electric Company | Durable membranes and methods for improving membrane durability |
| US8834564B2 (en) | 2006-09-19 | 2014-09-16 | Medtronic, Inc. | Sinus-engaging valve fixation member |
| US8052750B2 (en) | 2006-09-19 | 2011-11-08 | Medtronic Ventor Technologies Ltd | Valve prosthesis fixation techniques using sandwiching |
| ES2382364T3 (es) | 2006-09-28 | 2012-06-07 | St George Medical Inc | Dispositivo de reparación de aneurismas de aorta torácica. |
| EP2088969B1 (en) | 2006-11-30 | 2014-08-20 | Cook Medical Technologies LLC | Implant release mechanism |
| US8133270B2 (en) * | 2007-01-08 | 2012-03-13 | California Institute Of Technology | In-situ formation of a valve |
| US7731783B2 (en) | 2007-01-24 | 2010-06-08 | Pratt & Whitney Rocketdyne, Inc. | Continuous pressure letdown system |
| US7967853B2 (en) | 2007-02-05 | 2011-06-28 | Boston Scientific Scimed, Inc. | Percutaneous valve, system and method |
| US9415567B2 (en) | 2007-02-05 | 2016-08-16 | Boston Scientific Scimed, Inc. | Synthetic composite structures |
| WO2008097592A2 (en) | 2007-02-05 | 2008-08-14 | Boston Scientific Limited | Synthetic composite structures |
| WO2008103295A2 (en) | 2007-02-16 | 2008-08-28 | Medtronic, Inc. | Replacement prosthetic heart valves and methods of implantation |
| US20080208327A1 (en) | 2007-02-27 | 2008-08-28 | Rowe Stanton J | Method and apparatus for replacing a prosthetic valve |
| US7914807B2 (en) | 2007-03-05 | 2011-03-29 | Boston Scientific Scimed, Inc. | Medical devices having improved performance |
| US8092523B2 (en) | 2007-03-12 | 2012-01-10 | St. Jude Medical, Inc. | Prosthetic heart valves with flexible leaflets |
| US8409274B2 (en) | 2007-04-26 | 2013-04-02 | St. Jude Medical, Inc. | Techniques for attaching flexible leaflets of prosthetic heart valves to supporting structures |
| FR2915678B1 (fr) | 2007-05-02 | 2010-04-16 | Lapeyre Ind Llc | Valve cardiaque prothetique mecanique |
| CN100502811C (zh) | 2007-05-29 | 2009-06-24 | 中国人民解放军第二军医大学 | 一种带瓣膜肺动脉支架 |
| ES2788453T3 (es) | 2007-06-04 | 2020-10-21 | St Jude Medical Llc | Válvulas cardíacas protésicas |
| CN101091675B (zh) | 2007-07-19 | 2010-06-16 | 中国人民解放军第二军医大学 | 双盘状带人工瓣膜房室瓣支架 |
| BRPI0815751A2 (pt) | 2007-08-24 | 2015-02-18 | St Jude Medical | Válvula aórtica protética. |
| US8425593B2 (en) | 2007-09-26 | 2013-04-23 | St. Jude Medical, Inc. | Collapsible prosthetic heart valves |
| US8454686B2 (en) | 2007-09-28 | 2013-06-04 | St. Jude Medical, Inc. | Two-stage collapsible/expandable prosthetic heart valves and anchoring systems |
| US8784481B2 (en) | 2007-09-28 | 2014-07-22 | St. Jude Medical, Inc. | Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features |
| US7803186B1 (en) | 2007-09-28 | 2010-09-28 | St. Jude Medical, Inc. | Prosthetic heart valves with flexible leaflets and leaflet edge clamping |
| US8637144B2 (en) | 2007-10-04 | 2014-01-28 | W. L. Gore & Associates, Inc. | Expandable TFE copolymers, method of making, and porous, expended articles thereof |
| US20090138079A1 (en) | 2007-10-10 | 2009-05-28 | Vector Technologies Ltd. | Prosthetic heart valve for transfemoral delivery |
| ES2781686T3 (es) | 2007-12-14 | 2020-09-04 | Edwards Lifesciences Corp | Armazón de unión de valvas para una válvula protésica |
| WO2009094197A1 (en) | 2008-01-24 | 2009-07-30 | Medtronic, Inc. | Stents for prosthetic heart valves |
| US8398704B2 (en) | 2008-02-26 | 2013-03-19 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
| WO2010086460A1 (en) | 2009-02-25 | 2010-08-05 | Jenavalve Technology Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
| DE102008012113A1 (de) | 2008-03-02 | 2009-09-03 | Transcatheter Technologies Gmbh | Stent, welcher vom expandierten Zustand erneut im Durchmesser kontrolliert verringerbar ist |
| US8313525B2 (en) | 2008-03-18 | 2012-11-20 | Medtronic Ventor Technologies, Ltd. | Valve suturing and implantation procedures |
| US20090287305A1 (en) | 2008-05-19 | 2009-11-19 | Amalaha Leonard D | Wholly implantable non-natural heart for humans |
| JP5536763B2 (ja) | 2008-06-04 | 2014-07-02 | ゴア エンタープライズ ホールディングス，インコーポレイティド | 制御展開可能な医療デバイス及びその製造方法 |
| HUE047246T2 (hu) | 2008-06-06 | 2020-04-28 | Edwards Lifesciences Corp | Kis profilú transzkatéteres szívbillentyû |
| US20110160836A1 (en) | 2008-06-20 | 2011-06-30 | Vysera Biomedical Limited | Valve device |
| EP2331018B1 (en) | 2008-06-20 | 2021-11-17 | Coloplast A/S | Intraluminal device |
| JP5123433B2 (ja) | 2008-07-17 | 2013-01-23 | エヌヴェーテー アーゲー | 人工心臓弁システム |
| US20100023114A1 (en) | 2008-07-24 | 2010-01-28 | Cook Incorporated | Valve device with biased leaflets |
| EP2367505B1 (en) | 2008-09-29 | 2020-08-12 | Edwards Lifesciences CardiAQ LLC | Heart valve |
| EP4321134A3 (en) | 2008-11-21 | 2024-05-01 | Percutaneous Cardiovascular Solutions Pty Limited | Heart valve prosthesis and method |
| US8591573B2 (en) | 2008-12-08 | 2013-11-26 | Hector Daniel Barone | Prosthetic valve for intraluminal implantation |
| US20100217382A1 (en) | 2009-02-25 | 2010-08-26 | Edwards Lifesciences | Mitral valve replacement with atrial anchoring |
| US9139669B2 (en) | 2009-03-24 | 2015-09-22 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expandable functional products obtained therefrom and reaction of the expanded products |
| GB0906065D0 (en) | 2009-04-07 | 2009-05-20 | Angiomed Ag | Delivery system for a prosthesis |
| WO2010121076A2 (en) | 2009-04-15 | 2010-10-21 | Cardiaq Valve Technologies, Inc. | Vascular implant and delivery system |
| DE102009037739A1 (de) | 2009-06-29 | 2010-12-30 | Be Innovative Gmbh | Perkutan implantierbarer Klappenstent, Vorrichtung zu seiner Applizierung sowie Verfahren zur Herstellung des Klappenstents |
| US20110054515A1 (en) | 2009-08-25 | 2011-03-03 | John Bridgeman | Device and method for occluding the left atrial appendage |
| EP2470119B1 (en) | 2009-08-27 | 2017-05-10 | Medtronic Inc. | Transcatheter valve delivery systems |
| CN102905646B (zh) | 2009-08-28 | 2016-01-20 | 美敦力3F医疗有限公司 | 外科输送装置和使用方法 |
| US8591932B2 (en) | 2009-09-17 | 2013-11-26 | W. L. Gore & Associates, Inc. | Heparin entities and methods of use |
| EP3308816B1 (en) | 2009-10-29 | 2020-02-12 | W.L. Gore & Associates, Inc | Syringe stopper coated with densified expanded ptfe |
| GR1007028B (el) | 2009-11-11 | 2010-10-22 | Ευσταθιος-Ανδρεας Αγαθος | Υποστηρικτης βιοπροσθετικων βαλβιδων με διαγλωχινικο συνδεσμο σχηματος καρδιας |
| US20130190861A1 (en) | 2012-01-23 | 2013-07-25 | Tendyne Holdings, Inc. | Prosthetic Valve for Replacing Mitral Valve |
| US9504562B2 (en) * | 2010-01-12 | 2016-11-29 | Valve Medical Ltd. | Self-assembling modular percutaneous valve and methods of folding, assembly and delivery |
| US9226826B2 (en) | 2010-02-24 | 2016-01-05 | Medtronic, Inc. | Transcatheter valve structure and methods for valve delivery |
| US9522062B2 (en) | 2010-02-24 | 2016-12-20 | Medtronic Ventor Technologies, Ltd. | Mitral prosthesis and methods for implantation |
| CN106943208B (zh) | 2010-03-01 | 2020-01-24 | 科利柏心脏瓣膜有限责任公司 | 可经皮输送的心脏瓣膜及相关制备方法 |
| US8795354B2 (en) | 2010-03-05 | 2014-08-05 | Edwards Lifesciences Corporation | Low-profile heart valve and delivery system |
| US9833314B2 (en) | 2010-04-16 | 2017-12-05 | Abiomed, Inc. | Percutaneous valve deployment |
| RU2434604C1 (ru) | 2010-04-30 | 2011-11-27 | Лео Антонович Бокерия | Аортальный трехстворчатый протез клапана сердца |
| FI126855B (fi) | 2010-07-08 | 2017-06-30 | Aalto-Korkeakoulusäätiö | Menetelmä ja laitteisto orgaanisten liuottimien ja alkoholien tuottamiseksi mikrobeilla |
| EP2598044B1 (en) | 2010-07-27 | 2019-03-13 | Incept, LLC | Apparatus for treating neurovascular venous outflow obstruction |
| US8808848B2 (en) | 2010-09-10 | 2014-08-19 | W. L. Gore & Associates, Inc. | Porous article |
| AU2011305153A1 (en) | 2010-09-23 | 2013-05-02 | Colibri Heart Valve Llc | Percutaneously deliverable heart or blood vessel valve with frame having abluminally situated tissue membrane |
| US8845720B2 (en) | 2010-09-27 | 2014-09-30 | Edwards Lifesciences Corporation | Prosthetic heart valve frame with flexible commissures |
| DE202011111125U1 (de) | 2010-10-05 | 2020-05-20 | Edwards Lifesciences Corporation | Prothetische Herzklappe |
| US8568475B2 (en) | 2010-10-05 | 2013-10-29 | Edwards Lifesciences Corporation | Spiraled commissure attachment for prosthetic valve |
| US20120116498A1 (en) | 2010-11-05 | 2012-05-10 | Chuter Timothy A | Aortic valve prostheses |
| US20120116496A1 (en) | 2010-11-05 | 2012-05-10 | Chuter Timothy A | Stent structures for use with valve replacements |
| US9468547B2 (en) | 2010-11-11 | 2016-10-18 | W. L. Gore & Associates, Inc. | Deployment of endoluminal devices |
| AU2011343755A1 (en) | 2010-12-14 | 2013-06-06 | Colibri Heart Valve Llc | Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets |
| DE102010061371A1 (de) | 2010-12-20 | 2012-06-21 | Transcatheter Technologies Gmbh | Vorrichtung mit individuellen Schaftfasern und Set zum Falten oder Entfalten eines medizinischen Implantats und Verfahren |
| US9198787B2 (en) | 2010-12-31 | 2015-12-01 | Cook Medical Technologies Llc | Conformable prosthesis delivery system and method for deployment thereof |
| GB2488530A (en) | 2011-02-18 | 2012-09-05 | David J Wheatley | Heart valve |
| US20140163671A1 (en) | 2011-04-01 | 2014-06-12 | W. L. Gore & Associates, Inc. | Leaflet and valve apparatus |
| US8961599B2 (en) | 2011-04-01 | 2015-02-24 | W. L. Gore & Associates, Inc. | Durable high strength polymer composite suitable for implant and articles produced therefrom |
| US9801712B2 (en) | 2011-04-01 | 2017-10-31 | W. L. Gore & Associates, Inc. | Coherent single layer high strength synthetic polymer composites for prosthetic valves |
| US20140163673A1 (en) | 2011-04-01 | 2014-06-12 | W. L. Gore & Associates, Inc. | Prosthetic heart valve leaflet adapted for external imaging |
| US8945212B2 (en) | 2011-04-01 | 2015-02-03 | W. L. Gore & Associates, Inc. | Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom |
| US9554900B2 (en) | 2011-04-01 | 2017-01-31 | W. L. Gore & Associates, Inc. | Durable high strength polymer composites suitable for implant and articles produced therefrom |
| EP2522308B1 (de) | 2011-05-10 | 2015-02-25 | Biotronik AG | Mechanische Transkatheter-Herzklappenprothese |
| US10117765B2 (en) | 2011-06-14 | 2018-11-06 | W.L. Gore Associates, Inc | Apposition fiber for use in endoluminal deployment of expandable implants |
| EP4623867A3 (en) | 2011-06-21 | 2025-11-05 | Twelve, Inc. | Prosthetic heart valve devices |
| US8852272B2 (en) | 2011-08-05 | 2014-10-07 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
| US20140324164A1 (en) | 2011-08-05 | 2014-10-30 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
| CN103826669A (zh) | 2011-09-23 | 2014-05-28 | 宙斯工业产品股份有限公司 | 复合假体分流器装置 |
| US9730726B2 (en) | 2011-10-07 | 2017-08-15 | W. L. Gore & Associates, Inc. | Balloon assemblies having controllably variable topographies |
| AU2012325813A1 (en) * | 2011-10-19 | 2014-04-03 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
| PL2787926T3 (pl) | 2011-12-09 | 2022-11-14 | Edwards Lifesciences Corporation | Usprawnione wsporniki spojeń zastawki protetycznej serca |
| WO2013096854A2 (en) | 2011-12-23 | 2013-06-27 | Abiomed, Inc. | Heart valve prosthesis with open stent |
| US9375308B2 (en) | 2012-03-13 | 2016-06-28 | W. L. Gore & Associates, Inc. | External steerable fiber for use in endoluminal deployment of expandable devices |
| CN102764169B (zh) | 2012-04-19 | 2015-07-29 | 杭州启明医疗器械有限公司 | 人工心脏瓣膜及其瓣膜支架 |
| CN102652694B (zh) | 2012-05-24 | 2014-06-25 | 上海欣吉特生物科技有限公司 | 人工心脏瓣膜 |
| US9554902B2 (en) | 2012-06-28 | 2017-01-31 | St. Jude Medical, Cardiology Division, Inc. | Leaflet in configuration for function in various shapes and sizes |
| US9283072B2 (en) | 2012-07-25 | 2016-03-15 | W. L. Gore & Associates, Inc. | Everting transcatheter valve and methods |
| US10376360B2 (en) | 2012-07-27 | 2019-08-13 | W. L. Gore & Associates, Inc. | Multi-frame prosthetic valve apparatus and methods |
| EP2712633B1 (de) | 2012-10-02 | 2015-04-29 | Biotronik AG | Bioprosthetische Komponenten für ein Implantat, insbesondere teilvernetzte biologische Herzklappen |
| US20140106951A1 (en) | 2012-10-15 | 2014-04-17 | W. L. Gore & Associates, Inc. | Methods and systems for securing a sleeve for endoluminal devices |
| US10327901B2 (en) | 2012-11-20 | 2019-06-25 | Innovheart S.R.L. | Device for the deployment of a system of guide wires within a cardiac chamber for implanting a prosthetic heart valve |
| US9144492B2 (en) | 2012-12-19 | 2015-09-29 | W. L. Gore & Associates, Inc. | Truncated leaflet for prosthetic heart valves, preformed valve |
| US10039638B2 (en) | 2012-12-19 | 2018-08-07 | W. L. Gore & Associates, Inc. | Geometric prosthetic heart valves |
| US9498361B2 (en) | 2012-12-19 | 2016-11-22 | Cook Medical Technologies Llc | Repositionable diameter constraints |
| US9398952B2 (en) * | 2012-12-19 | 2016-07-26 | W. L. Gore & Associates, Inc. | Planar zone in prosthetic heart valve leaflet |
| US9968443B2 (en) | 2012-12-19 | 2018-05-15 | W. L. Gore & Associates, Inc. | Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet |
| US10321986B2 (en) | 2012-12-19 | 2019-06-18 | W. L. Gore & Associates, Inc. | Multi-frame prosthetic heart valve |
| US9737398B2 (en) | 2012-12-19 | 2017-08-22 | W. L. Gore & Associates, Inc. | Prosthetic valves, frames and leaflets and methods thereof |
| US9101469B2 (en) | 2012-12-19 | 2015-08-11 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with leaflet shelving |
| US10966820B2 (en) | 2012-12-19 | 2021-04-06 | W. L. Gore & Associates, Inc. | Geometric control of bending character in prosthetic heart valve leaflets |
| US10654200B2 (en) | 2013-03-07 | 2020-05-19 | S.M. Scienzia Machinale S.R.L. | Apparatus and method for producing a biocompatible three-dimensional object |
| EP2967858B1 (en) | 2013-03-15 | 2023-01-18 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems |
| US9232994B2 (en) | 2013-03-15 | 2016-01-12 | Medtronic Vascular Galway Limited | Stented prosthetic heart valve and methods for making |
| US20140296969A1 (en) | 2013-04-02 | 2014-10-02 | Tendyne Holdlings, Inc. | Anterior Leaflet Clip Device for Prosthetic Mitral Valve |
| GB2513194A (en) | 2013-04-19 | 2014-10-22 | Strait Access Tech Holdings Pty Ltd | A valve |
| JP6561044B2 (ja) | 2013-05-03 | 2019-08-14 | メドトロニック，インコーポレイテッド | 弁搬送ツール |
| US9867700B2 (en) | 2013-05-20 | 2018-01-16 | Edwards Lifesciences Corporation | Prosthetic heart valve delivery apparatus |
| WO2014188430A2 (en) | 2013-05-23 | 2014-11-27 | CardioSonic Ltd. | Devices and methods for renal denervation and assessment thereof |
| CA2914856C (en) | 2013-06-25 | 2021-03-09 | Chad Perrin | Thrombus management and structural compliance features for prosthetic heart valves |
| US10524904B2 (en) | 2013-07-11 | 2020-01-07 | Medtronic, Inc. | Valve positioning device |
| US9561103B2 (en) | 2013-07-17 | 2017-02-07 | Cephea Valve Technologies, Inc. | System and method for cardiac valve repair and replacement |
| WO2015028209A1 (en) | 2013-08-30 | 2015-03-05 | Jenavalve Technology Gmbh | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
| US10441415B2 (en) | 2013-09-20 | 2019-10-15 | Edwards Lifesciences Corporation | Heart valves with increased effective orifice area |
| EP3051933B1 (en) | 2013-09-24 | 2018-08-29 | Fuji Machine Mfg. Co., Ltd. | Mounting apparatus |
| US10226333B2 (en) | 2013-10-15 | 2019-03-12 | Cedars-Sinai Medical Center | Anatomically-orientated and self-positioning transcatheter mitral valve |
| US9504565B2 (en) | 2013-12-06 | 2016-11-29 | W. L. Gore & Associates, Inc. | Asymmetric opening and closing prosthetic valve leaflet |
| US20170189175A1 (en) | 2014-05-07 | 2017-07-06 | Baylor College Of Medicine | Artificial, flexible valves and methods of fabricating and serially expanding the same |
| EP3142608B1 (en) | 2014-05-16 | 2024-05-15 | TruLeaf Medical Ltd. | Replacement heart valve |
| CA2914094C (en) | 2014-06-20 | 2021-01-05 | Edwards Lifesciences Corporation | Surgical heart valves identifiable post-implant |
| EP3182929B1 (en) | 2014-08-18 | 2023-08-09 | Edwards Lifesciences Corporation | Frame with integral sewing cuff for prosthetic valves |
| US9827094B2 (en) | 2014-09-15 | 2017-11-28 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with retention elements |
| US9937037B2 (en) | 2014-12-18 | 2018-04-10 | W. L. Gore & Associates, Inc. | Prosthetic valved conduits with mechanically coupled leaflets |
| EP3232989B1 (en) | 2014-12-18 | 2020-05-06 | W. L. Gore & Associates, Inc. | Prosthetic valves with mechanically coupled leaflets |
| US20160235525A1 (en) | 2015-02-12 | 2016-08-18 | Medtronic, Inc. | Integrated valve assembly and method of delivering and deploying an integrated valve assembly |
| US10441416B2 (en) | 2015-04-21 | 2019-10-15 | Edwards Lifesciences Corporation | Percutaneous mitral valve replacement device |
| WO2016186909A1 (en) | 2015-05-18 | 2016-11-24 | Mayo Foundation For Medical Education And Research | Percutaneously-deployable prosthetic tricuspid valve |
| US10575951B2 (en) | 2015-08-26 | 2020-03-03 | Edwards Lifesciences Cardiaq Llc | Delivery device and methods of use for transapical delivery of replacement mitral valve |
| US10470876B2 (en) | 2015-11-10 | 2019-11-12 | Edwards Lifesciences Corporation | Transcatheter heart valve for replacing natural mitral valve |
| US10583007B2 (en) | 2015-12-02 | 2020-03-10 | Edwards Lifesciences Corporation | Suture deployment of prosthetic heart valve |
| US9931204B2 (en) | 2015-12-10 | 2018-04-03 | Medtronic, Inc. | Transcatheter heart valve replacement systems, heart valve prostheses, and methods for percutaneous heart valve replacement |
| EP3389562B1 (en) | 2015-12-14 | 2024-05-08 | Medtronic Vascular, Inc. | Devices and methods for transcatheter valve loading and implantation |
| US10758350B2 (en) | 2016-06-06 | 2020-09-01 | Medtronic Vascular, Inc. | Transcatheter prosthetic heart valve delivery system with protective feature |
| CR20190381A (es) | 2017-01-23 | 2019-09-27 | Cephea Valve Tech Inc | Valvulas mitrales de reemplazo |
| AU2018334191B2 (en) | 2017-09-12 | 2021-04-08 | Edwards Lifesciences Corporation | Leaflet frame attachment for prosthetic valves |
| CA3178271A1 (en) | 2017-09-27 | 2019-04-04 | W.L. Gore & Associates, Inc. | Prosthetic valve with expandable frame and associated systems and methods |
| CA3155761C (en) | 2017-09-27 | 2025-11-18 | Gore & Ass | Prosthetic valves with mechanically coupled leaflets |
| JP7036912B2 (ja) | 2017-10-13 | 2022-03-15 | ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド | 嵌込式人工弁および送達システム |
| CA3078608C (en) | 2017-10-31 | 2023-03-28 | W.L. Gore & Associates, Inc. | Prosthetic heart valve |
| US10987218B2 (en) | 2017-10-31 | 2021-04-27 | W. L. Gore & Associates, Inc. | Transcatheter deployment systems and associated methods |
| US11154397B2 (en) | 2017-10-31 | 2021-10-26 | W. L. Gore & Associates, Inc. | Jacket for surgical heart valve |
| US11439502B2 (en) | 2017-10-31 | 2022-09-13 | W. L. Gore & Associates, Inc. | Medical valve and leaflet promoting tissue ingrowth |
| US11497601B2 (en) | 2019-03-01 | 2022-11-15 | W. L. Gore & Associates, Inc. | Telescoping prosthetic valve with retention element |
-
2013
- 2013-12-18 US US14/133,491 patent/US10039638B2/en active Active
- 2013-12-19 JP JP2015549695A patent/JP6463693B2/ja active Active
- 2013-12-19 KR KR1020157019566A patent/KR20150097757A/ko not_active Ceased
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| CA2891968A1 (en) | 2014-06-26 |
| JP6463693B2 (ja) | 2019-02-06 |
| US11039917B2 (en) | 2021-06-22 |
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| CA2891968C (en) | 2018-09-11 |
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| EP2934391A1 (en) | 2015-10-28 |
| JP2016501113A (ja) | 2016-01-18 |
| KR20150097757A (ko) | 2015-08-26 |
| AU2013361283A1 (en) | 2015-06-11 |
| US20140172083A1 (en) | 2014-06-19 |
| AU2013361283B2 (en) | 2017-04-27 |
| CN104869949B (zh) | 2017-07-21 |
| EP2934391B1 (en) | 2017-03-08 |
| AU2017208257A1 (en) | 2017-08-10 |
| CN104869949A (zh) | 2015-08-26 |
| WO2014100394A1 (en) | 2014-06-26 |
| US20180318070A1 (en) | 2018-11-08 |
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