ES2625538T3 - Composiciones de proteínas estabilizadas basadas en alcanos semifluorados - Google Patents

Composiciones de proteínas estabilizadas basadas en alcanos semifluorados Download PDF

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Publication number
ES2625538T3
ES2625538T3 ES13700911.4T ES13700911T ES2625538T3 ES 2625538 T3 ES2625538 T3 ES 2625538T3 ES 13700911 T ES13700911 T ES 13700911T ES 2625538 T3 ES2625538 T3 ES 2625538T3
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ES
Spain
Prior art keywords
composition
protein
semi
bioactive
suspension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13700911.4T
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English (en)
Spanish (es)
Inventor
Bernhard GÜNTHER
Bastian Theisinger
Sonja Theisinger
Dieter Scherer
Clive Wilson
Anthony PETTIGREW
Annette HÜTTIG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novaliq GmbH
Original Assignee
Novaliq GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novaliq GmbH filed Critical Novaliq GmbH
Application granted granted Critical
Publication of ES2625538T3 publication Critical patent/ES2625538T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/23Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • A61K38/385Serum albumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4826Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21001Chymotrypsin (3.4.21.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES13700911.4T 2012-01-23 2013-01-22 Composiciones de proteínas estabilizadas basadas en alcanos semifluorados Active ES2625538T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12152159 2012-01-23
EP12152159 2012-01-23
PCT/EP2013/051163 WO2013110621A1 (en) 2012-01-23 2013-01-22 Stabilised protein compositions based on semifluorinated alkanes

Publications (1)

Publication Number Publication Date
ES2625538T3 true ES2625538T3 (es) 2017-07-19

Family

ID=47598843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13700911.4T Active ES2625538T3 (es) 2012-01-23 2013-01-22 Composiciones de proteínas estabilizadas basadas en alcanos semifluorados

Country Status (14)

Country Link
US (2) US9757460B2 (enExample)
EP (1) EP2806886B1 (enExample)
JP (1) JP6084987B2 (enExample)
KR (1) KR101989648B1 (enExample)
CN (1) CN104066442B (enExample)
AU (1) AU2013211645B2 (enExample)
BR (1) BR112014017719A8 (enExample)
CA (1) CA2862974C (enExample)
DK (1) DK2806886T3 (enExample)
ES (1) ES2625538T3 (enExample)
MX (1) MX361681B (enExample)
PL (1) PL2806886T3 (enExample)
PT (1) PT2806886T (enExample)
WO (1) WO2013110621A1 (enExample)

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ES2625538T3 (es) 2012-01-23 2017-07-19 Novaliq Gmbh Composiciones de proteínas estabilizadas basadas en alcanos semifluorados
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AU2020340561B2 (en) 2019-09-06 2026-01-22 Novaliq Gmbh Ophthalmic composition for the treatment of uveitis
JP7761562B2 (ja) * 2019-11-27 2025-10-28 ノバリック ゲーエムベーハー 非水性溶媒で懸濁されたタンパク質粒子を含む懸濁製剤
CN115487305A (zh) * 2022-09-21 2022-12-20 江苏君隽生物科技有限公司 一种用于递送活性药物成分的液体组合物
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CN113662929A (zh) 2015-09-30 2021-11-19 诺瓦利克有限责任公司 用于眼部给药的半氟化化合物

Also Published As

Publication number Publication date
CA2862974A1 (en) 2013-08-01
JP2015504082A (ja) 2015-02-05
PL2806886T3 (pl) 2017-08-31
CN104066442B (zh) 2018-05-18
WO2013110621A1 (en) 2013-08-01
EP2806886B1 (en) 2017-03-01
AU2013211645B2 (en) 2017-06-15
CA2862974C (en) 2021-11-16
BR112014017719A2 (enExample) 2017-06-20
MX2014008929A (es) 2015-06-02
MX361681B (es) 2018-12-13
PT2806886T (pt) 2017-03-24
US20140369993A1 (en) 2014-12-18
BR112014017719A8 (pt) 2017-07-11
KR101989648B1 (ko) 2019-06-14
JP6084987B2 (ja) 2017-02-22
DK2806886T3 (en) 2017-06-06
EP2806886A1 (en) 2014-12-03
KR20140125353A (ko) 2014-10-28
CN104066442A (zh) 2014-09-24
AU2013211645A1 (en) 2014-07-17
USRE49758E1 (en) 2023-12-19
US9757460B2 (en) 2017-09-12

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