ES2618035T3 - Instrumento de análisis de sangre - Google Patents
Instrumento de análisis de sangre Download PDFInfo
- Publication number
- ES2618035T3 ES2618035T3 ES10179313.1T ES10179313T ES2618035T3 ES 2618035 T3 ES2618035 T3 ES 2618035T3 ES 10179313 T ES10179313 T ES 10179313T ES 2618035 T3 ES2618035 T3 ES 2618035T3
- Authority
- ES
- Spain
- Prior art keywords
- disposable cartridge
- diaphragm
- receptacles
- instrument
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000009534 blood test Methods 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 239000012470 diluted sample Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- 238000007789 sealing Methods 0.000 abstract 2
- 210000000601 blood cell Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/4875—Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L1/00—Enclosures; Chambers
- B01L1/52—Transportable laboratories; Field kits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Ecology (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Instrumento de análisis de sangre para su uso con un cartucho desechable, en el que dicho cartucho desechable se coloca de manera desmontable en el instrumento, comprendiendo dicho instrumento de análisis de sangre un medio adaptado para producir la mezcla de una muestra de sangre (S) y un agente líquido (D1, D2, H) en dicho cartucho desechable, y un sistema de medición que incluye dos estaciones de recuento de células, comprendiendo cada una, un orificio (75, 76) que permite estadísticamente que pase sólo una célula sanguínea a la vez y que cada una esté conectada a un conducto (71, 72), caracterizado por un medio de accionamiento de presión (92) adaptado para aplicar una presión sobre al menos una parte de un diafragma (40) que sella un receptáculo seleccionado de dicho cartucho desechable; comprendiendo dicho cartucho desechable una pluralidad de receptáculos (28-30, 32-33) formados por una pluralidad de depresiones sobre una superficie (27) de un alojamiento (21) sellado por dicho diafragma (40), y una pluralidad de canales (35-38) adaptados para conectar dichos receptáculos, sellando partes de dicho diafragma (40) dichas depresiones que son flexibles; y estando dicho medio de accionamiento de presión (92) adaptado para aplicar una presión sobre partes de dicho diafragma (40) en receptáculos seleccionados (29, 30) de dicho cartucho desechable cuando dicho cartucho desechable está colocado en dicho instrumento para producir el flujo de una mezcla de dicha muestra de sangre y dicho agente líquido hacia adelante y hacia atrás entre dichos receptáculos seleccionados (29, 30) para influir en la mezcla de dicha mezcla en dicho cartucho desechable, formando de ese modo una muestra diluida; y conectándose cada conducto (71, 72) a una estación de recuento de células correspondiente en un extremo y teniendo una parte de aguja (73, 74) en otro extremo, estando dicha parte de aguja adaptada para ser insertada a través de una abertura sellada (60, 61) de dicho cartucho desechable para retirar dicha muestra diluida de un receptáculo seleccionado (30, 33) de dicho cartucho desechable a dicha estación de recuento de células correspondiente de dicho instrumento de medición.
Description
Claims (1)
-
imagen1 imagen2
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0203435 | 2002-11-20 | ||
SE0203435A SE524730C2 (sv) | 2002-11-20 | 2002-11-20 | Blodprovsapparat |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2618035T3 true ES2618035T3 (es) | 2017-06-20 |
Family
ID=20289627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10179313.1T Expired - Lifetime ES2618035T3 (es) | 2002-11-20 | 2003-11-19 | Instrumento de análisis de sangre |
Country Status (7)
Country | Link |
---|---|
US (3) | US7608223B2 (es) |
EP (2) | EP2263798B1 (es) |
JP (2) | JP4675107B2 (es) |
AU (1) | AU2003282642A1 (es) |
ES (1) | ES2618035T3 (es) |
SE (1) | SE524730C2 (es) |
WO (1) | WO2004045770A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050118061A1 (en) * | 2003-11-28 | 2005-06-02 | Sysmex Corporation | Analyzer, assay cartridge and analyzing method |
US8343074B2 (en) * | 2004-06-30 | 2013-01-01 | Lifescan Scotland Limited | Fluid handling devices |
EP1891413B1 (en) * | 2005-02-10 | 2018-01-24 | Koninklijke Philips N.V. | Dual sample cartridge and method for characterizing particle in liquid |
JP5305361B2 (ja) | 2007-05-04 | 2013-10-02 | オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニー | 流体コネクタおよびマイクロ流体システム |
US8187538B2 (en) | 2008-01-17 | 2012-05-29 | Ortho-Clinical Diagnostics, Inc. | Diluent wells produced in card format for immunodiagnostic testing |
US8247191B2 (en) | 2008-11-13 | 2012-08-21 | Ritzen Kalle | Disposable cassette and method of use for blood analysis on blood analyzer |
EP2373422A4 (en) * | 2008-12-04 | 2017-01-18 | Büchi Labortechnik AG | Methods and apparatus for moving aliquot samples of fluid |
DE202010018623U1 (de) | 2009-02-02 | 2018-12-07 | Opko Diagnostics, Llc | Strukturen zur Steuerung der Lichtwechselwirkung mit mikrofluidischen Vorrichtungen |
KR101372233B1 (ko) * | 2009-10-09 | 2014-03-11 | 한국전자통신연구원 | 미세 유체 소자 및 이를 이용한 유체 흐름 제어 방법 |
WO2011130625A1 (en) | 2010-04-16 | 2011-10-20 | Claros Diagnostics, Inc. | Feedback control in microfluidic systems |
US9417210B2 (en) | 2011-09-30 | 2016-08-16 | Pandora Genomics, LLC | System, apparatus and method for evaluating samples or analytes using a point-of-care device |
ES2427548B1 (es) * | 2012-02-02 | 2014-10-01 | Fundación Gaiker | Dispositivo de preparación de muestras de análisis, soporte, sistema de preparación de muestras de análisis, método de preparación de muestras y método de análisis de una muestra |
TWI638277B (zh) | 2012-03-05 | 2018-10-11 | Opko診斷法有限責任公司 | 用於確定前列腺癌相關事件之機率之分析系統及方法 |
US9204833B2 (en) * | 2012-03-27 | 2015-12-08 | Phlebotics, Inc. | Cartridge for automated blood sampling system |
US9075042B2 (en) | 2012-05-15 | 2015-07-07 | Wellstat Diagnostics, Llc | Diagnostic systems and cartridges |
US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
EP2912432B1 (en) * | 2012-10-24 | 2018-07-04 | Genmark Diagnostics Inc. | Integrated multiplex target analysis |
WO2015083166A1 (en) * | 2013-12-04 | 2015-06-11 | Pocared Diagnostics Ltd. | Method and apparatus for processing and analyzing particles extracted from tangential filtering |
EP2982436B1 (en) * | 2014-08-04 | 2020-09-09 | Skyla Corporation Hsinchu Science Park Branch | Testing module for testing a sample |
WO2016064787A1 (en) | 2014-10-20 | 2016-04-28 | Keurig Green Mountain, Inc. | Mixing chamber for beverage machine |
US20170328924A1 (en) | 2014-11-26 | 2017-11-16 | Ronald Jones | Automated microscopic cell analysis |
US11478789B2 (en) | 2014-11-26 | 2022-10-25 | Medica Corporation | Automated microscopic cell analysis |
CN105136776A (zh) * | 2015-07-21 | 2015-12-09 | 贵研检测科技(云南)有限公司 | 汽车催化剂中锆铈镧镨钕钡镁铝的一种快速测定方法 |
EP3482189A4 (en) * | 2016-07-08 | 2020-08-19 | Medica Corporation | AUTOMATED MICROSCOPIC CELL ANALYSIS |
US10349589B2 (en) | 2016-09-08 | 2019-07-16 | Hemex Health, Inc. | Diagnostics systems and methods |
WO2018048488A1 (en) * | 2016-09-08 | 2018-03-15 | Hemex Health, Inc. | Diagnostics systems and methods |
WO2020264182A1 (en) | 2019-06-25 | 2020-12-30 | Hemex Health, Inc. | Diagnostics systems and methods |
CN111617812B (zh) * | 2019-10-17 | 2021-12-03 | 北京京东方健康科技有限公司 | 微流控基板及其流体驱动方法、微流控装置 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4690801A (en) * | 1986-06-03 | 1987-09-01 | Allelix Inc. | Device for performing enzyme immunoassays |
GB8720470D0 (en) | 1987-08-29 | 1987-10-07 | Emi Plc Thorn | Sensor arrangements |
US5230866A (en) * | 1991-03-01 | 1993-07-27 | Biotrack, Inc. | Capillary stop-flow junction having improved stability against accidental fluid flow |
WO1993017328A1 (en) | 1992-02-20 | 1993-09-02 | Drew Scientific Limited | Liquid chromatography apparatus |
US5500187A (en) * | 1992-12-08 | 1996-03-19 | Westinghouse Electric Corporation | Disposable optical agglutination assay device and method for use |
FR2723735B1 (fr) * | 1994-08-18 | 1996-10-31 | Abx Sa | Boitier a branchement automatique pour distribution de reactifs dans un appareil notamment un analyseur hematologique. |
US5863502A (en) * | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
SE515424C2 (sv) | 1997-07-01 | 2001-07-30 | Boule Medical Ab | Engångs provtagningsanordning för en partikelräknare |
SE515423C2 (sv) | 1998-02-06 | 2001-07-30 | Boule Medical Ab | Förfarande och anordning för spädning av ett blodprov |
US6004821A (en) * | 1998-03-07 | 1999-12-21 | Levine; Robert A. | Method and apparatus for performing chemical, qualitative, quantitative, and semi-quantitative analyses of a urine sample |
JP2000002677A (ja) * | 1998-06-15 | 2000-01-07 | Asahi Chem Ind Co Ltd | 分析装置 |
WO2001007892A1 (en) * | 1999-07-27 | 2001-02-01 | Esperion Therapeutics, Inc. | Method and device for measurement of cholesterol efflux |
TW517154B (en) * | 1999-08-11 | 2003-01-11 | Asahi Chemical Ind | Analyzing cartridge and liquid feed control device |
US6261065B1 (en) * | 1999-09-03 | 2001-07-17 | Baxter International Inc. | System and methods for control of pumps employing electrical field sensing |
US6875191B2 (en) * | 1999-09-03 | 2005-04-05 | Baxter International Inc. | Blood processing systems and methods that alternate flow of blood component and additive solution through an in-line leukofilter |
SE515538C2 (sv) | 2000-03-31 | 2001-08-27 | Boule Medical Ab | Anordning för spädning och blandning av ett vätskeformigt prov |
JP3418727B2 (ja) * | 2000-04-27 | 2003-06-23 | 独立行政法人産業技術総合研究所 | マイクロバルブ装置及びその製作方法 |
AU2001288668A1 (en) * | 2000-08-31 | 2002-03-13 | Advanced Sensor Technologies | Micro-fluidic system |
US6949377B2 (en) * | 2001-03-05 | 2005-09-27 | Ho Winston Z | Chemiluminescence-based microfluidic biochip |
SE521252C2 (sv) | 2001-11-21 | 2003-10-14 | Boule Medical Ab | Engångsapparat för användning vid blodprov och instrument för användning med apparaten |
-
2002
- 2002-11-20 SE SE0203435A patent/SE524730C2/sv not_active IP Right Cessation
-
2003
- 2003-11-19 EP EP10179313.1A patent/EP2263798B1/en not_active Expired - Fee Related
- 2003-11-19 ES ES10179313.1T patent/ES2618035T3/es not_active Expired - Lifetime
- 2003-11-19 EP EP03774422.4A patent/EP1562707B1/en not_active Expired - Lifetime
- 2003-11-19 WO PCT/SE2003/001796 patent/WO2004045770A1/en active Application Filing
- 2003-11-19 US US10/533,790 patent/US7608223B2/en not_active Expired - Fee Related
- 2003-11-19 AU AU2003282642A patent/AU2003282642A1/en not_active Abandoned
- 2003-11-19 JP JP2004553357A patent/JP4675107B2/ja not_active Expired - Fee Related
-
2008
- 2008-05-09 US US12/118,603 patent/US7833746B2/en not_active Expired - Fee Related
-
2010
- 2010-09-15 JP JP2010206940A patent/JP5425735B2/ja not_active Expired - Fee Related
- 2010-10-22 US US12/910,097 patent/US8304207B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2263798A1 (en) | 2010-12-22 |
EP2263798B1 (en) | 2017-01-18 |
EP1562707B1 (en) | 2014-06-11 |
US8304207B2 (en) | 2012-11-06 |
US7608223B2 (en) | 2009-10-27 |
JP4675107B2 (ja) | 2011-04-20 |
AU2003282642A1 (en) | 2004-06-15 |
US20110039298A1 (en) | 2011-02-17 |
US7833746B2 (en) | 2010-11-16 |
JP2006506638A (ja) | 2006-02-23 |
JP5425735B2 (ja) | 2014-02-26 |
JP2011017717A (ja) | 2011-01-27 |
SE0203435L (sv) | 2004-05-21 |
SE0203435D0 (sv) | 2002-11-20 |
US20060013740A1 (en) | 2006-01-19 |
SE524730C2 (sv) | 2004-09-21 |
WO2004045770A1 (en) | 2004-06-03 |
US20080220464A1 (en) | 2008-09-11 |
EP1562707A1 (en) | 2005-08-17 |
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