ES2614878T3 - Métodos y composiciones para terapia farmacéutica oral - Google Patents
Métodos y composiciones para terapia farmacéutica oral Download PDFInfo
- Publication number
- ES2614878T3 ES2614878T3 ES11758551.3T ES11758551T ES2614878T3 ES 2614878 T3 ES2614878 T3 ES 2614878T3 ES 11758551 T ES11758551 T ES 11758551T ES 2614878 T3 ES2614878 T3 ES 2614878T3
- Authority
- ES
- Spain
- Prior art keywords
- subject
- agent
- neoplastic disease
- transfer agent
- methylol transfer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title description 3
- 239000000203 mixture Substances 0.000 title description 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000002775 capsule Substances 0.000 abstract description 8
- 239000003795 chemical substances by application Substances 0.000 abstract description 8
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 abstract description 6
- 229960004267 taurolidine Drugs 0.000 abstract description 6
- 210000001198 duodenum Anatomy 0.000 abstract description 3
- 239000007903 gelatin capsule Substances 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 230000001613 neoplastic effect Effects 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- 210000001630 jejunum Anatomy 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- RJGYJMFQWGPBGM-UHFFFAOYSA-N 1,2,4-thiadiazinane 1,1-dioxide Chemical compound O=S1(=O)CCNCN1 RJGYJMFQWGPBGM-UHFFFAOYSA-N 0.000 abstract 1
- MVQXBXLDXSQURK-UHFFFAOYSA-N 2-aminoethanesulfonamide Chemical compound NCCS(N)(=O)=O MVQXBXLDXSQURK-UHFFFAOYSA-N 0.000 abstract 1
- 239000008203 oral pharmaceutical composition Substances 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 229950007343 taurultam Drugs 0.000 abstract 1
- 230000032258 transport Effects 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 229920003134 Eudragit® polymer Polymers 0.000 description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000007654 immersion Methods 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229960000890 hydrocortisone Drugs 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229960005205 prednisolone Drugs 0.000 description 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35018310P | 2010-06-01 | 2010-06-01 | |
| US350183P | 2010-06-01 | ||
| US37031510P | 2010-08-03 | 2010-08-03 | |
| US370315P | 2010-08-03 | ||
| PCT/IB2011/001539 WO2011151722A2 (en) | 2010-06-01 | 2011-06-01 | Methods and compositions for oral pharmaceutical therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2614878T3 true ES2614878T3 (es) | 2017-06-02 |
Family
ID=45067142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11758551.3T Active ES2614878T3 (es) | 2010-06-01 | 2011-06-01 | Métodos y composiciones para terapia farmacéutica oral |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9028866B2 (enExample) |
| EP (1) | EP2575783B1 (enExample) |
| JP (2) | JP5926243B2 (enExample) |
| CN (1) | CN103118669B (enExample) |
| AU (1) | AU2011262308B2 (enExample) |
| BR (1) | BR112012030641B8 (enExample) |
| CA (1) | CA2801309C (enExample) |
| ES (1) | ES2614878T3 (enExample) |
| WO (1) | WO2011151722A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9301374B2 (en) * | 2012-05-15 | 2016-03-29 | Koninklijke Philips N.V. | Control of lighting devices |
| US20190381060A1 (en) | 2016-01-11 | 2019-12-19 | Cormedix Inc. | Taurolidine treatment for myc-expressing tumors in mammalian bodies |
| CA3010981C (en) * | 2016-01-11 | 2024-09-17 | Cormedix Inc. | Therapeutic nanoparticles for the treatment of neuroblastoma and other cancers |
| US20190381058A1 (en) * | 2016-01-11 | 2019-12-19 | Cormedix Inc. | Methods and compositions for treating neuroblastoma in a juvenile mammalian body |
| US11541061B2 (en) | 2016-01-11 | 2023-01-03 | Cormedix Inc. | Neuroblastoma treatment with taurolidine hydrolysis products |
| PL3709979T3 (pl) | 2017-11-17 | 2025-03-24 | Evonik Operations Gmbh | Sposób wytwarzania powlekanej kapsułki twardej |
| CN113347976A (zh) * | 2018-08-28 | 2021-09-03 | 科医公司 | 用牛磺罗定水解产物进行的神经母细胞瘤治疗 |
| WO2020047530A1 (en) * | 2018-08-31 | 2020-03-05 | Cormedix Inc. | Taurolidine treatment for myc-expressing tumors in mammalian bodies |
| WO2020234833A1 (en) | 2019-05-22 | 2020-11-26 | Geistlich Pharma Ag | Method for treating, preventing, inhibiting or reducing cytokine release |
| US20220323452A1 (en) * | 2019-05-22 | 2022-10-13 | Geistlich Pharma Ag | Methods and compositions for inhibiting gapdh |
| CN111671758A (zh) * | 2020-07-06 | 2020-09-18 | 长春迈灵生物工程有限公司 | 牛磺罗定在制备抗hiv病毒药物中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5210083A (en) | 1986-07-17 | 1993-05-11 | Ed. Geistlich Sohne A.G. Fur Chemische Industrie | Pharmaceutical compositions |
| IE66933B1 (en) * | 1990-01-15 | 1996-02-07 | Elan Corp Plc | Controlled absorption naproxen formulation for once-daily administration |
| US20030027818A1 (en) * | 2001-04-03 | 2003-02-06 | Redmond H. Paul | Treatment of cancers |
| US5972933A (en) * | 1998-01-08 | 1999-10-26 | Ed. Geistlich Sohne Ag Fur Chemische Industrie | Method of treating microbial infections |
| US6555534B1 (en) * | 1998-09-11 | 2003-04-29 | Medpointe Healthcare Inc. | Method and compositions for the control or eradication of Helicobacter pylori |
| US6251896B1 (en) * | 1999-03-24 | 2001-06-26 | Carter-Wallace, Inc. | Compositions and methods for the management of Crohn's disease |
| WO2001013957A2 (en) * | 1999-08-24 | 2001-03-01 | Cellgate, Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
| EP1246617B1 (en) * | 1999-12-06 | 2006-09-13 | Rhode Island Hospital | Use of taurolidine or taurultam for the manufacture of a medicament for the treatment of ovarian cancer |
| US20020004502A1 (en) * | 2000-01-05 | 2002-01-10 | Redmond H. Paul | Treatment of inflammatory bowel disease |
| US20040170617A1 (en) * | 2000-06-05 | 2004-09-02 | Finegold Sydney M. | Method of treating diseases associated with abnormal gastrointestinal flora |
| AU779362B2 (en) * | 2000-10-27 | 2005-01-20 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of tumor metastases and cancer |
| JP5502254B2 (ja) * | 2001-01-31 | 2014-05-28 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | 少なくとも２種類の異なる被覆ペレット形から成る多粒子剤形 |
| US20030092707A1 (en) * | 2001-10-19 | 2003-05-15 | Redmond H. Paul | Treatment of breast cancer |
| EP2260845A3 (fr) | 2002-06-21 | 2012-08-22 | L'Oréal | Utilisation de polyphénol pour le traitement de l'alopécie |
| US20060198886A1 (en) * | 2005-03-01 | 2006-09-07 | Jenkins Richard B | Medicament having coated methenamine combined with acidifier |
| EA015781B1 (ru) * | 2005-10-21 | 2011-12-30 | Панацея Биотек Лимитед | Композиции для лечения рака |
| ATE414518T1 (de) * | 2006-07-25 | 2008-12-15 | Claus Herdeis | Herstellung von antimikrobiellen formulierungen unter verwendung von 7-oxa-2-thia 1,5- diazabicycloä3.3.1ünonan-2,2-dion |
-
2011
- 2011-06-01 ES ES11758551.3T patent/ES2614878T3/es active Active
- 2011-06-01 EP EP11758551.3A patent/EP2575783B1/en active Active
- 2011-06-01 JP JP2013513002A patent/JP5926243B2/ja active Active
- 2011-06-01 AU AU2011262308A patent/AU2011262308B2/en active Active
- 2011-06-01 WO PCT/IB2011/001539 patent/WO2011151722A2/en not_active Ceased
- 2011-06-01 US US13/701,372 patent/US9028866B2/en active Active
- 2011-06-01 CN CN201180036488.8A patent/CN103118669B/zh active Active
- 2011-06-01 BR BR112012030641A patent/BR112012030641B8/pt not_active IP Right Cessation
- 2011-06-01 CA CA2801309A patent/CA2801309C/en active Active
-
2016
- 2016-02-29 JP JP2016037487A patent/JP2016155826A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2801309C (en) | 2018-07-17 |
| US20130089606A1 (en) | 2013-04-11 |
| BR112012030641B8 (pt) | 2022-06-14 |
| CA2801309A1 (en) | 2011-12-08 |
| AU2011262308A1 (en) | 2013-01-10 |
| JP2013527224A (ja) | 2013-06-27 |
| HK1183228A1 (zh) | 2013-12-20 |
| AU2011262308B2 (en) | 2014-07-31 |
| WO2011151722A2 (en) | 2011-12-08 |
| US9028866B2 (en) | 2015-05-12 |
| CN103118669B (zh) | 2016-01-13 |
| JP2016155826A (ja) | 2016-09-01 |
| JP5926243B2 (ja) | 2016-05-25 |
| BR112012030641B1 (pt) | 2022-05-24 |
| BR112012030641A2 (pt) | 2016-08-16 |
| WO2011151722A3 (en) | 2012-05-24 |
| EP2575783B1 (en) | 2017-01-11 |
| EP2575783A2 (en) | 2013-04-10 |
| CN103118669A (zh) | 2013-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2606593C1 (ru) | Покрытая кишечнорастворимой оболочкой композиция масла мяты перечной с контролируемым высвобождением, состоящая из множества частиц, и связанные с ней способы | |
| ES2189232T5 (es) | Microgránulos de omeprazol protegidos gástricamente, procedimiento de obtención y preparaciones farmacéuticas | |
| RU2428176C2 (ru) | Системы доставки лекарственного средства, содержащие слабоосновные лекарственные средства и органические кислоты | |
| KR20210134313A (ko) | 심리적, 인지적, 행동적 및/또는 기분 장애의 치료를 위한 5ht 수용체 아고니스트를 포함하는 조성물 및 방법 | |
| ES2241603T3 (es) | Formulacion oral para la administracion al ileon que comprende un compuesto inhibidor del transporte de acidos biliares presentes en el ileon. | |
| ES2568746T3 (es) | Sistemas de liberación pulsátil controlada | |
| CL2022000033A1 (es) | Composición farmacéutica para suministro nasal | |
| BRPI0711606A2 (pt) | formulações de hidrocloreto de duloxetina de liberação retardada | |
| KR20100014629A (ko) | 타크로리무스의 변형제형 | |
| ME02946B (me) | Dimer buprenorfina i njegova upotreba u lecenju gastrointestinalnih poremecaja | |
| JP2008280351A5 (enExample) | ||
| RU2621128C2 (ru) | Фармацевтическая композиция для пролонгированного высвобождения триметазидина | |
| KR102023559B1 (ko) | 제어형 하이드로코티손 방출 제형 | |
| JP2016155826A (ja) | 経口薬物療法のための方法および組成物 | |
| JP2019509345A5 (enExample) | ||
| US20140356440A1 (en) | Enteric Coated Multiparticulate Controlled Release Peppermint Oil Composition and Related Methods | |
| CN104940169A (zh) | 一种右兰索拉唑缓释胶囊及其制备方法 | |
| JP6114612B2 (ja) | 薬剤コート層の水不溶性薬剤の形態型を制御する方法 | |
| ES2261006B1 (es) | Pellet multicapa de liberacion controlada de metilfenidato. | |
| ES2373164T3 (es) | Composición farmacéutica de liberación controlada de clorhidrato de venlafaxina, y procedimiento para la preparación de la misma. | |
| Lee et al. | Modulating drug release from gastric-floating microcapsules through spray-coating layers | |
| WO2014163092A1 (ja) | 薬剤コート層、薬剤コート層の形態型を制御する方法および医療機器 | |
| KR20090016612A (ko) | 피페리디노알칸올 및 충혈완화제의 복합제를 포함하는 약학조성물 | |
| JP2016504390A5 (enExample) | ||
| ES2774473T3 (es) | Forma de dosificación combinada de un antagonista del receptor opioide mu y un agente opioide |