ES2613630T3 - Métodos y composiciones que utilizan Listeria para un tratamiento auxiliar del cáncer - Google Patents
Métodos y composiciones que utilizan Listeria para un tratamiento auxiliar del cáncer Download PDFInfo
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- ES2613630T3 ES2613630T3 ES11787200.2T ES11787200T ES2613630T3 ES 2613630 T3 ES2613630 T3 ES 2613630T3 ES 11787200 T ES11787200 T ES 11787200T ES 2613630 T3 ES2613630 T3 ES 2613630T3
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| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| US9737592B1 (en) | 2014-02-14 | 2017-08-22 | David Gordon Bermudes | Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment |
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| WO2016073866A1 (en) * | 2014-11-07 | 2016-05-12 | The Johns Hopkins University | Polyfunctional lymphocytes as a biomarker of antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN108601731A (zh) | 2015-12-16 | 2018-09-28 | 磨石肿瘤生物技术公司 | 新抗原的鉴别、制造及使用 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| CN107213458A (zh) * | 2017-03-14 | 2017-09-29 | 中国人民解放军第三军医大学 | 一种使用载体组合的新型治疗性疫苗及使用方法 |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| EP3714275A4 (en) | 2017-11-22 | 2021-10-27 | Gritstone bio, Inc. | REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS |
| BR112020010499A2 (pt) | 2017-12-13 | 2020-11-24 | Inovio Pharmaceuticals, Inc. | vacinas de câncer de alvo de mesotelina e usos das mesmas |
| CN108714210B (zh) * | 2018-08-06 | 2022-09-30 | 苏州圣苏新药开发有限公司 | 重组减毒李斯特菌在制备间皮素高表达癌症治疗性疫苗中的应用 |
| US12285437B2 (en) | 2019-10-30 | 2025-04-29 | The Research Foundation For The State University Of New York | Reversing the undesirable pH-profile of doxorubicin via activation of a disubstituted maleamic acid prodrug at tumor acidity |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
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| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
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| IT1253009B (it) | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| US20020150588A1 (en) | 2000-09-21 | 2002-10-17 | Allison James P. | SPAS-1 cancer antigen |
| US20050175625A1 (en) * | 2002-07-12 | 2005-08-11 | The Johns Hopkins University | Mesothelin vaccines and model systems |
| PT1592441E (pt) | 2003-02-06 | 2012-05-21 | Aduro Biotech | Listeria atenuada relativamente à entrada em células não patogénicas, vacinas compreendendo a listeria e métodos para sua utilização |
| WO2004084936A2 (en) | 2003-02-06 | 2004-10-07 | Cerus Corporation | Modified free-living microbes, vaccine compositions and methods of use thereof |
| JP2007509067A (ja) | 2003-10-15 | 2007-04-12 | メディミューン，インコーポレーテッド | リステリアに基づくＥｐｈＡ２ワクチン |
| US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| WO2007002395A1 (en) * | 2005-06-23 | 2007-01-04 | Arbor Vita Corporation | Methods and compositions for modulating cox |
| TW200811289A (en) * | 2005-08-19 | 2008-03-01 | Cerus Corp | Listeria-mediated immunorecruitment and activation, and methods of use thereof |
| US20070207171A1 (en) | 2006-03-01 | 2007-09-06 | Cerus Corporation | Engineered listeria and methods of use thereof |
| EP1991263B8 (en) * | 2006-03-01 | 2015-02-25 | Aduro Biotech | Engineered listeria and methods of use thereof |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| US8926993B2 (en) | 2006-07-17 | 2015-01-06 | Aduro Biotech | Methods and compositions using Listeria for enhancing immunogenicity by prime boost |
| US8268326B2 (en) | 2006-08-15 | 2012-09-18 | The Trustees Of The University Of Pennsylvania | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof |
| CN102076843A (zh) * | 2008-05-19 | 2011-05-25 | 艾杜罗生物科技公司 | 包含prfa*突变体李斯特菌的组合物及其使用方法 |
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