ES2610908T3 - Cepas de bifidobacterium bifidum para su aplicación en enfermedades gastrointestinales - Google Patents
Cepas de bifidobacterium bifidum para su aplicación en enfermedades gastrointestinales Download PDFInfo
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- ES2610908T3 ES2610908T3 ES11000744.0T ES11000744T ES2610908T3 ES 2610908 T3 ES2610908 T3 ES 2610908T3 ES 11000744 T ES11000744 T ES 11000744T ES 2610908 T3 ES2610908 T3 ES 2610908T3
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Landscapes
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| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| CN103266076B (zh) * | 2013-06-04 | 2014-10-29 | 神舟太空产品高科技成果推广中心集团有限公司 | 太空诱变高效两歧双歧杆菌、其应用及其胶囊制剂的制备方法 |
| CN104546945A (zh) * | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 两歧双歧杆菌在治疗或预防类风湿性关节炎或其相关疾病中的用途 |
| PT3065748T (pt) | 2014-12-23 | 2018-02-28 | 4D Pharma Res Ltd | Uma estirpe de bacteroides thetaiotaomicron e o seu uso na redução da inflamação |
| BR112017013274A2 (pt) | 2014-12-23 | 2018-02-06 | 4D Pharma Research Limited | polipeptídeo e imunomodulação |
| JP2018507872A (ja) * | 2015-03-09 | 2018-03-22 | バイオイミュナイザー・ソチエタ・ア・ガランツィア・リミタータＢｉｏｉｍｍｕｎｉｚｅｒ ＳＡＧＬ | ビフィズス菌およびプロバイオティクスから単離された細胞壁をともなう抗酸化剤の組み合わせを含むアンチエイジング組成物 |
| SMT201900588T1 (it) | 2015-06-15 | 2019-11-13 | 4D Pharma Res Limited | Blautia stercoris e wexlerae per uso nel trattamento di malattie infiammatorie ed autoimmuni |
| PL3307288T3 (pl) | 2015-06-15 | 2019-12-31 | 4D Pharma Research Limited | Kompozycje zawierające szczepy bakteryjne |
| PT3360559T (pt) | 2015-06-15 | 2020-01-06 | 4D Pharma Res Ltd | Composições compreendendo estirpes bacterianas |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| JP6637725B2 (ja) * | 2015-10-28 | 2020-01-29 | ビオフェルミン製薬株式会社 | ウイルス感染症の予防及び／又は治療剤 |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| HUE036362T2 (hu) | 2015-11-20 | 2018-07-30 | 4D Pharma Res Ltd | Baktériumtörzseket tartalmazó készítmények |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| PL3313423T3 (pl) | 2016-03-04 | 2019-09-30 | 4D Pharma Plc | Kompozycje zawierające szczepy bakteryjne blautia do leczenia nadwrażliwości trzewnej |
| CA3020389A1 (en) * | 2016-04-14 | 2017-10-19 | Dupont Nutrition Biosciences Aps | Bifidobacteria for increasing lean body mass |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| CN106579414A (zh) * | 2016-12-26 | 2017-04-26 | 北京康比特体育科技股份有限公司 | 一种缓解运动性腹泻的组合物 |
| CN106834187B (zh) * | 2017-03-06 | 2020-08-25 | 江南大学 | 一种两歧双歧杆菌及其用途 |
| WO2018165563A1 (en) * | 2017-03-09 | 2018-09-13 | The Clorox Company | Probiotic capsule and methods of preparing the same |
| JP2018177703A (ja) * | 2017-04-14 | 2018-11-15 | 株式会社明治 | Ｔｏｌｌ様受容体２活性化用組成物 |
| JP7212945B2 (ja) | 2017-05-22 | 2023-01-26 | フォーディー ファーマ リサーチ リミテッド | 細菌株を含む組成物 |
| MA41708A (fr) | 2017-05-24 | 2020-04-08 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| HUE059249T2 (hu) | 2017-06-14 | 2022-11-28 | 4D Pharma Res Limited | Baktériumtörzseket tartalmazó készítmények |
| PT3638271T (pt) | 2017-06-14 | 2021-01-05 | 4D Pharma Res Ltd | Composições contendo estirpes bacterianas |
| AU2018285445B2 (en) | 2017-06-14 | 2020-03-26 | Cj Bioscience, Inc. | Compositions comprising bacterial strains |
| KR102760825B1 (ko) * | 2018-01-29 | 2025-02-03 | 프리시젼바이오틱스 그룹 리미티드 | 과민성 대장 증후군의 예방 및 치료를 위한 조합 생성물 |
| KR102023700B1 (ko) * | 2018-01-31 | 2019-09-20 | 주식회사 비피도 | 비피도박테리움을 함유한 류마티스관절염 개선용, 치료용 또는 예방용 조성물 |
| AU2019289987A1 (en) * | 2018-06-22 | 2020-12-24 | Synformulas Gmbh | Non-viable Bifidobacterium bifidum bacteria and uses thereof |
| BR112021007249A2 (pt) * | 2019-01-16 | 2021-08-10 | N.V. Nutricia | composições nutricionais |
| IT201900011193A1 (it) * | 2019-07-08 | 2021-01-08 | Sofar Spa | Ceppo di batteri Bifidobacterium bifidum, sue composizioni e relativi usi |
| WO2021044376A1 (en) * | 2019-09-05 | 2021-03-11 | White Dog Labs, Inc. | Mixotrophic probiotic compositions and uses thereof in the treatment of bloating |
| IT201900016811A1 (it) * | 2019-09-20 | 2021-03-20 | Sofar Spa | Ceppi batterici, loro composizioni e loro uso per il trattamento di disturbi gastrointestinali |
| CN118924795A (zh) * | 2019-11-29 | 2024-11-12 | 内蒙古伊利实业集团股份有限公司 | 乳双歧杆菌bl-99提升肠道细菌感染抗性和肠道免疫力的应用 |
| CN111110704B (zh) * | 2020-02-14 | 2023-03-28 | 上海城建职业学院 | 一种益生菌菌剂、滴剂及其制备方法和应用 |
| CN111743998A (zh) * | 2020-06-04 | 2020-10-09 | 中通美雅生命健康(深圳)有限公司 | 用于辅助治疗肠炎组合物及其制备方法 |
| RU2735717C1 (ru) * | 2020-06-15 | 2020-11-06 | Общество с ограниченной ответственностью "АВАН" | Штамм Bifidobacterium bifidum, используемый в качестве пробиотика |
| JP2023542547A (ja) * | 2020-09-23 | 2023-10-10 | ピービーエルバイオラブ | 新規乳酸菌およびその用途 |
| CN113943682B (zh) * | 2020-11-12 | 2023-07-04 | 江南大学 | 缓解便秘的长双歧杆菌长亚种及其制备的发酵食品与益生菌制剂 |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| US20240000808A1 (en) * | 2020-11-16 | 2024-01-04 | Orcosa Inc. | Improved use of cannabinoids in the treatment of alzheimer's disease |
| CN112980734B (zh) * | 2021-03-24 | 2022-07-22 | 江南大学 | 一株缓解便秘并调节肠道菌群紊乱的两歧双歧杆菌及其应用 |
| CN113025526B (zh) * | 2021-03-24 | 2022-09-27 | 江南大学 | 一株减少结肠病理损伤且具有缓解便秘作用的两歧双歧杆菌 |
| CN113234619B (zh) * | 2021-04-10 | 2022-07-05 | 江南大学 | 一株两歧双歧杆菌及其在缓解肠道损伤中的应用 |
| CN118291322A (zh) * | 2022-07-13 | 2024-07-05 | 四川大学 | 一株婴幼儿肠道来源的两歧双歧杆菌 |
| CN116286439A (zh) * | 2022-07-13 | 2023-06-23 | 四川大学 | 一株婴幼儿肠道来源的两歧双歧杆菌及应用 |
| CN115838662A (zh) * | 2022-11-02 | 2023-03-24 | 江南大学 | 一株具有缓解克罗恩病潜力的两歧双歧杆菌 |
| WO2024193633A1 (zh) * | 2023-03-21 | 2024-09-26 | 四川厌氧生物科技有限责任公司 | 一种益生菌及其应用 |
| CN118044616A (zh) * | 2023-09-05 | 2024-05-17 | 厦门大学 | 一种合生元及其用途 |
| WO2025059424A1 (en) * | 2023-09-15 | 2025-03-20 | Biohm Health Inc. | Pro-biotic compositions and methods for treatment of stress |
| CN118879582B (zh) * | 2024-09-19 | 2025-03-25 | 微康益生菌(苏州)股份有限公司 | 一种细胞完整、分散均匀、稳定性强的后生元制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID29150A (id) | 1999-01-15 | 2001-08-02 | Entpr Ireland Cs | Penggunaan lactobacillus salivarius |
| RU2152993C1 (ru) * | 1999-11-30 | 2000-07-20 | Государственный научный центр РФ Институт медико-биологических проблем | Штамм bifidobacterium bifidum вкпм ас-1578, используемый для приготовления бактериальных препаратов и продуктов питания |
| RU2184146C1 (ru) * | 2001-01-29 | 2002-06-27 | Закрытое акционерное общество "Партнер" | Штамм bifidobacterium bifidum 45 вкпм ас-1621, используемый для приготовления бактериальных препаратов и продуктов питания |
| DE602004006133T3 (de) * | 2003-06-30 | 2014-12-24 | Clasado Inc. | Neue galactooligosaccharidzusammensetzung und herstellung davon |
| PL1673100T3 (pl) * | 2004-08-05 | 2008-01-31 | Anidral Srl | Szczepy bakterii Bifidobacterium wytwarzające kwas foliowy, preparaty i ich zastosowanie |
| AR053805A1 (es) * | 2005-05-31 | 2007-05-23 | Iams Company | Bifidobacterias probioticas para felinos |
| CN100490826C (zh) * | 2005-07-05 | 2009-05-27 | 广州市微生物研究所 | 多联活性双歧杆菌产品的制备方法 |
| JP4881304B2 (ja) * | 2005-07-21 | 2012-02-22 | 株式会社ヤクルト本社 | 新規ビフィドバクテリウム属細菌及びその利用 |
| US9084434B2 (en) * | 2006-09-27 | 2015-07-21 | Little Calumet Holdings Llc | Probiotic oral dosage forms |
| CN101636173A (zh) * | 2007-03-27 | 2010-01-27 | 宝洁公司 | 施用益生菌剂的方法及试剂盒 |
| DK2270133T3 (en) * | 2008-04-22 | 2015-09-07 | Corporación Alimentaria Peñasanta Capsa | Method of obtaining a new strain of Bifidobacterium bidifum with effect against infection with Helicobacter pylori |
| RU2010143460A (ru) * | 2008-05-01 | 2012-06-10 | Дзе Проктер Энд Гэмбл Компани (US) | Способы и наборы для терапии восстановительных состояний кишечника |
| WO2009151329A1 (en) * | 2008-06-13 | 2009-12-17 | N.V. Nutricia | Nutrition for prevention of infections |
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| HRP20161792T1 (hr) | 2017-03-10 |
| CA2825980A1 (en) | 2012-08-09 |
| BR112013019258B1 (pt) | 2021-09-08 |
| AU2012213576B2 (en) | 2015-07-23 |
| DK2481299T3 (en) | 2017-02-06 |
| RU2013137404A (ru) | 2015-03-10 |
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