ES2608781T3 - Compuestos 3,4-bis(catecol)pirrol-N-sustituidos, su preparación y su utilización en el tratamiento del cáncer - Google Patents
Compuestos 3,4-bis(catecol)pirrol-N-sustituidos, su preparación y su utilización en el tratamiento del cáncer Download PDFInfo
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- ES2608781T3 ES2608781T3 ES13779187.7T ES13779187T ES2608781T3 ES 2608781 T3 ES2608781 T3 ES 2608781T3 ES 13779187 T ES13779187 T ES 13779187T ES 2608781 T3 ES2608781 T3 ES 2608781T3
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- 230000014399 negative regulation of angiogenesis Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229910052762 osmium Inorganic materials 0.000 description 1
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 description 1
- 229940127084 other anti-cancer agent Drugs 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 108030002458 peroxiredoxin Proteins 0.000 description 1
- 210000000680 phagosome Anatomy 0.000 description 1
- LIGACIXOYTUXAW-UHFFFAOYSA-N phenacyl bromide Chemical compound BrCC(=O)C1=CC=CC=C1 LIGACIXOYTUXAW-UHFFFAOYSA-N 0.000 description 1
- 229940100595 phenylacetaldehyde Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000003906 phosphoinositides Chemical class 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 230000000861 pro-apoptotic effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000005748 tumor development Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1259868 | 2012-10-16 | ||
| FR1259868A FR2996847B1 (fr) | 2012-10-16 | 2012-10-16 | Composes 3,4-bis(catechol)pyrrole-n-substitues, leur preparation et utilisation dans le traitement du cancer |
| PCT/EP2013/071445 WO2014060366A1 (fr) | 2012-10-16 | 2013-10-14 | Composes 3,4-bis(catechol)pyrrole-n-substitues, leur preparation et utilisation dans le traitement du cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2608781T3 true ES2608781T3 (es) | 2017-04-17 |
Family
ID=47425104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13779187.7T Active ES2608781T3 (es) | 2012-10-16 | 2013-10-14 | Compuestos 3,4-bis(catecol)pirrol-N-sustituidos, su preparación y su utilización en el tratamiento del cáncer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9546159B2 (https=) |
| EP (1) | EP2909171B1 (https=) |
| JP (1) | JP6423349B2 (https=) |
| AU (1) | AU2013331764B2 (https=) |
| CA (1) | CA2888379A1 (https=) |
| ES (1) | ES2608781T3 (https=) |
| FR (1) | FR2996847B1 (https=) |
| WO (1) | WO2014060366A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3022244B1 (fr) * | 2014-06-17 | 2016-07-01 | Centre Nat De La Rech Scient (Cnrs) | Utilisation d'un nouveau compose 3-aryl-4-catechol-pyrrole-n-propanol et ses derives pour le traitement du cancer et des pathologies associees a une angiogenese excessive |
| CN121154883A (zh) * | 2020-05-25 | 2025-12-19 | 医工瑞思(福建)工程研究中心有限公司 | 一种大面积创伤急救敷料套件及其使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993019045A1 (en) * | 1992-03-26 | 1993-09-30 | E.I. Du Pont De Nemours And Company | Arthropodicidal amides |
| DE19756261A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide |
| GB9821975D0 (en) * | 1998-10-08 | 1998-12-02 | Pharma Mar Sa | New cytotoxic alkaloids |
| WO2008064317A1 (en) * | 2006-11-22 | 2008-05-29 | University Of Medicine And Dentistry Of New Jersey | Lipophilic opioid receptor active compounds |
| WO2008064318A2 (en) * | 2006-11-22 | 2008-05-29 | University Of Medicine And Dentistry Of New Jersey | Peripheral opioid receptor active compounds |
-
2012
- 2012-10-16 FR FR1259868A patent/FR2996847B1/fr not_active Expired - Fee Related
-
2013
- 2013-10-14 EP EP13779187.7A patent/EP2909171B1/fr not_active Not-in-force
- 2013-10-14 ES ES13779187.7T patent/ES2608781T3/es active Active
- 2013-10-14 JP JP2015537212A patent/JP6423349B2/ja not_active Expired - Fee Related
- 2013-10-14 WO PCT/EP2013/071445 patent/WO2014060366A1/fr not_active Ceased
- 2013-10-14 US US14/435,768 patent/US9546159B2/en not_active Expired - Fee Related
- 2013-10-14 CA CA2888379A patent/CA2888379A1/fr not_active Abandoned
- 2013-10-14 AU AU2013331764A patent/AU2013331764B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2888379A1 (fr) | 2014-04-24 |
| JP2015534958A (ja) | 2015-12-07 |
| FR2996847B1 (fr) | 2014-12-05 |
| JP6423349B2 (ja) | 2018-11-14 |
| AU2013331764B2 (en) | 2017-11-16 |
| EP2909171A1 (fr) | 2015-08-26 |
| WO2014060366A1 (fr) | 2014-04-24 |
| FR2996847A1 (fr) | 2014-04-18 |
| AU2013331764A1 (en) | 2015-05-21 |
| US9546159B2 (en) | 2017-01-17 |
| EP2909171B1 (fr) | 2016-09-28 |
| US20150344460A1 (en) | 2015-12-03 |
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