ES2605471T3 - Variantes de CRIg de afinidad madurada - Google Patents
Variantes de CRIg de afinidad madurada Download PDFInfo
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- ES2605471T3 ES2605471T3 ES09743591.1T ES09743591T ES2605471T3 ES 2605471 T3 ES2605471 T3 ES 2605471T3 ES 09743591 T ES09743591 T ES 09743591T ES 2605471 T3 ES2605471 T3 ES 2605471T3
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| EP0824583A1 (en) | 1995-05-04 | 1998-02-25 | City Of Hope | Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states |
| SE9604470D0 (sv) | 1996-12-04 | 1996-12-04 | Tamas Bartfai Konsulting Ab | Transmembrane component of tight junction |
| JP2001524814A (ja) | 1997-03-14 | 2001-12-04 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | 28種類のヒト分泌タンパク質 |
| JP2002503955A (ja) | 1997-03-21 | 2002-02-05 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌蛋白およびそれらをコードするポリヌクレオチド |
| WO1999002561A1 (en) | 1997-07-10 | 1999-01-21 | Smithkline Beecham Corporation | Human f11 antigen: a cell surface receptor involved in platelet aggregation |
| US6410708B1 (en) | 1997-11-21 | 2002-06-25 | Genentech, Inc. | Nucleic acids encoding A-33 related antigen polypeptides |
| EP2014677A1 (en) | 1997-11-21 | 2009-01-14 | Genentech, Inc. | A-33 related antigens and their pharmacological uses |
| US7282565B2 (en) | 1998-03-20 | 2007-10-16 | Genentech, Inc. | PRO362 polypeptides |
| US7192589B2 (en) | 1998-09-16 | 2007-03-20 | Genentech, Inc. | Treatment of inflammatory disorders with STIgMA immunoadhesins |
| US7419663B2 (en) * | 1998-03-20 | 2008-09-02 | Genentech, Inc. | Treatment of complement-associated disorders |
| US8088386B2 (en) * | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
| AU2577799A (en) | 1998-02-09 | 1999-08-23 | Human Genome Sciences, Inc. | 45 human secreted proteins |
| US6022708A (en) | 1998-02-26 | 2000-02-08 | Genentech, Inc. | Fused |
| PT1490386E (pt) | 1998-03-10 | 2008-11-24 | Genentech Inc | Novos polipéptidos e ácidos nucleicos que os codificam |
| EP1108019A2 (en) | 1998-08-27 | 2001-06-20 | Incyte Pharmaceuticals, Inc. | Protein transport-associated molecules |
| WO2000029583A2 (en) | 1998-11-19 | 2000-05-25 | Incyte Pharmaceuticals, Inc. | Immunoglobulin superfamily proteins |
| MXPA01006057A (es) | 1998-12-16 | 2003-09-10 | Genentech Inc | Polipeptidos secretados y transmembranales y acidos nucleicos que los codifican. |
| AU768230B2 (en) | 1998-12-22 | 2003-12-04 | Genentech Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| JP2004516227A (ja) | 1999-03-08 | 2004-06-03 | ジェネンテック・インコーポレーテッド | 免疫関連疾患を治療するための組成物と方法 |
| CA2388777A1 (en) | 1999-11-19 | 2001-05-25 | Human Genome Sciences, Inc. | 18 human secreted proteins |
| EP1250426A2 (en) | 1999-12-01 | 2002-10-23 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding same |
| EP1309620A2 (en) | 2000-06-23 | 2003-05-14 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| JP2004516013A (ja) | 2000-07-20 | 2004-06-03 | ジェネンテック・インコーポレーテッド | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
| WO2004022594A2 (en) * | 2002-09-06 | 2004-03-18 | Cytos Biotechnology Ag | Immune modulatory compounds and methods |
| JP2010505743A (ja) * | 2006-06-01 | 2010-02-25 | ジェネンテック インコーポレイテッド | CRIg及びC3b:CRIg複合体の結晶構造 |
| US7776573B2 (en) | 2006-06-01 | 2010-08-17 | Genentech, Inc. | Crystal structure of CRIg and C3b:CRIg complex |
| AU2008247958A1 (en) | 2007-05-01 | 2008-11-13 | Genentech, Inc. | CRIg antagonists |
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