ES2601849T3 - Sintones de fosfonatos para la síntesis de derivados de fosfonatos que muestran mejor biodisponibilidad - Google Patents

Sintones de fosfonatos para la síntesis de derivados de fosfonatos que muestran mejor biodisponibilidad Download PDF

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Publication number
ES2601849T3
ES2601849T3 ES10725716.4T ES10725716T ES2601849T3 ES 2601849 T3 ES2601849 T3 ES 2601849T3 ES 10725716 T ES10725716 T ES 10725716T ES 2601849 T3 ES2601849 T3 ES 2601849T3
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group
formula
branched
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nmr
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ES10725716.4T
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English (en)
Spanish (es)
Inventor
Luigi A. Agrofoglio
Vincent Roy
Ugo Pradere
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Centre National de la Recherche Scientifique CNRS
Universite d Orleans UFR de Sciences
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Centre National de la Recherche Scientifique CNRS
Universite d Orleans UFR de Sciences
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES10725716.4T 2009-06-18 2010-06-17 Sintones de fosfonatos para la síntesis de derivados de fosfonatos que muestran mejor biodisponibilidad Active ES2601849T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09305562 2009-06-18
EP09305562A EP2270021A1 (en) 2009-06-18 2009-06-18 Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
PCT/EP2010/058567 WO2010146127A1 (en) 2009-06-18 2010-06-17 Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability

Publications (1)

Publication Number Publication Date
ES2601849T3 true ES2601849T3 (es) 2017-02-16

Family

ID=41171101

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10725716.4T Active ES2601849T3 (es) 2009-06-18 2010-06-17 Sintones de fosfonatos para la síntesis de derivados de fosfonatos que muestran mejor biodisponibilidad

Country Status (6)

Country Link
US (1) US8785629B2 (https=)
EP (2) EP2270021A1 (https=)
JP (1) JP2012530113A (https=)
CA (1) CA2764827C (https=)
ES (1) ES2601849T3 (https=)
WO (1) WO2010146127A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012034719A1 (en) * 2010-09-14 2012-03-22 Centre National De La Recherche Scientifique Novel antiviral acyclic nucleoside phosphonates
WO2021177339A1 (ja) * 2020-03-04 2021-09-10 富士フイルム和光純薬株式会社 ホスホン酸エステルの製造方法、リン酸エステルの製造方法
JP2024526730A (ja) * 2021-07-15 2024-07-19 アルナイラム ファーマシューティカルズ， インコーポレイテッド ２，６－ジアミノプリン及び２－アミノアデニンのコンジュゲートをオリゴヌクレオチドに導入するための簡便な化学的アプローチ

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6814978A (https=) 1967-10-30 1969-05-02
BR6914868D0 (pt) * 1969-01-23 1973-03-20 & Co Inc Merck Processos quimicos
JPS6069089A (ja) 1983-09-26 1985-04-19 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホネ−ト誘導体およびその製造法
ATE131825T1 (de) * 1990-06-13 1996-01-15 Arnold Glazier Phosphorylierte prodrugs
EP0521622B1 (en) 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
ZA941088B (en) * 1993-02-19 1995-09-27 Symphar Sa Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them
DE4343599A1 (de) 1993-12-21 1995-06-22 Bayer Ag Verwendung von Phosphonsäureestern zur Behandlung von Hirnleistungsstörungen und Depressionen
US5635449A (en) * 1995-04-07 1997-06-03 American Cyanamid Company Arylthioalkyl- and arylthioalkenylphosphonic acids and derivatives thereof useful as herbicidal agents
IT1281498B1 (it) * 1995-06-07 1998-02-18 Sardinian Antiviral Research C Pirazolo - derivati ad attivita' antitumorale, processo per la loro preparazione e composizioni farmaceutiche che li contengono , e
ES2218660T3 (es) * 1996-01-16 2004-11-16 Bristol-Myers Squibb Company Inhibidores aromaticos conformacionalmente restringidos de la proteina de transferencia de trigliceridos microsomales y procedimiento.
IT1290444B1 (it) 1997-03-27 1998-12-03 Boehringer Mannheim Italia Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
DE60038038T2 (de) * 1999-12-03 2009-02-12 The Regents of The University of California at San Diego, La Jolla Phosphonatverbindungen
AU2003231765B9 (en) 2002-04-26 2010-01-28 Gilead Sciences, Inc. Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
WO2004026315A1 (en) 2002-09-19 2004-04-01 Ilex Oncology Research, Sarl Substituted ketophosphonate compounds having bone anabolic activity
US20040157804A1 (en) * 2002-10-16 2004-08-12 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
JP2010535701A (ja) * 2003-04-25 2010-11-25 ギリアード サイエンシーズ， インコーポレイテッド 抗癌ホスホネートアナログ
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
US20080261923A1 (en) * 2004-08-04 2008-10-23 Etzkorn Felicia A Alkene Mimics
WO2008096002A1 (en) 2007-02-08 2008-08-14 Tibotec Pharmaceuticals Ltd. Hcv inhibiting macrocyclic phosphonates and amidophosphates

Also Published As

Publication number Publication date
EP2443130B1 (en) 2016-08-03
US8785629B2 (en) 2014-07-22
JP2012530113A (ja) 2012-11-29
EP2270021A1 (en) 2011-01-05
CA2764827A1 (en) 2010-12-23
EP2443130A1 (en) 2012-04-25
WO2010146127A1 (en) 2010-12-23
CA2764827C (en) 2018-08-21
US20120142897A1 (en) 2012-06-07

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