ES259580A1 - Procedimiento para la preparacion de nuevas indolietilaminas farmacologicamente activas - Google Patents

Procedimiento para la preparacion de nuevas indolietilaminas farmacologicamente activas

Info

Publication number
ES259580A1
ES259580A1 ES0259580A ES259580A ES259580A1 ES 259580 A1 ES259580 A1 ES 259580A1 ES 0259580 A ES0259580 A ES 0259580A ES 259580 A ES259580 A ES 259580A ES 259580 A1 ES259580 A1 ES 259580A1
Authority
ES
Spain
Prior art keywords
compound
formula
alkyl
reacting
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0259580A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Philips Gloeilampenfabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Gloeilampenfabrieken NV filed Critical Philips Gloeilampenfabrieken NV
Publication of ES259580A1 publication Critical patent/ES259580A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Procedimiento para la preparación de nuevas indolietilminas farmacológicamente activas o sales de adición de ácidos de las mismascaracterizado porque son preparados compuestos de acuerdo con la fórmula Io sales de adición de ácidos de los mismos**(Ver fórmula)** fórmula en que R1 representa un grupo hidroxi posiblemente eterificado substituído en el anillo bencénico del esqueleto indoly n es un número entero con el valor 012 ó 3R2 es un grupo hidrocarburo alifático con 3-8 átomos de carbonoen que por lo menos un átomo de hidrógeno está reemplazado por un grupo OHposiblemente eterificado o esterificadoy R3 es un átomo de hidrógeno o un grupo alquilo que tiene 1-8 átomos de carbonoen que uno o más atomos de H pueden estar reemplazados por grupos OHposiblemente eterificados o esterificadosde acuerdo con métodos ya conocidos para la preparación de este tipo de compuestos y métodos análogos a los mismos.
ES0259580A 1959-07-13 1960-07-11 Procedimiento para la preparacion de nuevas indolietilaminas farmacologicamente activas Expired ES259580A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL241228 1959-07-13

Publications (1)

Publication Number Publication Date
ES259580A1 true ES259580A1 (es) 1961-01-16

Family

ID=19751827

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0259580A Expired ES259580A1 (es) 1959-07-13 1960-07-11 Procedimiento para la preparacion de nuevas indolietilaminas farmacologicamente activas

Country Status (3)

Country Link
ES (1) ES259580A1 (es)
FR (1) FR705M (es)
GB (1) GB962793A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208337A (en) * 1983-06-10 1988-10-28 Bristol Myers Co 2-(2-hydroxy-3-((2-(ar-hydroxy-1h-aminopropoxy-yl)ethyl benzonitriles and pharmaceutical compositions

Also Published As

Publication number Publication date
FR705M (es) 1961-07-31
GB962793A (en) 1964-07-01

Similar Documents

Publication Publication Date Title
US2673205A (en) 3-disubstituted dioxopiperidines and the manufacture thereof
FR2672598A1 (fr) Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US3699123A (en) 4-(3-amino-2-hydroxy-propoxy) indole derivatives
ES259580A1 (es) Procedimiento para la preparacion de nuevas indolietilaminas farmacologicamente activas
PT99142B (pt) Processo para a preparacao de pro-medicamentos de sertindole e de composicoes farmaceuticas que os contem
US3043849A (en) 3-(3-substituted amino-1-propenyl) indoles
US4005206A (en) [9H]-Pyrido-[3,4-b]-indoles
GB886684A (en) Improvements in or relating to heterocyclic compounds and the manufacture thereof
ES8609195A1 (es) Un nuevo procedimiento para la preparacion de derivados del acido cicloalquilidenmetilfenilacetico.
ES487175A1 (es) Un procedimiento de preparacion de derivados de piperi- dil-indol
US3872130A (en) 1-hydroxyisoquinolones
GB981192A (en) Improvements in or relating to 4 hydroxytryptamine esters
DAHLBOM et al. Some 3-Dialkylaminomethylindoles and 3, 3’-Diindolylmethanes
GB961265A (en) 3,4-dihydroxyphenyl-acetic acid ester derivatives
US3641032A (en) N n-disubstituted 2-alkyl-3-hydroxy-1(2h)-isoquinolonecarbamates
US3882143A (en) 4-(2-hydroxy-3-aminopropoxy)oxindole derivatives
GB1109689A (en) Improvements in or relating to 3,4,5,6-tetrahydro-1h-azepino[4,3,2-cd]indoles and the manufacture thereof
GB1043675A (en) 17ª‡-halogenoethinyl-estranes
GB853295A (en) Benzoic acid amides and a process for their manufacture
GB813218A (en) Nor-tropines and nor-pseudo-tropines and process for their production
US4173635A (en) Hypotensive ajmalicine derivatives
GB873777A (en) 5-hydroxy-ª--alkyltryptophans
GB1503551A (en) 4-piperidylureas
GB933082A (en) Improvements in or relating to lysergic acid derivatives
SU527134A3 (ru) Способ получени производных бензиламина или их солей