ES2584606T3 - Microesferas que comprenden ONO-1301 - Google Patents
Microesferas que comprenden ONO-1301 Download PDFInfo
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- ES2584606T3 ES2584606T3 ES11010286.0T ES11010286T ES2584606T3 ES 2584606 T3 ES2584606 T3 ES 2584606T3 ES 11010286 T ES11010286 T ES 11010286T ES 2584606 T3 ES2584606 T3 ES 2584606T3
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002298079 | 2002-10-10 | ||
| JP2002298079 | 2002-10-10 | ||
| JP2002318830 | 2002-10-31 | ||
| JP2002318830 | 2002-10-31 | ||
| JP2003117604 | 2003-04-22 | ||
| JP2003117604 | 2003-04-22 |
Publications (1)
| Publication Number | Publication Date |
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| ES2584606T3 true ES2584606T3 (es) | 2016-09-28 |
Family
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| ES03754060T Expired - Lifetime ES2393321T3 (es) | 2002-10-10 | 2003-10-09 | Promotores de la producción de factores de reparación endógenos |
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| Application Number | Title | Priority Date | Filing Date |
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| ES03754060T Expired - Lifetime ES2393321T3 (es) | 2002-10-10 | 2003-10-09 | Promotores de la producción de factores de reparación endógenos |
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| US (3) | US7547715B2 (https=) |
| EP (2) | EP1563846B1 (https=) |
| JP (2) | JP4497320B2 (https=) |
| AU (1) | AU2003272963A1 (https=) |
| DK (2) | DK2465537T3 (https=) |
| ES (2) | ES2584606T3 (https=) |
| HU (1) | HUE029417T2 (https=) |
| PT (2) | PT1563846E (https=) |
| TW (1) | TW200413000A (https=) |
| WO (1) | WO2004032965A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2584606T3 (es) | 2002-10-10 | 2016-09-28 | Ono Pharmaceutical Co., Ltd. | Microesferas que comprenden ONO-1301 |
| WO2005072743A1 (ja) * | 2004-01-30 | 2005-08-11 | Ono Pharmaceutical Co., Ltd. | 気管支拡張剤 |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| WO2006103770A1 (ja) * | 2005-03-30 | 2006-10-05 | Osaka Prefectural Hospital Organization | 血管新生制御方法 |
| GB2444686B (en) * | 2005-09-12 | 2010-08-25 | Es Cell Int Pte Ltd | Differentiation of pluripotent stem cells using p38 MAPK inhibitors or prostaglandins |
| KR20080084808A (ko) | 2005-11-17 | 2008-09-19 | 바이오미메틱 세라퓨틱스, 인크. | ｒｈＰＤＧＦ-ＢＢ 및 생체적합성 매트릭스를 사용하는상악안면골 보강 |
| ES2443581T3 (es) | 2006-02-09 | 2014-02-19 | Biomimetic Therapeutics, Llc | Composiciones y métodos para el tratamiento de hueso |
| RU2425876C2 (ru) | 2006-03-24 | 2011-08-10 | Чилдрен'З Медикал Сентер Корпорейшн | Способ модулирования роста гематопоэтических стволовых клеток |
| AU2007269712B2 (en) | 2006-06-30 | 2013-02-07 | Biomimetic Therapeutics, Llc | PDGF-biomatrix compositions and methods for treating rotator cuff injuries |
| US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| US20080171972A1 (en) * | 2006-10-06 | 2008-07-17 | Stopek Joshua B | Medical device package |
| PL2087890T3 (pl) | 2006-10-19 | 2014-08-29 | Ono Pharmaceutical Co | Preparat o przedłużonym uwalnianiu do terapii regeneracyjnej tkanki |
| AU2013213727B2 (en) * | 2006-10-20 | 2016-03-17 | Children's Medical Center Corporation | Method to enhance tissue regeneration |
| EP3824885A1 (en) * | 2006-10-20 | 2021-05-26 | Children's Medical Center Corporation | Method to enhance tissue regeneration |
| US8410171B2 (en) * | 2006-10-26 | 2013-04-02 | Ono Pharmaceutical Co., Ltd. | Adhesive preparation |
| WO2008073628A2 (en) | 2006-11-03 | 2008-06-19 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| EP2269611B1 (en) | 2006-11-16 | 2016-03-23 | Gemmus Pharma Inc. | EP2 and EP4 agonists as agents for the treatment of influenza A viral infection |
| JP2008195660A (ja) * | 2007-02-14 | 2008-08-28 | Kitasato Institute | 中枢循環改善薬 |
| AU2009212151C1 (en) | 2008-02-07 | 2015-09-17 | Stryker Corporation | Compositions and methods for distraction osteogenesis |
| EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
| HRP20151443T1 (hr) * | 2008-06-23 | 2016-01-29 | Nippon Shinyaku Co., Ltd. | Terapijsko sredstvo protiv stenoze kralježniäśnog kanala |
| BR122020000059B8 (pt) | 2008-09-09 | 2021-06-22 | Biomimetic Therapeutics Inc | composição que compreende uma matriz biocompatível e um fator de crescimento derivado de plaqueta e kit |
| WO2010091052A2 (en) | 2009-02-03 | 2010-08-12 | Children's Medical Center Corporation | Methods for enhancing hematopoietic stem/progenitor cell engraftment |
| WO2010096264A2 (en) | 2009-02-03 | 2010-08-26 | Children's Medical Center Corporation | Methods for enhancing hematopoietic stem/progenitor cell engraftment |
| US20100267826A1 (en) * | 2009-04-20 | 2010-10-21 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of ischemic episodes and cerebroprotection through Prostaglandin E2 (PGE2) EP2 and/or EP4 receptor agonists |
| EP3167875A1 (en) * | 2009-05-27 | 2017-05-17 | Alkermes Pharma Ireland Limited | Reduction of flake-like aggregation in nanoparticulate meloxicam compositions |
| EP2435049A1 (en) * | 2009-05-27 | 2012-04-04 | Sucampo AG | Pharmaceutical composition comprising prostaglandin derivatives for use in modulating claudin mediated functions and in the treatment of dermatological disorders |
| US8569279B2 (en) | 2009-05-27 | 2013-10-29 | Sucampo Ag | Method for modulating claudin mediated functions |
| US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
| EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| BR112012020566B1 (pt) | 2010-02-22 | 2021-09-21 | Biomimetic Therapeutics, Llc | Composição de fator de crescimento derivado de plaqueta |
| US20120136011A1 (en) * | 2010-07-30 | 2012-05-31 | Allergan, Inc. | Compounds and methods for skin repair |
| US20120142684A1 (en) * | 2010-12-02 | 2012-06-07 | Allergan, Inc. | Compounds and methods for skin repair |
| AU2012217630A1 (en) * | 2011-02-17 | 2013-09-05 | Allergan, Inc. | Compositions and improved soft tissue replacement methods |
| EP2678022A2 (en) * | 2011-02-23 | 2014-01-01 | Allergan, Inc. | Compositions and improved soft tissue replacement methods |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| KR101937782B1 (ko) | 2011-03-01 | 2019-01-11 | 파넥스트 | 바클로펜 및 아캄프로세이트에 기초한 신경 장애의 치료 |
| US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
| US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| EP2785350B1 (en) | 2011-12-02 | 2018-05-02 | Fate Therapeutics, Inc. | Improved methods of treating ischemia |
| JP6220791B2 (ja) | 2011-12-02 | 2017-10-25 | フェイト セラピューティクス，インコーポレイテッド | 増強された幹細胞組成物 |
| ES2730410T3 (es) | 2012-09-21 | 2019-11-11 | Univ Osaka | Material para el tratamiento de insuficiencia cardíaca avanzada como dispositivo de regeneración miocárdica/cardiovascular |
| EP2913047B1 (en) * | 2012-10-29 | 2019-05-08 | Cardio Incorporated | Pulmonary disease-specific therapeutic agent |
| CA2890034A1 (en) * | 2012-11-16 | 2014-05-22 | Allergan, Inc. | Skin wound healing and scar reduction with prostaglandin ep4 agonist combinations |
| WO2014150602A1 (en) | 2013-03-15 | 2014-09-25 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US9968716B2 (en) | 2013-10-15 | 2018-05-15 | Ono Pharmaceutical Co., Ltd. | Drug-eluting stent graft |
| US9763911B2 (en) * | 2013-12-12 | 2017-09-19 | Mayo Foundation For Medical Education And Research | Prostacyclin compositions for regulation of fracture repair and bone formation |
| US9918994B2 (en) | 2016-03-04 | 2018-03-20 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for muscle regeneration using prostaglandin E2 |
| EP3569249A4 (en) | 2016-12-27 | 2020-11-11 | Osaka University | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF REFRACTORY HEART DISEASE |
| WO2018227138A1 (en) | 2017-06-09 | 2018-12-13 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for preventing or treating muscle conditions |
| US20200206309A1 (en) * | 2017-07-27 | 2020-07-02 | The Mclean Hospital Corporation | METHODS AND COMPOSITIONS RELATED TO THE TREATMENT OF NURR1- AND PPARy-MEDIATED CONDITIONS |
| EP3718537A4 (en) | 2017-11-27 | 2021-11-10 | Osaka University | DISEASE-SPECIFIC LIPOSOMAL FORMULATION |
| JP7233087B2 (ja) * | 2019-03-18 | 2023-03-06 | 公立大学法人横浜市立大学 | 抗動脈硬化剤 |
| EP4051276B1 (en) | 2019-10-28 | 2025-08-06 | Seyltx, Inc. | Use of glutamate 2b receptor antagonists and sigma receptor agonsists as antitussives |
| WO2021163400A1 (en) | 2020-02-12 | 2021-08-19 | Cytoagents, Inc. | Compositions and methods for treating coronavirus infections |
| WO2021202708A1 (en) * | 2020-03-31 | 2021-10-07 | Ensysce Biosciences, Inc. | Methods for treating viral infections with nafamostat |
| KR20220040169A (ko) * | 2020-09-23 | 2022-03-30 | (주)아이엠디팜 | 나파모스타트 또는 이의 약제학적으로 허용가능한 염을 포함하는 경구투여용 제제 |
| GB202211232D0 (en) | 2022-08-02 | 2022-09-14 | Heptares Therapeutics Ltd | Prostaglandin EP4 receptor agonist compounds |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE555319A (https=) | 1956-03-21 | 1900-01-01 | ||
| US3095355A (en) | 1961-10-12 | 1963-06-25 | Revlon | Aerosol composition |
| JPS503362B1 (https=) | 1970-06-10 | 1975-02-04 | ||
| JPS5231404B1 (https=) | 1971-04-28 | 1977-08-15 | ||
| US3965143A (en) | 1974-03-26 | 1976-06-22 | G. D. Searle & Co. | 16-Oxygenated prostanoic acid derivatives |
| US4132738A (en) | 1978-02-23 | 1979-01-02 | Miles Laboratories, Inc. | Preparation of 15-deoxy-16-hydroxyprostaglandins |
| GB2017699B (en) | 1978-03-31 | 1983-01-12 | Ono Pharmaceutical Co | 6,9-methano-pgi2 analogues |
| JPS54130543A (en) | 1978-03-31 | 1979-10-09 | Ono Pharmaceut Co Ltd | Prostagladin i2 analog, and its preparation |
| JPS57156460A (en) | 1981-03-20 | 1982-09-27 | Ono Pharmaceut Co Ltd | Stabilized composition of prostaglandin and prostaglandin mimic compound, and its preparation |
| US4650804A (en) | 1984-03-30 | 1987-03-17 | Fujisawa Pharmaceutical Co., Ltd. | Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents |
| JPS6130519A (ja) | 1984-07-23 | 1986-02-12 | Dainippon Pharmaceut Co Ltd | 脳神経細胞の酸素欠乏性疾患治療剤 |
| JPS62134787A (ja) | 1985-12-06 | 1987-06-17 | 株式会社クボタ | 自動販売機の商品払出し装置 |
| CA2100918C (en) * | 1992-07-21 | 1997-01-21 | Nobuyuki Hamanaka | Oxime derivative |
| US5462968A (en) | 1994-01-19 | 1995-10-31 | Allergan, Inc. | EP2 -receptor agonists as agents for lowering intraocular pressure |
| US5698598A (en) | 1995-08-04 | 1997-12-16 | Allergan | EP2 -receptor agonists as agents for lowering intraocular pressure |
| UA59384C2 (uk) | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
| JP3162668B2 (ja) | 1997-02-04 | 2001-05-08 | 小野薬品工業株式会社 | ω−シクロアルキル−プロスタグランジンＥ２誘導体 |
| NO317155B1 (no) | 1997-02-04 | 2004-08-30 | Ono Pharmaceutical Co | <omega>-cykloalkyl-prostagladin-E<N>2</N>-derivater |
| JP4044967B2 (ja) | 1997-02-10 | 2008-02-06 | 小野薬品工業株式会社 | １１，１５−ｏ−ジアルキルプロスタグランジンｅ誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 |
| AU7349298A (en) | 1997-06-23 | 1999-01-04 | Pfizer Inc. | Prostaglandin agonists |
| SE9702681D0 (sv) | 1997-07-10 | 1997-07-10 | Pharmacia & Upjohn Ab | Method and composition for treatment of impotence |
| WO1999009992A1 (en) | 1997-08-27 | 1999-03-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Neovascularization promoters |
| US6124314A (en) | 1997-10-10 | 2000-09-26 | Pfizer Inc. | Osteoporosis compounds |
| UA67754C2 (uk) | 1997-10-10 | 2004-07-15 | Пфайзер, Інк. | Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти) |
| US5877211A (en) * | 1997-11-21 | 1999-03-02 | Allergan | EP2 receptor agonists as neuroprotective agents for the eye |
| DE69821987T2 (de) | 1997-12-25 | 2004-12-16 | Ono Pharmaceutical Co. Ltd. | Omega-cycloalkyl-prostaglandin e2 derivate |
| EP1065233A1 (en) | 1998-02-27 | 2001-01-03 | Ono Pharmaceutical Co., Ltd. | Carrier polymers migrating into target organs and drug-containing polymers |
| JP4123568B2 (ja) | 1998-05-06 | 2008-07-23 | 小野薬品工業株式会社 | ６−オキソ−ｐｇｅ１化合物、それらの製造方法およびそれらを有効成分として含有するプロスタグランジンｅ２受容体作働薬 |
| TWI249520B (en) | 1998-07-15 | 2006-02-21 | Ono Pharmaceutical Co | 5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient |
| US6235780B1 (en) | 1998-07-21 | 2001-05-22 | Ono Pharmaceutical Co., Ltd. | ω-cycloalkyl-prostaglandin E1 derivatives |
| JP2000086517A (ja) * | 1998-09-16 | 2000-03-28 | Ono Pharmaceut Co Ltd | アロディニア治療剤 |
| AUPP608898A0 (en) | 1998-09-23 | 1998-10-15 | Fujisawa Pharmaceutical Co., Ltd. | New use of prostaglandin E2 antagonists |
| US6437146B1 (en) | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| WO2000021542A1 (en) | 1998-10-15 | 2000-04-20 | Merck & Co., Inc. | Methods for stimulating bone formation |
| JP2000239188A (ja) | 1998-12-22 | 2000-09-05 | Mitsubishi Chemicals Corp | 育毛剤 |
| WO2000038667A2 (en) | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Prostaglandin e agonists for treatment of glaucoma |
| AU2183900A (en) | 1998-12-24 | 2000-07-31 | Alcon Laboratories, Inc. | Ep4 receptor agonists for treatment of dry eye |
| US6462080B1 (en) | 1998-12-24 | 2002-10-08 | Alcon Manufacturing, Ltd. | Prostaglandin E receptor agonists for treatment of dry eye |
| SE9900025D0 (sv) | 1999-01-08 | 1999-01-08 | Synphora Ab | Method and composition for treatment of female sexual dysfunction |
| CN1304318A (zh) | 1999-03-16 | 2001-07-18 | 东丽株式会社 | 前列腺素ep4受体作用药和治疗方法 |
| CA2332375A1 (en) | 1999-03-16 | 2000-09-21 | Masafumi Isogaya | Cervical ripening agent and cervical ripening method |
| AU6836200A (en) | 1999-08-10 | 2001-03-05 | Glaxo Group Limited | Use of ep4 receptor ligands in the treatment of, inter alia, neuropathic pain and colon cancer |
| AUPQ253199A0 (en) | 1999-08-30 | 1999-09-23 | Fujisawa Pharmaceutical Co., Ltd. | Non-prostanoid prostaglandin I2-agonist |
| AP2001002357A0 (en) | 1999-12-22 | 2001-12-31 | Pfizer Prod Inc | EP4 receptor selective agonists in the treatment of osteoporosis. |
| DE60120007T2 (de) | 2000-01-31 | 2006-11-16 | Pfizer Products Inc., Groton | Verwendung von Aktivatoren des Prostaglandinrezeptores 4 zur Behandlung von akuter oder chronischer Niereninsuffizienz |
| US20010056060A1 (en) | 2000-02-07 | 2001-12-27 | Cameron Kimberly O. | Treatment of osteoporsis with EP2/EP4 receptor selective agonists |
| WO2001072268A1 (en) | 2000-03-31 | 2001-10-04 | Toray Industries, Inc. | Hair growth or hair formation controlling agents |
| FR2812190B1 (fr) | 2000-07-28 | 2003-01-31 | Oreal | Utilisation d'agonistes non prostanoiques des recepteurs des prostaglandines ep-2 et/ou ep-4 comme agent cosmetique permettant d'attenuer, de diminuer ou d'arreter la chute des cheveux et des poils |
| US6376533B1 (en) | 2000-10-20 | 2002-04-23 | Allergan Sales, Inc. | Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists |
| US20020161026A1 (en) | 2000-11-07 | 2002-10-31 | Paralkar Vishwas M. | Combination therapies for the stimulation of bone growth |
| PT1339678E (pt) | 2000-11-27 | 2007-11-30 | Pfizer Prod Inc | Agonistas selectivos do receptor ep4 no tratamento de osteoporose |
| GB0030541D0 (en) | 2000-12-14 | 2001-01-31 | Glaxo Group Ltd | Medical uses |
| GB0103269D0 (en) | 2001-02-09 | 2001-03-28 | Glaxo Group Ltd | Napthalene derivatives |
| JP4550417B2 (ja) | 2001-10-23 | 2010-09-22 | メルク セローノ ソシエテ アノニム | プロスタグランジンｅｐ２及び／又はｅｐ４受容体のリガンドとしてのポリアゾリジノン化合物 |
| DE60235198D1 (de) | 2001-12-20 | 2010-03-11 | Merck Serono Sa Coinsins | Pyrrolidin-derivatie als prostaglandin-modulatoren |
| ES2584606T3 (es) | 2002-10-10 | 2016-09-28 | Ono Pharmaceutical Co., Ltd. | Microesferas que comprenden ONO-1301 |
| PL2087890T3 (pl) | 2006-10-19 | 2014-08-29 | Ono Pharmaceutical Co | Preparat o przedłużonym uwalnianiu do terapii regeneracyjnej tkanki |
-
2003
- 2003-10-09 ES ES11010286.0T patent/ES2584606T3/es not_active Expired - Lifetime
- 2003-10-09 AU AU2003272963A patent/AU2003272963A1/en not_active Abandoned
- 2003-10-09 EP EP03754060A patent/EP1563846B1/en not_active Expired - Lifetime
- 2003-10-09 TW TW092128052A patent/TW200413000A/zh unknown
- 2003-10-09 DK DK11010286.0T patent/DK2465537T3/en active
- 2003-10-09 EP EP11010286.0A patent/EP2465537B1/en not_active Expired - Lifetime
- 2003-10-09 PT PT03754060T patent/PT1563846E/pt unknown
- 2003-10-09 WO PCT/JP2003/012981 patent/WO2004032965A1/ja not_active Ceased
- 2003-10-09 ES ES03754060T patent/ES2393321T3/es not_active Expired - Lifetime
- 2003-10-09 JP JP2005501023A patent/JP4497320B2/ja not_active Expired - Fee Related
- 2003-10-09 US US10/530,685 patent/US7547715B2/en not_active Expired - Lifetime
- 2003-10-09 DK DK03754060.6T patent/DK1563846T3/da active
- 2003-10-09 PT PT110102860T patent/PT2465537T/pt unknown
- 2003-10-09 HU HUE11010286A patent/HUE029417T2/en unknown
-
2008
- 2008-02-20 US US12/034,614 patent/US8436026B2/en active Active
-
2010
- 2010-02-22 JP JP2010036052A patent/JP5287761B2/ja not_active Expired - Fee Related
-
2013
- 2013-04-04 US US13/856,538 patent/US8642630B2/en not_active Expired - Fee Related
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| EP1563846A1 (en) | 2005-08-17 |
| AU2003272963A1 (en) | 2004-05-04 |
| HUE029417T2 (en) | 2017-02-28 |
| ES2393321T3 (es) | 2012-12-20 |
| US20080299089A1 (en) | 2008-12-04 |
| PT2465537T (pt) | 2016-08-03 |
| US8436026B2 (en) | 2013-05-07 |
| DK1563846T3 (da) | 2012-12-17 |
| TW200413000A (en) | 2004-08-01 |
| JP2010120964A (ja) | 2010-06-03 |
| EP2465537B1 (en) | 2016-06-29 |
| WO2004032965A1 (ja) | 2004-04-22 |
| US20060069018A1 (en) | 2006-03-30 |
| EP1563846B1 (en) | 2012-08-29 |
| DK2465537T3 (en) | 2016-09-19 |
| US8642630B2 (en) | 2014-02-04 |
| JP5287761B2 (ja) | 2013-09-11 |
| US20130225643A1 (en) | 2013-08-29 |
| JP4497320B2 (ja) | 2010-07-07 |
| PT1563846E (pt) | 2012-11-13 |
| EP2465537A1 (en) | 2012-06-20 |
| EP1563846A4 (en) | 2009-11-04 |
| JPWO2004032965A1 (ja) | 2006-02-09 |
| US7547715B2 (en) | 2009-06-16 |
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