ES2579964T3 - Granulado de carnitina y métodos para su producción - Google Patents
Granulado de carnitina y métodos para su producción Download PDFInfo
- Publication number
- ES2579964T3 ES2579964T3 ES10790620.8T ES10790620T ES2579964T3 ES 2579964 T3 ES2579964 T3 ES 2579964T3 ES 10790620 T ES10790620 T ES 10790620T ES 2579964 T3 ES2579964 T3 ES 2579964T3
- Authority
- ES
- Spain
- Prior art keywords
- carnitine
- production
- methods
- granulate
- vehicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 title abstract description 6
- 229960004203 carnitine Drugs 0.000 title abstract description 6
- 239000008187 granular material Substances 0.000 title abstract description 4
- 238000000034 method Methods 0.000 title abstract description 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract description 6
- 239000007864 aqueous solution Substances 0.000 abstract description 4
- 239000002245 particle Substances 0.000 abstract description 3
- 239000000377 silicon dioxide Substances 0.000 abstract description 3
- 238000001035 drying Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/10—Securing foodstuffs on a non-edible supporting member
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Husbandry (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fodder In General (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un método para la producción de un granulado de carnitina, que comprende las etapas de (a) proporcionar una disolución acuosa que comprende por lo menos 65% (peso/peso) de carnitina, (b) proporcionar un vehículo en partículas que comprende sílice, teniendo el vehículo un tamaño medio de partícula de más de 150 μm, y (c) mezclar la disolución acuosa y el vehículo. por lo que se excluye una etapa de secado.
Description
pulverización o tubo/tubería abierta. En la primera etapa de alimentación aprox. 2/3 de la disolución acuosa se alimentan al mezclador en 20 minutos o más. Después de la terminación de la primera etapa de alimentación la sílice/carnitina/agua se mezcla durante 15 min sin
5 la alimentación de la disolución de carnitina/agua. En la segunda etapa de alimentación el resto de la disolución acuosa se alimenta al mezclador en 10 minutos o más. 684 g de un agente antiaglomerante (sílice) se añaden de una vez. Después de otros 7 minutos de tiempo de mezcla se descarga el producto. 67 kg de carnitina granulada se obtienen.
10 Se obtuvo un granulado con buena fluidez y baja higroscopicidad. El diámetro de partícula medio d50 era de
alrededor de 262 µm. El diámetro medio de partícula (d50 µm) se determinó según la ISO 13320:2009. Se determinó que el ángulo de reposo del granulado era 34,5º, en comparación con 53,3º de una formulación de pienso disponible comercialmente. El ángulo de reposo se determinó por el método de la norma DIN ISO 4324.
Se determinó que el índice de Hausner era 1,18 (que indica flujo libre), en comparación con 1,41 (que indica no flujo) 15 de una formulación de pienso disponible comercialmente. El índice de Hausner se determinó según la norma DIN 53194
7
Claims (1)
-
imagen1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28580509P | 2009-12-11 | 2009-12-11 | |
EP09015339A EP2335495A1 (en) | 2009-12-11 | 2009-12-11 | Carnitine granulate and methods for its production |
EP09015339 | 2009-12-11 | ||
US285805P | 2009-12-11 | ||
PCT/EP2010/007479 WO2011069654A1 (en) | 2009-12-11 | 2010-12-09 | Carnitine granulate and methods for its production |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2579964T3 true ES2579964T3 (es) | 2016-08-17 |
Family
ID=41691995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10790620.8T Active ES2579964T3 (es) | 2009-12-11 | 2010-12-09 | Granulado de carnitina y métodos para su producción |
Country Status (11)
Country | Link |
---|---|
US (2) | US8470382B2 (es) |
EP (2) | EP2335495A1 (es) |
JP (2) | JP5911806B2 (es) |
KR (1) | KR101761958B1 (es) |
CN (1) | CN102651974B (es) |
AR (1) | AR079439A1 (es) |
ES (1) | ES2579964T3 (es) |
HK (1) | HK1169280A1 (es) |
IN (1) | IN2012DN04941A (es) |
TW (1) | TWI469797B (es) |
WO (1) | WO2011069654A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL169678A (en) | 2005-07-14 | 2010-11-30 | Innova Sa | Sweetener compositions |
EP2335495A1 (en) * | 2009-12-11 | 2011-06-22 | Lonza Ltd. | Carnitine granulate and methods for its production |
KR102196004B1 (ko) * | 2011-07-08 | 2020-12-31 | 푸락 바이오켐 비.브이. | 사료 산물에 사용하기 위한 활성 제형 |
JP5933383B2 (ja) * | 2012-07-26 | 2016-06-08 | ロート製薬株式会社 | 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法 |
US10231476B2 (en) | 2014-04-04 | 2019-03-19 | Douxmatok Ltd | Sweetener compositions and foods, beverages, and consumable products made thereof |
US10207004B2 (en) * | 2014-04-04 | 2019-02-19 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
US20160242439A1 (en) | 2014-04-04 | 2016-08-25 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
US20170223988A1 (en) * | 2014-07-31 | 2017-08-10 | Benemilk Oy | Coated feed compositions and methods of making and using thereof |
JP6100939B2 (ja) * | 2016-02-26 | 2017-03-22 | ロート製薬株式会社 | 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法 |
CN106901042A (zh) * | 2017-04-27 | 2017-06-30 | 上海美嘉饲料有限公司 | 一种提高种公猪精子活力的饲料添加剂 |
JP7235501B2 (ja) * | 2017-12-28 | 2023-03-08 | アリナミン製薬株式会社 | ビタミンb1類及びカルニチン類を含有する顆粒 |
WO2022258631A1 (en) * | 2021-06-07 | 2022-12-15 | Kaesler Nutrition Gmbh | Carnitine formulation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5073376A (en) | 1989-12-22 | 1991-12-17 | Lonza Ltd. | Preparations containing l-carnitine |
JPH0812569A (ja) | 1994-06-24 | 1996-01-16 | Takeda Chem Ind Ltd | 塩化カルニチン吸着固形物 |
IT1305308B1 (it) | 1999-03-26 | 2001-05-04 | Biosint S P A | Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione |
CN101120935A (zh) * | 1999-09-03 | 2008-02-13 | 希格马托健康科学股份公司 | 超细l-肉碱、其制备方法、含有它的组合物及其使用方法 |
AU2006265280B2 (en) | 2005-07-05 | 2011-07-14 | Lonza Ag | Spray-drying process for producing a dry carnitine powder or granulate |
JP5069416B2 (ja) * | 2006-03-15 | 2012-11-07 | サントリーホールディングス株式会社 | 吸湿性の改善された飲食品用組成物 |
EP2335495A1 (en) * | 2009-12-11 | 2011-06-22 | Lonza Ltd. | Carnitine granulate and methods for its production |
-
2009
- 2009-12-11 EP EP09015339A patent/EP2335495A1/en not_active Ceased
-
2010
- 2010-12-09 ES ES10790620.8T patent/ES2579964T3/es active Active
- 2010-12-09 WO PCT/EP2010/007479 patent/WO2011069654A1/en active Application Filing
- 2010-12-09 EP EP10790620.8A patent/EP2509436B1/en active Active
- 2010-12-09 US US12/964,187 patent/US8470382B2/en active Active
- 2010-12-09 KR KR1020127017960A patent/KR101761958B1/ko active IP Right Grant
- 2010-12-09 JP JP2012542397A patent/JP5911806B2/ja active Active
- 2010-12-09 CN CN201080056055.4A patent/CN102651974B/zh active Active
- 2010-12-10 AR ARP100104597A patent/AR079439A1/es unknown
- 2010-12-10 TW TW99143177A patent/TWI469797B/zh active
-
2012
- 2012-06-05 IN IN4941DEN2012 patent/IN2012DN04941A/en unknown
- 2012-10-12 HK HK12110094.0A patent/HK1169280A1/xx not_active IP Right Cessation
-
2013
- 2013-06-03 US US13/908,645 patent/US9066868B2/en active Active
-
2015
- 2015-12-25 JP JP2015254564A patent/JP6239579B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
KR20120104315A (ko) | 2012-09-20 |
US9066868B2 (en) | 2015-06-30 |
TW201127407A (en) | 2011-08-16 |
JP2013513557A (ja) | 2013-04-22 |
TWI469797B (zh) | 2015-01-21 |
EP2335495A1 (en) | 2011-06-22 |
EP2509436B1 (en) | 2016-04-06 |
JP2016117736A (ja) | 2016-06-30 |
CN102651974B (zh) | 2015-04-01 |
HK1169280A1 (en) | 2013-01-25 |
EP2509436A1 (en) | 2012-10-17 |
WO2011069654A1 (en) | 2011-06-16 |
US20130273165A1 (en) | 2013-10-17 |
AR079439A1 (es) | 2012-01-25 |
JP5911806B2 (ja) | 2016-04-27 |
CN102651974A (zh) | 2012-08-29 |
IN2012DN04941A (es) | 2015-09-25 |
US20110190394A1 (en) | 2011-08-04 |
JP6239579B2 (ja) | 2017-11-29 |
KR101761958B1 (ko) | 2017-07-26 |
US8470382B2 (en) | 2013-06-25 |
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