ES2575549T3 - Comprimido de melatonina y métodos de preparación y uso - Google Patents

Comprimido de melatonina y métodos de preparación y uso Download PDF

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Publication number
ES2575549T3
ES2575549T3 ES08742710.0T ES08742710T ES2575549T3 ES 2575549 T3 ES2575549 T3 ES 2575549T3 ES 08742710 T ES08742710 T ES 08742710T ES 2575549 T3 ES2575549 T3 ES 2575549T3
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Spain
Prior art keywords
melatonin
dissolved
dosage form
pharmaceutically acceptable
preparation
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ES08742710.0T
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English (en)
Spanish (es)
Inventor
John A. Mccarty
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Individual
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES08742710.0T 2007-04-11 2008-04-10 Comprimido de melatonina y métodos de preparación y uso Active ES2575549T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92292107P 2007-04-11 2007-04-11
US922921P 2007-04-11
PCT/US2008/004615 WO2008127609A1 (en) 2007-04-11 2008-04-10 Melatonin tablet and methods of preparation and use

Publications (1)

Publication Number Publication Date
ES2575549T3 true ES2575549T3 (es) 2016-06-29

Family

ID=39864239

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08742710.0T Active ES2575549T3 (es) 2007-04-11 2008-04-10 Comprimido de melatonina y métodos de preparación y uso

Country Status (11)

Country Link
US (3) US20100119601A1 (enExample)
EP (2) EP3056220A1 (enExample)
JP (2) JP5600058B2 (enExample)
CN (1) CN101677994B (enExample)
AU (1) AU2008239683B2 (enExample)
CA (1) CA2683436C (enExample)
ES (1) ES2575549T3 (enExample)
IL (2) IL201383A (enExample)
MX (1) MX2009010878A (enExample)
RU (1) RU2485949C2 (enExample)
WO (1) WO2008127609A1 (enExample)

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WO2008127609A1 (en) * 2007-04-11 2008-10-23 Mccarty John A Melatonin tablet and methods of preparation and use
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TR200907338A1 (tr) * 2009-09-28 2011-04-21 Yed�Tepe �N�Vers�Tes� Doğal bileşenler içeren bir film şeridi.
EA201391053A1 (ru) 2011-01-17 2013-12-30 Такеда Фармасьютикал Компани Лимитед Таблетка, диспергируемая в ротовой полости
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
WO2012103411A2 (en) 2011-01-28 2012-08-02 Zx Pharma, Llc Controlled-release melatonin composition and related methods
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EP2570126B1 (en) * 2011-09-16 2014-03-26 Darius Rassoulian Use of melatonin for treating acute alcohol intoxication
ITMI20112042A1 (it) * 2011-11-10 2013-05-11 Eratech S R L Polvere da ricostituire prima dell'uso comprendente melatonina e preparazione iniettabile ottenibile da tale polvere.
RU2488388C1 (ru) 2012-05-24 2013-07-27 Ооо "Валента Интеллект" Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
UA107653U (uk) 2012-10-01 2016-06-24 Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів
CN113842362A (zh) 2012-11-14 2021-12-28 格雷斯公司 含有生物活性材料与无序无机氧化物的组合物
US20140303128A1 (en) * 2013-03-14 2014-10-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
BR112015006499A2 (pt) 2013-04-23 2017-07-04 Zx Pharma Llc composição de óleo de horlelã-pimenta de liberação controlada microparticulada com revestimento entérico e métodos relacionados
EP3171871B1 (en) * 2014-07-21 2024-10-23 Pharmaceutical Productions, Inc. Solid dosage form composition for buccal or sublingual administration of cannabinoids
CN105663061A (zh) * 2014-11-16 2016-06-15 刘佳迪 褪黑素滴丸的制法和用法
NL2015272B1 (en) * 2015-08-05 2017-05-02 Versailles B V Melatonin formulations and methods for preparation and use.
US20200030450A1 (en) * 2017-03-16 2020-01-30 Repoceuticals Aps Compositions for retarding the decomposition of melatonin in solution
US10806789B2 (en) * 2017-05-12 2020-10-20 The LIV Group Inc. Composition for enhanced absorption of supplements
CN110913853A (zh) 2017-06-20 2020-03-24 医师印章有限责任公司 具有使褪黑激素可溶于唾液的酸化剂的口腔溶解褪黑激素制剂
WO2019038586A1 (en) 2017-08-19 2019-02-28 Ftf Pharma Private Limited PHARMACEUTICAL COMPOSITION OF MELATONIN
CN109953953B (zh) * 2017-12-22 2021-09-21 深圳大学 一种褪黑素纳米缓释给药系统的制备方法
JP2021517150A (ja) 2018-03-11 2021-07-15 ナノロジカ アーベー 圧縮医薬剤形にて使用するための多孔質シリカ粒子
WO2021205053A1 (es) * 2020-04-09 2021-10-14 Universidad De Granada Composición inyectable de melatonina para el tratamiento de enfermedades virales
KR102506059B1 (ko) * 2020-10-20 2023-03-07 코스맥스 주식회사 멜라토닌을 포함하는 항산화용 화장료 조성물
CN112426408B (zh) * 2020-12-08 2023-12-19 广州帝奇医药技术有限公司 一种褪黑素组合物及其制备工艺
CN112870193B (zh) * 2021-03-11 2022-07-08 大连医科大学附属第二医院 褪黑素在制备治疗对靶向药物耐药的her2阳性乳腺癌的药物中的应用
JP2025119064A (ja) * 2022-04-28 2025-08-14 日本たばこ産業株式会社 無機多孔質材料を含む口腔用組成物
JP2025119063A (ja) * 2022-04-28 2025-08-14 日本たばこ産業株式会社 無機多孔質材料を含む口腔用組成物
JP2025119061A (ja) * 2022-04-28 2025-08-14 日本たばこ産業株式会社 無機多孔質材料を含む口腔用組成物
JP2025119062A (ja) * 2022-04-28 2025-08-14 日本たばこ産業株式会社 無機多孔質材料を含む口腔用組成物

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Also Published As

Publication number Publication date
MX2009010878A (es) 2010-03-26
RU2485949C2 (ru) 2013-06-27
WO2008127609A1 (en) 2008-10-23
EP2144610A1 (en) 2010-01-20
RU2009137472A (ru) 2011-05-20
IL201383A0 (en) 2010-05-31
JP2010523673A (ja) 2010-07-15
CN101677994A (zh) 2010-03-24
IL201383A (en) 2017-01-31
JP5600058B2 (ja) 2014-10-01
US20100119601A1 (en) 2010-05-13
EP2144610A4 (en) 2013-08-07
AU2008239683A1 (en) 2008-10-23
JP2014237700A (ja) 2014-12-18
US20130028943A1 (en) 2013-01-31
CA2683436C (en) 2016-07-26
EP2144610B1 (en) 2016-04-06
CA2683436A1 (en) 2008-10-23
US8992948B2 (en) 2015-03-31
US20150174101A1 (en) 2015-06-25
US9381190B2 (en) 2016-07-05
AU2008239683B2 (en) 2014-03-27
CN101677994B (zh) 2015-07-22
IL249102A0 (en) 2017-01-31
EP3056220A1 (en) 2016-08-17

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