ES2571035T3 - Aspirina no cristalina estable a temperatura ambiente - Google Patents

Aspirina no cristalina estable a temperatura ambiente

Info

Publication number
ES2571035T3
ES2571035T3 ES08840270T ES08840270T ES2571035T3 ES 2571035 T3 ES2571035 T3 ES 2571035T3 ES 08840270 T ES08840270 T ES 08840270T ES 08840270 T ES08840270 T ES 08840270T ES 2571035 T3 ES2571035 T3 ES 2571035T3
Authority
ES
Spain
Prior art keywords
stable
aspirin
room temperature
crystalline aspirin
laser radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08840270T
Other languages
English (en)
Inventor
John Scott Strachan
Todd F Ovokaitys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2571035T3 publication Critical patent/ES2571035T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings

Abstract

Aspirina no cristalina, que puede obtenerse mediante un procedimiento que comprende aplicar radiación de láser procedente de al menos dos láseres diferentes a una disolución de aspirina en un disolvente, y evaporar el disolvente, en la que la radiación de láser es opcionalmente pulsada, que tiene impulsos con una longitud de impulso promedio eficaz de no más de 10-9 segundos, y la radiación de láser procedente de cada láser tiene una longitud de onda diferente, y en la que la aspirina no cristalina no se cristaliza durante el almacenamiento durante al menos 30 días a una temperatura de desde 20º hasta 30ºC.
ES08840270T 2007-10-17 2008-10-16 Aspirina no cristalina estable a temperatura ambiente Active ES2571035T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99946207P 2007-10-17 2007-10-17
US99948307P 2007-10-17 2007-10-17
US99944507P 2007-10-17 2007-10-17
PCT/US2008/080098 WO2009052248A1 (en) 2007-10-17 2008-10-16 Room temperature stable non-crystalline aspirin
US12/252,447 US8377989B2 (en) 2007-10-17 2008-10-16 Room temperature stable non-crystalline aspirin and method for the preparation thereof

Publications (1)

Publication Number Publication Date
ES2571035T3 true ES2571035T3 (es) 2016-05-23

Family

ID=40567778

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08840270T Active ES2571035T3 (es) 2007-10-17 2008-10-16 Aspirina no cristalina estable a temperatura ambiente

Country Status (13)

Country Link
US (1) US8377989B2 (es)
EP (1) EP2212274B1 (es)
JP (1) JP5524851B2 (es)
CN (1) CN101977888B (es)
AP (1) AP2010005266A0 (es)
BR (1) BRPI0818776A2 (es)
CA (1) CA2702909C (es)
EA (1) EA027333B1 (es)
ES (1) ES2571035T3 (es)
IL (1) IL205157A (es)
SG (1) SG185309A1 (es)
WO (1) WO2009052248A1 (es)
ZA (1) ZA201003354B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2757722C (en) 2009-04-01 2018-05-22 Matrix Laboratories Ltd. Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CA2953527A1 (en) * 2014-05-30 2015-12-03 Todd Frank OVOKAITYS Method and system for generation and use of activated stem cells
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
WO2015187974A1 (en) 2014-06-06 2015-12-10 Ovokaitys Todd Frank Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
US20200188298A1 (en) 2018-12-14 2020-06-18 NuVessl, Inc. Method For Using Composition With Enhanced Passenger Molecule Loading

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US644077A (en) 1898-08-01 1900-02-27 Farbenfabriken Of Elberfeld Company Acetyl salicylic acid.
US3703576A (en) * 1969-08-08 1972-11-21 Fuji Photo Film Co Ltd Method of producing micro-capsules enclosing acetylsalicylic acid therein
JP3159723B2 (ja) * 1991-03-22 2001-04-23 武田薬品工業株式会社 非晶質組成物およびその製造方法
RU2099059C1 (ru) 1994-03-15 1997-12-20 Петербургский научно-исследовательский институт травматологии и ортопедии им.Р.Р.Вредена Способ получения высокоактивного аспирина
GB9525103D0 (en) 1995-12-08 1996-02-07 Strachan John S Optical device and method of manufacture
IT1312115B1 (it) * 1999-06-24 2002-04-04 Nicox Sa Composti amorfi e relative composizioni farmaceutiche
GB9920351D0 (en) * 1999-08-28 1999-11-03 Strachen John S Sparse constructive node stimulation of cell surface molecular resonance in vivo
DE19949252B4 (de) * 1999-10-13 2004-02-12 Lts Lohmann Therapie-Systeme Ag Verwendung eines superfiziellen therapeutischen Systems zur topischen Applikation von Acetylsalicylsäure zur Behandlung von Akne-Erkrankungen und Verfahren zu seiner Herstellung
US20060083784A1 (en) * 2002-08-07 2006-04-20 Smithkline Beecham Corporation Amorphous pharmaceutical compositions
TW200410714A (en) 2002-08-07 2004-07-01 Smithkline Beecham Corp Electrospun amorphous pharmaceutical compositions
DE10254942B3 (de) * 2002-11-25 2004-08-12 Siemens Ag Verfahren zur automatischen Ermittlung der Koordinaten von Abbildern von Marken in einem Volumendatensatz und medizinische Vorrichtung
CA2523432C (en) * 2003-04-25 2014-10-28 Microchips, Inc. Solid drug formulation and device for storage and controlled delivery thereof
US20050188921A1 (en) 2004-02-27 2005-09-01 Anthony Malone Matrix assisted pulsed-laser evaporation technique for coating a medical device and associated system and medical device
CA2611741A1 (en) * 2005-06-13 2006-12-28 Elan Pharma International, Limited Nanoparticulate clopidogrel and aspirin combination formulations
CN101969766B (zh) * 2007-10-17 2015-05-06 托德·F·奥沃凯泰斯 固态化合物的改良方法及使用其制备的共-无定形组合物

Also Published As

Publication number Publication date
CN101977888B (zh) 2014-05-28
US8377989B2 (en) 2013-02-19
WO2009052248A1 (en) 2009-04-23
CA2702909A1 (en) 2009-04-23
IL205157A (en) 2015-03-31
JP5524851B2 (ja) 2014-06-18
EA027333B1 (ru) 2017-07-31
EP2212274A4 (en) 2011-08-31
AP2010005266A0 (en) 2010-06-30
EP2212274B1 (en) 2016-05-04
JP2011500710A (ja) 2011-01-06
BRPI0818776A2 (pt) 2015-04-14
SG185309A1 (en) 2012-11-29
US20090131710A1 (en) 2009-05-21
CA2702909C (en) 2016-05-10
CN101977888A (zh) 2011-02-16
IL205157A0 (en) 2010-11-30
EA201070468A1 (ru) 2011-06-30
EP2212274A1 (en) 2010-08-04
ZA201003354B (en) 2011-11-30

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