EA201070468A1 - Стабильный при комнатной температуре некристаллический аспирин - Google Patents

Стабильный при комнатной температуре некристаллический аспирин

Info

Publication number
EA201070468A1
EA201070468A1 EA201070468A EA201070468A EA201070468A1 EA 201070468 A1 EA201070468 A1 EA 201070468A1 EA 201070468 A EA201070468 A EA 201070468A EA 201070468 A EA201070468 A EA 201070468A EA 201070468 A1 EA201070468 A1 EA 201070468A1
Authority
EA
Eurasian Patent Office
Prior art keywords
room temperature
aspirin
crystal
stable
temperature non
Prior art date
Application number
EA201070468A
Other languages
English (en)
Other versions
EA027333B1 (ru
Inventor
Тодд Ф. Овокайтис
Джон Скотт Страчан
Original Assignee
Тодд Ф. Овокайтис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тодд Ф. Овокайтис filed Critical Тодд Ф. Овокайтис
Publication of EA201070468A1 publication Critical patent/EA201070468A1/ru
Publication of EA027333B1 publication Critical patent/EA027333B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение предлагает стабильный некристаллический аспирин, который не кристаллизуется при комнатной температуре во время хранения в течение продолжительных периодов времени, и способы получения стабильного некристаллического аспирина.
EA201070468A 2007-10-17 2008-10-16 Стабильный при комнатной температуре некристаллический аспирин EA027333B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99946207P 2007-10-17 2007-10-17
US99944507P 2007-10-17 2007-10-17
US99948307P 2007-10-17 2007-10-17
US12/252,447 US8377989B2 (en) 2007-10-17 2008-10-16 Room temperature stable non-crystalline aspirin and method for the preparation thereof
PCT/US2008/080098 WO2009052248A1 (en) 2007-10-17 2008-10-16 Room temperature stable non-crystalline aspirin

Publications (2)

Publication Number Publication Date
EA201070468A1 true EA201070468A1 (ru) 2011-06-30
EA027333B1 EA027333B1 (ru) 2017-07-31

Family

ID=40567778

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070468A EA027333B1 (ru) 2007-10-17 2008-10-16 Стабильный при комнатной температуре некристаллический аспирин

Country Status (13)

Country Link
US (1) US8377989B2 (ru)
EP (1) EP2212274B1 (ru)
JP (1) JP5524851B2 (ru)
CN (1) CN101977888B (ru)
AP (1) AP2010005266A0 (ru)
BR (1) BRPI0818776A2 (ru)
CA (1) CA2702909C (ru)
EA (1) EA027333B1 (ru)
ES (1) ES2571035T3 (ru)
IL (1) IL205157A (ru)
SG (1) SG185309A1 (ru)
WO (1) WO2009052248A1 (ru)
ZA (1) ZA201003354B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2414529A2 (en) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CA2953527A1 (en) * 2014-05-30 2015-12-03 Todd Frank OVOKAITYS Method and system for generation and use of activated stem cells
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
US10040728B2 (en) 2014-06-06 2018-08-07 Todd Frank Ovokaitys Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
US20200188301A1 (en) 2018-12-14 2020-06-18 NuVessl, Inc. Method for Enhancing Passenger Molecule Loading

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US644077A (en) 1898-08-01 1900-02-27 Farbenfabriken Of Elberfeld Company Acetyl salicylic acid.
US3703576A (en) * 1969-08-08 1972-11-21 Fuji Photo Film Co Ltd Method of producing micro-capsules enclosing acetylsalicylic acid therein
JP3159723B2 (ja) * 1991-03-22 2001-04-23 武田薬品工業株式会社 非晶質組成物およびその製造方法
RU2099059C1 (ru) 1994-03-15 1997-12-20 Петербургский научно-исследовательский институт травматологии и ортопедии им.Р.Р.Вредена Способ получения высокоактивного аспирина
GB9525103D0 (en) 1995-12-08 1996-02-07 Strachan John S Optical device and method of manufacture
IT1312115B1 (it) * 1999-06-24 2002-04-04 Nicox Sa Composti amorfi e relative composizioni farmaceutiche
GB9920351D0 (en) 1999-08-28 1999-11-03 Strachen John S Sparse constructive node stimulation of cell surface molecular resonance in vivo
DE19949252B4 (de) * 1999-10-13 2004-02-12 Lts Lohmann Therapie-Systeme Ag Verwendung eines superfiziellen therapeutischen Systems zur topischen Applikation von Acetylsalicylsäure zur Behandlung von Akne-Erkrankungen und Verfahren zu seiner Herstellung
TW200410714A (en) * 2002-08-07 2004-07-01 Smithkline Beecham Corp Electrospun amorphous pharmaceutical compositions
US20060083784A1 (en) * 2002-08-07 2006-04-20 Smithkline Beecham Corporation Amorphous pharmaceutical compositions
DE10254942B3 (de) * 2002-11-25 2004-08-12 Siemens Ag Verfahren zur automatischen Ermittlung der Koordinaten von Abbildern von Marken in einem Volumendatensatz und medizinische Vorrichtung
ES2359243T3 (es) * 2003-04-25 2011-05-19 Boston Scientific Scimed, Inc. Formulación de fármaco sólida y dispositivo para el almacenamiento y la administración controlada de la misma.
US20050188921A1 (en) * 2004-02-27 2005-09-01 Anthony Malone Matrix assisted pulsed-laser evaporation technique for coating a medical device and associated system and medical device
KR20080016952A (ko) * 2005-06-13 2008-02-22 엘란 파마 인터내셔널 리미티드 나노입자형 클로피도그렐과 아스피린의 배합 제제
US8173632B2 (en) * 2007-10-17 2012-05-08 Todd F. Ovokaitys Process for the modification of the solid state of a compound and co-amorphous compositions produced with same

Also Published As

Publication number Publication date
BRPI0818776A2 (pt) 2015-04-14
CA2702909C (en) 2016-05-10
ZA201003354B (en) 2011-11-30
ES2571035T3 (es) 2016-05-23
CA2702909A1 (en) 2009-04-23
WO2009052248A1 (en) 2009-04-23
EP2212274B1 (en) 2016-05-04
US8377989B2 (en) 2013-02-19
US20090131710A1 (en) 2009-05-21
CN101977888B (zh) 2014-05-28
SG185309A1 (en) 2012-11-29
CN101977888A (zh) 2011-02-16
EP2212274A1 (en) 2010-08-04
IL205157A (en) 2015-03-31
JP2011500710A (ja) 2011-01-06
JP5524851B2 (ja) 2014-06-18
EA027333B1 (ru) 2017-07-31
AP2010005266A0 (en) 2010-06-30
IL205157A0 (en) 2010-11-30
EP2212274A4 (en) 2011-08-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM RU