ES2570152T3 - Uso de derivados benzotropolona como absorbentes de UV y antioxidantes y su uso en filtros solares y/o composiciones cosméticas - Google Patents

Uso de derivados benzotropolona como absorbentes de UV y antioxidantes y su uso en filtros solares y/o composiciones cosméticas

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ES2570152T3
ES2570152T3 ES09769173T ES09769173T ES2570152T3 ES 2570152 T3 ES2570152 T3 ES 2570152T3 ES 09769173 T ES09769173 T ES 09769173T ES 09769173 T ES09769173 T ES 09769173T ES 2570152 T3 ES2570152 T3 ES 2570152T3
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alkyl
substituted
aryl
hydrogen
interrupted
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Barbara Wagner
Reinhold Öhrlein
Bernd Herzog
Kai Eichin
Gabriele Baisch
Stephanie Portmann
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BASF SE
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BASF SE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/16—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings
    • C07C305/18—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Derivados de benzotropolona representados por la fórmula**Fórmula** en donde R2, R3, R4, R5 y R6 independientemente uno de otro son hidrógeno; OH; alquilo C1-C30, alquenilo C2-C30, alcoxi C1-C30, cicloalquilo C3-C12 o hidroxialquilo C1-C30, que puede estar sustituido por una o más E y/o interrumpido por una o más D; arilo C6-C20, que puede estar sustituido por una o más G: heteroarilo C4-C20, que puede estar sustituido por una o más G, alquenilo C2-C18, alquinilo C2-C18, aralquilo C7-C25, CN, o -CO-R17; mono- o dialquilamino C1-C30; COR9; COOR9; CONR9R10; CN; SO2R9; OCOOR9; OCOR9; NHCOOR9; NR9COR10; NH2; *-(CO)-NH-(CH2)n1-(PO)-(OR11)2; -(CO)-O- (CH2)n1-(PO)-(OR11)2; sulfato; sulfonato: fosfato; fosfonato; -(CH2)n2-[O-(SO2)]n3-OR11; -O-(CH2)n4(CO)n5-R11; -(O)n6- (CH2)n7-(PO)-(OR9)2; -(O)n6-(CH2)n7-SO2-OR9; halógeno; organosilanilo; organosiloxanilo; o un residuo de azúcar unido directamente de un modo a- o b- a través del oxígeno anomérico al sistema benzotropolona o a través de un espaciador alquileno, alquenileno, alcadieno o alcatrieno lineal o ramificado (azúcar- (CH2)n-(X1)1 o 0 -sistema benzotropolona, en donde n >= 1-10 y X1 >= -O-; -(CO)-; -O-CO-; -COO-, -NH-; -S-; -SO2-); R1, R7 y R8 independientemente uno de otro son hidrógeno; alquilo C1-C12 o cicloalquilo C3-C12, que puede estar sustituido por una o más E y/o interrumpido por una o más D; arilo C6-C20, que puede estar sustituido por una o más G; heteroarilo C4-C20, que puede estar sustituido por una o más G, alquenilo C2-C18, alquinilo C2-C18, aralquilo C7-C25, o COOR9; COR9; CONR9R10; SO3R9; SO2R9; PO3(R9)2; PO2(R9)2; organosilanilo; organosiloxanilo; o un residuo de azúcar unido directamente de un modo a- o b- a través del oxígeno anomérico al sistema benzotropolona o a través de un espaciador alquileno, alquenileno, alcadieno o alcatrieno lineal o ramificado (azúcar-(CH2)n-(X2)1 o 0-*, en donde n >= 1 -10 y X2 >= -C(>=O)-; -O-CO-*): R9 y R10 independientemente de cada uno son hidrógeno; alquilo C1-C18 o cicloalquilo C3-C12 que puede estar sustituido por una o más E y/o interrumpido por una o más D; arilo C6-C20, que puede estar sustituido por una o más G; heteroarilo C4-C20, que puede estar sustituido por una o más G; organosilanilo; organosiloxanilo; o un residuo de azúcar unido directamente de un modo a- o b- a través del oxígeno anomérico o a través de un espaciador alquileno, alquenileno, alcadieno o alcatrieno lineal o ramificado (azúcar- (CH2)n-*, en donde n >= 1 -10); o R9 y R10 juntos forman un anillo de cinco o seis miembros, R11 es hidrógeno; o alquilo C1-C5; n1, n2, n4 y n7 independientemente de cada uno son un número desde 1 a 5; n3, n5 y n6 independientemente de cada uno son un 0; o 1; D es -CO-; -COO-; -S-; -SO-; -SO2-; -O-; -NR14-; -SiR19R20-; -POR11-; -GR12>=CR13-; o -C≡C-; y E es -OR18; -SR18; -NR14R15; -NR14COR15; -COR17; -COOR16; -CONR14R15; -CN; halógeno; o SO3R18; SO2R18; PO3(R18)2; PO2(R18)2; organosilanilo; organosiloxanilo; o un residuo de azúcar unido directamente de un modo a- o b- a través del oxígeno anomérico o a través de un espaciador alquileno, alquenileno, alcadieno o alcatrieno lineal o ramificado (azúcar-(CH2)n-(X1)1 o 0-*, en donde n >= 1 -10 y X1 >= -O-; -C(>=O)-; -O-CO-; -COO-; -NH-; -S-; -SO2-); G es E; alquilo C1-C18, que está opcionalmente interrumpido por D; perfluoroalquilo C1-C18; alcoxi C1-C18, que está opcionalmente sustituido por E y/o interrumpido por D; en donde R12, R13, R14 y R15 independientemente el uno del otro son hidrógeno; arilo C6-C18 que está opcionalmente sustituido por OH, alquilo C1-C18 o alcoxi C1-C18; alquilo C1-C18, que está opcionalmente interrumpido por -O-; o R14 y R15 juntos forman un anillo de cinco o seis miembros, R16 es hidrógeno; arilo C6-C18 que está opcionalmente sustituido por OH, alquilo C1-C18 o alcoxi C1-C18; alquilo C1-C18 que está opcionalmente interrumpido por -O-; R17 es H; arilo C6-C18 que está opcionalmente sustituido por OH, alquilo C1-C18 o alcoxi C1-C18; o alquilo C1-C18 que está opcionalmente interrumpido por -O-; R18 es hidrógeno; arilo C6-C18, que está opcionalmente sustituido por OH, alquilo C1-C18 o alcoxi C1-C18; alquilo C1-C18, que está opcionalmente interrumpido por -O-; R19 y R20 independientemente el uno del otro son hidrógeno; alquilo C1-C18; arilo C6-C18 que está opcionalmente sustituido por alquilo C1-C18; y * significa, que este radical se refiere a la unidad estructural benzotropolona; para el uso en un método para la protección de piel humana y de animal contra la radiación UV.
ES09769173T 2008-06-25 2009-06-18 Uso de derivados benzotropolona como absorbentes de UV y antioxidantes y su uso en filtros solares y/o composiciones cosméticas Active ES2570152T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP08158977 2008-06-25
EP08166349 2008-10-10
EP09155560 2009-03-19
PCT/EP2009/057587 WO2009156324A2 (en) 2008-06-25 2009-06-18 Use of benzotropolone derivatives as uv absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions

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US (1) US9707417B2 (es)
EP (1) EP2296760B1 (es)
JP (2) JP2012500186A (es)
KR (1) KR101346442B1 (es)
CN (1) CN102238983B (es)
BR (1) BRPI0914926B1 (es)
ES (1) ES2570152T3 (es)
WO (1) WO2009156324A2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG194410A1 (en) * 2008-10-06 2013-11-29 Elizabeth Arden International Sarl Skin treatments containing carboxylic acid-substituted idebenone derivatives and methods of preparation and use thereof
JP5788395B2 (ja) * 2009-10-06 2015-09-30 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ベンゾトロポロン含有植物エキス及び／又は関連ベンゾトロポロン誘導体を使用することによる家庭用品、ボディケア製品及び食品の安定化
US8940343B2 (en) * 2010-04-06 2015-01-27 Conopco Inc. Personal care composition
US20110293543A1 (en) * 2010-05-27 2011-12-01 Wei Yu Anhydrous composition comprising a dibenzoylmethane compound and a color pigment
US8846723B2 (en) 2010-07-29 2014-09-30 Eastman Chemical Company Esters of O-substituted hydroxy carboxylic acids and preparations thereof
US8613940B2 (en) 2010-09-03 2013-12-24 Eastman Chemical Company Carbonate derivatives as skin care
WO2012086811A1 (ja) 2010-12-22 2012-06-28 味の素株式会社 摂食抑制剤及び抗肥満剤
US8329938B2 (en) 2011-02-21 2012-12-11 Eastman Chemical Company Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol
CN102559797A (zh) * 2012-02-15 2012-07-11 安徽大学 一种白藜芦醇多聚体的制备方法
EP2879669A4 (en) * 2012-07-29 2016-04-13 Univ Colorado Regents ANTAGONISTS OF THE TOLL-TYPE 1/2 RECEIVER COMPLEX
KR101413232B1 (ko) 2012-08-31 2014-08-06 한국기계연구원 경조직 재생용 지지체 조성물 및 이를 포함하는 경조직 재생용 지지체 및 이들의 제조방법
CN103565852B (zh) * 2012-12-26 2015-10-28 中国辐射防护研究院 用于受照人体放射性核素促排的中药提取物及其提取方法
FR3004108B1 (fr) * 2013-04-09 2015-04-10 Jean-Noel Thorel Extrait d'arthrobacter agilis pour son utilisation en cosmetique
WO2016020541A1 (en) * 2014-08-08 2016-02-11 L'oreal Soap based sunscreen composition
KR101711603B1 (ko) * 2015-11-03 2017-03-03 윤철식 스티피탈리드를 유효성분으로 포함하는 조성물
US11001601B2 (en) * 2015-11-04 2021-05-11 The Penn State Research Foundation Compounds, compositions and methods for coloring edible materials
WO2018098156A1 (en) * 2016-11-23 2018-05-31 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
WO2018096088A1 (en) * 2016-11-24 2018-05-31 Universiteit Antwerpen Halogenated benzotropolones as atg4b inhibitors
KR102040230B1 (ko) * 2017-09-25 2019-11-04 제주대학교 산학협력단 푸르푸로갈린을 포함하는, 활성산소종, 자외선 또는 미세먼지에 대한 피부 보호용 화장료 조성물
CN108276935B (zh) * 2018-01-18 2020-06-02 中国科学院理化技术研究所 一种基于丙烯酸类树脂的负离子环保胶及其制备方法
WO2020001166A1 (zh) * 2018-06-27 2020-01-02 上海和黄药业有限公司 糖苷类化合物、其制备方法、组合物、应用及中间体
KR102311011B1 (ko) * 2018-09-12 2021-10-08 주식회사 엘지생활건강 인간지방줄기세포의 증식 촉진용 조성물
KR102010211B1 (ko) * 2019-01-22 2019-08-12 이재현 하르가이 추출물을 함유하는 샴푸 조성물 및 그 제조 방법
KR102614802B1 (ko) * 2021-02-02 2023-12-19 대구대학교 산학협력단 갈릭산 산화물로부터 분리된 화합물을 유효성분으로 함유하는 피부 주름 개선용 조성물
CN114163322B (zh) * 2021-11-23 2023-09-12 中国农业科学院农业环境与可持续发展研究所 紫外线吸收剂、制备方法和用途
CN114369340B (zh) * 2021-11-23 2023-09-08 中国农业科学院农业环境与可持续发展研究所 含有紫外线吸收剂的材料及制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2770545A (en) * 1953-10-02 1956-11-13 Universal Oil Prod Co Stabilization of organic compounds
DE1091114B (de) * 1959-02-07 1960-10-20 Hoechst Ag Verfahren zur Herstellung von Benzotropolonderivaten
JPS568309A (en) * 1979-06-29 1981-01-28 Yasuaki Fukuda White cosmetic
JP3019996B2 (ja) * 1990-03-01 2000-03-15 三井農林株式会社 白癬治療剤
WO1992020332A1 (en) * 1991-05-16 1992-11-26 Wu Tai Wing Pharmaceutical composition comprising purpurogallin useful as an antioxidant and cytoprotective agent
US20050058709A1 (en) * 1997-06-04 2005-03-17 Fisher Gary J. Methods for inhibiting photoaging of human skin using orally-administered agent
US6602527B1 (en) * 2000-11-22 2003-08-05 Thomas J. Slaga Processing method for manufacturing black tea and an improved black tea
US6831191B2 (en) * 2001-12-20 2004-12-14 Em Industries Photo stable organic sunscreen compounds with antioxidant properties and compositions obtained therefrom
US7087790B2 (en) * 2003-08-29 2006-08-08 Rutgers, The State University Of New Jersey Benzotropolone derivatives and modulation of inflammatory response
JP2005281247A (ja) * 2004-03-30 2005-10-13 Hirobumi Nakano 新規フェノール性化合物及びその製造方法
GB2412866A (en) * 2004-04-02 2005-10-12 Ciba Sc Holding Ag Amino-benzophenone UV filter formulations for the prevention of tanning

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BRPI0914926A2 (pt) 2015-10-20
EP2296760A2 (en) 2011-03-23
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US9707417B2 (en) 2017-07-18
JP5992010B2 (ja) 2016-09-14
KR20110023892A (ko) 2011-03-08
CN102238983A (zh) 2011-11-09
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