ECSP078009A - Derivados del 4,5-diarilpirrol, su preparación y su aplicación en terapéutica - Google Patents
Derivados del 4,5-diarilpirrol, su preparación y su aplicación en terapéuticaInfo
- Publication number
- ECSP078009A ECSP078009A EC2007008009A ECSP078009A ECSP078009A EC SP078009 A ECSP078009 A EC SP078009A EC 2007008009 A EC2007008009 A EC 2007008009A EC SP078009 A ECSP078009 A EC SP078009A EC SP078009 A ECSP078009 A EC SP078009A
- Authority
- EC
- Ecuador
- Prior art keywords
- substituted
- unsubstituted
- therapeutics
- preparation
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
Abstract
La presente invención tiene por objeto compuestos que responden a la fórmula (I) ; en la que : X representa un grupo (II) ; R1 representa un átomo de hidrógeno o un grupo alquilo(C1-C4) ; R2 representa : un alquilo(Cl-C12) ; un radical carbocíclico no aromático de (C3-C12) no sustituido o sustituido ; un metilo sustituido con un radical carbocíclico no aromático de (C3-C12) no sustituido o sustituido ; un radical fenilo, bencilo, bencidrilo no sustituidos o sustituidos ; un radical heterocíclico no sustituido o sustituido ; un metilo sustituido con un radical carbocíclico no aromático de C3-C12 no sustituido o sustituido ; R3 representa un alquilo(C1-C5) o un cicloalquilo(C3-C7) ; R4 representa un fenilo no sustituido o sustituido; R5 representa un fenilo no sustituido o sustituido. Procedimiento de preparación y aplicación en terapéutica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0506609A FR2887548B1 (fr) | 2005-06-27 | 2005-06-27 | Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique |
PCT/FR2006/001416 WO2007000505A2 (fr) | 2005-06-27 | 2006-06-22 | Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP078009A true ECSP078009A (es) | 2008-01-23 |
Family
ID=35884019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2007008009A ECSP078009A (es) | 2005-06-27 | 2007-12-13 | Derivados del 4,5-diarilpirrol, su preparación y su aplicación en terapéutica |
Country Status (28)
Country | Link |
---|---|
US (1) | US7618995B2 (es) |
EP (1) | EP1899298B1 (es) |
JP (1) | JP5142152B2 (es) |
KR (1) | KR20080019641A (es) |
CN (1) | CN101208300A (es) |
AR (1) | AR057401A1 (es) |
AT (1) | ATE478045T1 (es) |
AU (1) | AU2006263781A1 (es) |
BR (1) | BRPI0612497A2 (es) |
CA (1) | CA2610805A1 (es) |
CR (1) | CR9565A (es) |
DE (1) | DE602006016285D1 (es) |
DO (1) | DOP2006000133A (es) |
EA (1) | EA200800149A1 (es) |
EC (1) | ECSP078009A (es) |
FR (1) | FR2887548B1 (es) |
IL (1) | IL188032A0 (es) |
MA (1) | MA29559B1 (es) |
MX (1) | MX2007016383A (es) |
NO (1) | NO20080458L (es) |
NZ (1) | NZ564195A (es) |
PA (1) | PA8681701A1 (es) |
PE (1) | PE20070169A1 (es) |
SV (1) | SV2007002580A (es) |
TN (1) | TNSN07439A1 (es) |
TW (1) | TW200740753A (es) |
UY (1) | UY29631A1 (es) |
WO (1) | WO2007000505A2 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2874012B1 (fr) * | 2004-08-09 | 2008-08-22 | Sanofi Synthelabo | Derives de pyrrole, leur preparation et leur utlisation en therapeutique |
JP2011520809A (ja) * | 2008-05-05 | 2011-07-21 | アムジエン・インコーポレーテツド | γセクレターゼモジュレーターとしての尿素化合物 |
FR2930939B1 (fr) * | 2008-05-09 | 2010-07-30 | Sanofi Aventis | Derives de pyrrole, leur preparation et leur application en therapeutique |
GB201103419D0 (es) | 2011-02-28 | 2011-04-13 | Univ Aberdeen | |
AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
CH710832A1 (de) | 2015-03-09 | 2016-09-15 | Kaba Ag | Programmierbarer Schliesszylinder. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4335136A (en) * | 1980-04-18 | 1982-06-15 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines |
FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
AU5377698A (en) * | 1996-12-10 | 1998-07-03 | G.D. Searle & Co. | Substituted pyrrolyl compounds for the treatment of inflammation |
GB0230088D0 (en) * | 2002-12-24 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
FR2874012B1 (fr) * | 2004-08-09 | 2008-08-22 | Sanofi Synthelabo | Derives de pyrrole, leur preparation et leur utlisation en therapeutique |
-
2005
- 2005-06-27 FR FR0506609A patent/FR2887548B1/fr not_active Expired - Fee Related
-
2006
- 2006-06-12 DO DO2006000133A patent/DOP2006000133A/es unknown
- 2006-06-22 CN CNA2006800230670A patent/CN101208300A/zh active Pending
- 2006-06-22 BR BRPI0612497-6A patent/BRPI0612497A2/pt not_active Application Discontinuation
- 2006-06-22 KR KR1020077030262A patent/KR20080019641A/ko not_active Application Discontinuation
- 2006-06-22 PA PA20068681701A patent/PA8681701A1/es unknown
- 2006-06-22 NZ NZ564195A patent/NZ564195A/en unknown
- 2006-06-22 CA CA002610805A patent/CA2610805A1/fr not_active Abandoned
- 2006-06-22 MX MX2007016383A patent/MX2007016383A/es not_active Application Discontinuation
- 2006-06-22 AT AT06764809T patent/ATE478045T1/de not_active IP Right Cessation
- 2006-06-22 AU AU2006263781A patent/AU2006263781A1/en not_active Abandoned
- 2006-06-22 JP JP2008518897A patent/JP5142152B2/ja not_active Expired - Fee Related
- 2006-06-22 EA EA200800149A patent/EA200800149A1/ru unknown
- 2006-06-22 WO PCT/FR2006/001416 patent/WO2007000505A2/fr active Application Filing
- 2006-06-22 DE DE602006016285T patent/DE602006016285D1/de active Active
- 2006-06-22 EP EP06764809A patent/EP1899298B1/fr active Active
- 2006-06-23 AR ARP060102708A patent/AR057401A1/es unknown
- 2006-06-23 SV SV2006002580A patent/SV2007002580A/es not_active Application Discontinuation
- 2006-06-23 PE PE2006000721A patent/PE20070169A1/es not_active Application Discontinuation
- 2006-06-26 TW TW095122990A patent/TW200740753A/zh unknown
- 2006-06-27 UY UY29631A patent/UY29631A1/es unknown
-
2007
- 2007-11-26 TN TNP2007000439A patent/TNSN07439A1/en unknown
- 2007-12-06 CR CR9565A patent/CR9565A/es not_active Application Discontinuation
- 2007-12-07 US US11/952,224 patent/US7618995B2/en not_active Expired - Fee Related
- 2007-12-10 IL IL188032A patent/IL188032A0/en unknown
- 2007-12-13 EC EC2007008009A patent/ECSP078009A/es unknown
- 2007-12-24 MA MA30500A patent/MA29559B1/fr unknown
-
2008
- 2008-01-24 NO NO20080458A patent/NO20080458L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20080019641A (ko) | 2008-03-04 |
MA29559B1 (fr) | 2008-06-02 |
ATE478045T1 (de) | 2010-09-15 |
SV2007002580A (es) | 2007-02-19 |
CA2610805A1 (fr) | 2007-01-04 |
BRPI0612497A2 (pt) | 2010-11-23 |
EP1899298B1 (fr) | 2010-08-18 |
WO2007000505A2 (fr) | 2007-01-04 |
MX2007016383A (es) | 2008-03-07 |
AU2006263781A1 (en) | 2007-01-04 |
US20080176924A1 (en) | 2008-07-24 |
EA200800149A1 (ru) | 2008-04-28 |
PE20070169A1 (es) | 2007-03-07 |
FR2887548B1 (fr) | 2007-09-21 |
FR2887548A1 (fr) | 2006-12-29 |
DE602006016285D1 (de) | 2010-09-30 |
AR057401A1 (es) | 2007-12-05 |
NZ564195A (en) | 2010-01-29 |
IL188032A0 (en) | 2008-03-20 |
CR9565A (es) | 2008-04-10 |
US7618995B2 (en) | 2009-11-17 |
EP1899298A2 (fr) | 2008-03-19 |
WO2007000505A3 (fr) | 2007-11-15 |
PA8681701A1 (es) | 2007-01-17 |
TNSN07439A1 (en) | 2009-03-17 |
JP2008546829A (ja) | 2008-12-25 |
NO20080458L (no) | 2008-01-24 |
UY29631A1 (es) | 2007-01-31 |
DOP2006000133A (es) | 2007-02-28 |
JP5142152B2 (ja) | 2013-02-13 |
TW200740753A (en) | 2007-11-01 |
CN101208300A (zh) | 2008-06-25 |
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