DOP2007000067A - Derivados de aminometilpiridina, su preparación y su aplicación en terapéutica - Google Patents

Derivados de aminometilpiridina, su preparación y su aplicación en terapéutica

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Publication number
DOP2007000067A
DOP2007000067A DO2007000067A DO2007000067A DOP2007000067A DO P2007000067 A DOP2007000067 A DO P2007000067A DO 2007000067 A DO2007000067 A DO 2007000067A DO 2007000067 A DO2007000067 A DO 2007000067A DO P2007000067 A DOP2007000067 A DO P2007000067A
Authority
DO
Dominican Republic
Prior art keywords
alkyl group
group
phenyl
aminometilipiridine
therapeutics
Prior art date
Application number
DO2007000067A
Other languages
English (en)
Inventor
Philippe Pointeau
Christian Congy
Murielle Rinaldi-Carmona
Lionel Barre
Francis Barth
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of DOP2007000067A publication Critical patent/DOP2007000067A/es

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

La presente invención tiene como objetivo compuestos que responden a la fórmula: en la que: - Z representa un grupo N(R3)XR4, N(R3)COOR5 o OCON(R3)R5; - X representa un grupo -CO-, -SO2-, -CON(R6)- o -CSN(R6)-; - R1 y R2 representan cada uno independientemente del otro un átomo de hidrógeno o un alquilo (C1-C7) o junto con el átomo de nitrógeno al que están unidos constituyen un radical heterocíclico saturado o insaturado; - R3 y R6 representa un átomo de hidrógeno o un grupo alquilo (C1-C4); - R4 representa: . un grupo alquilo (C3-C10); un radical carbocíclico; un radical heterocíclico; un indolilo; un tetrahidronaftalenilo, un naftalenilo; un benzotiofenilo o un benzofurilo; un fenilo; un benzodioxilo; un fenoximetileno, un 1-fenoxietileno; un fenilciclopropilo; - R5 representa un fenilo; - Ar1 y Ar2 representan cada uno independientemente del otro un fenilo sin sustituir o sustituido; - n representa 0, 1 o 2; - Alk representa un grupo alquilo(C1-C7); en forma de base o de sal de adición, así como en forma de hidrato o de solvato.
DO2007000067A 2006-04-14 2007-04-10 Derivados de aminometilpiridina, su preparación y su aplicación en terapéutica DOP2007000067A (es)

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FR0603382A FR2899899A1 (fr) 2006-04-14 2006-04-14 Derives d'aminomethyl pyridine, leur preparation et leur application en therapeutique

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DOP2007000067A true DOP2007000067A (es) 2007-10-31

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US (1) US20090203699A1 (es)
EP (1) EP2010492A2 (es)
JP (1) JP2009533400A (es)
KR (1) KR20080108540A (es)
CN (1) CN101421240A (es)
AR (1) AR060800A1 (es)
AU (1) AU2007239344A1 (es)
BR (1) BRPI0710741A2 (es)
CA (1) CA2645961A1 (es)
DO (1) DOP2007000067A (es)
FR (1) FR2899899A1 (es)
IL (1) IL194573A0 (es)
MX (1) MX2008013208A (es)
PE (1) PE20071224A1 (es)
RU (1) RU2008144952A (es)
TW (1) TW200813037A (es)
UY (1) UY30285A1 (es)
WO (1) WO2007119001A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU2011281132B2 (en) * 2010-07-20 2014-01-30 Council Of Scientific & Industrial Research Pyridin- 2 - YL sulfanyl acid esters and process for the preparation thereof
GB201103419D0 (es) 2011-02-28 2011-04-13 Univ Aberdeen
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
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AR060800A1 (es) 2008-07-16
US20090203699A1 (en) 2009-08-13
RU2008144952A (ru) 2010-05-20
EP2010492A2 (fr) 2009-01-07
JP2009533400A (ja) 2009-09-17
TW200813037A (en) 2008-03-16
FR2899899A1 (fr) 2007-10-19
MX2008013208A (es) 2008-10-27
BRPI0710741A2 (pt) 2011-06-07
CN101421240A (zh) 2009-04-29
CA2645961A1 (fr) 2007-10-25
KR20080108540A (ko) 2008-12-15
AU2007239344A1 (en) 2007-10-25
PE20071224A1 (es) 2008-01-23

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