ES2558581T3 - Procesos de purificación de teicoplanina - Google Patents

Procesos de purificación de teicoplanina Download PDF

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Publication number
ES2558581T3
ES2558581T3 ES12784004.9T ES12784004T ES2558581T3 ES 2558581 T3 ES2558581 T3 ES 2558581T3 ES 12784004 T ES12784004 T ES 12784004T ES 2558581 T3 ES2558581 T3 ES 2558581T3
Authority
ES
Spain
Prior art keywords
teicoplanin
water
solution
ultrafiltration
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12784004.9T
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English (en)
Inventor
Samo Andrensek
David Senica
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals dd filed Critical Lek Pharmaceuticals dd
Application granted granted Critical
Publication of ES2558581T3 publication Critical patent/ES2558581T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

Un proceso para preparar teicoplanina purificada; el proceso comprende los pasos de a) adsorber teicoplanina en una resina hidrófoba de adsorción; b) desorber teicoplanina de dicha resina usando un medio que contiene agua y un solvente orgánico miscible con agua; c) tratar una solución que comprende teicoplanina con carbón vegetal, seguido de la remoción del carbón vegetal; d) someter una solución que comprende teicoplanina a un proceso de ultrafiltración sobre membranas con un corte de 3-100 kDa, en cuyo caso la solución contiene más de 20 % (v/v) de un solvente orgánico miscible con agua y no más de 90 % (v/v) de un solvente orgánico miscible con agua; e) opcionalmente concentrar y/o desalinizar una solución que contiene teicoplanina después de la ultrafiltración definida en el paso d) mediante ultrafiltración sobre membranas con un corte de 1000 Da; f) obtener teicoplanina purificada.
ES12784004.9T 2011-11-11 2012-11-09 Procesos de purificación de teicoplanina Active ES2558581T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11188759.2A EP2592089A1 (en) 2011-11-11 2011-11-11 Process of purification of teicoplanin
EP11188759 2011-11-11
PCT/EP2012/072279 WO2013068538A1 (en) 2011-11-11 2012-11-09 Process of purification of teicoplanin

Publications (1)

Publication Number Publication Date
ES2558581T3 true ES2558581T3 (es) 2016-02-05

Family

ID=47148819

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12784004.9T Active ES2558581T3 (es) 2011-11-11 2012-11-09 Procesos de purificación de teicoplanina

Country Status (10)

Country Link
EP (2) EP2592089A1 (es)
KR (1) KR20140091739A (es)
CN (1) CN104066747A (es)
DK (1) DK2776452T3 (es)
ES (1) ES2558581T3 (es)
HU (1) HUE026335T2 (es)
IN (1) IN2014KN01209A (es)
PL (1) PL2776452T3 (es)
SI (1) SI2776452T1 (es)
WO (1) WO2013068538A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104231044B (zh) * 2014-08-13 2017-03-22 甘肃汇能生物工程有限公司 那西肽过柱纯化工艺
CN104371011A (zh) * 2014-10-21 2015-02-25 福建省微生物研究所 高纯度替考拉宁精粉的纯化方法
CN104910259A (zh) * 2015-06-02 2015-09-16 苏州纳微科技有限公司 一种替考拉宁的层析纯化方法
CN106589075B (zh) * 2017-01-23 2020-05-05 福建省微生物研究所 一种替考拉宁的提纯方法
CN109608523B (zh) * 2018-11-23 2023-01-10 江苏九阳生物制药有限公司 一种高纯度替考拉宁的生产工艺
CN113637050B (zh) * 2021-09-15 2023-03-31 丽珠集团福州福兴医药有限公司 一种替考拉宁的脱色方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1496386A (en) 1975-03-05 1977-12-30 Lepetit Spa Antibiotics
GB8608798D0 (en) 1986-04-11 1986-05-14 Lepetit Spa Recovery of glycopeptide antibiotics from aqueous solutions
US4845194A (en) 1987-02-27 1989-07-04 Eli Lilly And Company Glycopeptide recovery process
DE69112750T2 (de) 1990-10-01 1996-09-19 Lepetit Spa Verfahren zur Gewinnung von Teicoplanin.
KR100321304B1 (ko) 1999-04-16 2002-03-18 박호군 테이코플라닌의 정제방법
KR100367890B1 (ko) 2000-03-02 2003-01-14 은언기 랩핑/폴리싱 휠 및 그 제조방법
KR20030017067A (ko) 2001-08-23 2003-03-03 정용진 변이주 액티노플라네스 테이코마이세티커스 지안네시스 및이로부터 테이코플라닌을 생산하는 방법
KR100459289B1 (ko) 2002-05-30 2004-12-03 이연제약주식회사 발효액으로부터 테이코플라닌ａ₂의 회수방법
KR100476818B1 (ko) 2002-07-19 2005-03-17 종근당바이오 주식회사 테이코플라닌 에이 투 정제 방법
KR100474653B1 (ko) 2004-04-16 2005-03-14 동국제약 주식회사 타이코플라닌의 고순도 생산방법
CN101423547B (zh) * 2007-10-31 2012-10-17 浙江医药股份有限公司新昌制药厂 替考拉宁的提纯方法

Also Published As

Publication number Publication date
EP2776452A1 (en) 2014-09-17
SI2776452T1 (sl) 2016-04-29
IN2014KN01209A (es) 2015-10-16
EP2776452B1 (en) 2015-10-07
DK2776452T3 (en) 2016-01-18
CN104066747A (zh) 2014-09-24
EP2592089A1 (en) 2013-05-15
PL2776452T3 (pl) 2016-03-31
KR20140091739A (ko) 2014-07-22
HUE026335T2 (en) 2016-05-30
WO2013068538A1 (en) 2013-05-16

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