IN2014KN01209A - - Google Patents
Info
- Publication number
- IN2014KN01209A IN2014KN01209A IN1209KON2014A IN2014KN01209A IN 2014KN01209 A IN2014KN01209 A IN 2014KN01209A IN 1209KON2014 A IN1209KON2014 A IN 1209KON2014A IN 2014KN01209 A IN2014KN01209 A IN 2014KN01209A
- Authority
- IN
- India
- Prior art keywords
- elution
- organic solvent
- teicoplanin
- purification
- ultrafiltration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
143424The invention relates to a process for purification of teicoplanin in particular to a process for an efficient removal of impurities by means of adsorption of particular dissolved components from the filtrate of fermentation broth of Actinoplanes teichomyceticus culture on commercial hydrophobic or slightly polar adsorbent resins with further selective elution of the product from the resin. According to the invention the process involves the use of a mixture of a watermiscible organic solvent in an aqueous solution at various steps of the purification process such as in the above mentioned elution step and/or in an ultrafiltration step on membranes with a cut off of 3 100kDa. The process further involves treating a teicoplanin solution with charcoal e.g. after elution and before ultrafiltration. Preferably the water miscible organic solvent is selected from the group consisting of C C alcohols C C ketones or C C nitrites.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11188759.2A EP2592089A1 (en) | 2011-11-11 | 2011-11-11 | Process of purification of teicoplanin |
| PCT/EP2012/072279 WO2013068538A1 (en) | 2011-11-11 | 2012-11-09 | Process of purification of teicoplanin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014KN01209A true IN2014KN01209A (en) | 2015-10-16 |
Family
ID=47148819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1209KON2014 IN2014KN01209A (en) | 2011-11-11 | 2012-11-09 |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP2592089A1 (en) |
| KR (1) | KR20140091739A (en) |
| CN (1) | CN104066747A (en) |
| DK (1) | DK2776452T3 (en) |
| ES (1) | ES2558581T3 (en) |
| HU (1) | HUE026335T2 (en) |
| IN (1) | IN2014KN01209A (en) |
| PL (1) | PL2776452T3 (en) |
| SI (1) | SI2776452T1 (en) |
| WO (1) | WO2013068538A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104231044B (en) * | 2014-08-13 | 2017-03-22 | 甘肃汇能生物工程有限公司 | Process for purifying nosiheptide by passing through column |
| CN104371011A (en) * | 2014-10-21 | 2015-02-25 | 福建省微生物研究所 | Purification method of high-purity teicoplanin refined powder |
| CN104910259A (en) * | 2015-06-02 | 2015-09-16 | 苏州纳微科技有限公司 | Chromatographic purification method for teicoplanin |
| CN106589075B (en) * | 2017-01-23 | 2020-05-05 | 福建省微生物研究所 | Purification method of teicoplanin |
| CN109608523B (en) * | 2018-11-23 | 2023-01-10 | 江苏九阳生物制药有限公司 | Production process of high-purity teicoplanin |
| CN113637050B (en) * | 2021-09-15 | 2023-03-31 | 丽珠集团福州福兴医药有限公司 | Decoloration method of teicoplanin |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1496386A (en) | 1975-03-05 | 1977-12-30 | Lepetit Spa | Antibiotics |
| GB8608798D0 (en) | 1986-04-11 | 1986-05-14 | Lepetit Spa | Recovery of glycopeptide antibiotics from aqueous solutions |
| US4845194A (en) | 1987-02-27 | 1989-07-04 | Eli Lilly And Company | Glycopeptide recovery process |
| ES2076436T3 (en) | 1990-10-01 | 1995-11-01 | Lepetit Spa | TEICOPLANIN RECOVERY PROCEDURE. |
| KR100321304B1 (en) | 1999-04-16 | 2002-03-18 | 박호군 | Process for Purifying Teicoplanin |
| KR100367890B1 (en) | 2000-03-02 | 2003-01-14 | 은언기 | Lappimg/Polishing Wheel and the manufacturing method thereof |
| KR20030017067A (en) | 2001-08-23 | 2003-03-03 | 정용진 | Mutation Strain Actinoplanes Teichomyceticus var jianesis And The Method For Producing Teicoplanin Therefrom |
| KR100459289B1 (en) | 2002-05-30 | 2004-12-03 | 이연제약주식회사 | Method for recovering teicoplanin a2 from fermentation broth |
| KR100476818B1 (en) | 2002-07-19 | 2005-03-17 | 종근당바이오 주식회사 | Purification method for teicoplanin A2 |
| KR100474653B1 (en) * | 2004-04-16 | 2005-03-14 | 동국제약 주식회사 | Preparation Method of Teicoplanin with High Productivity and Purity |
| CN101423547B (en) * | 2007-10-31 | 2012-10-17 | 浙江医药股份有限公司新昌制药厂 | Purification method of teicoplanin |
-
2011
- 2011-11-11 EP EP11188759.2A patent/EP2592089A1/en not_active Ceased
-
2012
- 2012-11-09 KR KR1020147015313A patent/KR20140091739A/en not_active Application Discontinuation
- 2012-11-09 WO PCT/EP2012/072279 patent/WO2013068538A1/en active Application Filing
- 2012-11-09 SI SI201230427T patent/SI2776452T1/en unknown
- 2012-11-09 PL PL12784004T patent/PL2776452T3/en unknown
- 2012-11-09 IN IN1209KON2014 patent/IN2014KN01209A/en unknown
- 2012-11-09 HU HUE12784004A patent/HUE026335T2/en unknown
- 2012-11-09 CN CN201280066349.4A patent/CN104066747A/en active Pending
- 2012-11-09 EP EP12784004.9A patent/EP2776452B1/en active Active
- 2012-11-09 ES ES12784004.9T patent/ES2558581T3/en active Active
- 2012-11-09 DK DK12784004.9T patent/DK2776452T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2592089A1 (en) | 2013-05-15 |
| DK2776452T3 (en) | 2016-01-18 |
| EP2776452A1 (en) | 2014-09-17 |
| EP2776452B1 (en) | 2015-10-07 |
| WO2013068538A1 (en) | 2013-05-16 |
| CN104066747A (en) | 2014-09-24 |
| SI2776452T1 (en) | 2016-04-29 |
| KR20140091739A (en) | 2014-07-22 |
| HUE026335T2 (en) | 2016-05-30 |
| ES2558581T3 (en) | 2016-02-05 |
| PL2776452T3 (en) | 2016-03-31 |
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