ES2558581T3 - Procesos de purificación de teicoplanina - Google Patents
Procesos de purificación de teicoplanina Download PDFInfo
- Publication number
- ES2558581T3 ES2558581T3 ES12784004.9T ES12784004T ES2558581T3 ES 2558581 T3 ES2558581 T3 ES 2558581T3 ES 12784004 T ES12784004 T ES 12784004T ES 2558581 T3 ES2558581 T3 ES 2558581T3
- Authority
- ES
- Spain
- Prior art keywords
- teicoplanin
- water
- solution
- ultrafiltration
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108010053950 Teicoplanin Proteins 0.000 title abstract 8
- DDTDNCYHLGRFBM-YZEKDTGTSA-N chembl2367892 Chemical compound CC(=O)N[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1O[C@@H]([C@H]1C(N[C@@H](C2=CC(O)=CC(O[C@@H]3[C@H]([C@H](O)[C@H](O)[C@@H](CO)O3)O)=C2C=2C(O)=CC=C(C=2)[C@@H](NC(=O)[C@@H]2NC(=O)[C@@H]3C=4C=C(O)C=C(C=4)OC=4C(O)=CC=C(C=4)[C@@H](N)C(=O)N[C@H](CC=4C=C(Cl)C(O5)=CC=4)C(=O)N3)C(=O)N1)C(O)=O)=O)C(C=C1Cl)=CC=C1OC1=C(O[C@H]3[C@H]([C@@H](O)[C@H](O)[C@H](CO)O3)NC(C)=O)C5=CC2=C1 DDTDNCYHLGRFBM-YZEKDTGTSA-N 0.000 title abstract 8
- 229960001608 teicoplanin Drugs 0.000 title abstract 8
- 238000000746 purification Methods 0.000 title 1
- 239000003960 organic solvent Substances 0.000 abstract 3
- 238000000108 ultra-filtration Methods 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 239000003610 charcoal Substances 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 239000012141 concentrate Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11188759 | 2011-11-11 | ||
| EP11188759.2A EP2592089A1 (en) | 2011-11-11 | 2011-11-11 | Process of purification of teicoplanin |
| PCT/EP2012/072279 WO2013068538A1 (en) | 2011-11-11 | 2012-11-09 | Process of purification of teicoplanin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2558581T3 true ES2558581T3 (es) | 2016-02-05 |
Family
ID=47148819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12784004.9T Active ES2558581T3 (es) | 2011-11-11 | 2012-11-09 | Procesos de purificación de teicoplanina |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP2592089A1 (enExample) |
| KR (1) | KR20140091739A (enExample) |
| CN (1) | CN104066747A (enExample) |
| DK (1) | DK2776452T3 (enExample) |
| ES (1) | ES2558581T3 (enExample) |
| HU (1) | HUE026335T2 (enExample) |
| IN (1) | IN2014KN01209A (enExample) |
| PL (1) | PL2776452T3 (enExample) |
| SI (1) | SI2776452T1 (enExample) |
| WO (1) | WO2013068538A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104231044B (zh) * | 2014-08-13 | 2017-03-22 | 甘肃汇能生物工程有限公司 | 那西肽过柱纯化工艺 |
| CN104371011A (zh) * | 2014-10-21 | 2015-02-25 | 福建省微生物研究所 | 高纯度替考拉宁精粉的纯化方法 |
| CN104910259A (zh) * | 2015-06-02 | 2015-09-16 | 苏州纳微科技有限公司 | 一种替考拉宁的层析纯化方法 |
| CN106589075B (zh) * | 2017-01-23 | 2020-05-05 | 福建省微生物研究所 | 一种替考拉宁的提纯方法 |
| CN109608523B (zh) * | 2018-11-23 | 2023-01-10 | 江苏九阳生物制药有限公司 | 一种高纯度替考拉宁的生产工艺 |
| CN113637050B (zh) * | 2021-09-15 | 2023-03-31 | 丽珠集团福州福兴医药有限公司 | 一种替考拉宁的脱色方法 |
| CN115260294B (zh) * | 2022-08-23 | 2025-09-02 | 北大方正集团有限公司 | 一种替考拉宁的分离纯化方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1496386A (en) | 1975-03-05 | 1977-12-30 | Lepetit Spa | Antibiotics |
| GB8608798D0 (en) | 1986-04-11 | 1986-05-14 | Lepetit Spa | Recovery of glycopeptide antibiotics from aqueous solutions |
| US4845194A (en) | 1987-02-27 | 1989-07-04 | Eli Lilly And Company | Glycopeptide recovery process |
| ES2076436T3 (es) | 1990-10-01 | 1995-11-01 | Lepetit Spa | Procedimiento de recuperacion de teicoplanina. |
| KR100321304B1 (ko) | 1999-04-16 | 2002-03-18 | 박호군 | 테이코플라닌의 정제방법 |
| KR100367890B1 (ko) | 2000-03-02 | 2003-01-14 | 은언기 | 랩핑/폴리싱 휠 및 그 제조방법 |
| KR20030017067A (ko) | 2001-08-23 | 2003-03-03 | 정용진 | 변이주 액티노플라네스 테이코마이세티커스 지안네시스 및이로부터 테이코플라닌을 생산하는 방법 |
| KR100459289B1 (ko) | 2002-05-30 | 2004-12-03 | 이연제약주식회사 | 발효액으로부터 테이코플라닌ａ₂의 회수방법 |
| KR100476818B1 (ko) | 2002-07-19 | 2005-03-17 | 종근당바이오 주식회사 | 테이코플라닌 에이 투 정제 방법 |
| KR100474653B1 (ko) * | 2004-04-16 | 2005-03-14 | 동국제약 주식회사 | 타이코플라닌의 고순도 생산방법 |
| CN101423547B (zh) * | 2007-10-31 | 2012-10-17 | 浙江医药股份有限公司新昌制药厂 | 替考拉宁的提纯方法 |
-
2011
- 2011-11-11 EP EP11188759.2A patent/EP2592089A1/en not_active Ceased
-
2012
- 2012-11-09 IN IN1209KON2014 patent/IN2014KN01209A/en unknown
- 2012-11-09 CN CN201280066349.4A patent/CN104066747A/zh active Pending
- 2012-11-09 EP EP12784004.9A patent/EP2776452B1/en active Active
- 2012-11-09 DK DK12784004.9T patent/DK2776452T3/en active
- 2012-11-09 ES ES12784004.9T patent/ES2558581T3/es active Active
- 2012-11-09 SI SI201230427T patent/SI2776452T1/sl unknown
- 2012-11-09 WO PCT/EP2012/072279 patent/WO2013068538A1/en not_active Ceased
- 2012-11-09 KR KR1020147015313A patent/KR20140091739A/ko not_active Ceased
- 2012-11-09 HU HUE12784004A patent/HUE026335T2/en unknown
- 2012-11-09 PL PL12784004T patent/PL2776452T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2776452T3 (pl) | 2016-03-31 |
| HUE026335T2 (en) | 2016-05-30 |
| EP2776452B1 (en) | 2015-10-07 |
| CN104066747A (zh) | 2014-09-24 |
| DK2776452T3 (en) | 2016-01-18 |
| EP2592089A1 (en) | 2013-05-15 |
| WO2013068538A1 (en) | 2013-05-16 |
| EP2776452A1 (en) | 2014-09-17 |
| IN2014KN01209A (enExample) | 2015-10-16 |
| SI2776452T1 (sl) | 2016-04-29 |
| KR20140091739A (ko) | 2014-07-22 |
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