ES2544942T3 - Células diferenciadas adecuadas para tratamiento humano - Google Patents
Células diferenciadas adecuadas para tratamiento humano Download PDFInfo
- Publication number
- ES2544942T3 ES2544942T3 ES01986488.3T ES01986488T ES2544942T3 ES 2544942 T3 ES2544942 T3 ES 2544942T3 ES 01986488 T ES01986488 T ES 01986488T ES 2544942 T3 ES2544942 T3 ES 2544942T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- cell
- differentiated cells
- cells suitable
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004027 cell Anatomy 0.000 abstract description 42
- 210000000130 stem cell Anatomy 0.000 abstract description 6
- 150000007523 nucleic acids Chemical class 0.000 abstract description 4
- 108020004707 nucleic acids Proteins 0.000 abstract description 3
- 102000039446 nucleic acids Human genes 0.000 abstract description 3
- 231100000518 lethal Toxicity 0.000 abstract 2
- 230000001665 lethal effect Effects 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000288906 Primates Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 description 8
- 102000040430 polynucleotide Human genes 0.000 description 8
- 239000002157 polynucleotide Substances 0.000 description 8
- 239000002243 precursor Substances 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000001010 compromised effect Effects 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000000877 morphologic effect Effects 0.000 description 3
- 210000002242 embryoid body Anatomy 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 210000003494 hepatocyte Anatomy 0.000 description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 108010017842 Telomerase Proteins 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 210000003061 neural cell Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000004248 oligodendroglia Anatomy 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 238000004114 suspension culture Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25335700P | 2000-11-27 | 2000-11-27 | |
| US25344300P | 2000-11-27 | 2000-11-27 | |
| US253357P | 2000-11-27 | ||
| US253443P | 2000-11-27 | ||
| US09/783,203 US6576464B2 (en) | 2000-11-27 | 2001-02-13 | Methods for providing differentiated stem cells |
| US783203 | 2001-02-13 | ||
| PCT/US2001/044309 WO2002042445A2 (en) | 2000-11-27 | 2001-11-26 | Differentiated cells suitable for human therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2544942T3 true ES2544942T3 (es) | 2015-09-07 |
Family
ID=27400669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01986488.3T Expired - Lifetime ES2544942T3 (es) | 2000-11-27 | 2001-11-26 | Células diferenciadas adecuadas para tratamiento humano |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6576464B2 (https=) |
| EP (1) | EP1337632B1 (https=) |
| JP (1) | JP2004523217A (https=) |
| KR (1) | KR20030081334A (https=) |
| CN (2) | CN101928692A (https=) |
| AU (2) | AU3768102A (https=) |
| CA (1) | CA2434760C (https=) |
| ES (1) | ES2544942T3 (https=) |
| GB (1) | GB2386120B (https=) |
| IL (2) | IL155695A0 (https=) |
| WO (1) | WO2002042445A2 (https=) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
| US7410798B2 (en) * | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| WO2001029206A1 (en) * | 1999-10-15 | 2001-04-26 | Advanced Cell Technology, Inc. | Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| US6576464B2 (en) * | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
| US6921665B2 (en) * | 2000-11-27 | 2005-07-26 | Roslin Institute (Edinburgh) | Selective antibody targeting of undifferentiated stem cells |
| US20030104426A1 (en) * | 2001-06-18 | 2003-06-05 | Linsley Peter S. | Signature genes in chronic myelogenous leukemia |
| EP1480992A4 (en) * | 2001-10-22 | 2007-02-07 | Univ Rochester | TELOMERASEINTERFERENZ |
| US9597395B2 (en) * | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US7595043B2 (en) | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
| US8404229B2 (en) | 2001-12-07 | 2013-03-26 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to treat acute tubular necrosis |
| US7514075B2 (en) | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
| US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| US7771716B2 (en) * | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| US7651684B2 (en) | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
| US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
| US20030153082A1 (en) | 2001-12-07 | 2003-08-14 | The John P. Robarts Research Institute | Hematopoietic cells from human embryonic stem cells |
| JP4653952B2 (ja) | 2001-12-07 | 2011-03-16 | サイトリ セラピューティクス インコーポレイテッド | 処理済み脂肪吸引細胞で患者を治療するためのシステムと方法 |
| US20050048035A1 (en) | 2001-12-07 | 2005-03-03 | Fraser John K. | Methods of using regenerative cells in the treatment of stroke and related diseases and disorders |
| US20030134422A1 (en) * | 2002-01-16 | 2003-07-17 | Sayre Chauncey Bigelow | Stem cell maturation for all tissue lines |
| US20050090004A1 (en) * | 2003-01-16 | 2005-04-28 | Sayre Chauncey B. | Stem cell maturation for all tissue lines |
| US20050170506A1 (en) * | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
| AU2003208580A1 (en) * | 2002-02-05 | 2003-09-02 | Technion Research And Development Foundation Ltd | Lineage committed stem cells selected for telomerase promoter activity |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| CA2488013A1 (en) * | 2002-05-30 | 2003-12-11 | Celgene Corporation | Methods of using jnk or mkk inhibitors to modulate cell differentiation and to treat myeloproliferative disorders and myelodysplastic syndromes |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US20050265983A1 (en) * | 2002-11-17 | 2005-12-01 | Eldad Melamed | Methods, nucleic acid constructs and cells for treating neurodegenerative disorders |
| US20050014116A1 (en) * | 2002-11-27 | 2005-01-20 | Reid Gregory S. | Testing information comprehension of contact center users |
| WO2004053084A2 (en) * | 2002-12-09 | 2004-06-24 | The Mclean Hospital Corporation | Dopaminergic neurons differentiated from embryonic cells for treating neurodegenerative diseases |
| ES2705683T3 (es) | 2002-12-16 | 2019-03-26 | Technion Res & Dev Foundation | Medio de cultivo de células madre pluripotentes |
| US20060211111A1 (en) * | 2002-12-18 | 2006-09-21 | Maisam Mitalipova | Compositions and methods for neural cell production and stabilization |
| US7153650B2 (en) | 2003-03-13 | 2006-12-26 | Geron Corporation | Marker system for preparing and characterizing high-quality human embryonic stem cells |
| WO2004104184A1 (ja) * | 2003-05-20 | 2004-12-02 | Riken | 内胚葉系幹細胞の調製 |
| US9321997B2 (en) | 2003-06-20 | 2016-04-26 | Axiogenesis Ag | Tissue modeling in embryonic stem (ES) cell system |
| AR046076A1 (es) * | 2003-07-18 | 2005-11-23 | Otsuka Pharma Co Ltd | Procedimiento para obtener una poblacion homogenea de celulas precursoras de oligodendrocitos y poblacion obtenida |
| US20050054100A1 (en) * | 2003-09-08 | 2005-03-10 | Rennard Stephen I. | Methods for fibroblast differentiation |
| US8304189B2 (en) | 2003-12-01 | 2012-11-06 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
| BRPI0507074A (pt) | 2004-01-23 | 2007-06-19 | Advanced Cell Tech Inc | modalidades aperfeiçoadas para o tratamento de doenças degenerativas da retina |
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| US20070264241A1 (en) * | 2004-02-25 | 2007-11-15 | Ekstrom Tomas J | Compounds for Enhanced Cancer Therapy |
| US20050277124A1 (en) * | 2004-06-10 | 2005-12-15 | White Steven M | Cardiac conduction system cells and uses thereof |
| WO2006014159A2 (en) * | 2004-07-01 | 2006-02-09 | Macropore Biosurgery Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| CA2583473A1 (en) * | 2004-10-05 | 2007-04-04 | University Of Georgia Research Foundation, Inc. | Neuronal progenitors from feeder-free human embryonic stem cell culture |
| US20060148080A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Methods for supporting and producing human cells and tissues in non-human mammal hosts |
| US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
| JP5006312B2 (ja) * | 2005-05-27 | 2012-08-22 | エイジェンシー フォー サイエンス, テクノロジー アンド リサーチ | バキュロウイルスベクターを使用して核酸分子を胚性幹細胞に送達する方法 |
| EP1893747B1 (en) | 2005-06-16 | 2014-09-03 | Ramot at Tel Aviv University Ltd. | Isolated cells and populations comprising same for the treatment of cns diseases |
| KR20160116024A (ko) * | 2005-06-22 | 2016-10-06 | 아스테리아스 바이오세라퓨틱스, 인크. | 인간 배아 줄기 세포의 현탁 배양 |
| WO2007026353A2 (en) | 2005-08-29 | 2007-03-08 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
| CN1966080B (zh) * | 2005-11-17 | 2011-06-08 | 李凌松 | 一种治疗老年痴呆症、帕金森病的神经干细胞注射液 |
| WO2007066338A1 (en) * | 2005-12-08 | 2007-06-14 | Ramot At Tel Aviv University Ltd. | Isolated oligodendrocyte-like cells and populations comprising same for the treatment of cns diseases |
| US20090304644A1 (en) * | 2006-05-30 | 2009-12-10 | Cytori Therapeutics, Inc. | Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue |
| US20100015104A1 (en) * | 2006-07-26 | 2010-01-21 | Cytori Therapeutics, Inc | Generation of adipose tissue and adipocytes |
| EP2059586B1 (en) | 2006-08-02 | 2016-07-20 | Technion Research & Development Foundation Ltd. | Methods of expanding embryonic stem cells in a suspension culture |
| US20080081370A1 (en) * | 2006-09-28 | 2008-04-03 | Peiman Hematti | Directed differentiation of human embryonic stem cells into mesenchymal/stromal cells |
| IL292561A (en) | 2007-10-12 | 2022-06-01 | Astellas Inst For Regenerative Medicine | Improved methods of rpe cell production and rpe cell preparations |
| US8501474B2 (en) * | 2007-10-15 | 2013-08-06 | Technion Research & Development Foundation Limited | Methods of generating embryoid bodies and uses of same |
| EP2620493B1 (en) | 2008-05-28 | 2019-03-27 | Ramot at Tel Aviv University Ltd. | Mesenchymal stem cells for the treatment of CNS diseases |
| WO2010021993A1 (en) | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
| US8735152B2 (en) * | 2009-03-30 | 2014-05-27 | Daiichi Sankyo Company, Limited | Methods for inducing cell death in pluripotent stem cells and differentiated cells other than cardiac myocytes |
| KR101738324B1 (ko) * | 2009-05-01 | 2017-05-19 | 비미니 테크놀로지스 엘엘씨 | 조직 및 세포 부유화 이식편의 최적화 시스템, 방법 및 조성물 |
| CN102803472B (zh) * | 2009-06-25 | 2014-04-23 | 吉隆公司 | 去除了外来表型的由多能干细胞分化的子代细胞 |
| EP3633025B1 (en) | 2009-11-12 | 2022-09-14 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| US10485829B2 (en) | 2009-11-17 | 2019-11-26 | Astellas Institute For Regenerative Medicine | Methods of producing human RPE cells and pharmaceutical preparations of human RPE cells |
| US9029145B2 (en) | 2010-04-08 | 2015-05-12 | The University Court Of The University Of Edinburgh | Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof |
| EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| WO2012133674A1 (ja) * | 2011-03-29 | 2012-10-04 | 国立大学法人 鹿児島大学 | 幹細胞における腫瘍化原因細胞の除去方法 |
| US10233424B2 (en) | 2011-12-22 | 2019-03-19 | Elwha Llc | Compositions and methods including cytotoxic B lymphocyte cell line expressing exogenous membrane immunoglobulin different from secreted immunoglobulin |
| US9175072B2 (en) | 2011-12-22 | 2015-11-03 | Elwha Llc | Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen |
| US8962315B2 (en) | 2011-12-22 | 2015-02-24 | Elwha Llc | Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen |
| US10745468B2 (en) | 2011-12-22 | 2020-08-18 | Kota Biotherapeutics, Llc | Compositions and methods for modified B cells expressing reassigned biological agents |
| US9879278B2 (en) | 2012-03-05 | 2018-01-30 | Wake Forest University Health Sciences | Non-viral episomal suicide construct |
| SG11201510177WA (en) | 2013-06-11 | 2016-01-28 | Harvard College | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
| JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| JP7034949B2 (ja) | 2016-05-25 | 2022-03-14 | テルモ ビーシーティー、インコーポレーテッド | 細胞の増殖 |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| WO2017214376A1 (en) | 2016-06-10 | 2017-12-14 | Elwha Llc | Compositions and methods including b lymphocyte cell line expressing membrane immunoglobulin different from secreted immunoglobulin and cytolytic function |
| KR102106895B1 (ko) * | 2017-02-16 | 2020-05-07 | 고려대학교 산학협력단 | 골재생 효능이 우수한 골질환 예방 또는 치료용 조성물 |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| EP3692139B1 (en) | 2017-10-03 | 2024-11-06 | SDF BioPharma Inc. | Treating diabetes with genetically modified beta cells |
| KR20250048146A (ko) | 2017-11-15 | 2025-04-07 | 셈마 테라퓨틱스, 인크. | 섬세포 제조 조성물 및 사용 방법 |
| WO2020033879A1 (en) | 2018-08-10 | 2020-02-13 | Semma Therapeutics, Inc. | Stem cell derived islet differentiation |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| CN119184024A (zh) * | 2024-08-27 | 2024-12-27 | 南京农业大学 | 一种提高动物早期胚胎定植数量和促进胚胎发育的方法 |
| CN119709646A (zh) * | 2024-09-14 | 2025-03-28 | 青岛阿尔泰基因工程有限公司 | 一种治疗颅咽管瘤的慢病毒及其制备方法和应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4959313A (en) | 1987-06-22 | 1990-09-25 | The Jackson Laboratory | Cellular enhancer for expressing genes in undifferentiated stem cells |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5068191A (en) * | 1989-08-31 | 1991-11-26 | The Biomembrane Institute | Purified histo-blood group a glycosyltransferase and antibodies thereto |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5639613A (en) | 1992-05-13 | 1997-06-17 | Board Of Regents, University Of Texas System | Methods for cancer diagnosis and prognosis |
| JPH08500245A (ja) | 1992-07-27 | 1996-01-16 | カリフォルニア インスティテュート オブ テクノロジー | 哺乳動物の多能性神経幹細胞 |
| US5928947A (en) | 1992-07-27 | 1999-07-27 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| US5766948A (en) | 1993-01-06 | 1998-06-16 | The Regents Of The University Of California | Method for production of neuroblasts |
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US5409813A (en) * | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US6015671A (en) * | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| US6204431B1 (en) * | 1994-03-09 | 2001-03-20 | Abbott Laboratories | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
| US5489304A (en) | 1994-04-19 | 1996-02-06 | Brigham & Women's Hospital | Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft |
| US5639618A (en) | 1994-05-13 | 1997-06-17 | Plurion, Inc. | Method of isolating a lineage specific stem cell in vitro |
| GB9417831D0 (en) | 1994-09-05 | 1994-10-26 | Biotech & Biolog Scien Res | Biological manipulation |
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| GB9505663D0 (en) | 1995-03-21 | 1995-05-10 | Stringer Bradley M J | Genetically modified neural cells |
| US6117985A (en) * | 1995-06-16 | 2000-09-12 | Stemcell Technologies Inc. | Antibody compositions for preparing enriched cell preparations |
| GB9526509D0 (en) | 1995-12-23 | 1996-02-28 | Univ Dundee | Gene control |
| GB9807935D0 (en) | 1998-04-14 | 1998-06-10 | Univ Edinburgh | Lineage specific cells and progenitor cells |
| WO1997032025A1 (en) | 1996-03-01 | 1997-09-04 | Regents Of The University Of Minnesota | Method for selective engraftment of drug-resistant hematopoietic stem cells |
| AU741438B2 (en) | 1996-08-26 | 2001-11-29 | Hemasure, Inc. | Method for removing tumor cells from tumor cell-contaminated stem cell products |
| EP0932686A2 (en) | 1996-10-01 | 1999-08-04 | Geron Corporation | Telomerase reverse transcriptase |
| GB9621383D0 (en) | 1996-10-14 | 1996-12-04 | Roslin Inst Edinburgh | Transgene expression |
| EP0991321A4 (en) | 1997-02-05 | 2002-01-30 | Gen Hospital Corp | TOLERANCE TO ANTIGENT NATURAL ANTIBODIES |
| AU6346898A (en) | 1997-03-06 | 1998-09-22 | University Of Massachusetts | Gene therapy using bone marrow transplants transfected with therapeutic genes under the control of tissue-specific promoters |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| DE19727962A1 (de) | 1997-07-02 | 1999-01-14 | Juergen Hescheler | Fluoreszierende Proteine als zelltypspezifische Reporter |
| AU9200298A (en) | 1997-08-22 | 1999-03-16 | Yale University | A process to study changes in gene expression in stem cells |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| US6482937B1 (en) | 1997-10-09 | 2002-11-19 | Biotransplant, Inc. | Porcine Oct-4 promoter |
| AU729377B2 (en) | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
| WO1999027076A1 (en) | 1997-11-25 | 1999-06-03 | Arc Genomic Research | Pluripotent embryonic stem cells and methods of obtaining them |
| DE19757984A1 (de) | 1997-12-24 | 1999-07-01 | Bayer Ag | Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung |
| JP2002505100A (ja) | 1998-03-02 | 2002-02-19 | ユニヴァーシティー オヴ マサチューセッツ アパブリック インスティテューション オヴ ハイアー エデュケイション オヴ ザ コモンウェルス オヴ マサチューセッツ リプレゼンティド バイイッツ アム | 種間核移植によって作製された胚性または幹細胞様細胞株 |
| GB9811859D0 (en) | 1998-06-02 | 1998-07-29 | Biotech & Biolog Scien Res | Biological manipulation |
| GB9819912D0 (en) | 1998-09-11 | 1998-11-04 | Univ Edinburgh | Propagation and/or derivation of embryonic stem cells |
| JP2003523166A (ja) | 1998-09-29 | 2003-08-05 | ガミダ セル リミテッド | 幹細胞および前駆細胞の増殖と分化を制御する方法 |
| US7410798B2 (en) * | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US6087168A (en) | 1999-01-20 | 2000-07-11 | Cedars Sinai Medical Center | Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells |
| CA2362367C (en) | 1999-02-04 | 2004-08-03 | Geron Corporation | Telomerase reverse transcriptase transcriptional regulatory sequences |
| EP2348104A1 (en) | 1999-08-05 | 2011-07-27 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
| US6458589B1 (en) * | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| JP5943533B2 (ja) * | 2000-05-17 | 2016-07-06 | アステリアス バイオセラピューティクス インコーポレイテッド | 神経前駆細胞の集団 |
| US6921665B2 (en) * | 2000-11-27 | 2005-07-26 | Roslin Institute (Edinburgh) | Selective antibody targeting of undifferentiated stem cells |
| EP1379624A2 (en) | 2000-11-27 | 2004-01-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Transfection of human embryonic stem cells |
| US6576464B2 (en) | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
-
2001
- 2001-02-13 US US09/783,203 patent/US6576464B2/en not_active Expired - Lifetime
- 2001-11-26 CN CN2009102249802A patent/CN101928692A/zh active Pending
- 2001-11-26 WO PCT/US2001/044309 patent/WO2002042445A2/en not_active Ceased
- 2001-11-26 GB GB0313389A patent/GB2386120B/en not_active Expired - Fee Related
- 2001-11-26 CA CA 2434760 patent/CA2434760C/en not_active Expired - Fee Related
- 2001-11-26 IL IL15569501A patent/IL155695A0/xx active IP Right Grant
- 2001-11-26 CN CNA018196470A patent/CN1478145A/zh active Pending
- 2001-11-26 KR KR10-2003-7007100A patent/KR20030081334A/ko not_active Withdrawn
- 2001-11-26 JP JP2002545150A patent/JP2004523217A/ja active Pending
- 2001-11-26 AU AU3768102A patent/AU3768102A/xx active Pending
- 2001-11-26 ES ES01986488.3T patent/ES2544942T3/es not_active Expired - Lifetime
- 2001-11-26 EP EP01986488.3A patent/EP1337632B1/en not_active Expired - Lifetime
- 2001-11-26 AU AU2002237681A patent/AU2002237681B2/en not_active Ceased
-
2002
- 2002-05-07 US US10/141,220 patent/US20030040111A1/en not_active Abandoned
-
2003
- 2003-04-30 IL IL155695A patent/IL155695A/en not_active IP Right Cessation
-
2006
- 2006-02-21 US US11/359,341 patent/US8426198B2/en not_active Expired - Fee Related
-
2013
- 2013-03-15 US US13/837,522 patent/US9023645B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB0313389D0 (en) | 2003-07-16 |
| CA2434760A1 (en) | 2002-05-30 |
| AU2002237681B2 (en) | 2007-03-22 |
| IL155695A (en) | 2007-10-31 |
| US20020098582A1 (en) | 2002-07-25 |
| KR20030081334A (ko) | 2003-10-17 |
| CA2434760C (en) | 2013-09-24 |
| US9023645B2 (en) | 2015-05-05 |
| US8426198B2 (en) | 2013-04-23 |
| EP1337632B1 (en) | 2015-05-20 |
| IL155695A0 (en) | 2003-11-23 |
| US20130273651A1 (en) | 2013-10-17 |
| WO2002042445A3 (en) | 2003-01-16 |
| EP1337632A2 (en) | 2003-08-27 |
| AU3768102A (en) | 2002-06-03 |
| CN101928692A (zh) | 2010-12-29 |
| GB2386120B (en) | 2005-03-09 |
| US20030040111A1 (en) | 2003-02-27 |
| GB2386120A (en) | 2003-09-10 |
| CN1478145A (zh) | 2004-02-25 |
| WO2002042445A2 (en) | 2002-05-30 |
| JP2004523217A (ja) | 2004-08-05 |
| US6576464B2 (en) | 2003-06-10 |
| US20060134782A1 (en) | 2006-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2544942T3 (es) | Células diferenciadas adecuadas para tratamiento humano | |
| Conti et al. | Neural stem cell systems: physiological players or in vitro entities? | |
| US12116594B2 (en) | Methods for differentiating cells | |
| DK2694644T3 (en) | Priming of pluripotent stem cells for neural differentiation | |
| Tada et al. | Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells | |
| EP3000877A1 (en) | Neural stem cells | |
| JP2008099662A (ja) | 幹細胞の培養方法 | |
| CN108350431A (zh) | 用于确定候选药物的功效特征的方法 | |
| JP2017525351A (ja) | 多能性幹細胞の培養用培地 | |
| EP2142641A2 (en) | Undifferentiated stem cell culture systems | |
| CN114174493A (zh) | 使用带电表面从诱导多能干细胞产生多个谱系的方法 | |
| CN110396499A (zh) | 一种诱导神经干细胞的方法及其应用 | |
| EP2721143A1 (en) | Growth of cells | |
| CN101563449A (zh) | 干细胞培养基及干细胞培养方法 | |
| CN101402943B (zh) | 一种体外诱导和培养多潜能干细胞的方法 | |
| CN113272422B (zh) | 用于无载体3d球体悬浮培养中视网膜神经元生成的方法和组合物 | |
| Zhang | Embryonic stem cells for neural replacement therapy: prospects and challenges | |
| Parsons | Human stem cell derivatives retain more open epigenomic landscape when derived from pluripotent cells than from tissues | |
| Jang et al. | Neural stem cells derived from epiblast stem cells display distinctive properties | |
| ES2351620T3 (es) | Procedimiento de preparación de células aviarias diferenciadas y genes implicados en el mantenimiento de la pluripotencia. | |
| Perugini et al. | Hyperbranched poly (ϵ-lysine) substrate presenting the laminin sequence YIGSR induces the formation of spheroids in adult bone marrow stem cells | |
| WO2023077050A1 (en) | Dopaminergic neurons comprising mutations and methods of use thereof | |
| Zheng et al. | Comparation of enhanced green fluorescent protein gene transfected and wild-type porcine neural stem cells | |
| CN102816796A (zh) | c-Jun的N端缺失诱导多能性干细胞的方法和应用 | |
| Kramer et al. | Chondrocytes derived from mouse embryonic stem cells |