ES2542514T3 - Uso de L. casei subsp. paracasei como anti-fúngico - Google Patents
Uso de L. casei subsp. paracasei como anti-fúngico Download PDFInfo
- Publication number
- ES2542514T3 ES2542514T3 ES08872207.9T ES08872207T ES2542514T3 ES 2542514 T3 ES2542514 T3 ES 2542514T3 ES 08872207 T ES08872207 T ES 08872207T ES 2542514 T3 ES2542514 T3 ES 2542514T3
- Authority
- ES
- Spain
- Prior art keywords
- paracasei
- fungal
- casei subsp
- casei
- actimel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 244000199866 Lactobacillus casei Species 0.000 title abstract description 8
- 230000000843 anti-fungal effect Effects 0.000 title abstract description 4
- 241000894006 Bacteria Species 0.000 abstract description 4
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 abstract description 4
- 235000014048 cultured milk product Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 7
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 2
- 102000014171 Milk Proteins Human genes 0.000 description 2
- 108010011756 Milk Proteins Proteins 0.000 description 2
- 241000031670 Saccharopolyspora thermophila Species 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 238000011483 antifungal activity assay Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/125—Casei
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
- C12R2001/245—Lactobacillus casei
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Dairy Products (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Uso de una bacteria de la especie L. casei subsp. paracasei para conferir propiedades anti-fúngicas a un producto lácteo fermentado, dicha bacteria de la especie L. casei subsp. paracasei que es una bacteria de la cepa CNCM I-1518.
Description
E08872207
14-07-2015
Los resultados de dos ensayos para cada una de las condiciones sometidas a ensayo se ilustran en la Tabla I siguiente.
5 TABLA I
- Diámetro del tallo después de la incubación (mm)
- Diámetro del tallo mm) después de 17 días a 10 ºC Diámetro del tallo después de 24 días a 10 ºC
- Ensayo 1 8 días a 25 ºC
- Ensayo 2 7 días a 25 ºC Ensayo 1 Ensayo 2 Ensayo 1 Ensayo 2
- Actimel® convencional (comercial)
- 17,6 ± 4,4 19,2 ± 4,8 9,6 ± 0,5 10 ± 0,9 10,9 ± 0,8 12,9 ± 1,8
- Actimel® sin L. casei
- > 65 > 65 > 65 > 65 > 65 > 65
- Mezcla láctea de Actimel® fermentada 24 h con L. casei en ausencia de S. thermophilus y L. bulgaricus
- 9,4 ± 1 8,8 ± 1 11,4 ± 1 15,1 ± 1,2 14,1 ± 0,9 17,2 ± 1,2
Los dos productos que contienen la cepa CNCM I-1518 (Actimel®; y la mezcla láctea de Actimel® fermentado 24 h con L. casei en ausencia de S. thermophilus y L. bulgaricus presentan actividad anti-fúngica, al contrario que el
10 producto que no la contiene (mezcla láctea de Actimel® sin L. casei).
EJEMPLO 2: CINÉTICA DE APARICIÓN DE ACTIVIDAD ANTI-FÚNGICA DURANTE LA FERMENTACIÓN POR
15 Se llevaron a cabo ensayo de actividad anti-fúngica sobre una mezcla (Mix) que consiste en leche desnatada suplementada con el 2% de glucosa y el 6% de proteínas de la leche (proteínas de leche desnatada convencionales), inoculada con 107 ufc/ml de la cepa CNCM I-1518 en forma liofilizada. Se tomaron muestras de mezcla antes y después de la inoculación con CNCM I-1518, y después de 15 h, 24 h, 48 h, y 72 h de fermentación. Antes de los ensayos de actividad anti-fúngica, las muestras tomadas y congeladas se irradiaron a 10 kG para
20 bloquear el crecimiento de las bacterias con el fin de impedir su desarrollo y su metabolismo durante la prueba. Las muestras de ensayo se descongelan antes de su uso y el pH de la muestra se ajustó a 6,2 (pH de la mezcla de partida). Los ensayos se realizaron tal como se describe en el Ejemplo 1 anterior.
Los resultados de estos ensayos (medición del diámetro del tallo) se dan en la Tabla II a continuación. Los términos
25 "Tallo sobre el disco" y "Agregados" se refieren a trazas de crecimiento de hongos observados solamente sobre el disco.
4
Claims (1)
-
imagen1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0708451A FR2924307B1 (fr) | 2007-12-04 | 2007-12-04 | Utilisation de l. casei ssp. paracasei comme antifongique |
| FR0708451 | 2007-12-04 | ||
| PCT/FR2008/001679 WO2009098411A2 (fr) | 2007-12-04 | 2008-12-03 | Utilisation de l. casei ssp. paracasei comme antifongique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2542514T3 true ES2542514T3 (es) | 2015-08-06 |
Family
ID=39590810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08872207.9T Active ES2542514T3 (es) | 2007-12-04 | 2008-12-03 | Uso de L. casei subsp. paracasei como anti-fúngico |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9439445B2 (es) |
| EP (1) | EP2242373B1 (es) |
| JP (1) | JP2011505162A (es) |
| CN (1) | CN101917861A (es) |
| AR (1) | AR069577A1 (es) |
| BR (1) | BRPI0819990A2 (es) |
| CA (1) | CA2708078A1 (es) |
| ES (1) | ES2542514T3 (es) |
| FR (1) | FR2924307B1 (es) |
| RU (1) | RU2505599C2 (es) |
| WO (1) | WO2009098411A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA028377B1 (ru) * | 2011-04-08 | 2017-11-30 | Кр. Хансен А/С | Противомикробная композиция |
| CN104284975B (zh) * | 2012-04-09 | 2016-08-24 | 科.汉森有限公司 | 应用鼠李糖乳杆菌菌株的生物保护 |
| EA034173B1 (ru) * | 2012-04-09 | 2020-01-14 | Кр. Хансен А/С | Противогрибковая композиция, содержащая штамм lactobacillus paracasei |
| CA2874421A1 (en) * | 2012-05-21 | 2013-11-28 | Dupont Nutrition Biosciences Aps | Strains of lactobacillus with antifungal properties |
| DK2777405T3 (en) * | 2013-03-13 | 2019-03-11 | Novozymes As | New Lactobacillus strains and uses thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3897307A (en) * | 1974-10-23 | 1975-07-29 | Hansens Lab Inc | Stabilized dry cultures of lactic acid-producing bacteria |
| CA1320165C (en) * | 1987-08-06 | 1993-07-13 | Microlife Technics, Inc. | Process for producing novel yeast and mold inhibiting products |
| FI92498C (fi) * | 1992-06-10 | 1994-11-25 | Valio Meijerien | Uusi mikro-organismikanta, sitä sisältävät bakteerivalmisteet ja näiden käyttö hiivojen ja homeiden torjuntaan |
| WO1996020607A1 (fr) * | 1995-01-02 | 1996-07-11 | Compagnie Gervais Danone | Ferment lactique, et son utilisation pour la preparation de produits anti-diarrheiques |
| AUPN907296A0 (en) * | 1996-04-02 | 1996-04-26 | Commonwealth Scientific And Industrial Research Organisation | Biocontrol agents for use in treatment of opportunistic infections |
| US6699517B2 (en) * | 1997-11-28 | 2004-03-02 | Compagnie Gervais Danone | Method for preparing food products by fermenting soy milk with streptococcus thermophilus |
| FR2775420B1 (fr) * | 1998-02-27 | 2000-05-05 | Texel | Composition pour l'aromatisation de fromages |
| US6399055B1 (en) * | 1998-10-27 | 2002-06-04 | Compagnie Gervais Danone | Method and composition for treatment of infant diarrhea |
| KR100753012B1 (ko) * | 1999-08-03 | 2007-08-30 | 가부시키가이샤 야쿠루트 혼샤 | 발효유 음식품 및 그의 제조방법 |
| DE60139167D1 (de) * | 2000-03-31 | 2009-08-13 | Centre Nat Rech Scient | Lactobacillus casei Mutanten mit einem Defekt in der Regulation des Kohlenstoffkatabolismus |
| RU2190015C1 (ru) * | 2001-04-27 | 2002-09-27 | Закрытое акционерное общество "Партнер" | Штамм lactobacillus brevis ba-13, используемый для приготовления пробиотических препаратов и продуктов питания |
| EP1308506A1 (en) * | 2001-11-06 | 2003-05-07 | Eidgenössische Technische Hochschule Zürich | Mixtures of Propionibacterium jensenii and Lactobacillus sp. with antimicrobial activities for use as a natural preservation system |
| KR100356672B1 (ko) * | 2001-12-27 | 2002-10-19 | 주식회사 바이로박트 | 신규한 락토바실러스 속 미생물 및 그 용도 |
| FR2863828B1 (fr) * | 2003-12-23 | 2007-02-02 | Gervais Danone Sa | Produit alimentaire liquide comprenant des granules de bacteries lactiques |
| JP4199685B2 (ja) * | 2004-03-04 | 2008-12-17 | 株式会社バイオバランス | 新規な乳酸菌 |
| WO2005104879A1 (ja) * | 2004-04-30 | 2005-11-10 | Kyowa Hakko Food Specialties Co., Ltd. | 飲食品の保存性向上方法 |
| EP2177229A3 (en) * | 2004-09-29 | 2010-11-03 | Asama Chemical Co., Ltd. | Functional composition or food comprising whey protein, antibody derived from milk or antibody |
| EP1683425A1 (en) * | 2005-01-21 | 2006-07-26 | Compagnie Gervais Danone | Use of a fermented milk containing L. Casei for the manufacture of a composition for the prevention or treatment of a delayed-type hypersensitivity reaction |
| ITMI20062451A1 (it) * | 2006-12-20 | 2008-06-21 | Mofin S R L | Metodo per la preparazione di un latte destinato ad applicazioni lattiero-casearie il latte ottenuto con detto metodo ed i suoi usi |
| EP2065048A1 (en) * | 2007-11-30 | 2009-06-03 | Institut Pasteur | Use of a L. casei strain, for the preparation of a composition for inhibiting mast cell activation |
| EP2153837A1 (en) * | 2008-08-14 | 2010-02-17 | Compagnie Gervais Danone | Compositions comprising Lactobacillus casei for improving resistance to common infectious diseases |
-
2007
- 2007-12-04 FR FR0708451A patent/FR2924307B1/fr not_active Expired - Fee Related
-
2008
- 2008-12-03 CN CN2008801239135A patent/CN101917861A/zh active Pending
- 2008-12-03 CA CA2708078A patent/CA2708078A1/fr not_active Abandoned
- 2008-12-03 WO PCT/FR2008/001679 patent/WO2009098411A2/fr active Application Filing
- 2008-12-03 EP EP08872207.9A patent/EP2242373B1/fr not_active Not-in-force
- 2008-12-03 RU RU2010127276/10A patent/RU2505599C2/ru not_active IP Right Cessation
- 2008-12-03 BR BRPI0819990-6A2A patent/BRPI0819990A2/pt not_active Application Discontinuation
- 2008-12-03 ES ES08872207.9T patent/ES2542514T3/es active Active
- 2008-12-03 JP JP2010536502A patent/JP2011505162A/ja active Pending
- 2008-12-03 US US12/746,125 patent/US9439445B2/en not_active Expired - Fee Related
- 2008-12-04 AR ARP080105293A patent/AR069577A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011505162A (ja) | 2011-02-24 |
| CN101917861A (zh) | 2010-12-15 |
| AR069577A1 (es) | 2010-02-03 |
| CA2708078A1 (fr) | 2009-08-13 |
| EP2242373A2 (fr) | 2010-10-27 |
| RU2505599C2 (ru) | 2014-01-27 |
| FR2924307A1 (fr) | 2009-06-05 |
| US20110045134A1 (en) | 2011-02-24 |
| EP2242373B1 (fr) | 2015-02-18 |
| WO2009098411A2 (fr) | 2009-08-13 |
| BRPI0819990A2 (pt) | 2014-10-07 |
| RU2010127276A (ru) | 2012-01-10 |
| FR2924307B1 (fr) | 2010-08-27 |
| US9439445B2 (en) | 2016-09-13 |
| WO2009098411A3 (fr) | 2009-10-29 |
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