ES2530872T3 - Organos y células modificados para xenotrasplante - Google Patents

Organos y células modificados para xenotrasplante Download PDF

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Publication number
ES2530872T3
ES2530872T3 ES02766869T ES02766869T ES2530872T3 ES 2530872 T3 ES2530872 T3 ES 2530872T3 ES 02766869 T ES02766869 T ES 02766869T ES 02766869 T ES02766869 T ES 02766869T ES 2530872 T3 ES2530872 T3 ES 2530872T3
Authority
ES
Spain
Prior art keywords
xenotransplantation
organs
cells modified
cells
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02766869T
Other languages
English (en)
Inventor
Alex Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RBC Biotechnology Inc
Original Assignee
RBC Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RBC Biotechnology Inc filed Critical RBC Biotechnology Inc
Application granted granted Critical
Publication of ES2530872T3 publication Critical patent/ES2530872T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un método para obtener un órgano, tejido o células porcinos modificados que son resistentes a rechazo mediado por anticuerpo preformado tras el trasplante a un ser humano, que comprende derivar las células, el tejido o el órgano de un cerdo que se ha modificado por ingeniería genética para evitar la expresión de CMP-ácido Nacetilneuramínico hidroxilasa y para evitar la expresión de α-1,3-galactosiltransferasa.
ES02766869T 2001-04-30 2002-04-29 Organos y células modificados para xenotrasplante Expired - Lifetime ES2530872T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28768401P 2001-04-30 2001-04-30
US30060401P 2001-06-22 2001-06-22
US33387601P 2001-11-28 2001-11-28
PCT/US2002/013564 WO2002088351A1 (en) 2001-04-30 2002-04-29 Modified organs and cells for xenotransplantation

Publications (1)

Publication Number Publication Date
ES2530872T3 true ES2530872T3 (es) 2015-03-06

Family

ID=27403740

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02766869T Expired - Lifetime ES2530872T3 (es) 2001-04-30 2002-04-29 Organos y células modificados para xenotrasplante

Country Status (7)

Country Link
US (3) US7166278B2 (es)
EP (1) EP1383889B1 (es)
JP (1) JP2004533242A (es)
AU (1) AU2002308533B2 (es)
CA (1) CA2445945A1 (es)
ES (1) ES2530872T3 (es)
WO (1) WO2002088351A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7368284B2 (en) 2003-06-06 2008-05-06 University Of Pittsburgh Porcine CMP-N-Acetylneuraminic acid hydroxylase gene
AU2004259019B2 (en) * 2003-07-21 2010-09-23 Lifecell Corporation Acellular tissue matrices made from galactose alpha-1,3-galactose-deficient tissue
NZ549953A (en) * 2004-03-17 2010-11-26 Revivicor Inc Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
JP2006129736A (ja) * 2004-11-02 2006-05-25 Nippon Dobutsu Kogaku Kenkyusho:Kk 異種移植用豚細胞、その選抜方法及び異種移植用豚
US20060147429A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
US20070010897A1 (en) * 2005-01-06 2007-01-11 Stone Kevin R Immunochemically modified and sterilized xenografts and allografts
WO2006133356A2 (en) * 2005-06-08 2006-12-14 The Regents Of The University Of California Elimination of n-glycolylneuraminic acid from mammalian products for human use
FI20055398A0 (fi) 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Menetelmä solupopulaatioiden evaluoimiseksi
FI20075030A0 (fi) 2007-01-18 2007-01-18 Suomen Punainen Risti Veripalv Menetelmä solujen modifioimiseksi
WO2009069986A2 (en) * 2007-11-30 2009-06-04 Korea Research Institute Of Bioscience And Biotechnology Genetically-modified cell line for producing cloned miniature pigs for xenotransplantation and method for preparing the same.
EP2166085A1 (en) 2008-07-16 2010-03-24 Suomen Punainen Risti Veripalvelu Divalent modified cells
EP2324110A4 (en) * 2008-09-09 2013-01-09 Univ California REMOVAL OF NON-HUMAN SIALIC ACID CONTAMINATED BY METABOLIC COMPETITION
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
KR101276801B1 (ko) * 2011-01-21 2013-06-19 한화엘앤씨 주식회사 ｓＴＮＦＲ1-Ｆｃ 유전자를 발현하는 형질전환 돼지 및 이의 용도
WO2013151649A1 (en) 2012-04-04 2013-10-10 Sialix Inc Glycan-interacting compounds
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
DK3065790T3 (da) 2013-11-04 2021-02-01 Lifecell Corp Fremgangsmåder til fjernelse af alpha-galactose
BR112017008251B1 (pt) 2014-10-22 2022-02-22 Indiana University Research And Technology Corporation Usos de um tecido de um porco transgênico que compreende um gene a(1,3) galactosiltransferase, cmah e ß4galnt2 interrompido e de um produto relacionado com a pele, e, métodos para preparação de um material de transplante para xenoenxerto, para produção de um composto de interesse e para produzir um reagente de cultura de células
EP3218005B1 (en) 2014-11-12 2023-01-04 Seagen Inc. Glycan-interacting compounds and methods of use
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
EP3229586A4 (en) 2014-12-10 2018-10-24 Regents of the University of Minnesota Genetically modified cells, tissues, and organs for treating disease
EP3373969A4 (en) 2015-11-12 2019-08-14 Siamab Therapeutics, Inc. GLYCANINTERAGING COMPOUNDS AND METHOD OF USE
EP3541847A4 (en) 2016-11-17 2020-07-08 Seattle Genetics, Inc. COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
EP3589319A4 (en) 2017-03-03 2021-07-14 Seagen Inc. COMPOUNDS INTERACTING WITH GLYCAN AND METHODS OF USE
CN116555353A (zh) 2017-04-20 2023-08-08 E开创生物技术股份有限公司 产生基因修改的动物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03255028A (ja) * 1990-03-01 1991-11-13 Imeeji Meekaa:Kk 免疫抑制剤
WO1992017189A1 (en) * 1991-03-29 1992-10-15 The Regents Of The University Of California Gangliosides with immunosuppressive activity
US6228631B1 (en) * 1992-10-22 2001-05-08 New York Blood Center, Inc. Recombinant α-N-acetylgalactosaminidase enzyme and cDNA encoding said enzyme
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
US6331658B1 (en) * 1993-04-20 2001-12-18 Integris Baptist Medical Center, Inc. Genetically engineered mammals for use as organ donors
WO1995020661A1 (en) 1994-01-27 1995-08-03 Bresatec Ltd. Materials and methods for management of hyperacute rejection in human xenotransplantation
US6166288A (en) 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
US6245890B1 (en) * 1999-03-26 2001-06-12 New York Blood Center, Inc. Porcine protein and uses thereof

Also Published As

Publication number Publication date
WO2002088351A1 (en) 2002-11-07
EP1383889B1 (en) 2014-11-19
US20030165480A1 (en) 2003-09-04
US20110301341A1 (en) 2011-12-08
US20070089178A1 (en) 2007-04-19
EP1383889A1 (en) 2004-01-28
JP2004533242A (ja) 2004-11-04
US8034330B2 (en) 2011-10-11
EP1383889A4 (en) 2005-01-26
CA2445945A1 (en) 2002-11-07
US7166278B2 (en) 2007-01-23
AU2002308533B2 (en) 2007-07-19

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