DE60140200D1 - Ex vivo verfahren und zusammensetzungen zur nukleinsäureverabreichung - Google Patents
Ex vivo verfahren und zusammensetzungen zur nukleinsäureverabreichungInfo
- Publication number
- DE60140200D1 DE60140200D1 DE60140200T DE60140200T DE60140200D1 DE 60140200 D1 DE60140200 D1 DE 60140200D1 DE 60140200 T DE60140200 T DE 60140200T DE 60140200 T DE60140200 T DE 60140200T DE 60140200 D1 DE60140200 D1 DE 60140200D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- methods
- administration
- vivo method
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000002378 acidificating effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 210000000056 organ Anatomy 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000008728 vascular permeability Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24023100P | 2000-10-13 | 2000-10-13 | |
PCT/US2001/032274 WO2002030470A1 (en) | 2000-10-13 | 2001-10-15 | Methods and compositions for nucleic acid delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60140200D1 true DE60140200D1 (de) | 2009-11-26 |
Family
ID=22905689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60140200T Expired - Lifetime DE60140200D1 (de) | 2000-10-13 | 2001-10-15 | Ex vivo verfahren und zusammensetzungen zur nukleinsäureverabreichung |
Country Status (8)
Country | Link |
---|---|
US (1) | US6992070B2 (de) |
EP (1) | EP1331950B1 (de) |
JP (1) | JP2004534719A (de) |
AT (1) | ATE445417T1 (de) |
AU (1) | AU2002214596A1 (de) |
CA (1) | CA2425835A1 (de) |
DE (1) | DE60140200D1 (de) |
WO (1) | WO2002030470A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8880701A (en) * | 2000-09-06 | 2002-03-22 | Univ Johns Hopkins | Cardiac arrhythmia treatment methods |
US20090175790A1 (en) * | 2000-09-06 | 2009-07-09 | The Johns Hopkins University | Cardiac arrhythmia treatment methods and biological pacemaker |
US6992070B2 (en) | 2000-10-13 | 2006-01-31 | The Johns Hopkins University | Methods and compositions for nucleic acid delivery |
IL158618A0 (en) * | 2001-04-27 | 2004-05-12 | Univ Johns Hopkins | Biological pacemaker |
US20080214437A1 (en) * | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
US8003618B2 (en) * | 2002-10-02 | 2011-08-23 | The John Hopkins University | Focal calcium channel modulation |
BR0314931A (pt) * | 2002-10-09 | 2005-08-02 | Pfizer Prod Inc | Composições estabilizadas de dna isolado |
US7488713B2 (en) * | 2004-03-18 | 2009-02-10 | University Of South Florida | Cancer treatment using C-type natriuretic peptides |
CA2559853A1 (en) * | 2004-02-17 | 2005-10-13 | University Of South Florida | Materials and methods for treatment of inflammatory and cell proliferation disorders |
US7722596B2 (en) * | 2004-02-26 | 2010-05-25 | Osprey Medical, Inc. | Regional cardiac tissue treatment |
US20070203445A1 (en) * | 2004-02-26 | 2007-08-30 | V-Kardia Pty Ltd | Isolating cardiac circulation |
US8759317B2 (en) | 2004-03-18 | 2014-06-24 | University Of South Florida | Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP) |
WO2006074443A2 (en) * | 2005-01-07 | 2006-07-13 | The Johns Hopkins University | Pde5 inhibitor compositions and methods for immunotherapy |
WO2006091542A2 (en) * | 2005-02-22 | 2006-08-31 | Cedars-Sinai Medical Center | Use of sildenafil, vardenafil and other 5-phosphodiesterase inhibitors to enhance permeability of the abnormal blood-brain barrier |
WO2006089340A2 (en) * | 2005-02-23 | 2006-08-31 | V-Kardia Pty Ltd | Polynucleotide delivery to cardiac tissue |
US20090304588A1 (en) * | 2005-10-14 | 2009-12-10 | The Johns Hopkins University | Biologically excitable cells |
US7825092B2 (en) * | 2006-08-08 | 2010-11-02 | University Of South Florida | Dendroaspis natriuretic peptide for treatment of cancer |
CA2663436A1 (en) * | 2006-10-04 | 2008-04-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
US8152786B2 (en) * | 2006-11-07 | 2012-04-10 | Osprey Medical, Inc. | Collection catheter and kit |
US20090047703A1 (en) * | 2007-08-17 | 2009-02-19 | University Of Maryland, Baltimore | ERG-1 Peptides and Polynucleotides and Their Use in the Treatment and Diagnosis of Disease |
AU2008350903B2 (en) | 2008-02-19 | 2015-04-02 | Celladon Corporation | Compositions for enhanced uptake of viral vectors in the myocardium |
US20100041984A1 (en) * | 2008-08-12 | 2010-02-18 | James Edward Shapland | Impedance sensing device and catheter system |
US9050400B2 (en) * | 2008-08-12 | 2015-06-09 | Osprey Medical, Inc. | Remote sensing catheter system and methods |
US9295816B2 (en) * | 2009-12-09 | 2016-03-29 | Osprey Medical, Inc. | Catheter with distal and proximal ports |
US10184942B2 (en) | 2011-03-17 | 2019-01-22 | University Of South Florida | Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer |
EP2741804B1 (de) | 2011-08-11 | 2017-04-26 | Osprey Medical Inc. | Systeme und verfahren zur behandlung der gliedmassen |
CN103920161A (zh) * | 2014-03-27 | 2014-07-16 | 浙江大学 | 一种在细胞膜微囊中高效装载药物的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516651A (en) * | 1991-11-15 | 1996-05-14 | The General Hospital Corporation | Nucleic acids encoding calcitonin receptor and uses thereof |
US6448235B1 (en) * | 1994-07-11 | 2002-09-10 | University Of Virginia Patent Foundation | Method for treating restenosis with A2A adenosine receptor agonists |
GB9423911D0 (en) * | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
US6376471B1 (en) * | 1997-10-10 | 2002-04-23 | Johns Hopkins University | Gene delivery compositions and methods |
US6237077B1 (en) | 1997-10-13 | 2001-05-22 | Idea Corporation | Instruction template for efficient processing clustered branch instructions |
EP1041882A4 (de) | 1997-12-19 | 2002-04-17 | Univ Pennsylvania | Transvaskuläre verabreichung einer zusammensetzung an ein extravaskuläres gewebe eines säugetieres |
US6214620B1 (en) * | 1998-09-29 | 2001-04-10 | The Johns Hopkins University | Inducible genetic suppression of cellular excitability |
US6992070B2 (en) | 2000-10-13 | 2006-01-31 | The Johns Hopkins University | Methods and compositions for nucleic acid delivery |
-
2001
- 2001-10-15 US US09/977,865 patent/US6992070B2/en not_active Expired - Lifetime
- 2001-10-15 WO PCT/US2001/032274 patent/WO2002030470A1/en active Application Filing
- 2001-10-15 AU AU2002214596A patent/AU2002214596A1/en not_active Abandoned
- 2001-10-15 JP JP2002533909A patent/JP2004534719A/ja active Pending
- 2001-10-15 AT AT01983146T patent/ATE445417T1/de not_active IP Right Cessation
- 2001-10-15 CA CA002425835A patent/CA2425835A1/en not_active Abandoned
- 2001-10-15 DE DE60140200T patent/DE60140200D1/de not_active Expired - Lifetime
- 2001-10-15 EP EP01983146A patent/EP1331950B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2425835A1 (en) | 2002-04-18 |
EP1331950A1 (de) | 2003-08-06 |
US20020094326A1 (en) | 2002-07-18 |
EP1331950B1 (de) | 2009-10-14 |
JP2004534719A (ja) | 2004-11-18 |
WO2002030470A9 (en) | 2003-02-06 |
AU2002214596A1 (en) | 2002-04-22 |
WO2002030470A1 (en) | 2002-04-18 |
US6992070B2 (en) | 2006-01-31 |
ATE445417T1 (de) | 2009-10-15 |
WO2002030470A8 (en) | 2004-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD., US |
|
R082 | Change of representative |
Ref document number: 1331950 Country of ref document: EP Representative=s name: PATENT- UND RECHTSANWAELTE KRAUS & WEISERT, 80539 |