ES2528032T3 - Inhibidores de Axl para su uso en terapia de combinación para prevenir, tratar o manejar cáncer metastásico - Google Patents

Inhibidores de Axl para su uso en terapia de combinación para prevenir, tratar o manejar cáncer metastásico Download PDF

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Publication number
ES2528032T3
ES2528032T3 ES10700686.8T ES10700686T ES2528032T3 ES 2528032 T3 ES2528032 T3 ES 2528032T3 ES 10700686 T ES10700686 T ES 10700686T ES 2528032 T3 ES2528032 T3 ES 2528032T3
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ES
Spain
Prior art keywords
optionally substituted
benzo
dihydro
cyclohepta
pyridazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10700686.8T
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English (en)
Spanish (es)
Inventor
Yasumichi Hitoshi
Sacha Holland
Donald G. Payan
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
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Publication of ES2528032T3 publication Critical patent/ES2528032T3/es
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES10700686.8T 2009-01-16 2010-01-15 Inhibidores de Axl para su uso en terapia de combinación para prevenir, tratar o manejar cáncer metastásico Active ES2528032T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14544809P 2009-01-16 2009-01-16
US145448P 2009-01-16
PCT/US2010/021275 WO2010083465A1 (en) 2009-01-16 2010-01-15 Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer

Publications (1)

Publication Number Publication Date
ES2528032T3 true ES2528032T3 (es) 2015-02-03

Family

ID=41683427

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10700686.8T Active ES2528032T3 (es) 2009-01-16 2010-01-15 Inhibidores de Axl para su uso en terapia de combinación para prevenir, tratar o manejar cáncer metastásico

Country Status (13)

Country Link
US (5) US8546433B2 (enExample)
EP (1) EP2387395B1 (enExample)
JP (2) JP5858789B2 (enExample)
CN (1) CN102281875B (enExample)
AU (1) AU2010204578B2 (enExample)
BR (1) BRPI1007046B1 (enExample)
CA (1) CA2749843C (enExample)
ES (1) ES2528032T3 (enExample)
PL (1) PL2387395T3 (enExample)
PT (1) PT2387395E (enExample)
RU (1) RU2555326C2 (enExample)
SG (1) SG172997A1 (enExample)
WO (1) WO2010083465A1 (enExample)

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Also Published As

Publication number Publication date
AU2010204578B2 (en) 2016-05-12
PT2387395E (pt) 2015-02-04
JP5858789B2 (ja) 2016-02-10
PL2387395T3 (pl) 2015-03-31
JP2015007135A (ja) 2015-01-15
BRPI1007046A2 (pt) 2015-07-21
RU2555326C2 (ru) 2015-07-10
US20170042891A1 (en) 2017-02-16
JP2012515225A (ja) 2012-07-05
RU2011132118A (ru) 2013-02-27
US8546433B2 (en) 2013-10-01
WO2010083465A1 (en) 2010-07-22
EP2387395A1 (en) 2011-11-23
US20210379064A1 (en) 2021-12-09
CA2749843A1 (en) 2011-07-22
CA2749843C (en) 2017-09-05
SG172997A1 (en) 2011-08-29
EP2387395B1 (en) 2014-10-15
CN102281875A (zh) 2011-12-14
HK1164146A1 (en) 2012-09-21
US20190336500A1 (en) 2019-11-07
BRPI1007046B1 (pt) 2019-07-16
AU2010204578A1 (en) 2011-07-28
US20130338161A1 (en) 2013-12-19
CN102281875B (zh) 2017-09-22
US20100196511A1 (en) 2010-08-05

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