ES2524699T3 - Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba - Google Patents
Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba Download PDFInfo
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- ES2524699T3 ES2524699T3 ES09756985.9T ES09756985T ES2524699T3 ES 2524699 T3 ES2524699 T3 ES 2524699T3 ES 09756985 T ES09756985 T ES 09756985T ES 2524699 T3 ES2524699 T3 ES 2524699T3
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| JP5694726B2 (ja) * | 2010-09-30 | 2015-04-01 | 富士フイルム株式会社 | 検査方法および装置 |
| KR20120132183A (ko) * | 2011-05-27 | 2012-12-05 | 포항공과대학교 산학협력단 | 종양 조직에서 유래한 나노소포체 및 이를 이용한 암 백신 |
| US20140112979A1 (en) * | 2011-07-04 | 2014-04-24 | Statens Serum Institut | Methods for producing liposomes |
| US20130039973A1 (en) * | 2011-08-03 | 2013-02-14 | Henry J. Smith | Viral Immunogenic Compositions |
| CN113876945A (zh) * | 2011-10-06 | 2022-01-04 | 免疫疫苗技术有限公司 | 包括激活或增加tlr2活性的佐剂的脂质体组合物及其应用 |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US10501513B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| KR101669142B1 (ko) * | 2012-10-10 | 2016-10-25 | 연세대학교 산학협력단 | 안약형 백신의 신규 아쥬반트 |
| AU2013384879B2 (en) * | 2013-03-27 | 2018-12-13 | Immunovaccine Technologies Inc. | Method for improving the efficacy of a survivin vaccine in the treatment of cancer |
| KR101501583B1 (ko) * | 2013-03-29 | 2015-03-12 | 주식회사 차백신연구소 | 리포펩티드 및 폴리(ｉ:ｃ)를 포함하는 아쥬반트 및 이를 이용한 개선된 제형의 백신 조성물 |
| WO2015035128A1 (en) * | 2013-09-06 | 2015-03-12 | Vaxin Inc. | Methods and compositions for viral vectored vaccines |
| CN107531736B (zh) | 2015-01-06 | 2022-04-15 | 免疫疫苗科技公司 | 脂质a模拟物、其制备方法和用途 |
| WO2016176761A1 (en) * | 2015-05-01 | 2016-11-10 | Immunovaccine Technologies Inc., | Methods for potentiating an immune response using depot-forming and non-depot-forming vaccines |
| JP6989134B2 (ja) | 2015-11-18 | 2022-01-05 | イミューノヴァクシーン テクノロジーズ インコーポレイテッドImmunovaccine Technologies Inc. | ポリｉ：ｃポリヌクレオチドアジュバント及び脂質系アジュバントを含むアジュバント系及び水を含まないワクチン組成物 |
| CA3019515A1 (en) | 2016-04-01 | 2017-10-05 | Colorado State University Research Foundation | Compositions and methods for enhanced innate immunity |
| EP3452083A4 (en) | 2016-05-04 | 2020-01-01 | ImmunoVaccine Technologies Inc. | VACCINE COMPOSITIONS COMPRISING AN AMPHIPATHIC COMPOUND, NEOANTIGEN AND HYDROPHOBIC SUPPORT, AND METHODS OF USE THEREOF |
| JP7140684B2 (ja) * | 2016-06-01 | 2022-09-21 | アクセス ツー アドバンスト ヘルス インスティチュート | サイジング剤含有ナノアラム粒子 |
| JP7125197B2 (ja) | 2016-09-27 | 2022-08-24 | イミューノヴァクシーン テクノロジーズ インコーポレイテッド | ヒト対象において抗体免疫応答を誘導するために低投与体積ｂ細胞エピトープ組成物を使用する方法 |
| CA3069019A1 (en) * | 2017-07-10 | 2019-01-17 | Immunovaccine Technologies Inc. | Pharmaceutical compositions, methods for preparation using lipid vesicle particles of defined size, and uses thereof |
| WO2019089410A1 (en) * | 2017-11-01 | 2019-05-09 | Merck Sharp & Dohme Corp. | Stable formulations of cytomegalovirus |
| EP3706713A4 (en) * | 2017-11-09 | 2021-06-16 | ImmunoVaccine Technologies Inc. | PHARMACEUTICAL COMPOSITIONS, METHOD OF MANUFACTURING THEREOF, INCLUDING SIZING OF LIPID VESICLE PARTICLES, AND USES |
| AU2019239785A1 (en) * | 2018-03-20 | 2020-10-08 | Immunovaccine Technologies Inc. | Methods and compositions for targeted delivery of active agents and immunomodulatory agents to lymph nodes |
| US10828351B2 (en) * | 2018-04-10 | 2020-11-10 | Ac Immune Sa | Anti-abeta therapeutic vaccines |
| CN112165956A (zh) * | 2018-04-10 | 2021-01-01 | Ac免疫有限公司 | 抗Aβ治疗性疫苗 |
| CN110917341A (zh) * | 2018-09-20 | 2020-03-27 | 天津贝罗尼生物科技有限公司 | 一种小鼠肿瘤疫苗及其制备方法 |
Family Cites Families (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3906092A (en) * | 1971-11-26 | 1975-09-16 | Merck & Co Inc | Stimulation of antibody response |
| GB2134869A (en) | 1983-02-15 | 1984-08-22 | Squibb & Sons Inc | Method of preparing liposomes and products produced thereby |
| US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
| US5897873A (en) * | 1984-04-12 | 1999-04-27 | The Liposome Company, Inc. | Affinity associated vaccine |
| US6090406A (en) * | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
| US5545412A (en) * | 1985-01-07 | 1996-08-13 | Syntex (U.S.A.) Inc. | N-[1, (1-1)-dialkyloxy]-and N-[1, (1-1)-dialkenyloxy]-alk-1-yl-n,n,n-tetrasubstituted ammonium lipids and uses therefor |
| US4806352A (en) * | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
| US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
| US4806350A (en) * | 1986-04-18 | 1989-02-21 | Norden Laboratories, Inc. | Vaccine formulation |
| US5084269A (en) * | 1986-11-06 | 1992-01-28 | Kullenberg Fred W | Adjuvant for dose treatment with antigens |
| US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US6093406A (en) * | 1988-06-02 | 2000-07-25 | The United States Of America As Represented By The Secretary Of The Army | Vaccine for induction of immunity to malaria |
| HU212924B (en) * | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| FR2649013B1 (fr) * | 1989-07-03 | 1991-10-25 | Seppic Sa | Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable |
| US5015476A (en) * | 1989-08-11 | 1991-05-14 | Paravax, Inc. | Immunization implant and method |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| IE904098A1 (en) * | 1989-11-13 | 1991-05-22 | Nova Pharm Corp | Lipospheres for controlled delivery of substances |
| US5091188A (en) | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| AU657907B2 (en) | 1990-05-29 | 1995-03-30 | Wyeth Holdings Corporation | Mycoplasma hyopneumoniae vaccine |
| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| FI925835L (fi) | 1990-06-29 | 1992-12-22 | Chiron Corp | Vacciner innehaollande liposomer |
| KR100252371B1 (ko) | 1990-12-12 | 2000-05-01 | 포터 더글라스 | 서브유니트 파필로마비루스 백신 및 그들에 사용하기 위한 펩티드 |
| CA2072249C (en) | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
| CZ28294A3 (en) | 1991-08-13 | 1994-05-18 | Biotech Australia Pty Ltd | Immunostimulation |
| US6037135A (en) * | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
| FI944052L (fi) | 1992-03-03 | 1994-09-02 | Daiichi Seiyaku Co | Oraalinen rokote |
| US5855894A (en) * | 1992-03-30 | 1999-01-05 | Pfizer Inc. | Pasteurella haemolytica type A-1 bacterin-toxoid vaccine |
| WO1993025231A1 (en) | 1992-06-05 | 1993-12-23 | Dalhousie University | Use of zona pellucida glycoproteins for immunocontraception |
| US5736141A (en) * | 1992-06-05 | 1998-04-07 | Dalhousie University | Method to prevent fertilization in mammals by administering a single dose of zona pellucida derived antigens, liposome and Freund's adjuvant |
| USRE37224E1 (en) | 1992-06-05 | 2001-06-12 | Dalhousie University | Method to prevent fertilization in mammals by administering a single dose of zona pellucida derived antigens, liposome and adjuvant |
| SI9300468A (en) * | 1992-10-14 | 1994-06-30 | Hoffmann La Roche | Injectable composition for the sustained release of biologically active compounds |
| US5820879A (en) * | 1993-02-12 | 1998-10-13 | Access Pharmaceuticals, Inc. | Method of delivering a lipid-coated condensed-phase microparticle composition |
| JPH06247842A (ja) * | 1993-02-23 | 1994-09-06 | Green Cross Corp:The | リポソーム組成物の製造方法 |
| EP0721341A4 (en) | 1993-08-06 | 1998-04-22 | Cytel Corp | CLONING AND DESCRIPTION OF FULL MAGE-1 GENE CHARACTERISTICS |
| US20050049197A1 (en) | 1993-09-14 | 2005-03-03 | Epimmune Inc. | Induction of immune response against desired determinants |
| JP3836874B2 (ja) | 1994-02-24 | 2006-10-25 | ノババックス インコーポレイテッド | 免疫アジュバントとして少ラメラ脂質小胞を含むワクチン |
| US5874560A (en) | 1994-04-22 | 1999-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Melanoma antigens and their use in diagnostic and therapeutic methods |
| WO1995031480A1 (en) | 1994-05-18 | 1995-11-23 | S.P.I. Synthetic Peptides Incorporated | Heterodimer polypeptide immunogen carrier composition and method |
| WO1995033835A1 (en) | 1994-06-02 | 1995-12-14 | Chiron Corporation | Nucleic acid immunization using a virus-based infection/transfection system |
| US5688772A (en) | 1994-08-01 | 1997-11-18 | University Of Saskatchewan | Quinoa saponin compositions and methods of use |
| US5637300A (en) * | 1994-08-03 | 1997-06-10 | Dunbar; Bonnie S. | Contraceptive vaccine comprising a glycosylated 55 kD zona pellucida protein immunogen and method of use of the same in contraception |
| US6355256B1 (en) | 1994-09-30 | 2002-03-12 | Ludwig Institute For Cancer Research | Compositions containing a p53 derived protein or peptide, an adjuvant, and interleukin-12 and uses thereof |
| FR2726764B1 (fr) * | 1994-11-14 | 1997-01-31 | Pasteur Merieux Serums Vacc | Adjuvant pour composition vaccinale |
| GB9422990D0 (en) | 1994-11-15 | 1995-01-04 | Cortecs Ltd | Immunogenic compositions |
| FR2732895B1 (fr) * | 1995-04-11 | 1997-05-16 | Pasteur Merieux Serums Vacc | Utilisation d'un compose amphipathique cationique comme agent de transfection, comme adjuvant de vaccin, ou comme medicament |
| US6846489B1 (en) * | 1995-04-25 | 2005-01-25 | Smithkline Beecham Biologicals S.A. | Vaccines containing a saponin and a sterol |
| US5705151A (en) * | 1995-05-18 | 1998-01-06 | National Jewish Center For Immunology & Respiratory Medicine | Gene therapy for T cell regulation |
| AU6330896A (en) * | 1995-06-07 | 1996-12-30 | Governors Of The University Of Alberta, The | A method for eliciting a th1-specific immune response |
| JP3098401B2 (ja) * | 1995-07-12 | 2000-10-16 | 株式会社エルティーティー研究所 | 経鼻投与用製剤 |
| TW389919B (en) * | 1995-09-27 | 2000-05-11 | Hitachi Ltd | Insulated type switching device |
| US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| US6096313A (en) * | 1996-02-09 | 2000-08-01 | Ludwig Institute For Cancer Research | Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant |
| US7019112B1 (en) * | 1996-03-19 | 2006-03-28 | University Of Virginia Patent Foundation | Peptides recognized by melanoma-specific A1-, A2- and A3-restricted cytoxic lymphocytes, and uses therefor |
| US6214367B1 (en) * | 1996-06-05 | 2001-04-10 | Ashmont Holdings Limited | Injectable compositions |
| US5919480A (en) * | 1996-06-24 | 1999-07-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal influenza vaccine composition and method |
| US6284267B1 (en) * | 1996-08-14 | 2001-09-04 | Nutrimed Biotech | Amphiphilic materials and liposome formulations thereof |
| US5910306A (en) * | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
| US20060002949A1 (en) * | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| CA2203843C (en) * | 1997-04-28 | 2013-07-23 | Her Majesty The Queen, In Right Of Canada, As Represented By The Ministe R Of National Defence | Liposome-encapsulated poly iclc |
| US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| WO1998053799A2 (en) | 1997-05-28 | 1998-12-03 | Jenner Biotherapies, Inc. | Immunogenic compositions |
| US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
| EP1015468A4 (en) * | 1997-08-29 | 2000-09-06 | Human Genome Sciences Inc | FOLLISTATINE-3 |
| GB9718901D0 (en) * | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
| US6291430B1 (en) * | 1997-09-12 | 2001-09-18 | Ludwig Institute For Cancer Research | Mage-3 peptides presented by HLA class II molecules |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6183746B1 (en) * | 1997-10-09 | 2001-02-06 | Zycos Inc. | Immunogenic peptides from the HPV E7 protein |
| AUPP060097A0 (en) * | 1997-11-28 | 1998-01-08 | Commonwealth Scientific And Industrial Research Organisation | Adjuvant system for enhanced response |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| WO1999030737A1 (en) * | 1997-12-16 | 1999-06-24 | Chiron Corporation | Use of microparticles combined with submicron oil-in-water emulsions |
| ES2284247T3 (es) | 1998-04-03 | 2007-11-01 | University Of Iowa Research Foundation | Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos. |
| US6588671B2 (en) | 1998-04-09 | 2003-07-08 | Dcard, Inc. | Positioning of a recording head for a data storage device |
| SE9801288D0 (sv) * | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
| US6472375B1 (en) * | 1998-04-16 | 2002-10-29 | John Wayne Cancer Institute | DNA vaccine and methods for its use |
| US6632447B1 (en) | 1998-05-07 | 2003-10-14 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| JP2002513773A (ja) | 1998-05-07 | 2002-05-14 | コリクサ コーポレイション | アジュバント組成物及びその使用法 |
| GB9810236D0 (en) * | 1998-05-13 | 1998-07-08 | Microbiological Res Authority | Improvements relating to encapsulation of bioactive agents |
| US6406719B1 (en) * | 1998-05-13 | 2002-06-18 | Microbiological Research Authority | Encapsulation of bioactive agents |
| ATE480566T1 (de) * | 1998-06-15 | 2010-09-15 | Quest Pharmatech Inc | Immuntherapeutische zusammensetzung und verfahren zur behandlung von prostatakrebs |
| WO2000000178A1 (en) * | 1998-06-30 | 2000-01-06 | Rohto Pharmaceutical Co., Ltd. | Compositions containing liposomes and/or emulsions and process for the preparation thereof |
| FR2781160B1 (fr) * | 1998-07-03 | 2000-08-18 | Pasteur Merieux Serums Vacc | Utilisation d'un compose amphipathique pour adjuver un vaccin sous-unitaire |
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| US7087236B1 (en) * | 1998-09-01 | 2006-08-08 | Merrion Research I Limited | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof |
| US20050084524A1 (en) * | 1998-09-30 | 2005-04-21 | Alza Corporation | Method for potentiating activity of a chemotherapeutic drug |
| US6787154B2 (en) * | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
| GB2345010B (en) * | 1998-12-17 | 2002-12-31 | Electrosols Ltd | A delivery device |
| CA2356452A1 (en) | 1998-12-22 | 2000-06-29 | Robert Brown | Compositions and methods for reducing or preventing fertilization in fish and birds |
| US6790457B1 (en) * | 1998-12-22 | 2004-09-14 | Dalhousie University | Compositions and methods for reducing or preventing fertilization in fish and birds |
| AU769539B2 (en) * | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
| US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| TR200103018T2 (tr) * | 1999-04-19 | 2002-02-21 | Beecham Biologicals S.A. Smithkline | İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri. |
| CZ20013916A3 (cs) | 1999-05-13 | 2002-06-12 | American Cyanamid Company | Adjuvantní kombinované prostředky |
| WO2000071671A2 (en) | 1999-05-26 | 2000-11-30 | New York University | New mutant genes in familial british dementia and familial danish dementia |
| EP1189597A4 (en) | 1999-06-04 | 2008-06-18 | Pacira Pharmaceuticals Inc | COMPOSITIONS USING AN OIL CORE FOR DELAYED RELEASE HYDROPHOLE MEDICAMENTS |
| GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
| JP2003511420A (ja) | 1999-10-13 | 2003-03-25 | カイロン コーポレイション | タンパク質から細胞性免疫応答を得る方法 |
| US6605696B1 (en) * | 1999-10-22 | 2003-08-12 | Pfizer, Inc. | Lawsonia intracellularis proteins, and related methods and materials |
| US6511676B1 (en) * | 1999-11-05 | 2003-01-28 | Teni Boulikas | Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes |
| US7026443B1 (en) | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| US6248353B1 (en) | 1999-12-10 | 2001-06-19 | Dade Behring Inc. | Reconstitution of purified membrane proteins into preformed liposomes |
| US6602510B1 (en) | 2000-04-05 | 2003-08-05 | Epimmune Inc. | HLA class I A2 tumor associated antigen peptides and vaccine compositions |
| US6228648B1 (en) | 2000-03-17 | 2001-05-08 | Isis Pharmaceuticals, Inc. | Antisense modulation of ADAM10 expression |
| AU2001245823A1 (en) | 2000-03-17 | 2001-10-03 | Corixa Corporation | Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors |
| AU6669401A (en) | 2000-06-02 | 2001-12-11 | Univ Connecticut Health Ct | Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy |
| AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| AU1486102A (en) * | 2000-11-07 | 2002-05-21 | Immunovaccine Technologies Inc | Vaccines with enhanced immune response and methods for their preparation |
| EP1343476B1 (en) | 2000-12-01 | 2008-05-28 | Biomira Inc. | Preparation of large liposomes by infusion into peg |
| WO2002070006A2 (en) | 2000-12-08 | 2002-09-12 | Academisch Ziekenhuis Leiden | Long peptides of 22-45 amino acid residues that induce and/or enhance antigen specific immune responses |
| US20030045467A1 (en) * | 2001-01-05 | 2003-03-06 | Tihamer Orban | Autoantigen composition |
| US6497896B2 (en) | 2001-02-12 | 2002-12-24 | Supergen, Inc. | Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin |
| CN1168740C (zh) * | 2001-04-04 | 2004-09-29 | 上海美恩生物技术有限公司 | 细胞因子基因修饰的抗原提呈细胞/肿瘤细胞偶联物、其制法和用途 |
| US6676958B2 (en) * | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
| US20050037061A1 (en) * | 2001-07-25 | 2005-02-17 | Saiko Hosokawa | Remedies for mammary cancer |
| CA2454750C (en) * | 2001-07-31 | 2012-09-18 | David M. Koelle | Immunologically significant herpes simplex virus antigens and methods for using same |
| GB0127564D0 (en) | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
| US6517816B1 (en) | 2001-12-26 | 2003-02-11 | Avon Products, Inc. | Sunscreen emulsion composition and method of use |
| WO2003066680A2 (en) | 2002-02-08 | 2003-08-14 | Immunovaccine Technologies Inc. | Antigens for immunocontraception |
| US7056515B2 (en) * | 2002-02-08 | 2006-06-06 | Immunovaccine Technologies Inc. | Antigens for immunocontraception |
| US20030220284A1 (en) | 2002-02-22 | 2003-11-27 | Patricia Yotnda | Delivery of adenoviral DNA in a liposomal formulation for treatment of disease |
| JP2005535627A (ja) | 2002-06-25 | 2005-11-24 | シティ・オブ・ホープ | アジュバント不含ペプチド・ワクチン |
| US20040213837A1 (en) | 2002-08-05 | 2004-10-28 | Sankaram Mantripragada | Oil-core compositions for the sustained release of hydrophobic drugs |
| WO2004017944A1 (en) | 2002-08-23 | 2004-03-04 | Neopharm, Inc. | Liposomal gemcitabine compositions for better drug delivery |
| EP1393720A1 (en) * | 2002-08-27 | 2004-03-03 | Universiteit Utrecht | Vesicle-encapsulated corticosteroids for treatment of cancer |
| US7179645B2 (en) | 2002-09-24 | 2007-02-20 | Antigen Express, Inc. | Ii-Key/antigenic epitope hybrid peptide vaccines |
| DE10249401A1 (de) | 2002-10-23 | 2004-05-13 | Bernina Biosystems Gmbh | Liposomen formende Zusammensetzung |
| US20050158375A1 (en) * | 2002-11-15 | 2005-07-21 | Toshikiro Kimura | Pharmaceutical composition containing liposomes for treating cancer |
| AU2003296330A1 (en) | 2002-12-10 | 2004-06-30 | Epimmune Inc. | Hla-a1, a2 -a3,-a24,-b7,and -b44 tumor associated antigen peptides and compositions |
| PT1575977E (pt) | 2002-12-23 | 2009-12-15 | Dynavax Tech Corp | Oligonucleótidos de sequência imunoestimuladora e métodos de utilização dos mesmos |
| WO2004060396A2 (en) | 2002-12-27 | 2004-07-22 | Chiron Corporation | Immunogenic compositions containing phospholpid |
| US20040223977A1 (en) | 2003-02-03 | 2004-11-11 | City Of Hope | Fusion peptide HIV vaccines |
| BRPI0407415A (pt) | 2003-02-11 | 2006-01-10 | Neopharm Inc | Método de fabricar um preparado lipossÈmico |
| JP2007524380A (ja) * | 2003-04-02 | 2007-08-30 | ボード オブ リージェンツ ザ ユニバーティー オブ テキサス システム | 抗腫瘍効果をもつＢｉｋ変異型 |
| CA2521051C (en) | 2003-04-04 | 2012-03-20 | Pfizer Products Inc. | Microfluidized oil-in-water emulsions and vaccine compositions |
| ES2456666T3 (es) | 2003-04-18 | 2014-04-23 | Biotech Synergy, Inc. | Péptidos antígenos HLA-A2 asociados a un tumor y composiciones |
| WO2005000272A1 (en) * | 2003-06-04 | 2005-01-06 | Isis Pharmaceuticals, Inc. | Long-circulating liposomal compositions |
| US20050013812A1 (en) * | 2003-07-14 | 2005-01-20 | Dow Steven W. | Vaccines using pattern recognition receptor-ligand:lipid complexes |
| EP1660636A4 (en) | 2003-08-26 | 2009-07-01 | Univ Texas | VACCINES AGAINST CANCER |
| US20050220781A1 (en) | 2003-09-04 | 2005-10-06 | Duen-Hwa Yan | IFIX, a novel HIN-200 protein, for cancer therapy |
| GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| GB0323965D0 (en) * | 2003-10-13 | 2003-11-19 | Glaxosmithkline Biolog Sa | Immunogenic compositions |
| US20050266066A1 (en) | 2003-10-20 | 2005-12-01 | Nof Corporation | Phospholipid membrane preparation |
| EP1677765A1 (en) * | 2003-10-24 | 2006-07-12 | Alza Corporation | Preparation of lipid particles |
| ATE434431T1 (de) * | 2003-11-14 | 2009-07-15 | Het Nl Kanker I The Netherland | Pharmazeutische formulierungen mit kurzketten- sphingolipiden und ihre verwendung |
| EP1550458A1 (en) | 2003-12-23 | 2005-07-06 | Vectron Therapeutics AG | Synergistic liposomal adjuvants |
| AU2005222776A1 (en) | 2003-12-31 | 2005-09-29 | Genimmune N.V. | Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions |
| JP2007522119A (ja) | 2004-01-28 | 2007-08-09 | キュリックス エーピーエス | アミロイド関連疾患用ワクチンとしてのアミロイドタンパク質のコンジュゲート |
| DK1737966T3 (da) | 2004-04-02 | 2012-07-09 | Univ Texas | Cancerspecifik promotorer |
| UA89631C2 (en) | 2004-04-05 | 2010-02-25 | Пфайзер Продактс Инк. | Vaccine composition |
| GB0408164D0 (en) * | 2004-04-13 | 2004-05-19 | Immune Targeting Systems Ltd | Antigen delivery vectors and constructs |
| US20050232981A1 (en) * | 2004-04-15 | 2005-10-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
| CA2566559C (en) * | 2004-05-17 | 2014-05-06 | Inex Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
| WO2006050155A2 (en) * | 2004-10-29 | 2006-05-11 | Biomune, Inc. | Cancer therapeutic compositions |
| US8337815B2 (en) | 2004-12-23 | 2012-12-25 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations |
| EP2351576A1 (en) | 2004-12-29 | 2011-08-03 | Mannkind Corporation | Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs |
| US8895717B2 (en) | 2005-04-15 | 2014-11-25 | The Board Of Regents Of The University Of Texas System | Delivery of siRNA by neutral lipid compositions |
| US20060275777A1 (en) | 2005-06-03 | 2006-12-07 | Waelti Ernst R | Novel strategies for protein vaccines |
| US8703095B2 (en) * | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| WO2007022152A2 (en) * | 2005-08-15 | 2007-02-22 | The Research Foundation Of State University Of New York | Lipid nano particulates containing antigens as cancer vaccines |
| CA2523032A1 (en) | 2005-10-07 | 2007-04-07 | Immunovaccine Technologies Inc. | Vaccines for cancer therapy |
| AU2006322073A1 (en) * | 2005-12-07 | 2007-06-14 | Hemispherx Biopharma, Inc. | dsRNAs as influenza virus vaccine adjuvants or immuno-stimulants |
| PL3017827T3 (pl) | 2005-12-22 | 2019-04-30 | Glaxosmithkline Biologicals Sa | Szczepionka z koniugatem polisacharydu pneumokokowego |
| ES2356574T3 (es) * | 2006-02-24 | 2011-04-11 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Péptidos inmunogénicos y métodos de uso. |
| CA2643322C (en) * | 2006-02-24 | 2015-07-21 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| EP1994409A2 (en) * | 2006-03-14 | 2008-11-26 | Oregon Health and Science University | Methods for producing an immune response to tuberculosis |
| WO2007117469A2 (en) | 2006-03-30 | 2007-10-18 | The Research Foundation Of State University Of New York | Compositions of less immunogenic and long-circulating protein-lipid complexes |
| RU2490024C2 (ru) * | 2006-06-28 | 2013-08-20 | Статенс Серум Инститьют | Расширение спектра т клеток для включения субдоминантных эпитопов путем вакцинации с антигенами, доставленными как белковые фрагменты или пептидные коктейли |
| US20080014217A1 (en) * | 2006-07-17 | 2008-01-17 | Emmanuel Jules Hanon | Influenza vaccine |
| US8877206B2 (en) * | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| EP2197497B1 (en) | 2007-09-27 | 2016-06-01 | ImmunoVaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
| CA2700828C (en) | 2007-10-03 | 2017-01-24 | Immunovaccine Technologies Inc. | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
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- 2009-05-22 JP JP2011511943A patent/JP5715051B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0913612A2 (pt) | 2015-11-24 |
| AU2009253780A1 (en) | 2009-12-10 |
| US20190290743A1 (en) | 2019-09-26 |
| CN102056622B (zh) | 2016-04-06 |
| JP2011523653A (ja) | 2011-08-18 |
| JP6448676B2 (ja) | 2019-01-09 |
| JP5715051B2 (ja) | 2015-05-07 |
| BRPI0913612B8 (pt) | 2021-05-25 |
| JP2017128576A (ja) | 2017-07-27 |
| EP2296696A4 (en) | 2012-04-04 |
| EP2296696B1 (en) | 2014-08-27 |
| JP2015096505A (ja) | 2015-05-21 |
| CN102056622A (zh) | 2011-05-11 |
| IL209775A0 (en) | 2011-02-28 |
| JP6143731B2 (ja) | 2017-06-07 |
| US11717563B2 (en) | 2023-08-08 |
| AU2009253780B2 (en) | 2014-08-14 |
| CA2723918C (en) | 2018-01-09 |
| CA2723918A1 (en) | 2009-12-10 |
| EP2296696A1 (en) | 2011-03-23 |
| US20110070298A1 (en) | 2011-03-24 |
| WO2009146523A1 (en) | 2009-12-10 |
| HK1155642A1 (en) | 2012-05-25 |
| IL209775B (en) | 2018-04-30 |
| BRPI0913612B1 (pt) | 2020-12-22 |
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